Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 46, Issue 4, Pages 247-253Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000159
Keywords
protein synthesis; skeletal muscle; cancer cachexia; mitochondrial function; quality control; muscle contraction; mTORC1; oxidative metabolism
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Funding
- National Institutes of Health (National Cancer Institute) [R01 CA121249]
- National Institutes of Health (National Institute of General Medical Science) [P20 RR-017698]
- SPARC Graduate Research Grant from the Office of the Vice President for Research at the University of South Carolina
- ACSM Foundation Research Grant from the American College of Sports Medicine Foundation
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Skeletal muscle has the dynamic capability to modulate protein turnover in response to anabolic stimuli, such as feeding and contraction. We propose that anabolic resistance, the suppressed ability to induce protein synthesis, is central to cancer-induced muscle wasting. Furthermore, we propose that resistance exercise training has the potential to attenuate or treat cancer-induced anabolic resistance through improvements in oxidative metabolism.
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