Article
Medicine, General & Internal
Almudena Gonzalez-Montaos, Cristina Ramos-Hernandez, Irene Lojo-Rodriguez, Marta Nunez-Fernandez, Alberto Fernandez-Villar
Summary: Nebulized hypertonic saline improves the quality of life and reduces exacerbations in patients with cystic fibrosis. However, it is unknown if it has the same benefits in other hypersecretory pathologies.
Article
Allergy
Abilash Ravi, Annika W. M. Goorsenberg, Annemiek Dijkhuis, Barbara S. Dierdorp, Tamara Dekker, Michel van Weeghel, Yanaika S. Sabogal, Pallav L. Shah, Nick H. T. ten Hacken, Jouke T. Annema, Peter J. Sterk, Frederic M. Vaz, Peter I. Bonta, Rene Lutter
Summary: The study revealed distinct differences in the transcriptomes and lipidomes of BECs in patients with asthma, with reduced expression of OXPHOS genes and altered lipid species levels. These metabolic differences were associated with inflammation and asthma severity, and could be reversed after bronchial thermoplasty.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adrianna Dabrowska, Miroslaw Zajac, Piotr Bednarczyk, Agnieszka Lukasiak
Summary: Particulate matter exposure increases reactive oxygen species levels, leading to cell death. Quercetin, through activation of mitoBK(Ca), can mitigate the adverse effects of particulate matter on airway epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Francesca Sposito, Sarah Northey, Amandine Charras, Paul S. McNamara, Christian M. Hedrich
Summary: This study aimed to investigate whether 3% NaCl triggers inflammation in human macrophages and identify the molecular mechanisms involved. The results showed that 3% NaCl induces inflammatory responses in human macrophages through NLRP1 and inflammasome assembly. Targeting inflammation in addition to inhalation with hypertonic saline may benefit patients with inflammatory airway disease.
GENES AND IMMUNITY
(2023)
Article
Respiratory System
Maria Budai-Szucs, Szilvia Berko, Anita Kovacs, Pongsiri Jaikumpun, Rita Ambrus, Adrien Halasz, Piroska Szabo-Revesz, Erzsebet Csanyi, Akos Zsembery
Summary: This study investigated the effect of hypertonic salt solutions on CF sputum viscoelasticity in vitro, using a rheometer to measure the rheological properties of samples. The results showed significant changes in gel strength when different additives were used at varying ratios, with NaHCO3 having the most pronounced effect. The study highlights the importance of individual evaluation of sputum samples based on their rheological properties for effective treatment.
BMC PULMONARY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Feng Guo, Yuan Hao, Li Zhang, Damien C. Croteau-Chonka, Derek Thibault, Parul Kothari, Lijia Li, Bruce D. Levy, Xiaobo Zhou, Benjamin A. Raby
Summary: GWAS-identified asthma susceptibility risk alleles increase the expression of ORMDL3, which promotes autophagy and cell death by impairing intracellular calcium mobilization through interacting with SERCA2, thereby impairing bronchial epithelial function in asthma.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Ophthalmology
Pia Inborr, Mika Harju, Tero T. Kivela
Summary: This study compared the effects of single versus split bolus of intravenous hypertonic saline on intraocular pressure and pain, finding that splitting the bolus did not reduce pain associated with IVHTS. Therefore, a single bolus is recommended.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Ulf Hedstrom, Lisa Oberg, Outi Vaarala, Goran Dellgren, Martin Silverborn, Leif Bjermer, Gunilla Westergren-Thorsson, Oskar Hallgren, Xiaohong Zhou
Summary: The study found that airway epithelial cells in patients with Chronic Obstructive Pulmonary Disease (COPD) are damaged, and COPD epithelial cells show differential gene expression on COPD airway scaffolds compared to normal epithelial cells, with increased proliferation and maintained basal cell phenotype.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Huang-Chi Chen, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Szu-Chia Chen, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chao-Hung Kuo
Summary: This study demonstrates that montelukast is effective at reducing arsenic-induced epithelial-mesenchymal transition (EMT) in human bronchial epithelial cells. By inhibiting arsenic-induced reactive oxygen species (ROS) generation and NF-kB activation, montelukast can suppress arsenic-induced cell migration and the expression of extracellular matrix proteins and EMT-regulating transcription factors. Combination treatment with fluticasone and montelukast can reverse the inhibitory effect of montelukast on arsenic-induced EMT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Ariel Berlinski
Summary: The study compared the aerosol characteristics of hypertonic saline delivered by nebulizers of different operating principles, finding that aerosols generated by the breath-enhanced and breath-actuated nebulizers were similar, while those generated by the continuous-output nebulizer were different. Airway delivery values were similar between the two breath-enhanced nebulizers and higher than those observed with the breath-actuated and continuous-output nebulizers.
