Article
Biology
Jeesan Lee, Oscar David Villarreal, Yu Chang Wang, Jiannis Ragoussis, Serge Rivest, David Gosselin, Stephane Richard
Summary: Failure of remyelination in multiple sclerosis leads to neurodegeneration and clinical decline. Microglia play a role in promoting remyelination, and PRMT1 is identified as a critical regulator for MHC-associated microglia activation.
LIFE SCIENCE ALLIANCE
(2022)
Article
Biology
Li-Ming Liu, Qiang Tang, Xin Hu, Jing-Jing Zhao, Yuan Zhang, Guo-Guang Ying, Fei Zhang
Summary: PRMT1 serves as a key regulator of p53 function in breast cancer cells, inhibiting the transcriptional activity of p53 and affecting cell growth and senescence. Inhibition of PRMT1 with specific inhibitors can significantly weaken p53 signals and impede cell growth in breast cancer cells, highlighting the important role of PRMT1 in breast tumorigenesis.
Article
Endocrinology & Metabolism
Seri Choi, Dahee Choi, Yun-Kyung Lee, Seung Hyun Ahn, Je Kyung Seong, Sung Wook Chi, Tae Jung Oh, Sung Hee Choi, Seung-Hoi Koo
Summary: PRMT1 plays a crucial role in maintaining metabolic balance in adipose tissues, with its depletion leading to increased lipid catabolism and adverse effects in conditions of high-fat diet or obesity, such as promotion of adipose tissue inflammation and ectopic accumulation of triglycerides.
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Zhihao Wang, Zhicheng Pan, Samir Adhikari, Bryan T. Harada, Lei Shen, Wei Yuan, Tharindumala Abeywardana, Qais Al-Hadid, Jeremy M. Stark, Chuan He, Lan Lin, Yanzhong Yang
Summary: The research reveals that arginine methylation of METTL14 is a novel pathway controlling m(6)A deposition in mammalian cells, with deficiency in this methylation leading to significantly reduced global m(6)A levels in mESCs. These findings highlight the importance of arginine methylation in RNA metabolism and its impact on various cellular processes, including stem cell maintenance and DNA repair.
Article
Multidisciplinary Sciences
Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M. Asara, Piotr Sicinski, Gordon J. Freeman, Wenyi Wei
Summary: The protein arginine methyltransferase PRMT1 suppresses the anti-tumor immune response by methylating cGAS and preventing its dimerization. Inhibition of PRMT1 activates the cGAS/STING-dependent DNA sensing signaling and increases the expression of interferon response genes, tumor-infiltrating lymphocytes, and tumoral PD-L1. Combination therapy of PRMT1 inhibitor with anti-PD-1 antibody enhances the anti-tumor therapeutic efficacy.
NATURE COMMUNICATIONS
(2023)
Review
Biology
Charlene Thiebaut, Louisane Eve, Coralie Poulard, Muriel Le Romancer
Summary: PRMT1, the major protein arginine methyltransferase in mammals, plays essential roles in various biological processes such as transcriptional regulation, signal transduction, and DNA repair. It catalyzes monomethylation and asymmetric dimethylation of arginine side chains in proteins, with a wide range of substrates identified including histone and non-histone proteins. The enzyme is also involved in embryonic development, DNA damage repair, and the progression of various cancers.
Article
Biochemistry & Molecular Biology
Antje Repenning, Daniela Happel, Caroline Bouchard, Marion Meixner, Yesim Verel-Yilmaz, Hartmann Raifer, Lena Holembowski, Eberhard Krause, Elisabeth Kremmer, Regina Feederle, Corinna U. Keber, Michael Lohoff, Emily P. Slater, Detlef K. Bartsch, Uta-Maria Bauer
Summary: The study reveals that PRMT1-mediated arginine methylation is crucial for triggering stress-induced tumor-suppressive function of p14(ARF). The interaction between PRMT1 and p14(ARF) leads to the release of p14(ARF) from nucleoli, promoting p53-independent apoptosis in response to genotoxic stress. This cooperation between PRMT1 and p14(ARF) has implications for cancer prognosis and chemotherapy response in pancreatic ductal adenocarcinoma.
Review
Biochemistry & Molecular Biology
Misuzu Hashimoto, Akiyoshi Fukamizu, Tsutomu Nakagawa, Yasuhiko Kizuka
Summary: PRMT1 is crucial for the development of neurons, astrocytes, and oligodendrocytes, requiring further investigation. The relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Cell Biology
Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Summary: This study identifies protein arginine methyltransferase 1 (PRMT1) as a critical regulator of the GATOR2 complex, which activates the mTORC1 pathway for tumor growth. Inhibition of the CDK5-PRMT1-WDR24 axis suppresses HCC cell proliferation and tumor growth. High PRMT1 protein expression is associated with elevated mTORC1 signaling in patients with HCC.
