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Medicine, General & Internal
Chloe C. Su, Julie T. Wu, Eunji Choi, Nathaniel J. Myall, Joel W. Neal, Allison W. Kurian, Henning Stehr, Douglas Wood, Solomon M. Henry, Leah M. Backhus, Ann N. Leung, Heather A. Wakelee, Summer S. Han
Summary: This study aimed to evaluate the impact of metastatic disease type on overall survival (OS) among patients with non-small cell lung cancer (NSCLC) and identify potential mechanisms underlying any survival difference.
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Cell Biology
Shuyan Han, Zhihua Tian, Huifang Tian, Haibo Han, Jun Zhao, Yanna Jiao, Chunli Wang, Huifeng Hao, Shan Wang, Jialei Fu, Dong Xue, Hong Sun, Pingping Li
Summary: This study examined the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in non-small cell lung cancer (NSCLC) and identified the underlying mechanisms. The results showed that HDGF overexpression aggravated the malignant phenotype of NSCLC cells, while HDGF knockdown reversed these effects. The overexpression of HDGF also led to gefitinib resistance, while knockdown enhanced gefitinib sensitivity. Higher levels of HDGF in plasma or tumor tissue were associated with gefitinib resistance. HDGF activated the Akt and ERK signaling pathways, independent of EGFR phosphorylation, contributing to gefitinib resistance.
CELL DEATH DISCOVERY
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Immunology
Pu Zhou, Diangang Chen, Bo Zhu, Wei Chen, Qichao Xie, Yali Wang, Qiulin Tan, Bibo Yuan, Xuejiao Zuo, Changlin Huang, Hongfan Zhu, Guanghui Li
Summary: The study found that the diversity of TCR repertoire and PD-L1 expression in the TME increased significantly after SBRT, with the most enriched term in gene ontology analysis being immune response genes. Although SBRT induced neo-mutation of genes in tumor cells, it did not increase the burden of tumor mutation in tissues. TME showed complex immune cell changes and infiltration, with expression of immune-regulating factors like CXCL10, CXCL16, IFNs, and IFN receptors.
FRONTIERS IN IMMUNOLOGY
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Multidisciplinary Sciences
Agata Dutkowska, Bartosz Szmyd, Marcin Kaszkowiak, Daria Domanska-Senderowska, Dorota Pastuszak-Lewandoska, Ewa Brzezianska-Lasota, Jacek Kordiak, Adam Antczak
Summary: Tumours have the ability to avoid immune destruction and exhibit cancer-associated inflammation. The upregulation of interleukins IL-1 beta and IL-6 in non-small cell lung cancer (NSCLC) tissues suggests that inflammatory processes play a role in NSCLC, with a strong influence of smoking history on inflammation in tumourigenesis.
SCIENTIFIC REPORTS
(2021)
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Multidisciplinary Sciences
Dongliang Yang, Xiaobin Ma, Peng Song
Summary: Bioinformatics methods were used to construct an immune gene prognosis assessment model for patients with non-small cell lung cancer (NSCLC), and to screen biomarkers that affect the occurrence and prognosis of NSCLC. The model's risk score was found to be an independent predictor of NSCLC prognosis and was correlated with the degree of neutrophil infiltration in the tumor microenvironment.
SCIENTIFIC REPORTS
(2022)
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Biochemistry & Molecular Biology
Jing Li, Tereza Brachtlova, Ida H. van der Meulen-muileman, Stijn Kleerebezem, Chang Liu, Peiyu Li, Victor W. van Beusechem
Summary: Non-small cell lung cancer (NSCLC) xenograft tumor assays were established on the chorioallantoic membrane (CAM) of chicken embryos to promote preclinical development of new treatments. The A549 and H460 cell lines showed promising results and were further characterized in terms of tumor growth and susceptibility to chemotherapy and gene delivery using viral vectors. The study demonstrated that systemic treatment with Pemetrexed and Cisplatin inhibited tumor growth, and adenoviral vectors showed higher transduction efficiency compared to lentiviral vectors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
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Oncology
Chen Wang, Xiangfeng Meng, Yu Zhou, Jing Yu, Qing Li, Zhicong Liao, Yuanyuan Gu, Jiayi Han, Shuo Linghu, Zichen Jiao, Tao Wang, Chen-Yu Zhang, Xi Chen
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Biochemistry & Molecular Biology
Cheng Zeng, Jing Guo, Jiajia Wu, Tiantian Che, Xiaoping Huang, Huawen Liu, Zhenghong Lin
Summary: The E3 ubiquitin ligase HRD1 regulates autophagy and is involved in non-small cell lung carcinoma (NSCLC) metastasis. HRD1 inhibits autophagy by promoting ATG3 ubiquitination and degradation, leading to the release of MIEN1 and the promotion of NSCLC metastasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
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Multidisciplinary Sciences
Sergey P. Primakov, Abdalla Ibrahim, Janita E. van Timmeren, Guangyao Wu, Simon A. Keek, Manon Beuque, Renee W. Y. Granzier, Elizaveta Lavrova, Madeleine Scrivener, Sebastian Sanduleanu, Esma Kayan, Iva Halilaj, Anouk Lenaers, Jianlin Wu, Rene Monshouwer, Xavier Geets, Hester A. Gietema, Lizza E. L. Hendriks, Olivier Morin, Arthur Jochems, Henry C. Woodruff, Philippe Lambin
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NATURE COMMUNICATIONS
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Biochemistry & Molecular Biology
Valsamo Anagnostou, Cheryl Ho, Garth Nicholas, Rosalyn Anne Juergens, Adrian Sacher, Andrea S. Fung, Paul Wheatley-Price, Scott A. Laurie, Benjamin Levy, Julie R. Brahmer, Archana Balan, Noushin Niknafs, Egor Avrutin, Liting Zhu, Mark Sausen, Penelope A. Bradbury, Jill O'Donnell-Tormey, Pierre Olivier Gaudreau, Keyue Ding, Janet Dancey
Summary: Circulating tumor DNA (ctDNA) is useful for capturing primary resistance to immunotherapy in lung cancer. The BR.36 trial demonstrates the correlation between ctDNA response and radiologic response, and identifies molecular response as a predictor of longer progression-free and overall survival.
