Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 45, Pages 25434-25440Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b08301
Keywords
solvent barriers; lateral flow devices; porous media; paper devices; microfluidics; pullulan
Funding
- Natural Sciences and Engineering Research Council of Canada through the SENTINEL Bioactive Paper Network
- Canadian Foundation for Innovation
- Ontario Ministry of Research and Innovation
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The utility of hydrophobic wax barriers in paper-based lateral flow and multiwell devices for containment of aqueous solvents was extended to organic solvents and challenging aqueous surfactant solutions by preparation of a three layer barrier, consisting of internal pullulan impregnated paper barriers surrounded by external wax barriers. When paper impregnated with pullulan solution dries, the polymer forms solvent blocking lenses in the paper structure. Lens formation was illustrated by forming pullulan lenses in glass capillaries. The lens shapes were less curved compared to the predictions of a model based upon minimizing surface area. For barriers on Whatman # 1 filter paper, the pullulan molecular weight must be greater than similar to 70 kDa, the mass fraction of pullulan in the barrier zone must be at least 32%, and there are restrictions on the minimum width of the pullulan impregnated zone.
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