Article
Genetics & Heredity
Muhammad Ahmad Yahaya, Hussein Shimelis, Baloua Nebie, Chris Ochieng Ojiewo, Abhishek Rathore, Roma Das
Summary: This study assessed the genetic diversity and population structure of 200 sorghum accessions using diversity arrays technology (DArT)-derived single nucleotide polymorphism (SNP) markers. The results showed a high level of genetic diversity among the accessions, which will be useful for enhancing sorghum breeding programs in West Africa by developing new gene pools and novel genotypes. Several distantly related sorghum accessions were identified, indicating the wide genetic diversity within the crop.
Article
Plant Sciences
Seoyeon Park, Ye-Ok Park, Younghoon Park
Summary: This study examined the genetic diversity and population structure of a persimmon collection in South Korea through the analysis of genome-wide single-nucleotide polymorphisms (SNPs) in 93 cultivars. The results showed clear separation between cultivar groups based on astringency types, with the highest genetic diversity observed in the pollination-variant nonastringent group. Analysis of molecular variance indicated that variation within individuals was higher than among groups, and there was a low level of cultivar type differentiation. These findings demonstrate the potential of biallelic SNPs in population genetics studies and provide important insights for persimmon breeding and cultivar identification.
Article
Biotechnology & Applied Microbiology
Dennis N. Lozada, Madhav Bhatta, Danise Coon, Paul W. Bosland
Summary: Genetic diversity among New Mexican chile peppers was assessed using GBS-derived SNP markers, revealing genetic relatedness among different populations. Introducing novel alleles from other breeding programs or wild species could help increase diversity in the current germplasm. Valuable information for future association mapping and genomic selection for genetic improvement through marker-assisted breeding in New Mexican chile peppers was presented.
Article
Plant Sciences
Zoe Andrijanic, Nelson Nazzicari, Hrvoje Sarcevic, Aleksandra Sudaric, Paolo Annicchiarico, Ivan Pejic
Summary: This study investigates the genetic diversity and structure of European soybean cultivars and American introductions registered in Europe, supporting optimal exploitation of genetic resources. Results show that the European soybean gene pool still has sufficient diversity due to differences in historical breeding practices and relatively short breeding period in Europe.
Article
Plant Sciences
Mbali Thembi Gumede, Abe Shegro Gerrano, Assefa Beyene Amelework, Albert Thembinkosi Modi
Summary: This study assessed the genetic diversity and population structure of 90 cowpea accessions using SNP markers. The results showed that cowpea has high tolerance to heat and drought stresses, making it important for improving crop production resilience. The study also revealed low genetic diversity and high homozygosity among cowpea accessions.
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Genetics & Heredity
Ziqi Jia, Yansong Huang, Jiaqi Liu, Gang Liu, Jiayi Li, Hengyi Xu, Yiwen Jiang, Song Zhang, Yidan Wang, Gang Chen, Guangdong Qiao, Yalun Li
Summary: Through a study on genetic polymorphisms, we found significant associations between breast cancer risk and SNPs rs12493607 (TGFBR2), rs4784227 (CASC16), and rs2046210 (ESR1) in the Chinese female population. Further analysis revealed associations between different subtypes of breast cancer and different SNPs. These findings provide important insights into breast cancer susceptibility and personalized treatment.
Article
Agriculture, Dairy & Animal Science
Zahangir M. Alam, Yun-Mi Lee, Hyo-Jung Son, Lauren H. Hanna, David G. Riley, Hideyuki Mannen, Shinji Sasazaki, Se Pill Park, Jong-Joo Kim
Summary: The study investigated the genetic diversity and population structure of three cattle breeds in the Korean peninsula, revealing the genetic uniqueness of Jeju Black cattle but also highlighting the need for a sustainable breeding policy due to the small effective population size.
Article
Veterinary Sciences
Shouzhi Wang, Yuxiang Wang, Yudong Li, Fan Xiao, Huaishun Guo, Haihe Gao, Ning Wang, Hui Zhang, Hui Li
Summary: This study identified SNPs and genes with significant effects on body weight in different weeks of age in a broiler population using genome-wide association study and selective sweep analysis. The findings provide valuable information for understanding the genetic architecture of growth traits in broilers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agronomy
Jinhui Li, Shouhui Wei, Zhaofeng Huang, Yuyong Zhu, Longlong Li, Yixiao Zhang, Ziqing Ma, Hongjuan Huang
Summary: The aim of this study was to understand the genetic diversity and population structure of Solanum nigrum in China. A total of 616,533 high-quality SNPs were identified from 66 populations using the SLAF sequencing method. The results showed a considerable amount of genetic diversity and low differentiation among the different geographical populations of S. nigrum. Populations of S. nigrum were divided into two subgroups, with some correlation between geographic origins. The genetic structure analysis suggested that the 66 samples could have originated from three different genetic clusters, with Xinjiang showing the highest genetic diversity.
