Article
Biochemistry & Molecular Biology
Belen Sanz-Castillo, Begona Hurtado, Diana Vara-Ciruelos, Aicha El Bakkali, Dario Hermida, Beatriz Salvador-Barbero, Diego Martinez-Alonso, Jose Gonzalez-Martinez, Clara Santiveri, Ramon Campos-Olivas, Pilar Ximenez-Embun, Javier Munoz, Monica Alvarez-Fernandez, Marcos Malumbres
Summary: This study reveals that the cell cycle kinase MASTL/Greatwall inhibits the activity of the PI3K-AKT signaling pathway by phosphorylating the PP2A/B55 inhibitor ENSA/ARPP19, thus limiting AKT activity. Furthermore, the study finds that MASTL is directly phosphorylated by mTORC1, which limits the dephosphorylation of IRS1 and GRB10 downstream of mTORC1, further restraining AKT activity. This research highlights the importance of the MASTL-PP2A/B55 kinase-phosphatase module in controlling AKT and maintaining metabolic homeostasis.
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Review
Biochemistry & Molecular Biology
Yu-Chieh Su, Wei-Chang Lee, Chih-Chun Wang, Shyh-An Yeh, Wen-Hui Chen, Po-Jen Chen
Summary: This review discusses the oncogenic significance of PI3K/AKT/mTOR signaling in HNSCC radiotherapy resistance and highlights the therapeutic potential of small molecule inhibitors against this pathway for radiosensitization in HNSCC treatment. It provides a mechanistic framework for the development of new drugs for radiosensitization in HNSCC radiotherapy via targeting the PI3K/AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Nutrition & Dietetics
Tzu-Shao Yeh, Tze-Huan Lei, Jen-Fang Liu, Mei-Chich Hsu
Summary: Astragalus membranaceus (AM) is a high-class traditional herbal medicine known for its vitality-enhancing and multifunctional pharmacological activities. This study found that AM promotes skeletal muscle hypertrophy by activating the PI3K/Akt/mTOR signaling pathway, potentially serving as a promising aid in preventing muscle wasting.
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kun Jiang, Li-zhe Xu, Jin-zhuo Ning, Fan Cheng
Summary: This study aimed to investigate the expression of FAP and its clinical implication in ccRCC. Computational tools analysis of gene databases revealed that FAP levels were significantly elevated in ccRCC. Higher expression levels of FAP were associated with poorer prognoses in ccRCC patients, and FAP may serve as a reliable biomarker for the diagnosis and prognosis of ccRCC.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Oncology
Hua Yu, Liang Chen, Xia Wang, Feng Tang, Ziyu Wan, Hao Wang, Qiqi Fu, Zhizhuang Chen, Jiageng Shi, Xuan Hu, Yisha Zuhaer, Madanyeti Aersi, Tao Liu, Huangheng Tao, Jianping Peng
Summary: This study investigated the role of STIL in bladder cancer for the first time. The researchers found that STIL is highly expressed in bladder cancer and is closely related to the cell cycle. Knocking out STIL led to a significant delay in the growth rate of bladder cancer cells and arrested the cell cycle in the G0/G1 phase. Mechanistically, STIL enhanced the PI3K/AKT/mTOR pathway, resulting in increased expression of c-myc, ultimately promoting the occurrence and progression of bladder cancer.
Article
Pharmacology & Pharmacy
Yunhao Ma, Hao Xu, Zhongkun Zhou, Yanan Tian, Kangjia Du, Hao Zhang, Xinrong Jiang, Juan Lu, Yuqing Niu, Lixue Tu, Huanxiang Liu, Hongmei Zhu, Peng Chen, Yingqian Liu
Summary: In the treatment of gastric cancer, natural products modified by structural modification can be a promising strategy for finding anti-gastric cancer drugs. In this study, a novel derivative CFNC was synthesized and found to have potential anti-gastric cancer effects by regulating the PI3K/AKT/mTOR signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengjun Zhang, Yuan Liu, Yue Yin, Zhenxing Sun, Yan Wang, Zexue Zhang, Fei Li, Xiuwei Chen
Summary: The study found that UBE2S is overexpressed in various cancers. Experimental results on ovarian cancer cells showed that knockdown of UBE2S can inhibit the proliferation, invasion, and prognosis of ovarian cancer cells, possibly through inhibiting the PI3K/AKT/mTOR pathway to block the cell cycle and promote apoptosis.
MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso, Sajad Fakhri, Haroon Khan
Summary: As a major public health concern, neurological diseases and neurodegenerative diseases significantly impact the growing aging population, leading to disability and mortality. Apoptosis, inflammation, and oxidative stress play crucial roles in the development of neurodegenerative diseases, with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway being a key player. The blood-brain barrier poses challenges for drug delivery, but exosomes have emerged as potential nano-sized vehicles for central nervous system drug delivery due to their ability to cross the blood-brain barrier and their unique characteristics such as low immunogenicity and great tissue/cell penetration capabilities. This systematic review highlights the therapeutic potential of exosomes targeting the PI3K/Akt/mTOR signaling pathway in the context of neurodegenerative diseases and neurological diseases.
Review
Biochemistry & Molecular Biology
Alireza Mardanshahi, Nasrin Abbasi Gharibkandi, Samaneh Vaseghi, Seyed Mohammad Abedi, Sajjad Molavipordanjani
Summary: Radiotherapy is a common cancer treatment modality that can activate the PI3K and AKT signaling pathway to enhance tumor cell radiosensitivity. By inhibiting downstream mediators like mTOR, combined with radiation, can increase malignant cell radiosensitivity through autophagy activation.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xin He, Ainong Zhu, Jianguo Feng, Xiaobin Wang
Summary: Neddylation is a crucial posttranslational protein modification that significantly impacts neurodevelopment and neurodegenerative diseases. Proper levels of neddylation contribute to neuronal growth and synaptic function, while overactivation of neddylation pathways can lead to neuronal death and tumor formation.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Behavioral Sciences
Yue Zhang, Jianguo Feng, Cehua Ou, Xue Zhou, Yonghong Liao
Summary: Neuropathic pain-induced cognitive impairment is associated with decreased expression of AQP4 protein and mRNA. AQP4 overexpression can restore cognitive deficits in mice. Furthermore, AQP4 overexpression also reduces the concentration of A beta 1-42 in the serum and hippocampus. In conclusion, AQP4 in astrocytes plays an important role in mitigating cognitive impairment caused by chronic neuropathic pain.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Immunology
Guo Mu, Changhe Ren, Yue Zhang, Bin Lu, Jianguo Feng, Dan Wu, Xinxin Xu, Cehua Ou
Summary: Trigeminal neuralgia is a complex neuropathic pain with a risk of central neurodegeneration. This study explored central neurodegeneration in TN rats and found that cognitive impairment is related to decreased docosahexaenoic acid (DHA) content in the central nervous system. By supplementing DHA, cognitive impairment was improved, possibly through the regulation of microglial polarization and neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Physiology
Hao Liu, Jianguo Feng, Liling Tang
Summary: Diabetic nephropathy is a serious complication of diabetes mellitus, and early diagnosis is crucial. Current clinical methods for assessing renal function have limitations, necessitating the search for biomarkers that can accurately characterize structural changes in the kidneys. This review summarizes potential biomarkers and discusses research methods for diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Feiyu Long, Liren Hu, Yingxu Chen, Xiaoxia Duan, Keliang Xie, Jianguo Feng, Maohua Wang
Summary: This study found that RBM3 was overexpressed in sepsis patients and LPS-induced mice, and its deficiency aggravates sepsis-associated acute lung injury through the NF-kappa B/NLRP3 pathway.
INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Ran Zhang, Xian Jiang, Jianguo Feng
Summary: An epiglottic cyst is a benign tumor formed due to the obstruction of the mucinous duct and retention of glandular secretion. When conventional anesthesia is administered to these patients, difficulties in ventilation may arise as the enlarged cyst can obstruct the glottis and cause airway blockage. This article emphasizes the importance of preoperative airway assessment and efficient management of airway difficulties and intubation failure in patients with epiglottic cysts to ensure patient safety.
