DTR-mediated conditional cell ablation-Progress and challenges

Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

(2018) Anna Baranska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

(2017) Laurent L. Reber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

(2017) Mafalda M. A. Pereira et al.   Nature Communications

CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin

(2016) Linda Männ et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CatacLysMic specificity when targeting myeloid cells?

(2016) Thomas Blank et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neurons exhibitLyz2promoter activity in vivo: Implications for using LysM-Cre mice in myeloid cell research

(2016) Johannes Orthgiess et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology

(2016) Aleksandra Deczkowska et al.   TRENDS IN IMMUNOLOGY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Depletion of CD11c+cells in the CD11c.DTR model drives expansion of unique CD64+Ly6C+monocytes that are poised to release TNF-α

(2015) Shivajanani Sivakumaran et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

XCR1+dendritic cells promote memory CD8+T cell recall upon secondary infections withListeria monocytogenesor certain viruses

(2015) Yannick O. Alexandre et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells

(2015) A R B M Muzaki et al.   Mucosal Immunology

Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

(2015) Meiyu Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

(2015) Tegest Aychek et al.   Nature Communications

Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity

(2014) Christina Purnama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered Lymph Node Composition in Diphtheria Toxin Receptor–Based Mouse Models To Ablate Dendritic Cells

(2014) Janneke van Blijswijk et al.   JOURNAL OF IMMUNOLOGY

Cell Depletion in Mice That Express Diphtheria Toxin Receptor under the Control of SiglecH Encompasses More Than Plasmacytoid Dendritic Cells

(2014) M. Swiecki et al.   JOURNAL OF IMMUNOLOGY

Binary recombinase systems for high-resolution conditional mutagenesis

(2014) Mario Hermann et al.   NUCLEIC ACIDS RESEARCH

The Axis of Tolerance

(2014) T. Aychek et al.   SCIENCE

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

(2013) E. A. Jacobsen et al.   ALLERGY

Advantages and limitations of mouse models to deplete dendritic cells

(2013) Janneke van Blijswijk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal monocytes and macrophages are required for T cell polarization in response toCitrobacter rodentium

(2013) Heidi A. Schreiber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1

(2013) C. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Ablation of Neurons Expressing Melanin-Concentrating Hormone (MCH) in Adult Mice Improves Glucose Tolerance Independent of MCH Signaling

(2013) B. B. Whiddon et al.   JOURNAL OF NEUROSCIENCE

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

(2013) Gretchen E. Diehl et al.   NATURE

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state

(2012) Matthew M. Meredith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria

(2012) L. Piva et al.   JOURNAL OF IMMUNOLOGY

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

(2012) André P Tittel et al.   NATURE METHODS

Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo

(2012) T. Fukaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation

(2011) Masato Fujioka et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers

(2011) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

(2010) Takeshi Wada et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection

(2009) Tobias M. Hohl et al.   Cell Host & Microbe

Insufficiency of Pro-heparin-binding Epidermal Growth Factor-like Growth Factor Shedding Enhances Hypoxic Cell Death in H9c2 Cardiomyoblasts via the Activation of Caspase-3 and c-Jun N-terminal Kinase

(2009) Teruyoshi Uetani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo

(2009) Johannes Hirrlinger et al.   PLoS One

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

(2008) Kristin Hochweller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Probing in vivo dendritic cell functions by conditional cell ablation

(2008) Anita Sapoznikov et al.   IMMUNOLOGY AND CELL BIOLOGY

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches

(2008) Anita Sapoznikov et al.   NATURE IMMUNOLOGY