Review
Genetics & Heredity
Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli
Summary: This review assessed the molecular pathology of diabetes in the Middle East population and explored the feasibility of introducing a SNP-based diagnostic panel for diabetes screening. With a population of 370 million, this study could serve as a reliable model for promoting the use of such diagnostic panels in other populations worldwide.
Article
Multidisciplinary Sciences
Jarmo Ritari, Kati Hyvarinen, Jukka Partanen, Satu Koskela
Summary: The KIR gene cluster encodes cell surface glycoproteins that are involved in tumor surveillance, viral infection clearance, and immune-mediated diseases. This study presents a reliable method for inferring KIR gene content with high accuracy.
Article
Oncology
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu
Summary: This study found that there is a potential association between CYP4F2 gene polymorphisms and lung cancer risk, and this association may be affected by gender and smoking status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Misteru Tesfaye, Tileye Feyissa, Teklehaimanot Hailesilassie, Selvaraju Kanagarajan, Li-Hua Zhu
Summary: This study investigated the genetic diversity and population structure of Ethiopian mustard (Brassica carinata) genotypes of different origins using high-throughput single nucleotide polymorphism (SNP) markers. The results revealed two distinct subpopulations, with the majority of accessions clustered in one subpopulation mainly obtained from specific regions. The analysis showed high genetic variation within populations and low genetic differentiation between populations, indicating the presence of gene flow and weak geographical structure. The study provides important information for future breeding and conservation efforts of B. carinata.
Article
Biochemistry & Molecular Biology
Lan-Ting Yuan, Yi-Chieh Yang, Hsiang-Lin Lee, Pei-Chun Shih, Li-Hsin Chen, Chih-Hsin Tang, Lun-Ching Chang, Hsiang-Ling Wang, Shun-Fa Yang, Ming-Hsien Chien
Summary: The genetic variant rs9914618 of the LINC00673 gene may serve as a promising biomarker for hepatocellular carcinoma (HCC), especially in elderly populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Hardware & Architecture
Jianhai Chen, Huapu Zeng, Yunming Pu
Summary: This paper proposes a feature fusion-based neighbor (FbN) model for calibrating voice sensors using real-time low-cost ambient sensors. By collecting voice data and external low-cost sensor data, selecting and fusing features, and calculating and sorting distances between sensor data and represented features, the calibration is achieved.
JOURNAL OF CIRCUITS SYSTEMS AND COMPUTERS
(2023)
Article
Genetics & Heredity
Yangying Jia, Jianhai Chen, Jie Zhong, Xuefei He, Li Zeng, Yanmin Wang, Jiakun Li, Shengqian Xia, Erdengqieqieke Ye, Jing Zhao, Bin Ke, Chunyu Li
Summary: Hypoplastic left heart syndrome (HLHS) is a rare and fatal birth defect. A study identified a mutation in the PTPRB gene associated with HLHS.
Article
Orthopedics
Jiabao Ju, Mingtai Ma, Yichong Zhang, Zhentao Ding, Zhongguo Fu, Jianhai Chen
Summary: This study aimed to analyze the fracture line morphology and location relationship of the greater tuberosity (GT) fragments in complicated Neer three- and four-part proximal humerus fractures (PHF). The results showed that the GT fragments exhibited a fan-shaped morphology and could be classified based on their location and morphology. The coverage of GT fragments provided by the locking plate varied depending on the fragment types, and the anterior-avulsion, posterior-avulsion, and posterior-split type GT fragments were identified as high-risk fragments in Neer three- and four-part PHFs.
ORTHOPAEDIC SURGERY
(2023)
Article
Genetics & Heredity
Hafiz Ishfaq Ahmad, Faheem Ahmed Khan, Musarrat Abbas Khan, Safdar Imran, Rana Waseem Akhtar, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Jinping Chen
Summary: The BPIFA1 gene shows evidence of positive selection in different mammalian species, indicating its evolutionary role in the antibacterial and antiviral defenses of mammals.
Article
Orthopedics
Jiabao Ju, Mingtai Ma, Zhentao Ding, Yichong Zhang, Zhongguo Fu, Jianhai Chen
Summary: This study analyzed the reinforcement effects on the anterior-avulsion GT fragment in Neer three-part proximal humeral fractures using transosseous suture and suture anchor techniques. The results showed that transosseous suture was superior to the suture only in reinforcing the anterior-avulsion GT fragment and had comparable biomechanical strength to the suture anchor.
