Article
Chemistry, Multidisciplinary
Y. Hong, J. Wang, J. Li, Z. Xu, X. Yang, M. Bai, P. Gong, Y. Xie, X. Zhang, P. Xu, X. Chen, R. Li, X. Liu, G. Ruan, G. Xu
Summary: This study explores an alternative strategy of non-invasive brain delivery of nanoparticles and finds that this method can enhance the neural stimulation effects of transcranial magnetic stimulation (TMS). The use of Tat-SPIONs in combination with TMS shows significant improvement in stroke recovery in rats. Mechanistic studies suggest that the neural stimulation enhancement is mediated by neuroplasticity and magnetoelectric effect, primarily through the binding of Tat-SPIONs to neurons' plasma membranes. This research provides a technological platform for the medical applications of nanoparticles in remote brain stimulation for stroke and other neurological disorders.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Rehabilitation
Ellen E. R. Williams, Sabrina Sghirripa, Nigel C. Rogasch, Brenton Hordacre, Stacie Attrill
Summary: This review summarized the existing literature on non-invasive brain stimulation (NIBS) as a treatment for post-stroke aphasia and provided recommendations for future research. Quantitative analysis showed that ipsilesional anodal transcranial direct current stimulation and contralesional 1-Hz repetitive transcranial magnetic stimulation were the most commonly used forms of NIBS. Qualitative analysis revealed four key themes. The results highlighted systemic challenges in the field.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Jodi D. Edwards, Adan Ulises Dominguez-Vargas, Charlotte Rosso, Meret Branscheidt, Lisa Sheehy, Fanny Quandt, Simon A. Zamora, Melanie K. Fleming, Valentina Azzollini, Ronan A. Mooney, Charlotte J. Stagg, Chiristian Gerloff, Simone Rossi, Leonardo G. Cohen, Pablo Celnik, Michael A. Nitsche, Cathrin M. Buetefisch, Numa Dancause
Summary: The purpose of this study was to address the translation barriers in stroke rehabilitation research using non-invasive brain stimulation techniques, and to provide consensus recommendations to overcome these barriers. The study identified five key barriers and formulated five core consensus recommendations, including increased understanding of NIBS mechanisms, improved methodological rigor, standardization of outcome measures, increased clinical relevance in preclinical animal models, and optimization and individualization of NIBS protocols.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Review
Rehabilitation
Ishtiaq Ahmed, Rustem Mustafaoglu, Simone Rossi, Fatih A. Cavdar, Seth Kwame Agyenkwa, Marco Y. C. Pang, Sofia Straudi
Summary: This study compared the efficacy of non-invasive brain stimulation techniques in upper limb stroke rehabilitation. The results indicated that excitatory stimulation protocols showed the most promising effects on improving motor function and activities of daily living in stroke patients. Transcutaneous vagus nerve stimulation appeared to be a potentially effective intervention, but further research is needed to confirm its relative superiority.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Behavioral Sciences
Elisa Tatti, Angela L. Phillips, Rachel Paciorek, Sara M. Romanella, Davide Dettore, Giorgio Di Lorenzo, Giulio Ruffini, Simone Rossi, Emiliano Santarnecchi
Summary: Mental health disorders and substance use disorders pose significant challenges to public health systems. Evidence-based psychotherapy is commonly used to address mental health issues, but treatment adherence, relapses, and practical barriers hinder psychological change. Non-invasive brain stimulation techniques have emerged as promising tools to directly target dysfunctional neural circuitry and promote lasting plastic changes. Combining psychotherapy with brain stimulation may personalize treatment and provide more direct control of neuronal changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Xiaofang Wu, Rui Wang, Qunqiang Wu, Chunhua Liao, Jianshe Zhang, Huiduo Jiao, Baolin Chen, Shuyan Wang, Rui Liu
Summary: Upper limb motor impairments after stroke severely impact the quality of life of patients and their families. Transcranial magnetic stimulation (TMS) has been shown to be effective in promoting upper limb motor recovery. This study investigated the combined effect of high frequency repetitive TMS and cervical nerve root magnetic stimulation on functional improvement in stroke patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jodi D. Edwards, Adan Ulises Dominguez-Vargas, Charlotte Rosso, Meret Branscheidt, Lisa Sheehy, Fanny Quandt, Simon A. Zamora, Melanie K. Fleming, Valentina Azzollini, Ronan A. Mooney, Charlotte J. Stagg, Chiristian Gerloff, Simone Rossi, Leonardo G. Cohen, Pablo Celnik, Michael A. Nitsche, Cathrin M. Buetefisch, Numa Dancause
Summary: The aim of this study was to develop consensus recommendations for the translation of preclinical and clinical research using non-invasive brain stimulation techniques in stroke recovery and rehabilitation. A panel of international experts reached five core consensus recommendations, highlighting the need for improved understanding of NIBS mechanisms, methodological rigor, outcome measure standardization, clinical relevance in animal models, and optimization and individualization of NIBS protocols.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Stefanie Liebl, Tim Tischendorf, Julia Winterlich, Tom Schaal
Summary: The study found that doctors are open-minded towards new technical rehabilitation systems, emphasizing the importance of understanding the system's functionality and meaningfulness, as well as its motivational and meaningful movement generation for individuals. The system should be easy to use, evidence-based, and quick to set up, but concerns exist regarding the understanding of the system's processes in the acute phase after a stroke and the excessive expectation of results from the system.
