Article
Engineering, Environmental
Ting Fan, Wenping Ye, Pengxuan Zhao, Weixin Zhou, Yan Chen, Chuanchuan He, Xiaojuan Zhang, Ruicong Yan, Chen Chen, Jun Luo, Tan Yang, Xiang Ma, Guangya Xiang, Yao Lu
Summary: The study demonstrates the use of pH-responsive core-shell nanoparticles for co-delivery of oxaliplatin intermediate and CpG oligodeoxynucleotides to enhance cancer treatment. The nanoparticles induced immunogenic cell death and increased antigen presentation, leading to enhanced anti-tumor immune response. In addition, the nanoparticles increased the infiltration of CD8+ T cells in the tumor microenvironment, eliciting significant tumor immunity and abscopal effect.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Dominic M. Gray, Adam R. Town, Edyta Niezabitowska, Steve P. Rannard, Tom O. McDonald
Summary: In this study, we report the synthesis of core-shell nanogels by sequential addition of thermoresponsive monomers. The aggregation behavior of these particles in the presence of salt can be controlled by varying the monomer ratio. The inclusion of a degradable cross-linker allows the nanogels to degrade in the presence of a reducing agent, with different degradation levels observed for nanogels composed of different monomer compositions. These findings are important under physiological conditions.
Article
Polymer Science
Anne Huppertsberg, Christian Leps, Irina Alberg, Christine Rosenauer, Svenja Morsbach, Katharina Landfester, Stefan Tenzer, Rudolf Zentel, Lutz Nuhn
Summary: After intravenous administration of nanocarriers, plasma proteins rapidly adsorb onto their surfaces, hampering the prediction of their pharmacokinetics. Investigating the interaction between nanocarriers and plasma proteins is essential for clinical translation. This study evaluates a highly PEGylated squaric ester-based nanogel and finds that the proteins detected on the nanogels are likely a result of passive diffusion rather than specific interactions at the plasma particle interface.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qiu-Yi Duan, Ya-Xuan Zhu, Hao-Ran Jia, Yuxin Guo, Xinping Zhang, Ruihan Gu, Chengcheng Li, Fu-Gen Wu
Summary: A dual-responsive nanogel platform is constructed in this study, which possesses excellent drug loading and intracellular delivery capabilities. The nanogel can degrade and release drugs when encountering hyaluronidase or glutathione, and it can also deliver proteins without hinderance from serum proteins and maintain enzymatic activities. Furthermore, the nanogel can co-deliver different cargoes for combination therapy.
Article
Chemistry, Multidisciplinary
Micaela A. Macchione, Dariana Aristizabal Bedoya, Eva Rivero-Buceta, Pablo Botella, Miriam C. Strumia
Summary: Hybrid nanogels based on mesoporous silica nanoparticles were developed using ultrasound-assisted free radical precipitation/polymerization, characterized by various analytical techniques, and studied for their biological activity in cell lines and drug loading capacity. The results indicate excellent biocompatibility and drug release properties of these hybrid nanogels.
Article
Nanoscience & Nanotechnology
Teresa Guaragnone, Marta Rossi, David Chelazzi, Rosangela Mastrangelo, Mirko Severi, Emiliano Fratini, Piero Baglioni
Summary: A novel polymeric network, pHEMA/PAA, is proposed for the removal of corrosion layers on bronze artifacts. Compared to the previous pHEMA/PVP network, pHEMA/PAA has stronger ion-matrix interaction and can more effectively and rapidly remove corrosion products. This polymeric network has potential applications in various fields beyond Cultural Heritage conservation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Teresa Guaragnone, Marta Rossi, David Chelazzi, Rosangela Mastrangelo, Mirko Severi, Emiliano Fratini, Piero Baglioni
Summary: The novel pHEMA/PAA SIPNs can enhance the capture of copper ions and removal of corrosion products in bronze artifacts, outperforming the previous pHEMA/PVP networks. The pHEMA/PAA shows stronger and faster action with selectivity, promising applications in various fields.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Ali Maruf, Malgorzata Milewska, Anna Lalik, Ilona Wandzik
Summary: This study reports the synthesis of degradable pH/reduction dual-responsive nanogels for encapsulation and targeted release of doxorubicin hydrochloride (DOX) in conditions characteristic of the cancer microenvironment. The nanogels showed high drug loading capacity and stability in various biological media. In vitro experiments demonstrated enhanced cytotoxic effect of the DOX-loaded nanogels compared to free DOX.
Article
Pharmacology & Pharmacy
Kummara Madhusudana Rao, Maduru Suneetha, Dachuru Vinay Kumar, Hyeon Jin Kim, Yong Joo Seok, Sung Soo Han
Summary: This study developed Dox-encapsulated nanogels that can release the drug under dual stimuli conditions, showing potential for effective cancer treatment.
