Article
Pharmacology & Pharmacy
Mingyue Sheng, Xun Chen, Yan Yu, Qi Wu, Junping Kou, Gangling Chen
Summary: This study demonstrates that SR9009 can activate the Rev-erb alpha gene and provides protection against ischemic stroke damage, partly through the Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li, Lei Zhang
Summary: Rev-erb alpha plays a crucial role in AFL by inducing liver steatosis and promoting disease progression; inhibiting or downregulating Rev-erb alpha can improve steatosis, while enhancing autophagy activity helps in reversing the condition.
CELL AND BIOSCIENCE
(2021)
Article
Medicine, Research & Experimental
Zhihong Yang, Rana V. Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A. Delker, Nicholas J. Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul
Summary: This study identified a role for the SHP/REV-ERB alpha/CYP4A axis in the pathogenesis of ALD, highlighting REV-ERB alpha or CYP4A as potential therapeutic targets for ALD.
Article
Biochemistry & Molecular Biology
Yasmine Al-Sabagh, Hayley Thorpe, Bryan Jenkins, Shahnaza Hamidullah, Malik Talhat, Cara Suggett, Cristine Reitz, Mina Rasouli, Tami Martino, Jibran Khokhar
Summary: Alcohol misuse contributes to approximately 3 million premature deaths annually. Disruption of circadian rhythms is a risk factor for alcohol misuse, but this relationship is poorly understood. This study suggests that genetic variation in REV-ERB alpha may be involved in differences in alcohol drinking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da-Yoon Jang, Bohyun Yang, Min-Jung You, Chan Rim, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwon
Summary: This study investigates the mechanism by which fluoxetine affects microglial phagocytosis and finds that it reduces phagocytic function by impacting REV-ERB alpha and BMAL1 nucleocytoplasmic transport. The study also reveals that the inhibition of ERK mimics the effects of fluoxetine on microglia.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ya-Chien Chan, Eike Kienle, Martin Oti, Antonella Di Liddo, Maria Mendez-Lago, Dominik F. Aschauer, Manuel Peter, Michaela Pagani, Cosmas Arnold, Andreas Vonderheit, Christian Schoen, Sebastian Kreuz, Alexander Stark, Simon Rumpel
Summary: Enhancers are important cis-regulatory elements that control cell-type specific gene expression patterns. In this study, the Self-Transcribing Active Regulatory Region Sequencing (STARR-seq) technique was transposed to the mouse brain using adeno-associated-viruses (AAV) to identify enhancer activities. The study successfully constructed a genomic map of enhancer activities in the mouse brain and provided insights into their expression patterns in different cell types.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Huiling Hong, Yiu Ming Cheung, Xiaoyun Cao, Yalan Wu, Chenyang Li, Xiao Yu Tian
Summary: The circadian clock regulates inflammatory responses and the production of cytokines, with REV-ERB alpha and BMAL1 playing key roles in this process. Pharmacological activation of REV-ERB alpha can suppress inflammation, particularly in the NLRP3 inflammasome pathway, dependent on BMAL1 expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang, Meirong Du
Summary: Background: Sleep disturbance can affect pregnancy outcomes by altering the expression of circadian genes. This study investigated the role of Rev-erb alpha, a critical circadian gene, in regulating decidualization and its potential impact on early pregnancy outcomes. The results showed that sleep disturbance disrupted circadian rhythm and led to decreased Rev-erb alpha expression and defective decidualization. Rev-erb alpha was found to regulate decidualization by repressing IL-6, thereby inhibiting the expression of C/EBP beta and its target IGFBP1. Additionally, the mouse models with sleep disturbance demonstrated impaired decidualization, higher abortion rate, and lower implantation number compared to normal mice. Pharmacological activation of Rev-erb alpha or neutralization of IL-6 alleviated the adverse effects of sleep disturbance on pregnancy outcomes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jianfeng Shi, Renyang Tong, Meng Zhou, Yu Gao, Yichao Zhao, Yifan Chen, Wenhua Liu, Gaoxiang Li, Dong Lu, Guofeng Meng, Liuhua Hu, Ancai Yuan, Xiyuan Lu, Jun Pu
Summary: The study revealed that the circadian protein Rev-erb alpha is functionally expressed in platelets and enhances platelet activation and thrombus formation. This suggests that Rev-erb alpha could be a promising therapeutic target for managing thrombosis-related cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2022)
Article
Immunology
Ruizhuo Chen, Brandy N. Routh, Jillian E. Straetker, Cecily R. Gibson, Aidan S. Weitzner, Kiersten S. Bell, Andrew D. Gaudet, Laura K. Fonken
Summary: The circadian system regulates various physiological processes, and disruption of the circadian clock gene Rev-erb alpha can lead to behavioral changes and neuroinflammation. This study demonstrates that microglia depletion can ameliorate behavioral abnormalities in RKO mice and that male and female RKO mice show different alterations in the neuroimmune system.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Luyao Ma, Meiping Huang, Guanghui Sun, Yanke Lin, Danyi Lu, Baojian Wu
Summary: PLR has a significant protective effect against UVB-induced skin aging by reducing skin wrinkles, thickness, and oxidative stress, while increasing levels of antioxidant enzymes. This effect is mediated through the upregulation of BMAL1 and Nrf2 pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Feng Li, Luomin Lin, Yiting He, Guanghui Sun, Dong Dong, Baojian Wu
Summary: The study found that the central clock gene Bmal1 plays a role in acne-associated inflammation. Bmal1 disruption or jet lag led to exacerbated P. acnes-induced skin inflammation, while Bmal1 restricted P. acnes-induced inflammation by regulating the NF-kappa B/NLRP3 axis. These findings enhance our understanding of the pathogenesis of acne and suggest that targeting circadian rhythms may be an effective approach for managing acne.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yihao Tian, Zunlei Gong, Rui Zhao, Yue Zhu
Summary: Melatonin has been shown to inhibit RANKL-induced osteoclastogenesis by upregulating Rev-erb alpha expression and downregulating miR-882 expression. The miR-882/Rev-erb alpha axis may play a vital role in preventing osteoclastogenesis, suggesting that targeting Rev-erb alpha or inhibiting miR-882 could be potential mechanisms through which melatonin prevents osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fang-Yuan Mao, Yi-Pin Lv, Chuan-Jie Hao, Yong-Sheng Teng, Yu-Gang Liu, Ping Cheng, Shi-Ming Yang, Weisan Chen, Tao Liu, Quan-Ming Zou, Rui Xie, Jing-Yu Xu, Yuan Zhuang
Summary: This study reveals the important role of Rev-erb alpha in Helicobacter pylori infection, showing how it affects the host's defense mechanisms against the bacteria through regulation of gastric epithelial cells. The findings shed light on the pathogenesis of H. pylori infection and provide valuable insights into potential therapeutic strategies.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Behavioral Sciences
Zhao Changjiu, Chang Liza, Anthony P. Auger, Stephen C. Gammie, Lauren V. Riters
GENES BRAIN AND BEHAVIOR
(2020)
Article
Behavioral Sciences
Changjiu Zhao, Lauren V. Riters
Summary: The medial preoptic area (MPOA) plays a role in social play behavior through projections to the ventral tegmental area (VTA) and periaqueductal gray (PAG). Opioids may act through these projection pathways to govern social play, as shown by the increased activation of projection neurons expressing mu opioid receptors (MORs) from the MPOA to VTA or PAG after social play.
BEHAVIORAL NEUROSCIENCE
(2023)