Review
Neurosciences
Mengjie Zhang, Ting He, Quan Wang
Summary: NIBS has been shown to improve motor and cognitive function in patients with MSA-P and MSA-C, but further research is needed to explore its long-term effects and underlying mechanisms.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
G. Darmani, T. O. Bergmann, K. Butts Pauly, C. F. Caskey, L. de Lecea, A. Fomenko, E. Fouragnan, W. Legon, K. R. Murphy, T. Nandi, M. A. Phipps, G. Pinton, H. Ramezanpour, J. Sallet, S. N. Yaakub, S. S. Yoo, R. Chen
Summary: Transcranial ultrasound stimulation (TUS) has the potential to alter neural circuits non-invasively in both animals and humans. Unlike other non-invasive brain stimulation methods, TUS can focus on both cortical and deep brain targets with unprecedented spatial resolution. The neuromodulatory effects of TUS are derived from the interaction of ultrasound waves with neuronal membranes, resulting in changes in excitability and firing rate. After years of research, TUS is now being applied in human studies and can be assessed using non-invasive brain mapping techniques. This review provides a comprehensive overview of the principles, mechanisms, effects, and potential applications of TUS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Psychiatry
R. Maatoug, K. Bihan, P. Duriez, P. Podevin, L. Silveira-Reis-Brito, A. Benyamina, A. Valero-Cabre, B. Millet
Summary: Brain stimulation methods show promise for treating AUD, with DLPFC being a potential target for reducing craving and improving cognitive control. Both repetitive transcranial magnetic stimulation and transcranial direct current stimulation have shown potential in reducing alcohol craving. Deep brain stimulation also shows promising results in reducing craving and improving quality of life in AUD. However, more research is needed to confirm the efficacy and compare different stimulation approaches.
COMPREHENSIVE PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Xuan Liu, Lei Li, Ye Liu
Summary: This study compared the motor efficacy of different noninvasive brain stimulation techniques in patients with Parkinson's disease. The results showed that high-frequency repetitive transcranial magnetic stimulation (HFrTMS) was more effective than transcranial direct current stimulation in the on state, and combining HFrTMS with another NIBS technique produced better therapeutic effects. In the off state, there were no significant differences between treatments, but continuous theta burst stimulation and low-frequency TMS had the highest short- and long-term effects in improving motor function.
Review
Medicine, General & Internal
Takatoshi Hara, Aturan Shanmugalingam, Amanda McIntyre, Amer M. Burhan
Summary: NIBS shows promising positive effects on cognitive function deficits in post-stroke patients, especially in attention, memory, and working memory. However, further studies are needed to enhance precision in stimulation sites and stimulation parameters.
Article
Neurosciences
Shukun Hu, Gang Wu, Biwu Wu, Zhouying Du, Yi Zhang
Summary: The combination of proprioceptive stimulation and rehabilitative training significantly improved skilled motor function recovery post ischemic stroke, but had less impact on tactile sensory function recovery.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Cell Biology
Alberto Benussi, Giorgi Batsikadze, Carina Franca, Rubens G. Cury, Roderick P. P. W. M. Maas
Summary: This paper comprehensively reviews the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus deep brain stimulation (DBS) in patients with hereditary ataxias, as well as the underlying mechanisms at the cellular and network level and future research perspectives.
