Article
Endocrinology & Metabolism
Neda Rasouli, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, Anastassios G. Pittas
Summary: Supplementation with vitamin D-3 for 24 months did not improve beta-cell function in people with prediabetes, but showed benefits in those with very low baseline vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer Miao, Katherine N. Bachmann, Shi Huang, Yan Ru Su, Jeffery Dusek, Christopher Newton-Cheh, Pankaj Arora, Thomas J. Wang
Summary: Experimental and observational studies suggest a link between vitamin D and cardiovascular and metabolic disease, but randomized controlled trials have not confirmed this. High-dose vitamin D supplementation did not improve biomarkers of glycemia, inflammation, neurohormonal activation, or lipids in this study.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Chemistry, Medicinal
Majid Karandish, Hassan Mozaffari-Khosravi, Seyed Mohammad Mohammadi, Bahman Cheraghian, Maryam Azhdari
Summary: Management of prediabetes is crucial in preventing type-2 diabetes. This clinical trial examined the effects of curcumin and zinc supplementation on glycemic parameters, showing improvements in fasting plasma glucose, 2-hour postprandial glucose, HbA1C, insulin sensitivity, and insulin resistance. Dietary intake, physical activity, weight, and beta-cell function did not significantly differ among the groups after the intervention.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Laura Scandolin, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena
Summary: Recent evidence suggests that mildly increased fasting and post-oral load blood glucose concentrations are associated with organ damage in nondiabetic patients with hypertension. This study aimed to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension.
Review
Medicine, General & Internal
Giuseppe Morgante, Ilenia Darino, Amelia Spano, Stefano Luisi, Alice Luddi, Paola Piomboni, Laura Governini, Vincenzo De Leo
Summary: Recent literature highlights the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). VD deficiency is common in women with PCOS, especially those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, insulin resistance, and increased diabetes risk. VD deficiency may also be related to hyperandrogenism in PCOS patients. VD plays a crucial role in various physiological functions and has potential effects on glucose homeostasis, hormonal status, lipid concentrations, and inflammation and oxidative stress. VD supplementation has been shown to improve insulin resistance, lipid metabolism, and response to ovulation induction in PCOS women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Radmila Sparic, Mladen Andjic, Daniele Vergara, Andrea Morciano, Ottavia D'Oria, Giorgio Maria Baldini, Antonio Malvasi, Andrea Tinelli
Summary: There is a reported association between low vitamin D levels and PCOS as well as insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders, oxidative stress, and pro-inflammatory milieu in PCOS women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Nutrition & Dietetics
Xiaomin Sun, Tao Yan, Zhongying Li, Sirui Zhou, Wen Peng, Wei Cui, Jing Xu, Zhen-Bo Cao, Lin Shi, Youfa Wang
Summary: This study investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma lipidome of participants with type 2 diabetes. The interventions did not improve insulin resistance but led to changes in the plasma lipidome. Baseline plasma lipid levels could predict an individual's response to intervention.
Review
Nutrition & Dietetics
Agata Pienkowska, Justyna Janicka, Michal Duda, Karena Dzwonnik, Kamila Lip, Aleksandra Medza, Agnieszka Szlagatys-Sidorkiewicz, Michal Brzezinski
Summary: This study aimed to evaluate the potential benefits of vitamin D supplementation in preventing diabetes and found that it does not reduce insulin resistance or the risk of developing type 2 diabetes in prediabetes. Due to the variation in study designs and biases, clear interpretation of the results is not possible, and long-term and well-designed studies are still required.
Article
Endocrinology & Metabolism
Flavia Tosi, Michela Villani, Matteo Migazzi, Giulia Faccin, Sabrina Garofalo, Tom Fiers, Jean-Marc Kaufman, Enzo Bonora, Paolo Moghetti
Summary: Insulin-mediated substrate use is impaired in women with PCOS regardless of phenotype, with a greater impact in individuals with the classic phenotype. Free testosterone independently contributes to abnormalities in insulin action in glucose and lipid metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Flavia Tosi, Michela Villani, Matteo Migazzi, Giulia Faccin, Sabrina Garofalo, Tom Fiers, Jean-Marc Kaufman, Enzo Bonora, Paolo Moghetti
Summary: This study aimed to evaluate the effects of insulin on glucose and lipid oxidation as well as nonoxidative glucose metabolism in different PCOS phenotypes. The results show that insulin-mediated substrate use is impaired in women with PCOS, with greater dysfunction in individuals with the classic phenotype. Free testosterone plays an independent role in insulin action abnormalities in glucose and lipid metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Wan Nor Fazila Hafizan Wan Nik, Hani Ajrina Zulkeflee, Siti Nadirah Ab Rahim, Tuan Salwani Tuan Ismail
Summary: Insulin resistance increases the risk of diabetes, and improving insulin sensitivity is crucial for preventing complications. Vitamin D plays a role in insulin regulation, but more research is needed to confirm if supplementation improves insulin function. Magnesium, closely related to vitamin D, may also affect glycemic control. Combined supplementation of vitamin D and magnesium improves glycemic control in patients with diabetes.
