Article
Nutrition & Dietetics
Rosaria Del Giorno, Massimo Quarenghi, Kevyn Stefanelli, Alice Rigamonti, Carlotta Stanglini, Valentina De Vecchi, Luca Gabutti
Summary: Bioimpedance-derived phase angle (PA) serves as a predictor for clinical outcomes in patients hospitalized in internal-medicine wards, showing significant associations with length of hospital stay, hospital readmission, falls, and mortality. The findings suggest that PA assessment may be useful in identifying high-risk patients in need of specific nutritional support in the hospital setting.
Review
Medicine, General & Internal
Emily L. Boucher, Jasmine M. Gan, Peter M. Rothwell, Sasha Shepperd, Sarah T. Pendlebury
Summary: This study conducted a systematic review and meta-analysis to examine the prevalence of frailty and its outcomes in older adults with unplanned hospital admissions. The results indicated that frailty is common in this population and is associated with increased mortality, longer hospital stays, and discharge to a location other than home. The findings highlight the importance of implementing routine frailty screening using clinically administered tools.
Article
Endocrinology & Metabolism
Anthony J. Milto, Youssef El Bitar, Steven L. Scaife, Sowmyanarayanan Thuppal
Summary: This study examines the difference in length of stay and total hospital charge by income quartile in hip fracture patients. The length of stay increased in lower income groups, while total charge demonstrated a U-shaped relationship, with the highest charges in the highest and lowest income quartiles.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Rosanna Villani, Antonino Davide Romano, Roberta Rinaldi, Moris Sangineto, Mariateresa Santoliquido, Tommaso Cassano, Gaetano Serviddio
Summary: Hospital-acquired anemia refers to the development of anemia during hospitalization in patients with normal hemoglobin levels upon admission. A retrospective study found that the volume of blood drawn and the hemoglobin level at admission were associated with the development of anemia. Strategies to reduce blood loss and wastage in internal medicine patients during hospitalization are recommended.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Medicine, General & Internal
Swapna Gokhale, David Taylor, Jaskirath Gill, Yanan Hu, Nikolajs Zeps, Vincent Lequertier, Luis Prado, Helena Teede, Joanne Enticott
Summary: This study conducted a systematic review to assess the quality of risk prediction models for hospital length of stay (LOS) in general medicine and all admissions groups. It found that both machine learning and statistical modeling had good predictive performance, but there was limited external validation and poor overall study quality. Moving forward, there is a need to focus on quality methods, adopt existing guidelines, and conduct external validation before clinical application.
FRONTIERS IN MEDICINE
(2023)
Article
Computer Science, Information Systems
Md. Mahbubur Rahman, Dipanjali Kundu, Sayma Alam Suha, Umme Raihan Siddiqi, Samrat Kumar Dey
Summary: This study proposes a federated machine learning-based model for predicting patients' length of stay (LOS) in hospitals. The model combines locally trained models from decentralized and heterogeneous hospital clients while maintaining data privacy. The findings show that the aggregated model with federated learning has more reliable predictive performance, and integrating more clients' parameters improves the model's performance.
JOURNAL OF KING SAUD UNIVERSITY-COMPUTER AND INFORMATION SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Xinchen Ke, Wenrui Lin, Daishi Li, Shuang Zhao, Mingliang Chen, Yi Xiao, Xiang Chen, Minxue Shen, Juan Su
Summary: This study described the economic burden of melanoma patients in Hunan province, China, and investigated the factors influencing hospitalization spending and length of stay in patients undergoing melanoma surgery. The findings showed that melanoma imposes a heavy economic burden on patients, with middle-aged men with melanoma on the limbs experiencing the highest financial burden.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Nicoletta Miano, Maurizio Di Marco, Salvatore Alaimo, Giuseppe Coppolino, Giuseppe L'Episcopo, Stefano Leggio, Roberto Scicali, Salvatore Piro, Francesco Purrello, Antonino Di Pino
Summary: The CONUT score, which represents poor nutritional status, has been shown to be an indicator of adverse outcomes. This retrospective study analyzed data from 369 patients, divided into four groups based on the CONUT score. In-hospital all-cause mortality, length of hospital stay, and the prevalence of sepsis increased with higher CONUT scores. The increased risk associated with a high CONUT score remained significant even after adjusting for confounders. These findings highlight the importance of CONUT scores in predicting short-term in-hospital outcomes and complications.
Article
Anesthesiology
Xiaoying Wang, Yusuke Naito, Hitomi Nakatani, Mitsuru Ida, Masahiko Kawaguchi
Summary: Among 835 surgical patients, nutritional status was classified as normal (59.0%), at risk (29.6%), or malnutrition (11.4%). Linear regression analysis showed that nutritional status, serum albumin level, and anesthesia time were associated with the length of hospital stay.
