Pharmacology of Src family kinases and therapeutic implications of their modulators

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress

(2015) Yu-Chin Lin et al.   Oncotarget

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo

(2015) Anna Goc et al.   Oncotarget

SRC: A Century of Science Brought to the Clinic

(2015) Alexey Aleshin et al.   NEOPLASIA

Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management

(2014) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Requirement of N-Myristoyltransferase 1 in the Development of Monocytic Lineage

(2014) A. Shrivastav et al.   JOURNAL OF IMMUNOLOGY

Dasatinib is synergistic with cetuximab and cisplatin in triple-negative breast cancer cells

(2013) Elizabeth M.H. Kim et al.   JOURNAL OF SURGICAL RESEARCH

Lymphocyte Cell Kinase Activation Mediates Neuroprotection during Ischemic Preconditioning

(2012) O.-N. Bae et al.   JOURNAL OF NEUROSCIENCE

From axon–glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase

(2011) Eva-Maria Krämer-Albers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

(2011) N. S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Dasatinib: An Anti-Tumour Agent via Src Inhibition

(2011) Antonio Gnoni et al.   CURRENT DRUG TARGETS

Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes

(2011) Thomais Markou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The regulation of N-methyl-d-aspartate receptors by Src kinase

(2011) Bradley R. Groveman et al.   FEBS Journal

Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells

(2011) Elizabeth M Samuelson et al.   IMMUNOLOGY AND CELL BIOLOGY

Functional Activation of Src Family Kinase Yes Protein Is Essential for the Enhanced Malignant Properties of Human Melanoma Cells Expressing Ganglioside GD3

(2011) Kazunori Hamamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Src Family Kinase Fgr Is Critical for Activation of Mast Cells and IgE-Mediated Anaphylaxis in Mice

(2011) J. H. Lee et al.   JOURNAL OF IMMUNOLOGY

Involvement of src-kinase activation in ischemic preconditioning induced protection of mouse brain

(2011) Ashish K. Rehni et al.   LIFE SCIENCES

Targeted Nanogels: A Versatile Platform for Drug Delivery to Tumors

(2011) E. A. Murphy et al.   MOLECULAR CANCER THERAPEUTICS

Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: Correlations with angiogenesis and cerebral edema

(2011) Likun Zan et al.   NEUROCHEMISTRY INTERNATIONAL

The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells

(2011) Agustina Alaimo et al.   NEUROCHEMISTRY INTERNATIONAL

Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis

(2011) R. Marcotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

(2011) J. R. Schoenborn et al.   Science Signaling

Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on δ-opioid receptor stimulation

(2010) Mathivadhani Panneerselvam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma

(2010) Heather D. Brooks et al.   CANCER

Fyn

(2010) Yoshihito D. Saito et al.   CANCER

The Src, Syk, and Tec family kinases: Distinct types of molecular switches

(2010) J. Michael Bradshaw   CELLULAR SIGNALLING

Preconditioning by Subinotropic Doses of Ouabain in the Langendorff perfused Rabbit Heart

(2010) Eric E Morgan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Unexpected Role for the B Cell-Specific Src Family Kinase B Lymphoid Kinase in the Development of IL-17-Producing    T Cells

(2010) R. M. Laird et al.   JOURNAL OF IMMUNOLOGY

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

(2010) Ying Wang et al.   Journal of Neuroinflammation

Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection

(2010) Zhaokan Yuan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Correlation analysis between three novel SNPs of the Src gene in bovine and milk production traits

(2010) Wenyan Liu et al.   MOLECULAR BIOLOGY REPORTS

A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor

(2010) Tao Su et al.   NATURE CELL BIOLOGY

The Preconditioning Effect of Sevoflurane on the Oxygen Glucose-Deprived Hippocampal Slice: The Role of Tyrosine Kinases and Duration of Ischemia

(2009) Stéphanie Sigaut et al.   ANESTHESIA AND ANALGESIA

Nicotinic Receptor-Mediated Neuroprotection in Neurodegenerative Disease Models

(2009) Shun Shimohama   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Breast Cancer Src Activity: Bad to the Bone

(2009) Dennis C. Sgroi   CANCER CELL

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Sustained Src Inhibition Results in Signal Transducer and Activator of Transcription 3 (STAT3) Activation and Cancer Cell Survival via Altered Janus-Activated Kinase-STAT3 Binding

(2009) B. Sen et al.   CANCER RESEARCH

Multiple roles of Lyn kinase in myeloid cell signaling and function

(2009) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

The Absence of Hck, Fgr, and Lyn Tyrosine Kinases Augments Lung Innate Immune Responses to Pneumocystis murina

(2009) M. P. Nelson et al.   INFECTION AND IMMUNITY

Protein-tyrosine Phosphatase α Acts as an Upstream Regulator of Fyn Signaling to Promote Oligodendrocyte Differentiation and Myelination

(2009) Pei-Shan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Profile of Novel Src Kinase Inhibitors in Rodent Models of Cerebral Ischemia

(2009) S. Liang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cardioprotection with α-tocopheryl phosphate: Amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation

(2008) Subhendu Mukherjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lactation failure in Src knockout mice is due to impaired secretory activation

(2008) Harriet Watkin et al.   BMC DEVELOPMENTAL BIOLOGY

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Src Family Kinases as Potential Therapeutic Targets for Malignancies and Immunological Disorders

(2008) Daniela Benati et al.   CURRENT MEDICINAL CHEMISTRY

Involvement of Src Tyrosine Kinases (SFKs) and of Focal Adhesion Kinase (FAK) in the Injurious Mechanism in Rat Primary Neuronal Cultures Exposed to Chemical Ischemia

(2008) Vered Shani et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia

(2008) Kazutoshi Murotomi et al.   JOURNAL OF NEUROCHEMISTRY

Caveolin-1 expression is essential for N-methyl-d-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death

(2007) Brian P. Head et al.   FASEB JOURNAL