Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis

AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia

(2017) Shuai Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

(2017) Thomas Efferth   SEMINARS IN CANCER BIOLOGY

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis

(2017) Jun Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

(2017) Yu-Mei Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity

(2017) Yong Liu et al.   Cell Death & Disease

Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms

(2017) Hong Xiang et al.   Frontiers in Pharmacology

Role of Daphnetin in Rat Severe Acute Pancreatitis Through the Regulation of TLR4/NF-κB Signaling Pathway Activation

(2016) Zhiyong Liu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

(2016) Youyou Tu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways

(2016) Jianli Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Clinical practice guideline: management of acute pancreatitis

(2016) Joshua A. Greenberg et al.   CANADIAN JOURNAL OF SURGERY

Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung

(2016) Junfeng Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Formula Compatibility Identification of Dachengqi Decoction Based on the Effects of Absorbed Components in Cerulein-Injured Pancreatic AR42J Cells

(2016) Yumei Zhang et al.   Evidence-based Complementary and Alternative Medicine

Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitis

(2016) Fabíula Francisca Abreu et al.   FREE RADICAL RESEARCH

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

(2016) Yanyan Cen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ameliorative Effects of Curcumin on Fibrinogen-Like Protein-2 Gene Expression, Some Oxido-Inflammatory and Apoptotic Markers in a Rat Model of l -Arginine-Induced Acute Pancreatitis

(2016) Noha M. Shafik et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The Use of Complementary and Alternative Medicine is Frequent in Patients With Pancreatic Disorders

(2016) Serena Stigliano et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling

(2016) Nazima Bashir et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

(2016) Yingke Zhao et al.   Oxidative Medicine and Cellular Longevity

Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis

(2016) Ze-Si Lin et al.   PHYTOTHERAPY RESEARCH

Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis

(2016) Siu Wai Tsang et al.   Scientific Reports

Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

(2016) Ferda Nihat KOKSOY et al.   Turkish Journal of Gastroenterology

Inflammasomes in pancreatic physiology and disease

(2015) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Curcumin Mediates a Protective Effect Via TLR-4/NF-κB Signaling Pathway in Rat Model of Severe Acute Pancreatitis

(2015) Ke Zhong   CELL BIOCHEMISTRY AND BIOPHYSICS

Effect of Da-Cheng-Qi Decoction on Pancreatitis-Associated Intestinal Dysmotility in Patients and in Rat Models

(2015) Jianlei Zhao et al.   Evidence-based Complementary and Alternative Medicine

Dual pancreas- and lung-targeting therapy for local and systemic complications of acute pancreatitis mediated by a phenolic propanediamine moiety

(2015) Jianbo Li et al.   JOURNAL OF CONTROLLED RELEASE

Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives

(2015) Chenchen Shi et al.   MEDIATORS OF INFLAMMATION

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Metabolomic profiles illuminate the efficacy of Chinese herbal Da-Cheng-Qi decoction on acute pancreatitis in rats

(2015) Juan Li et al.   PANCREATOLOGY

Clinical update on fluid therapy and nutritional support in acute pancreatitis

(2015) Matthew J. DiMagno   PANCREATOLOGY

Protective effect of TMP on pancreas function of acute pancreatitis rats

(2015) Yuan-Chi Weng et al.   Asian Pacific Journal of Tropical Medicine

3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-κB signaling

(2014) Kang-Yi Su et al.   BMC Complementary and Alternative Medicine

Rhein Induces a Necrosis-Apoptosis Switch in Pancreatic Acinar Cells

(2014) Xianlin Zhao et al.   Evidence-based Complementary and Alternative Medicine

The effect of Chinese herbal medicine on non-biliogenic severe acute pancreatitis: A systematic review and meta-analysis

(2014) Xiaoguang Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The effects of resveratrol on tissue injury, oxidative damage, and pro-inflammatory cytokines in an experimental model of acute pancreatitis

(2014) Ahmet Gulcubuk et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Rutin modulates ASC expression in NLRP3 inflammasome: a study in alcohol and cerulein-induced rat model of pancreatitis

(2014) Ravikumar Aruna et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor-κB activation resulting in antioxidation

(2014) WEI-YAN YAO et al.   Molecular Medicine Reports

Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

(2014) Saurabh Bharti et al.   PLANTA MEDICA

Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial

(2014) Bing Wan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature

(2014) Jong-Min Park   WORLD JOURNAL OF GASTROENTEROLOGY

Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin

(2013) Mi Jeong Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

(2013) Anja M. Schaible et al.   BIOCHEMICAL PHARMACOLOGY

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

(2013) Deepti Shrimali et al.   CANCER LETTERS

The Subcellular Localization of the Receptor for Platelet-Activating Factor in Neutrophils Affects Signaling and Activation Characteristics