JOURNAL OF ANESTHESIA
(2022)
Article
Computer Science, Artificial Intelligence
Tianzi Zang, Yanmin Zhu, Xinrui Huang, Xinchen Yang, Qiuxia Chen, Jiadi Yu, Feilong Tang
Summary: This paper focuses on predicting the length of stay for patients on the first day of admission and proposes a predictive model named DGLoS. The model utilizes a deep neural network to model both patient information and diagnostic information, and employs graph representation learning to capture patient similarity and enhance predictions.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Article
Oncology
Cecelia MacFarling Meure, Belinda Steer, Judi Porter
Summary: The relationship between nutritional intake and clinical outcomes in hospitalised adult oncology patients remains unclear. This study found no significant relationship between nutritional intake and clinical outcomes. However, patients at risk of malnutrition had longer length of stay.
Article
Surgery
Daan M. Voeten, Leonie R. van der Werf, Johanna W. van Sandick, Richard van Hillegersberg, Mark I. van Berge Henegouwen
Summary: This study aimed to analyze Dutch hospital performance in terms of length of hospital stay after esophageal cancer surgery and its association with 30-day readmission rates. Results showed no significant association between length of hospital stay and readmission rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Health Care Sciences & Services
Andrew H. Hughes, David Jr Jr Horrocks, Curtis Leung, Melissa B. Richardson, Ann M. Sheehy, Charles F. S. Locke
Summary: The study found that outlier cases of length of stay are utilizing a growing share of hospital resources and beds, with both the mean outlier LOS and inpatient LOS excluding outliers increasing over the study period. Excluding these outliers from data reporting, based on the assumption of their rarity, may need to be reconsidered in order to implement targeted interventions that can effectively reduce length of stay, improve patient care, and maintain hospital capacity.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Medicine, General & Internal
Chanhyun Park, Sun-Kyeong Park, Jenica N. Upshaw, Mara A. Schonberg
Summary: This study examined the association between heart failure (HF) and hospital outcomes among hospitalized patients with breast cancer and found that HF has a substantial negative impact on health outcomes, including higher mortality, longer length of stay, and increased hospital costs. Efforts to effectively manage comorbid HF in breast cancer patients may help improve hospital outcomes in this population.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Endocrinology & Metabolism
Salvatore Corrao, Alessandro Nobili, Giuseppe Natoli, Pier Mannuccio Mannucci, Francesco Perticone, Antonello Pietrangelo, Christiano Argano
Summary: This study evaluated the impact of hyperglycemia, disability, and multimorbidity on mortality in elderly patients admitted to internal medicine wards. The study found that higher glycemia levels, lower Barthel Index scores, higher CIRS-SI scores, and male sex were strong predictors of in-hospital mortality for older patients in general wards.
ACTA DIABETOLOGICA
(2021)
Letter
Medicine, General & Internal
Marco Vincenzo Lenti, Maria Giovanna Ferrari, Nicola Aronico, Federica Melazzini, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
INTERNAL AND EMERGENCY MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Marco Vincenzo, Sara Cococcia, Emanuela Miceli, Giacomo Carganico, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Pathology
Alessandro Vanoli, Camilla Guerini, Federica Grillo, Catherine Klersy, Matteo Fassan, Giovanni Arpa, Giuseppe Neri, Ombretta Luinetti, Marco V. Lenti, Paola Ulivi, Gianluca Tedaldi, Daniela Furlan, Erica Quaquarini, Sandro Ardizzone, Gianluca Sampietro, Livia Biancone, Giovanni Monteleone, Enrico Solcia, Fausto Sessa, Marco Paulli, Nazmi V. Adsay, Antonio Di Sabatino
Summary: This study compares the clinicopathologic and immunophenotypical features of poorly cohesive carcinomas (PCCs) in the small bowel, and suggests that they should be considered a distinctive subtype separate from small bowel adenocarcinomas not otherwise specified (SBAs-NOS). The study also highlights the worse cancer-specific survival of patients with SB-PCCs and mixed-poorly-cohesive-glandular-SBAs compared to SBAs-NOS cases.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Emanuela Miceli, Alessandro Vanoli, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
Summary: Approximately half of potential autoimmune gastritis patients will progress to overt autoimmune gastritis within two years, especially those with concurrent autoimmune disorders.
DIGESTIVE AND LIVER DISEASE
(2022)
Letter
Dermatology
S. M. A. Ahmed, M. Volonte, E. Isoletta, C. Vassallo, C. F. Tomasini, D. Lilleri, P. Zelini, V. Musella, C. Klersy, V. Brazzelli
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Emanuele Cereda, Richard Tancredi, Catherine Klersy, Federica Lobascio, Silvia Crotti, Sara Masi, Silvia Cappello, Nicole Stobaus, Maja Tank, Sara Cutti, Luca Arcaini, Elisabetta Bonzano, Sara Colombo, Paolo Pedrazzoli, Kristina Norman, Riccardo Caccialanza
Summary: In cancer patients, muscle weakness is a more powerful predictor of survival than bioelectrical impedance analysis-estimated skeletal muscle mass, and should be considered as an additional key feature of sarcopenia.