Article
Biochemistry & Molecular Biology
Yuning Zhang, Joakim Hakansson, Yanmiao Fan, Oliver C. J. Andren, Jorge San Jacinto Garcia, Liguo Qin, Anita Umerska, Daniel J. Hutchinson, Mads Luchow, Margit Mahlapuu, Michael Malkoch
Summary: A hybrid hierarchical delivery system for topical delivery of antimicrobial peptides (AMPs) was developed by incorporating AMPs into dendritic nanogels (DNGs) and embedding them into poloxamer gel. The system exhibited a slower release rate compared to direct entrapment in the gels, and showed good biocompatibility and strong antibacterial effects against Staphylococcus aureus.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Panpan Song, Nannan Song, Li Li, Minghao Wu, Zhongxia Lu, Xia Zhao
Summary: A pH/reduction-sensitive carboxymethyl chitosan nanogel modified by targeting peptide angiopep-2 loaded with doxorubicin shows promising potential for targeted chemotherapy of glioblastoma. The targeted nanogel exhibited good stability, biocompatibility, and enhanced BBB penetration and tumor targeting ability, leading to higher drug uptake and stronger antitumor activity compared to nontargeted nanogels. This innovative nanogel platform with pH/reduction dual-stimuli response may hold great significance for GBM-targeted therapy.
Article
Chemistry, Multidisciplinary
Junjie Deng, Weide Xu, Siyun Lei, Wanyu Li, Qinghua Li, Kaiqiang Li, Jianxin Lyu, Jilong Wang, Zhen Wang
Summary: This study addresses the challenges in immunotherapy for low immunogenic tumors by using responsive nanogels to promote NK cell activation and induce DC recruitment. By modifying the tumor microenvironment, this strategy effectively inhibits tumor growth and recurrence.
Article
Polymer Science
Felix Reisbeck, Alexander Ozimkovski, Mariam Cherri, Mathias Dimde, Elisa Quaas, Ehsan Mohammadifar, Katharina Achazi, Rainer Haag
Summary: A dual-responsive drug delivery system was synthesized in this study, which exhibited enhanced drug release under different stimuli and efficient inhibition of cancer cell growth. The system showed good biocompatibility and tolerability while achieving targeted drug release and cytotoxic effects on cancer cells.
Article
Chemistry, Multidisciplinary
Shuhua Chang, Dawei Qin, Rongjun Yan, Mengli Zhang, Binglin Sui, Hui Xu, Zhaomin Zheng, Xiaoli Hou, Yonggang Wang, Chenggang Qi
Summary: pH- and temperature-sensitive nanogels were prepared from modified sodium alginate, showing potential application in solid tumor targeted therapy. The newly synthesized nanogels possess low cytotoxicity and high biocompatibility, demonstrating the capability to release drugs according to environmental changes.
Article
Polymer Science
Malihe Pooresmaeil, Hassan Namazi, Roya Salehi
Summary: In this research, a new double-responsive nanogel with pH and temperature sensitivity, as well as photoluminescent properties, was designed and fabricated. The success in fabrication was confirmed using common characterization techniques. The potential of the nanogel as a targeted drug carrier was evaluated, and it showed good performance in loading and controlled release of anticancer drugs. The nanogel also demonstrated good biocompatibility and bioimaging potential, making it a promising medical nanovehicle for cancer cells monitoring and co-drug delivery.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Neha Tiwari, Ernesto Rafael Osorio-Blanco, Ana Sonzogni, David Esporrin-Ubieto, Huiyi Wang, Marcelo Calderon
Summary: Nanosized carrier systems offer a promising alternative for improving skin penetration of therapeutic molecules with minimal damage to the skin's natural barrier. The use of nanoparticles for delivering drugs, genetic material, and vaccines into the skin is discussed, along with the importance of nanotoxicology studies and recent clinical developments in shedding light on their potential for market translation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Maria Soledad Orellano, Oihane Sanz, Sandra Camarero-Espinosa, Ana Beloqui, Marcelo Calderon
Review
Nanoscience & Nanotechnology
Huiyi Wang, Matias L. Picchio, Marcelo Calderon
Summary: Inspired by the development of nanomedicine and nanotechnology, the field of cancer theranostics has seen significant progress in recent years. Nanogels, with their unique attributes such as high stability and encapsulation capacity, have been extensively studied for drug delivery and various bioimaging techniques.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Emanuel A. Glitscher, Julian Bergueiro, Marcelo Calderon
Summary: The novel strategy of incorporating anisotropic gold nanoparticles into polymeric thermoresponsive nanogels has expanded their potential applications in the field of nanomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Meeting Abstract
Ophthalmology
Arantxa Acera, David Esporrin, Aitor Diaz, Juliana De Souza, Mercedes Fernandez, Jorge Burgos, Javier Zabalza, Xandra Pereiro, Marcelo Calderon, Damien Dupin, Elena Vecino
ACTA OPHTHALMOLOGICA
(2022)
Article
Pharmacology & Pharmacy
Maria Laura Soriano Perez, Javier Alejandro Funes, Carolina Flores Bracamonte, Luis Exequiel Ibarra, Marina Andrea Forrellad, Oscar Taboga, Laura Noelia Cariddi, Facundo Jose Salinas, Hugo Hector Ortega, Fabrisio Alustiza, Maria Molina
Summary: This study reported the synthesis and performance of thermoresponsive nanogels based on poly(N-isopropylacrylamide) (pNIPAM). The cytotoxicity, internalization ability, antigen protection and delivery capability of the nanogels were evaluated in vitro and in vivo. The results demonstrated that the pNIPAM nanogels can stimulate a humoral immune response.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Maria Beatrice Bianchi, Chunyang Zhang, Elise Catlin, Giuseppina Sandri, Marcelo Calderon, Eneko Larraneta, Ryan F. Donnelly, Matias L. Picchio, Alejandro J. Paredes
Summary: Egels are emerging soft ionic materials with excellent elasticity, non-volatile nature, and adhesion properties, making them suitable for drug delivery. This study reports the first example of adhesive Egels loading drug nanocrystals for controlled delivery to mucosal tissues.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Multidisciplinary
Rohit Pappu, Samuel R. Cohen, Furqan Dar, Mina Farag, Mrityunjoy Kar
Summary: In this review, we discuss the role of multivalent associative biomacromolecules, such as proteins and nucleic acids, in the formation and regulation of biomolecular condensates. We also explore the concepts of phase transitions in aqueous solutions of these associative biomacromolecules and their relevance to biomolecular condensates.