Article
Cell Biology
A. Brito, T. Santos, K. Herculano, M. Miranda, A. K. Sa, J. L. Carvalho, R. Albertini, H. Castro-Faria-Neto, A. P. Ligeiro-de-Oliveira, Flavio Aimbire
Summary: The study found that phototherapy has a dual effect on human bronchial epithelial cells activated by cigarette smoke extract. It downregulates the secretion of IL-8 and cAMP, while upregulating IL-10 through the Sp1 transcription factor.
Review
Ophthalmology
Shing-Chuen Chow, Jonathan Cheuk-Hung Chan
Summary: Topical ocular hypertonic saline appears to be a safe and effective treatment for less severe forms of corneal edema and other corneal disorders such as filamentary keratitis. The efficacy varies depending on the specific corneal disorder being treated.
Article
Food Science & Technology
Anita R. Iskandar, Aditya Reddy Kolli, Albert Giralt, Laurent Neau, Maria Fatarova, Athanasios Kondylis, Laura Ortega Torres, Shoaib Majeed, Celine Merg, Maica Corciulo, Keyur Trivedi, Emmanuel Guedj, Stefan Frentzel, Florian Calvino, Philippe Alexandre Guy, Nikolai Ivanov, Manuel C. Peitsch, Julia Hoeng
Summary: The fate of nebulized trehalose in human airway tissues and its potential adverse effects were investigated, showing that trehalose was metabolized into glucose without causing significant adverse effects. This in vitro testing approach may aid in selecting excipients for future inhalation products.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Antoine Roquilly, Jean Denis Moyer, Olivier Huet, Sigismond Lasocki, Benjamin Cohen, Claire Dahyot-Fizelier, Kevin Chalard, Philippe Seguin, Caroline Jeantrelle, Veronique Vermeersch, Thomas Gaillard, Raphael Cinotti, Dominique Demeure Dit Latte, Pierre Joachim Mahe, Mickael Vourc'h, Florian Pierre Martin, Alice Chopin, Celine Lerebourg, Laurent Flet, Anne Chiffoleau, Fanny Feuillet, Karim Asehnoune
Summary: This clinical trial conducted in France explores whether continuous infusion of hypertonic saline solution improves neurological outcome at 6 months in patients with traumatic brain injury.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Environmental Sciences
Zhigang Sui, Xiaoyao Song, Yujie Wu, Rui Hou, Jianhui Liu, Baofeng Zhao, Zhen Liang, Jiping Chen, Lihua Zhang, Yukui Zhang
Summary: This study evaluated the cytotoxicity of PM2.5 on BEAS-2B cells and investigated the changes of extracellular proteome after PM2.5 exposure. PM2.5 was found to promote the release of pro-apoptotic factors and induce dysregulated secretion of extracellular matrix.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Letter
Respiratory System
Kelsey B. Haywood, Jennifer L. Goralski
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew McCallister, Sang Hun Chung, Michael Antonacci, Margret Z. Powell, Agathe S. Ceppe, Scott H. Donaldson, Yueh Z. Lee, Rosa Tamara Branca, Jennifer L. Goralski
Summary: In CF subjects, ventilation abnormalities can be identified by both (19)F and (HPXe)-Xe-129 imaging, but these abnormalities are not entirely congruent. (19)F and (HPXe)-Xe-129 imaging provide complementary information that allows for differentiation of normally ventilated, slowly ventilated, and non-ventilated regions in the lungs.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Pediatrics
Jennifer L. Goralski, Neil J. Stewart, Jason C. Woods
Summary: This review discusses the latest developments in lung imaging modalities for CF patients, ranging from commonly used chest radiography and CT scans to emerging techniques like structural/functional proton and hyperpolarized gas MRI. These imaging tools offer new possibilities for early disease detection and monitoring treatment efficacy.