Letter
Medicine, General & Internal
F. Calabretta, P. S. Preti, M. Russo, C. Klersy, A. Di Sabatino
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Virginia V. Ferretti, Catherine Klersy, Raffaele Bruno, Sara Cutti, Rossella E. Nappi
Summary: There are differences in the severity and mortality rate of COVID-19 between the sexes, with women having better outcomes. The role of sex steroid hormones and menopause in causing this gender disparity has not been proven. A retrospective analysis in Italy showed that men had higher mortality rates after the age of 65, particularly among those aged over 80.
Article
Nutrition & Dietetics
Francesca Garofoli, Iolanda Mazzucchelli, Micol Angelini, Catherine Klersy, Virginia Valeria Ferretti, Barbara Gardella, Giulia Vittoria Carletti, Arsenio Spinillo, Chryssoula Tzialla, Stefano Ghirardello
Summary: This study investigated the association between perinatal leptin concentrations and growth trajectories of newborns during their first year. The results showed an inverse correlation between leptin levels and maternal plasma and milk. Premature infants seemed to be most affected by leptin, and low leptin levels appeared to hinder their ability to regain a normal body weight within one year.
Article
Medicine, General & Internal
Andrea Demarchi, Giulio Conte, Shih-Ann Chen, Li-Wei Lo, Wei-Tso Chen, Tom De Potter, Peter Geelen, Andrea Sarkozy, Francesco R. Spera, Tobias Reichlin, Laurent Roten, Pascal Defaye, Adrien Carabelli, Serge Boveda, Hamed Bourenane, Lisa Riesinger, Simon Kochhauser, Gala Caixal, Lluis Mont, Daniel Scherr, Martin Manninger, Francesco Pentimalli, Stefano Cornara, Catherine Klersy, Angelo Auricchio
Summary: This study evaluated the efficacy and long-term follow-up of catheter ablation in patients with previous pulmonary lobectomy/pneumonectomy history and atrial fibrillation. The results showed that catheter ablation by radiofrequency or cryoablation is feasible and safe for these patients, with similar efficacy observed in both males and females over a median follow up of 29.7 months.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Giulia Borgonovo, Elen Vettus, Alessandra Greco, Laura Anna Leo, Francesco Fulvio Faletra, Catherine Klersy, Moreno Curti, Mariacarla Valli
Summary: This study aims to investigate early tissue changes related to chemo-induced and radiation-induced cardiotoxicity in breast cancer patients using cardiac imaging and circulating biomarkers. The study will enroll 150 women with stage I-III unilateral breast cancer and collect baseline and follow-up data. The results will provide evidence on the optimal screening imaging for cardiotoxicity.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Cardiac & Cardiovascular Systems
Francesca Romana Gentile, Enrico Baldi, Catherine Klersy, Sebastian Schnaubelt, Maria Luce Caputo, Christian Clodi, Jolie Bruno, Sara Compagnoni, Alessandro Fasolino, Claudio Benvenuti, Hans Domanovits, Roman Burkart, Roberto Primi, Gerhard Ruzicka, Michael Holzer, Angelo Auricchio, Simone Savastano
Summary: A study found that ECG features can predict the 30-day survival rate of patients after out-of-hospital cardiac arrest. Age >62 years, female sex, QRS wider than 120 ms, the presence of a Brugada pattern, and ST-segment elevation in >1 segment were independently associated with 30-day mortality. By dividing the population into three risk classes based on a score, significant differences in survival rates at 30 days were observed.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Toto, Laura Leo, Catherine Klersy, Tiziano Torre, Thomas Theologou, Alberto Pozzoli, Elena Caporali, Stefanos Demertzis, Enrico Ferrari
Summary: The study evaluated the clinical outcomes and hemodynamic performance of two standard aortic bioprostheses. The results showed that the postoperative outcomes and mid-term follow-up were similar between the Trifecta and Perimount bioprostheses. Although the Trifecta valve showed better hemodynamic performance in the early postoperative period, this advantage did not persist over time. There was no difference in the reoperation rate for structural valve degeneration between the two valves.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Andreas Haeberlin, Fabian Noti, Alexander Breitenstein, Angelo Auricchio, Tobias Reichlin, Giulio Conte, Catherine Klersy, Moreno Curti, Etienne Pruvot, Giulia Domenichini, Beat Schaer, Michael Kuehne, Michal Gruszczynski, Haran Burri, Richard Kobza, Christian Grebmer, Francois D. Regoli, Francesco Pelliccia
Summary: This study analyzed the procedural outcomes of transvenous lead extraction (TLE) during device upgrade, and found that TLE is effective and does not pose a disproportionate risk to the upgrade procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Enrico Ferrari, Alberto Pozzoli, Catherine Klersy, Francesca Toto, Tiziano Torre, Tiziano Cassina, Giovanni Pedrazzini, Stefanos Demertzis
Summary: This study compared the outcomes of transcatheter aortic valve replacement (TAVR) procedures performed through alternative access routes. The results showed that both transapical and direct transaortic TAVR procedures provided satisfactory clinical results and had similar thirty-day outcomes in high-risk patients with severe aortic valve stenosis and diseased peripheral arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)