ORTHOPAEDIC SURGERY
(2023)
Article
Orthopedics
Jian Lin, Wei-Jin Sun, Jian-Hai Chen, Jing-Ming Dong, Ding-Su Bao, Ling Yan, Wei-Dong Ni, Ming Xiang, Jian Ding, Ming Cai, Jia-Xiang Song, Ming-Gui Mao, Xiao-Ming Wu
Summary: This study compared the interobserver agreement of four classification systems for lateral clavicle fractures used by shoulder specialists and general trauma surgeons. The results showed that when 3D-CT scan images were provided, the interobserver agreement was higher in the specialist group using the OTA, Jager/Breitner, and Gongji classification systems, and in the generalist group using the Gongji classification system. Overall, 3D-CT scans provided better results in most classification systems, emphasizing the value of digitization and specialization in diagnosis and treatment.
ORTHOPAEDIC SURGERY
(2023)
Editorial Material
Genetics & Heredity
Jianhai Chen, Nikica Sprem, Yongjie Wu, Shengqian Xia
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jahanzaib Azhar, Asif Nadeem, Maryam Javed, Hafiz Ishfaq Ahmad, Faiz-ul Hassan, Faisal Sheraz Shah
Summary: Dairy cows undergoing transition experience oxidative stress and autoimmunity, which can be managed by using phytochemicals derived from Thymus serpyllum as feed additives. These phytochemicals exhibit strong antioxidant activity and inhibit bovine nuclear factor kappa B (NF-kappa B). Through computational analysis, it was found that the screened compounds have promising pharmacokinetic parameters and can serve as potential drug candidates. The biochemical assays and computational studies support the use of Thymus serpyllum as a feed additive to manage oxidative stress in dairy cows during the transition period.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Evolutionary Biology
Hafiz Ishfaq Ahmad, Laraib Jameel, Quratulain Zahra, Jiabin Zhou, Linmiao Li, Xiujuan Zhang, Shakeel Ahmed, Daoud Ali, Gokhlesh Kumar, Aleena Safdar, Farhan Abbas, Jinping Chen
Summary: This study examines the molecular evolution of the IFN epsilon pseudogene in Manis javanica and its role in modulating the innate and specific antiviral immunity in this species. It finds evidence of positive selection in the human and primate IFN epsilon genes, suggesting their importance in the evolution of the immune system. Comparative genomic analysis reveals that the IFN epsilon pseudogene in pangolins originated from a gene duplication event and has lost its protein-coding function, but it may still play a regulatory role in antiviral immunity.
JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Abdur Rahman, Huma Kalsoom, Sadia Khanum, Muhammad Sajid, Muhammad Zaman Zahid, Zafar Hayat, Akhtar Rasool Asif, Mubarik Mahmood, Irfan Ahmed, Shah Nawaz, Muhammad Yousaf, Aziz ur Rehman, Sayyed Aun Muhammad, Hafiz Ishfaq Ahmad
Summary: Due to population growth, there is an increased demand for food, particularly meat. Increasing mutton production is a way to address this issue, but it is challenging due to high feeding costs. This study found that replacing corn grain with dried citrus pulp in the feed for mutton goats can be a cost-effective solution without any adverse effects on growth performance and blood parameters.
Article
Immunology
Fouzia Naheed, Rabia Mumtaz, Sana Shabbir, Arshad Jamil, Akhtar Rasool Asif, Abdur Rahman, Hafiz Ishfaq Ahmad, Muhammad Essa, Hammad Akhtar, Samy F. Mahmoud, Fatimah Othman Alghamdi, Hala Abdulrahman Al Amari, Jinping Chen
Summary: Our study analyzed the evolutionary patterns and genetic changes of CXCR4 protein in various mammalian species, revealing its important role in immune system function and disease processes. We also examined the three-dimensional structure and interactions of CXCR4, providing insights into the development of treatments or prevention strategies for emerging and re-emerging diseases. These findings highlight the potential of CXCR4 as a therapeutic target in human and animal health.
Article
Agriculture, Dairy & Animal Science
Huajiao Dong, Jie Zhang, Yingying Li, Hafiz Ishfaq Ahmad, Tiantian Li, Qianqian Liang, Yan Li, Min Yang, Jilong Han
Summary: This study utilized RNA-seq technology to analyze the differentially expressed genes in the liver of Yili geese and their hybrids, revealing enrichment of four pathways related to liver lipid and glucose metabolism. These findings provide insights into the deposition and metabolism of liver lipids in animals.
Article
Ecology
Changyi Xiao, Sara Duarri-Redondo, Dagny A. V. Thorhoelludottir, Yiwen Chen, Christian Schloetterer
Summary: Competitive fitness assays are commonly used in evolutionary biology, but the assumption that there is no interaction between competing genotypes may not hold true. Our study provides evidence for interaction between diverged genotypes, suggesting the need for reconsideration of this assumption.
ECOLOGY AND EVOLUTION
(2023)