Article
Medicine, Research & Experimental
Bo-Yi Sung, Yi-Hsin Lin, Qiongman Kong, Pali D. Shah, Joan Glick Bieler, Scott Palmer, Kent J. Weinhold, Hong-Ru Chang, Hailiang Huang, Robin K. Avery, Jonathan Schneck, Yen-Ling Chiu
Summary: This study reveals a molecular mechanism governing T cell polyfunctionality, involving the activation of Wnt signaling and the role of PRMT1. Wnt activation inhibits T cell differentiation and promotes the generation of highly polyfunctional cells, with persistent effects even after the removal of the drug. PRMT1 is involved in regulating T cell polyfunctionality, particularly the production of IL-2. These findings highlight PRMT1 as a potential target for T cell immunotherapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Alice Shi Ming Li, Charles Homsi, Eric Bonneil, Pierre Thibault, Alain Verreault, Masoud Vedadi
Summary: Protein arginine methyltransferases (PRMTs) catalyze methyl group transfer to specific arginine residues. PRMT1 is the dominant member in the PRMT family, but it is not active with recombinant nucleosome. This study discovered a novel crosstalk between histone modifications, indicating the potential regulation of PRMT1 activity by SETD8.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoyan Zhao, Yan Sun, Ziwei Xu, Li Cai, Yu Hu, Huafang Wang
Summary: Protein arginine methyl-transferase 1 (PRMT1) plays a critical role in graft-versus-host disease (GVHD). Inhibiting PRMT1 can prevent chronic and acute GVHD by reducing the percentage of Th17 cells and B cells, as well as controlling cell proliferation and antibody production. PRMT1 regulates B cell function by methylating isocitrate dehydrogenase 2 (IDH2).
Article
Oncology
Jingchao Wang, Zhen Wang, Hiroyuki Inuzuka, Wenyi Wei, Jing Liu
Summary: N6-methyladenosine (m6A) is a common mRNA modification in mammalian cells and plays a crucial role in mRNA stability and alternative splicing. The METTL3-METTL14-WTAP complex is responsible for m6A modification, but its regulation at the post-translational level is not well understood. In this study, it was found that protein arginine methyltransferase 1 (PRMT1) promotes arginine methylation of METTL14, which is essential for its function in m6A modification. Furthermore, arginine methylation of METTL14 by PRMT1 promotes cell proliferation, suggesting a potential role in tumorigenesis.
Article
Multidisciplinary Sciences
Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb A. Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Joseph R. Marszalek, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan
Summary: PRMT1 plays a critical role in the maintenance of pancreatic ductal adenocarcinoma (PDAC) growth by regulating RNA metabolism and influencing multiple cellular processes. Inhibition of PRMT1 leads to downregulation of pathways involved in DNA damage response, promoting genomic instability and inhibiting tumor growth.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Goo-Young Kim, Young Mok Lee, Jun-Ho Cho, Chi-Jiunn Pan, Hyun Sik Jun, Danielle A. Springer, Brian C. Mansfield, Janice Y. Chou
HUMAN MOLECULAR GENETICS
(2015)
Article
Biochemistry & Molecular Biology
Goo-Young Kim, Joon Hyun Kwon, Jun-Ho Cho, Lisa Zhang, Brian C. Mansfield, Janice Y. Chou
HUMAN MOLECULAR GENETICS
(2017)
Article
Biochemistry & Molecular Biology
Joon Hyun Kwon, Young Mok Lee, Jun-Ho Cho, Goo-Young Kim, Javier Anduaga, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou
HUMAN MOLECULAR GENETICS
(2017)
Article
Endocrinology & Metabolism
Goo-Young Kim, Young Mok Lee, Joon Hyun Kwon, Jun -Ho Cho, Chi-Jiunn Pan, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou
MOLECULAR GENETICS AND METABOLISM
(2017)
Article
Genetics & Heredity
Jun-Ho Cho, Goo-Young Kim, Chi-Jiunn Pan, Javier Anduaga, Eui-Ju Choi, Brian C. Mansfield, Janice Y. Chou
Article
Biochemistry & Molecular Biology
Jun-Ho Cho, Goo-Young Kim, Brian C. Mansfield, Janice Y. Chou
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Janice Y. Chou, Jun-Ho Cho, Goo-Young Kim, Brian C. Mansfield
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Endocrinology & Metabolism
Jun-Ho Cho, Goo-Young Kim, Brian C. Mansfield, Janice Y. Chou
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Biochemistry & Molecular Biology
J-H Cho, M-K Lee, K. W. Yoon, J. Lee, S-G Cho, E-J Choi
CELL DEATH AND DIFFERENTIATION
(2012)
Article
Endocrinology & Metabolism
Lisa Zhang, Jun-Ho Cho, Irina Arnaoutova, Brian C. Mansfield, Janice Y. Chou
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Endocrinology & Metabolism
Jun-Ho Cho, Young Mok Lee, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Jun-Ho Cho, Young Mok Lee, Seong-Ho Bae, Janice Y. Chou
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Endocrinology & Metabolism
Jun-Ho Cho, David A. Weinstein, Young Mok Lee
Summary: GSD-Ia is a genetic metabolic disease caused by a deficiency in glucose-6-phosphatase-alpha, leading to life-threatening hypoglycemia and liver issues. Studies have shown impaired autophagy in GSD-Ia model animals, but the molecular mechanisms and impact on GSD-Ia pathogenesis are still under investigation.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Gastroenterology & Hepatology
Lane H. Wilson, Jun-Ho Cho, Ana Estrella, Joan A. Smyth, Rong Wu, Tayoot Chengsupanimit, Laurie M. Brown, David A. Weinstein, Young Mok Lee
HEPATOLOGY COMMUNICATIONS
(2019)