WORLD JOURNAL OF DIABETES
(2023)
Article
Nutrition & Dietetics
Qunyan Xiang, Hui Xu, Junkun Zhan, Shuzhen Lu, Shuang Li, Yanjiao Wang, Yi Wang, Jieyu He, Yuqing Ni, Linsen Li, Yiyang Liu, Youshuo Liu
Summary: This study aimed to explore the association between insulin resistance (IR) and vitamin D deficiency (VDD). A negative correlation between the triglyceride-glucose (TyG) index and vitamin D level was found in patients with type 2 diabetes mellitus (T2DM). After adjusting for clinical and laboratory parameters, it was revealed that patients with higher TyG index had an increased risk of VDD in the T2DM population.
Article
Nutrition & Dietetics
Fatemeh Rahimi Sakak, Nazanin Moslehi, Mahtab Niroomand, Parvin Mirmiran
Summary: The daily intake of 360 μg vitamin K-2 in the form of MK-7 for 12 weeks reduced FPG and HbA1c in patients with T2DM, but did not have a lipid-lowering effect.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Immunology
Silvia D'Ippolito, Anna Capozzi, Giovanni Scambia, Roberto Sorge, Stefano Lello, Nicoletta Di Simone
Summary: This study found a significant correlation between insulin and insulin resistance in women with recurrent pregnancy loss, while a negative but non-significant correlation was observed between vitamin D levels and insulin. Vitamin D may play additional roles in the pathogenesis of recurrent pregnancy loss beyond its immunomodulatory role.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Maria Mercedes Chang Villacreses, Rudruidee Karnchanasorn, Panadeekarn Panjawatanan, Horng-Yih Ou, Ken C. Chiu
Summary: Vitamin D is known to play a vital role in bone health and calcium homeostasis, but its effects on glucose and fuel homeostasis remain controversial. Studies suggest that vitamin D supplementation is beneficial for individuals with vitamin D deficiency, while it does not show significant benefits for those with excessively high serum 25-hydroxyvitamin D levels. More research is needed to confirm these findings.
WORLD JOURNAL OF DIABETES
(2021)
Article
Nutrition & Dietetics
Nicholas Hutchings, Varta Babalyan, Annemieke C. Heijboer, Sisak Baghdasaryan, Mushegh Qefoyan, Arus Ivanyan, Mariette T. Ackermans, Anna Maria Formenti, Olga Lesnyak, Andrea Giustina, John P. Bilezikian
Summary: In Armenia, there is a high prevalence of vitamin D insufficiency among women, with the majority having levels below the standard. Supplementation with calcium, vitamin D, or multivitamins, as well as sun exposure, were associated with higher levels of vitamin D.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Sarah Collet, Noor Gieles, Chantal M. Wiepjes, Annemieke C. Heijboer, Tim Reyns, Tom Fiers, Bruno Lapauw, Martin den Heijer, Guy T'Sjoen
Summary: The study found that testosterone levels in transgender women remain stable after initiating feminizing hormone therapy. Adrenal androgens decrease in the first year of hormone therapy and remain unchanged after gonadectomy. The correlation with clinical symptoms still needs to be elucidated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simon Heller, Tadej Battelino, Timothy S. Bailey, Thomas R. Pieber, Ulrike Hoevelmann, Leona Plum-Moerschel, Anita E. Melgaard, Ronnie Aronson, Linda A. DiMeglio, Thue Johansen, Thomas Danne
Summary: This study analyzed the safety and efficacy of dasiglucagon, a glucagon analogue, in treating severe hypoglycemia in patients with type 1 diabetes. The results showed that dasiglucagon had a similar safety profile as reconstituted glucagon and was more effective in glucose recovery compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Medicine, General & Internal
Stefan Pilz, John P. A. Ioannidis
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Natasha M. Appelman-Dijkstra, Stefan Pilz
Summary: Taking care of pregnant patients with parathyroid disorders requires consideration of changes in bone and mineral metabolism. The diagnostic and therapeutic approaches differ from the nonpregnant population. Parathyroidectomy is recommended for primary hyperparathyroidism before pregnancy to reduce complications. Conservative treatment and active surveillance are recommended for hypoparathyroidism. Postpartum monitoring is necessary, as there is an increased risk of hypercalcemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
John P. Bilezikian, Neil Binkley, Hector F. De Luca, Angelo Fassio, Anna Maria Formenti, Ghada El-Hajj Fuleihan, Annemieke C. Heijboer, Andrea Giustina
Summary: This work reviews and discusses controversial topics regarding vitamin D, SARS-CoV-2 infection, and COVID-19. The International Conferences Controversies in Vitamin D are workshops that started in 2017 and feature international experts and leaders in the field. The fifth annual conference was held in Stresa, Italy, in September 2021.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Norbert J. Tripolt, Sebastian J. Hofer, Peter N. Pferschy, Faisal Aziz, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Mara Waltenstorfer, Tobias Eisenberg, Anna M. A. Obermayer, Regina Riedl, Harald Kojzar, Othmar Moser, Caren Sourij, Heiko Bugger, Abderrahim Oulhaj, Thomas R. Pieber, Matthias Zanker, Guido Kroemer, Frank Madeo, Harald Sourij
Summary: The effects of fasting on glucose metabolism were examined in non-obese and obese participants and people with type 2 diabetes. The results showed that after 36 hours of fasting, glucose, insulin, and C-peptide levels were significantly decreased. Non-obese participants had higher glucose levels but lower insulin levels after 36 hours of fasting, while no significant differences were observed in obese participants or people with diabetes. Insulin sensitivity improved in all cohorts after 36 hours of fasting. Metabolomics analysis revealed subtle baseline differences and attenuated metabolic response to fasting in obese participants and people with diabetes.