Article
Polymer Science
Miren Aguirre, Nicholas Ballard, Edurne Gonzalez, Shaghayegh Hamzehlou, Haritz Sardon, Marcelo Calderon, Maria Paulis, Radmila Tomovska, Damien Dupin, Ren H. Bean, Timothy E. Long, Jose R. Leiza, Jose M. Asua
Summary: The water-based emulsion polymerization process has led to the continuous growth in commercial use of polymer colloids due to its high efficiency and versatility in production. This perspective highlights the challenges in synthesis and application of polymer colloids, including the transition towards sustainable feedstocks and reduced environmental impact in their primary applications, as well as the design and application of novel polymer colloids in emerging areas. Unconventional processing techniques utilizing the unique colloidal nature are also presented.
Article
Nanoscience & Nanotechnology
Lucinda E. Mulko, Emma A. Cuello, Robert Baumann, Anthony R. Ramuglia, Inez M. Weidinger, Diego F. Acevedo, Cesar A. Barbero, Maria Molina, Andres Fabian Lasagni
Summary: In this study, a polyacrylamide graphene oxide hydrogel composite (GO@pAAm) was photo-converted and structured by ultra-short laser irradiation using a direct laser writing (DLW) approach. The laser structure generated surface foaming and patterning, enhanced selective water-swelling microdomains, and effective photo-reduction of graphene oxide. The reduction of graphene oxide was evidenced by changes in the Raman spectroscopy signals. Macroscopically, the conductivity of the material increased, suggesting a reduction in sheet resistance.
Article
Polymer Science
Alexis Wolfel, Huiyi Wang, Ernesto Rafael Osorio-Blanco, Julian Bergueiro, Marcelo Ricardo Romero, Cecilia Ines Alvarez Igarzabal, Marcelo Calderon
Summary: Advancements in nanogel applications require precise control over their size, structure, and functionalization. In this work, a post-synthesis reaction strategy was developed to modify the structure and functionalization of thermoresponsive nanogels. The incorporation of a cleavable crosslinker allows control over the crosslinking degree and architecture of the nanogels, and introduces alpha-oxoaldehydes for subsequent bio-conjugation. This strategy provides a valuable tool for fine-tuning drug delivery nanodevices in a post-synthetic step.
Meeting Abstract
Oncology
S. Deepika, P. Jain, P. Saha, S. G, R. K, M. Sultania, B. M. Padhy, B. Behera, M. Kar, D. Muduly
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
S. Deepika, P. Jain, P. Saha, M. Sultania, M. Kar, S. Majumdar, S. Barik, M. Sable, P. Mishra, D. Muduly
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Yannic Kerkhoff, Stefanie Wedepohl, Chuanxiong Nie, Vahid Ahmadi, Rainer Haag, Stephan Block
Summary: The ability to automatically analyze large quantities of image data is valuable in biochemical assays. This article introduces a fast and robust Fiji macro for analyzing cellular fluorescence microscopy images with single-cell resolution. The macro was validated and applied to quantify transfection efficiency and virus infection inhibition, showing good performance compared to manual image quantification. It is a versatile tool applicable to most monolayered cellular assays with nuclei staining.
Article
Materials Science, Biomaterials
Julian Bergueiro, Emanuel A. Glitscher, Marcelo Calderon
Summary: Temperature-trigger chemotherapy is an advanced anti-tumoral strategy in nanomedicine. A nanogel system composed of a thermoresponsive polymer cross-linked by plasmonic gold nanoparticles (AuNPs) has been constructed for temperature-trigger chemotherapy. Experimental results showed that the temperatures reached in the in vivo near infrared irradiation had a negative effect on the inhibition of the tumor growth, while the drug loaded systems considerably reduced the tumor sizes.
BIOMATERIALS ADVANCES
(2022)