(2013) Emil Andréasson et al.   Clinical & Developmental Immunology

Expression of caspase activation recruitment and pyrin domain levels of apoptosis-associated speck-like protein complex in the pancreas of rats subjected to experimental pancreatitis

(2013) R Aruna et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Pharmacokinetic and Pharmacodynamic Studies of Four Major Phytochemical Components of Da-Cheng-Qi Decoction to Treat Acute Pancreatitis

(2013) Jianlei Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome

(2013) QINGQIANG NI et al.   Molecular Medicine Reports

Emodin attenuates calcium overload and endoplasmic reticulum stress in AR42J rat pancreatic acinar cells

(2013) LI WU et al.   Molecular Medicine Reports

Ellagic Acid and Embelin Affect Key Cellular Components of Pancreatic Adenocarcinoma, Cancer, and Stellate Cells

(2013) Mouad Edderkaoui et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of curcumin on proinflammatory cytokines and tissue injury in the early and late phases of experimental acute pancreatitis

(2013) Ahmet Gulcubuk et al.   PANCREATOLOGY

Pancreatic stellate cells – Multi-functional cells in the pancreas

(2013) Atsushi Masamune et al.   PANCREATOLOGY

Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7receptor

(2013) Shuyan Zhu et al.   PHARMACEUTICAL BIOLOGY

Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions

(2012) A. R. Neves et al.   CURRENT MEDICINAL CHEMISTRY

Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis

(2012) Xi-Ping Zhang et al.   Hepatobiliary & Pancreatic Diseases International

Baicalin and Scutellarin Are Proteasome Inhibitors that Specifically Target Chymotrypsin-like Catalytic Activity

(2012) Yi-Xin Wu et al.   PHYTOTHERAPY RESEARCH

Acute lung injury in acute pancreatitis – Awaiting the big leap

(2012) Hamid Akbarshahi et al.   RESPIRATORY MEDICINE

Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats

(2012) Xian-Ming Xia   WORLD JOURNAL OF GASTROENTEROLOGY

Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice

(2011) Ujwal Mukund Mahajan et al.   APOPTOSIS

Resveratrol Ameliorates the Deleterious Effect of Severe Acute Pancreatitis

(2011) Rajiv K. Jha et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

(2011) Rafaz Hoque et al.   GASTROENTEROLOGY

Preventive action of curcumin in experimental acute pancreatitis in mouse

(2011) Ke-Li Tian et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis

(2011) X.P. Zhang et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Effect of Da-Cheng-Qi decoction on pancreatitis-associated lung injury in patients and anti-inflammatory responses in rat models

(2011) Jianlei Zhao et al.   PHARMACEUTICAL BIOLOGY

Breviscapine attenuates acute pancreatitis by inhibiting expression of PKCα and NF-κB in pancreas

(2011) Hong Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats

(2011) Run-Li Ji   WORLD JOURNAL OF GASTROENTEROLOGY

Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis

(2010) Hyeyoung Kim   Gut and Liver

XIAP Gene Expression Protects β-Cells and Human Islets from Apoptotic Cell Death

(2010) Hao Wu et al.   MOLECULAR PHARMACEUTICS

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders

(2010) Jui-Lung Shen et al.   MOLECULES

Curcumin Attenuates Airway Hyperreactivity Induced by Ischemia-Reperfusion of the Pancreas in Rats

(2010) K.H. Chen et al.   TRANSPLANTATION PROCEEDINGS

Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis

(2010) Xian-Ming Xia   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory cells regulate p53 and caspases in acute pancreatitis

(2009) Yuji Nakamura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Acute pancreatitis as a model of SIRS

(2009) Madhav Bhatia   Frontiers in Bioscience-Landmark

Effects of Baicalin and Octreotide on the Serum TNF-α Level and Apoptosis in Multiple Organs of Rats with Severe Acute Pancreatitis

(2009) Tian Hua et al.   INFLAMMATION

Effect of baicalin and octreotide on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis

(2009) Xiping Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Early Gut Mucosal Dysfunction in Patients With Acute Pancreatitis

(2009) Haiyan Liu et al.   PANCREAS

Protecting Effects of Emodin on Multiorgan Failure of Rats With Severe Acute Pancreatitis

(2009) Lihong Wan et al.   PANCREAS

Green Tea Polyphenols Ameliorate Pancreatic Injury in Cerulein-Induced Murine Acute Pancreatitis

(2009) Benoy I. Babu et al.   PANCREAS

Protective Effect of Resveratrol in Severe Acute Pancreatitis-Induced Brain Injury

(2009) Rajiv Kumar Jha et al.   PANCREAS

Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis

(2008) Zongfang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol ameliorates hepatic injury via the mitochondrial pathway in rats with severe acute pancreatitis

(2008) Huanchen Sha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis

(2008) Madhav Bhatia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic β-cell line, MIN6

(2008) Fumi Sawada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock

(2007) Lin-lin Liu et al.   BIOCHEMICAL PHARMACOLOGY