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Biochemistry & Molecular Biology
Misa Nozaki, Makoto Nishizuka
Summary: RhoJ plays a crucial role in the development of NSCLC, with its knockdown accelerating the metastatic process of cancer. Reduced expression of RhoJ increases Smad3 phosphorylation and Snail expression during the EMT process, enhancing the invasion capacity of lung cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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Medicine, General & Internal
Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Summary: PKC delta is identified as a critical factor in the non-inflamed tumor microenvironment (TME) of EGFR-mutated lung cancer. Inhibition of PKC delta enhances the infiltration of immune cells into tumors and increases the sensitivity of tumors to immune checkpoint blockade therapy.
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Multidisciplinary Sciences
Yingying Wang, Minli Wei, Min Su, Zhiyuan Du, Jiaxi Dong, Yu Zhang, Yingdi Wu, Xiaopeng Li, Ling Su, Xiangguo Liu
Summary: DIRAS3, a candidate tumor suppressor protein, inhibits the migration of NSCLC cells by promoting the polyubiquitination and degradation of RAC1 through the interaction with RNF19B. The DIRAS3-RNF19B-RAC1 axis is associated with the malignant progression of NSCLC.
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Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
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Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
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Critical Care Medicine
Chih-Hao Shen, Chung-Kan Peng, Yu-Ching Chou, Ke-Ting Pan, Shun-Cheng Chang, Shan-Yueh Chang, Kun-Lun Huang
JOURNAL OF CRITICAL CARE
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I-Duo Wang, Yung-Liang Liu, Chung-Kan Peng, Chi-Hsiang Chung, Shan-Yueh Chang, Chang-Huei Tsao, Wu-Chien Chien
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Clinical Neurology
I-Duo Wang, Yung-Liang Liu, Chung-Kan Peng, Chi-Hsiang Chung, Shan-Yueh Chang, Chang-Huei Tsao, Wu-Chien Chien
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Shan-Yueh Chang, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Yu-Ching Chou, Chung-Kan Peng, Chih-Hao Shen, Nian-Sheng Tzeng
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Nian-Sheng Tzeng, Hsin-An Chang, Chi-Hsiang Chung, Yu-Chen Kao, Chuan-Chia Chang, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Shan-Yueh Chang, Wu-Chien Chien
FRONTIERS IN PSYCHIATRY
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Yen-Liang Kuo, Chi-Hsiang Chung, Tsai-Wang Huang, Chang-Huei Tsao, Shan-Yueh Chang, Chung-Kan Peng, Wei-Erh Cheng, Wu-Chien Chien, Chih-Hao Shen
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Nian-Sheng Tzeng, Chi-Hsiang Chung, Shan-Yueh Chang, Chin-Bin Yeh, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Yu-Ching Chou, Hui-Wen Yeh, Wu-Chien Chien
JOURNAL OF INVESTIGATIVE MEDICINE
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Ti-Hui Wu, Shan-Yueh Chang, Yu-Lueng Shih, Tsai-Wang Huang, Hung Chang, Ya-Wen Lin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Ti-Hui Wu, Shan-Yueh Chang, Yu-Lueng Shih, Chih-Feng Chian, Hung Chang, Ya-Wen Lin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
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Shan-Yueh Chang, Ying-Chieh Chen, Chen-Liang Tsai, Shih-Wei Wu, Chung-Kan Peng, Chih-Hao Shen, Yu-Ching Chou, Chih-Feng Chian
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