Review
Chemistry, Medicinal
Yuxuan Zhu, Jianguo Feng, Rongxue Wan, Wenhua Huang
Summary: Chimeric antigen receptor (CAR) T cell therapy has played a significant role in cancer treatment, but there are challenges in its efficacy for solid tumors, particularly in efficiently delivering CAR T cells to tumor tissues. This review extensively studied and compared different injection methods and their impact on therapeutic efficacy. The difficulties in designing, homing, and working of CAR T cells were explored, and better solutions were proposed to enhance the efficiency and speed of CAR T cell delivery to tumor tissues. These findings are of great importance in guiding CAR T cell therapy in cancer treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Health Care Sciences & Services
Ya-Hong Li, Shun Zhang, Lu Tang, Jianguo Feng, Jing Jia, Ye Chen, Li Liu, Jun Zhou
Summary: This study found that hydrogen gas can protect neurons against ischemia/reperfusion injury by modulating the lincRNA-EPS/Sirt1/autophagy pathway. This suggests that lincRNA-EPS may be a potential target for the treatment of CI/R injury.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiang Huang, Wanrong Gou, Qinxian Song, Yan Huang, Chunlei Wen, Xue Bo, Xian Jiang, Jianguo Feng, Hong Gao
Summary: This study identified BRAF mutation-related genes and established a prognostic model for predicting the prognosis of melanoma. The study also found that the low-risk group had higher expression of immune checkpoint molecules, providing new insights into immunotherapy and precision medicine in melanoma.
Article
Neurosciences
Xing Liu, Qinxue Hu, Tianhao Xu, Qiaoli Yuan, Qin Hu, Na Hu, Weichao Sun, Yiping Bai, Li Liu, Jianguo Feng, Qian Yi
Summary: This study demonstrated that the deficiency of Fndc5/Irisin in mice causes depression-like behaviors by inducing dysbiosis of gut microbiota and changes in microbiota-related metabolites. The knockout mice showed altered diversity and richness of gut microbiota, with decreased Firmicutes and increased Bacteroidota populations. The results suggest that Irisin plays a role in regulating gut microbiota and may provide new insights into understanding the connection between exercise and mental health.
Article
Medicine, Research & Experimental
Ran Zhang, Wanrong Gou, Peng Yi, Zhengshan Qin, Danli Zhu, Jing Jia, Li Liu, Xian Jiang, Jianguo Feng
Summary: The cytotoxic effects of TTC on macrophages were evaluated in this study. TTC decreased cell viability, increased lactate dehydrogenase and IL-1β secretion, and induced morphological changes characteristic of pyroptosis. TTC-induced macrophage pyroptosis was mediated by GSDMD and regulated by caspase-1 and caspase-11. Furthermore, TTC and LPS exerted similar effects on macrophages, but the mechanism of pyroptosis induction by TTC was different from that of LPS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yang Yu, Haiqiong Yang, Qiuting Li, Nianhui Ding, Jiali Gao, Gan Qiao, Jianguo Feng, Xin Zhang, Jianming Wu, Yajun Yu, Xiangyu Zhou, Xiaobin Wang, Chunxiang Zhang
Summary: In this study, researchers found that the newly identified long noncoding RNA Morrbid in the heart plays a protective role in acute myocardial infarction (AMI). Morrbid exerts its effects through its target gene serpine1, reducing the infarct size and improving cardiac function. Therefore, Morrbid may be a promising therapeutic target for ischemic heart diseases such as AMI.
Review
Clinical Neurology
Cheng-Chuan Chen, Na Zhou, Na Hu, Jian-Guo Feng, Xiao-Bin Wang
Summary: This meta-analysis found that intravenous sub-anesthetic doses of ketamine and intranasal inhaled esketamine have significant anti-suicidal ideation effects. Specifically, ketamine produced a large anti-suicidal ideation effect within 4-6 hours and a medium-large effect within 24 hours. Esketamine, on the other hand, produced a small-medium anti-suicidal ideation effect within the 4-6 hours timeframe and the 24 hours.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Geriatrics & Gerontology
Yuru Xiao, Jianguo Feng, Jing Jia, Jie Li, Yingshun Zhou, Zhangyong Song, Fasheng Guan, Xuexin Li, Li Liu
Summary: This study investigated the effects of gut microbiota and metabolites on sepsis-associated muscle weakness. Vitamin K1 intervention was found to ameliorate LPS-triggered skeletal muscle damage by antagonizing NF-kappa B-mediated inflammation through upregulation of SIRT1 and regulating the balance between protein synthesis and catabolism.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Peng Yi, Yan Huang, Xin Zhao, Zhengshan Qin, Danli Zhu, Li Liu, Yuxi Zheng, Jianguo Feng, Menghong Long
Summary: This study identified 312 differentially expressed circRNAs in human keratinocytes after UVA irradiation using circRNA transcriptome sequencing. Among these circRNAs, circUBE2I, formed by exons 2-6 of the UBE2I gene, was the most significantly upregulated circRNA. Further experiments confirmed the increase of circUBE2I level after UVA irradiation or H2O2 treatment, and overexpression of circUBE2I induced ferroptosis.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