PEDIATRIC PULMONOLOGY
(2021)
Article
Medicine, General & Internal
Jennifer L. Goralski, Sang Hun Chung, Agathe S. Ceppe, Margret Z. Powell, Muthu Sakthivel, Brian D. Handly, Yueh Z. Lee, Scott H. Donaldson
Summary: The availability of highly effective CFTR modulators is revolutionizing the treatment of cystic fibrosis, and MRI-based imaging modalities are emerging as highly sensitive endpoints in monitoring the effectiveness of the treatment. This observational study demonstrates the ability of F-19 MRI and H-1 UTE MRI to detect improvements in lung structure and function after E/T/I treatment, further supporting their potential as outcome measures for cystic fibrosis research and drug development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Pediatrics
A. M. Stapleton, A. J. Kimple, J. L. Goralski, M. Nouraie, A. Shaffer, J. M. Pilewski, B. A. Senior, S. Lee, A. Zemke
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
C. J. Majoor, K. Van Brunt, C. Daines, I Durieu, I Fajac, J. L. Goralski, H. Heijerman, C. Knoop, J. Booth, S. M. Moskowitz, J. Savage, C. Wang, A. L. Quittner
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
M. Mihailescu, A. Ceppe, S. Chung, J. L. Goralski, K. Zeman, B. Handly, M. Sakthivel, M. R. Markovetz, W. D. Bennett, Y. Lee, S. H. Donaldson
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
K. S. Raraigh, K. C. Paul, J. L. Goralski, E. N. Worthington, A. Faino, S. Sciortino, Y. Wang, M. A. Aksit, H. Ling, D. L. Osorio, F. M. Onchiri, S. Patel, C. Merlo, K. Montemayor, R. Gibson, N. E. West, D. N. Sheppard, N. Sharma, G. R. Cutting
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
T. Girdwood, C. Jones, J. L. Goralski, A. Beeber
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
J. L. Goralski, S. Chung, M. Powell, A. Ceppe, M. Sakthivel, Y. Lee, S. H. Donaldson
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
A. J. Kimple, A. M. Stapleton, J. L. Goralski, M. Nouraie, A. Shaffer, J. M. Pilewski, B. A. Senior, A. Zemke, S. E. Lee
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
M. L. Buchanan, L. Rupcich, K. Wendel, J. L. Goralski, S. H. Donaldson, N. Sowa
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Pediatrics
I Fajac, K. Van Brunt, C. Daines, I Durieu, J. L. Goralski, H. Heijerman, C. Knoop, C. J. Majoor, J. Booth, S. M. Moskowitz, J. Savage, C. Wang, A. L. Quittner
PEDIATRIC PULMONOLOGY
(2020)
Meeting Abstract
Critical Care Medicine
E. Worthington, J. L. Goralski
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Medicine, Research & Experimental
Jennifer L. Goralski, Sang Hun Chung, Tyler M. Glass, Agathe S. Ceppe, Esther O. Akinnagbe-Zusterzeel, Aaron T. Trimble, Richard C. Boucher, Brian J. Soher, H. Cecil Charles, Scott H. Donaldson, Yueh Z. Lee