Journal
EXPERIMENTAL DERMATOLOGY
Volume 27, Issue 2, Pages 178-184Publisher
WILEY
DOI: 10.1111/exd.13484
Keywords
caspase-1; hyperlipidaemia; IL-1beta; Inflammasome; psoriasis
Categories
Funding
- Naito Foundation Research Grant
- [16K10130]
- [26293130]
- [16H05229]
- [15K15196]
- [15K15197]
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Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis; inflammasomes are activated by adipose tissue macrophages in obese subjects. We hypothesized that hyperlipidaemia is involved in the pathogenesis of psoriasis and examined the role of a high-fat diet (HFD) in the development of psoriasis in imiquimod (IMQ)-treated mice. The body weight and serum level of cholesterol were significantly higher in mice fed an HFD than in a regular diet (RD). HFD mice had higher psoriasis skin scores, and the number of neutrophils infiltrating into the lesional skin was elevated. IL-17A mRNA expression was significantly increased in the skin of IMQ-treated HFD mice; the expression of IL-22, IL-23 and TNF- mRNA was not enhanced. Caspase-1 and IL-1 were activated in the skin of IMQ-treated HFD mice, and their serum level of IL-17A, TNF- and IL-1 was significantly upregulated. Our findings strongly suggest that hyperlipidaemia is involved in the development and progression of psoriasis via systemic inflammation and inflammasome activation.
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