Review
Endocrinology & Metabolism
Niek F. Dirks, Etienne Cavalier, Annemieke C. Heijboer
Summary: Measurement of vitamin D metabolites is essential for assessing vitamin D status and diagnosing calcium homeostasis disorders. While most laboratories measure total 25-hydroxyvitamin D (25(OH)D), some also measure 25(OH)D-2, 25(OH)D-3, and additional metabolites. This review provides an overview of vitamin D metabolism markers, discusses the advantages and disadvantages of automated assays and LC-MS/MS, and emphasizes the need for understanding the limitations of each technique.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Thomas R. Pieber, Kristine N. Arfelt, Roman Cailleteau, Marlies Hart, Soumitra Kar, Ines Mursic, Eva Svehlikova, Martina Urschitz, Hanne Haahr
Summary: This study compared the frequency and recovery of hypoglycemia after double or triple doses of once-weekly insulin icodec and once-daily insulin glargine U100. The study also compared the symptomatic and hormonal responses to hypoglycemia between the two treatments. The results showed that there was no significant difference in the risk of hypoglycemia between icodec and glargine U100, but icodec elicited slightly higher symptomatic and endocrine responses during hypoglycemia compared to glargine U100.
Article
Endocrinology & Metabolism
Heleen Jansen, Marijn M. Bult, Peter H. Bisschop, Anita Boelen, Annemieke C. Heijboer, Jacquelien J. Hillebrand
Summary: In our hospital, physicians observed high fT4 concentrations without suppressed TSH in outpatient blood samples, which seemed to occur more frequently after the introduction of a new fT4 immunoassay. We aimed to determine the factors contributing to this discordance.
ENDOCRINE CONNECTIONS
(2023)
Article
Medical Laboratory Technology
Heleen I. Jansen, Heloise G. Gohy, Anita Boelen, Peter H. Bisschop, Jacquelien J. Hillebrand, Annemieke C. Heijboer
Summary: This study compared the performance of the Alinity, KRYPTOR, and Cobas immunoassays in measuring the concentration of TSH-receptor antibodies (TRAb) in blood samples of Graves' Disease patients. The results showed that the Alinity immunoassay yielded comparable results to KRYPTOR and Cobas, although slightly more negative results compared to Cobas were observed.
CLINICA CHIMICA ACTA
(2023)
Review
Medical Laboratory Technology
Annemieke C. Heijboer, Sabine E. Hannema
Summary: During the clinical interpretation of androgen measurements, it is crucial to consider preanalytical factors, such as the timing of blood withdrawal. Immunoassays have limitations, particularly in samples from women and neonates, so results should be interpreted cautiously. Reference intervals are only applicable to specific measurement techniques and assay standardizations. New androgens may be included in the future to enhance the diagnosis and monitoring of androgen imbalances.
CLINICAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Veronika Tandl, Christoph Haudum, Katharina Eberhard, Barbara Hutz, Ines Foessl, Ewald Kolesnik, Andreas Zirlik, Dirk von Lewinski, Daniel Scherr, Nicolas Verheyen, Thomas Pieber, Barbara Obermayer-Pietsch
Summary: Serum concentrations of AMH decrease with increasing BMI, possibly due to either an adverse effect of adiposity on AMH production or dilution from greater blood volume. We investigated the relationships between AMH levels and body composition parameters in adult males and found that body weight, lean mass, and body surface area were better predictors of AMH than measures of adiposity. Since both lean mass and body surface area correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Stan R. Ursem, Anita Boelen, Jacquelien J. Hillebrand, Wendy P. J. den Elzen, Annemieke C. Heijboer
Summary: This study compared the differences in TSH assay methods in the low concentration range and found that these differences could have limited clinical consequences. However, caution should be exercised when interpreting values close to the cut-offs mentioned in guidelines.
EUROPEAN THYROID JOURNAL
(2023)
Review
Endocrinology & Metabolism
Annemieke C. Heijboer, Etienne Cavalier
Summary: The hormone FGF23 plays a central role in regulating phosphate homeostasis and has been associated with certain diseases. Various immunoassays have been developed to measure FGF23 in blood, but standardization is lacking. Currently, FGF23 measurement is clinically used in the diagnosis of hereditary hypophosphatemic rickets and tumor-induced osteomalacia. However, its usefulness in predicting risks or as a treatment target in CKD patients requires further research.
CALCIFIED TISSUE INTERNATIONAL
(2023)