Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 58, Issue 6, Pages 2229-2242Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-018-1773-3
Keywords
Case-control study; Diet; Antioxidants; Colorectal neoplasms; Risk factors
Categories
Funding
- Accion Transversal del Cancer'
- Instituto de Salud Carlos III [PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, PI15/00069, PI12/00002]
- Fundacion Marques de Valdecilla [API 10/09]
- Junta de Castilla y Leon [LE22A10-2]
- Consejeria de Salud of the Junta de Andalucia [2009-S0143]
- Conselleria de Sanitat of the Generalitat Valenciana [AP 061/10]
- Recercaixa [2010ACUP 00310]
- Regional Government of the Basque Country
- Consejeria de Sanidad de la Region de Murcia
- European Commission [FOOD-CT-2006-036224-HIWATE]
- Spanish Association Against Cancer (AECC) Scientific Foundation
- Catalan Government DURSI [2014SGR647]
- Fundacion Caja de Ahorros de Asturias
- University of Oviedo
- Societat Catalana de Digestologia
- COST action Eucolongene [BM1206]
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Purpose Studies attempting to link dietary non-enzymatic antioxidant activity (NEAC) and colorectal cancer (CRC) risk have reported mixed results. We examined this association in the Spanish Multicase-Control Study considering the likely influence of coffee and other dietary factors. Methods 1718 CRC cases and 3312 matched-controls provided information about diet through a validated 140-item food frequency questionnaire. Dietary NEAC was estimated for three methods [total radical-trapping antioxidant parameters (TRAP), ferric reducing/antioxidant power (FRAP) and TEAC-ABTS] using published values of NEAC content in food, with and without coffee's NEAC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through unconditional logistic regression models adjusted for lifestyle and dietary factors. Results Overall dietary intake of NEAC was significantly lower in cases compared to controls and associated with a significantly reduced CRC risk, in both men (ORQ5vsQ1 = 0.67, 95% CI 0.47-0.96 for FRAP) and women (ORQ5vsQ1 = 0.53, 95% CI 0.32-085 for FRAP), in multivariate models with and without the antioxidant contribution from coffee. The effect was similar for all the NEAC methods evaluated and for both colon and rectum. The association between dietary NEAC and CRC risk became non-significant when adjusting for fiber intake. However, intakes of NEAC and fiber were correlated. Conclusion This study indicates that intake of an antioxidant-rich plant-based diet, both with and without NEAC from coffee, is associated with decreased CRC risk.
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