Article
Critical Care Medicine
Luis Bolivar Montero-Chacon, Juan Ignacio Padilla-Cuadra, Sy Han Chiou, Gabriel Torrealba-Acosta
JOURNAL OF INTENSIVE CARE MEDICINE
(2020)
Article
Neurosciences
Ross D. Zafonte, Felipe Fregni, Michael J. G. Bergin, Richard Goldstein, Nancy Boudreau, Iris Monge, Matthew Luz, Judith Frazier, Joseph T. Giacino
Article
Clinical Neurology
Bettega Costa Lopes, Liciane Fernandes Medeiros, Vanessa Silva de Souza, Stefania Giotti Cioato, Helouise Richardt Medeiros, Gabriela Gregory Regner, Camila Lino de Oliveira, Felipe Fregni, Wolnei Caumo, Iraci L. S. Torres
Article
Neurosciences
Hanan Ibrahim Zehry, Ahmed Maaty, Mirret M. El-Hagrassy, Akio Ueda, Hiroshi Kurumadani, Felipe Fregni, Toru Sunagawa
Article
Multidisciplinary Sciences
Ana Claudia Souza Palmer, Maxciel Zortea, Andressa Souza, Vinicius Santos, Jorge Villanova Biazus, Iraci L. S. Torres, Felipe Fregni, Wolnei Caumo
Review
Clinical Neurology
Adriano H. Moffa, Donel Martin, Angelo Alonzo, Djamila Bennabi, Daniel M. Blumberger, Isabela M. Bensenor, Zafiris Daskalakis, Felipe Fregni, Emmanuel Haffen, Sarah H. Lisanby, Frank Padberg, Ulrich Palm, Lais B. Razza, Bernardo Sampaio-Jr, Colleen Loo, Andre R. Brunoni
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Article
Anesthesiology
Marionna Munger, Camila B. Pinto, Kevin Pacheco-Barrios, Dante Duarte, Muhamed Enes Gunduz, Marcel Simis, Linamara R. Battistella, Felipe Fregni
Article
Medicine, General & Internal
Gabriel Torrealba-Acosta, Jennifer C. Martin, Yve Huttenbach, Catherine R. Garcia, Muhammad R. Sohail, Sandeep Krishna Agarwal, Carina Wasko, Eric M. Bershad, Mohammad Hirzallah
Summary: The patient presented with a series of symptoms after vaccination, diagnosed with Sweet syndrome, and all manifestations resolved with glucocorticoids treatment.
Article
Health Care Sciences & Services
Cesar E. Escamilla-Ocanas, Gabriel Torrealba-Acosta, Pitchaiah Mandava, Muhammad Suhaib Qasim, Barbara Gutierrez-Flores, Eric Bershad, Mohammad Hirzallah, Chethan P. Venkatasubba Rao, Rahul Damani
Summary: The implementation of systematic safety checklists in the neurocritical care unit was found to be effective in preventing complications and improving patient outcomes, including a reduced length of stay and infection rate.
Meeting Abstract
Clinical Neurology
A. Hernandez-Guillen, T. Lobo-Prada, J. Ruiz-Martinez, A. Gorostidi-Pagola, Z. Gan-Or, K. Carazo-Cespedes, J. Fornaguera-Trias, G. Torrealba-Acosta
MOVEMENT DISORDERS
(2020)
Meeting Abstract
Clinical Neurology
Margaret Lie, Gabriel Torrealba Acosta, Alexandria Melendez-Zaidi, Lydia Sharp
ANNALS OF NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
Cesar E. Escamilla-Ocanas, Gabriel Torrealba Acosta, Rahul Damani, Anthony Terrence O'Brien, Renyu Liu, Miguel Barboza-Elizondo, Kenneth Carazo-Cespedes, Huberth Fernandez-Morales
Meeting Abstract
Clinical Neurology
Cesar E. Escamilla-Ocanas, Gabriel Torrealba Acosta, Mohammad Hirzallah, Eric Bershad, Chethan Venkatasubba Rao, Rahul Damani
Meeting Abstract
Clinical Neurology
Gabriel Torrealba Acosta, Pedro Diaz Marchan, Cesar Escamilla Ocanas, Rahul Damani
Meeting Abstract
Clinical Neurology
Sixto Bogantes Ledezma, Maria Consuelo Rodriguez-Roblero, Gabriel Torrealba Acosta, Juan Luis Segura-Valverde, Roberto Brian-Gago