Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Clementina Lopez-Medina, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Sara Monti, Kim Tae-Jong, Mitsumasa Kishimoto, F. M. Pimentel-Santos, Jieruo Gu, Ruxandra Schiotis, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landew, Desiree van der Heijde, Maxime Dougados
Summary: This study included 4465 patients with SpA from 24 countries around the world, showing quantitative differences in peripheral manifestations among different subtypes but no significant qualitative differences. It was found that a high proportion of patients with SpA had both axial and peripheral manifestations coinciding.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Biochemistry & Molecular Biology
Krzysztof Bonek, Ewa Kuca Warnawin, Anna Kornatka, Magdalena Plebanczyk, Tomasz Burakowski, Wlodzimierz Maslinski, Malgorzata Wislowska, Piotr Gluszko, Marzena Ciechomska
Summary: This study investigates the associations between miR signatures and cytokines, serum lipids, and disease activity in patients with PsA, AS, and RA. The results show the superiority of miR expressions in distinguishing between RA, PsA, and AS, and a unique regulatory pathway in PsA.
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Vandana Bhushan, Susan Lester, Liz Briggs, Raif Hijjawi, E. Michael Shanahan, Eliza Pontifex, Jem Ninan, Catherine Hill, Fin Cai, Jennifer Walker, Fiona Goldblatt, Mihir D. Wechalekar
Summary: Similar retention rates of the second and third compared to the first b/tsDMARD in RA, PsA, and AS support a differential b/tsDMARDs use strategy based on patient presentation. The risk of b/tsDMARD failure was halved in PsA patients, and covariates were not associated with the risk of bDMARD failure. The most common reason for switching was treatment failure.
FRONTIERS IN MEDICINE
(2021)
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.
Article
Rheumatology
Emmerik Leijten, Weiyang Tao, Juliette Pouw, Tessa van Kempen, Michel Olde Nordkamp, Deepak Balak, J. Tekstra, Ernesto Munoz-Elias, Samuel DePrimo, Julia Drylewicz, Aridaman Pandit, Marianne Boes, Timothy Radstake
Summary: Novel serum proteins associated with the pathogenesis of PsA were identified by comparing PsA patients with healthy controls, psoriasis (Pso) patients, and ankylosing spondylitis (AS) patients. The study found 68 differentially expressed proteins in PsA compared to healthy controls, with the majority also dysregulated in Pso and/or AS. PsA and Pso patients shared a similar serum proteomic signature, suggesting a unified psoriatic disease spectrum.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Christina Charles-Schoeman, Ernest Choy, Iain B. McInnes, Eduardo Mysler, Peter Nash, Kunihiro Yamaoka, Ralph Lippe, Nasser Khan, Anna K. Shmagel, Hannah Palac, Jessica Suboticki, Jeffrey R. Curtis
Summary: This study provides an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) events in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients treated with upadacitinib. The results show that the rates of MACEs and VTE events with upadacitinib are similar to those reported for conventional synthetic and biologic disease-modifying drugs, and comparable to adalimumab and methotrexate.
Article
Rheumatology
T. Rusman, M. A. C. van der Weijden, M. T. Nurmohamed, C. J. van Denderen, R. B. M. Landewe, P. M. Bet, C. M. A. van der Bijl, C. J. Van der Laken, I. E. van der Horst-Bruinsma
Summary: The study found that 16 weeks of etanercept treatment did not have an impact on disease activity, the chance of biological treatment, or radiographic progression in patients with suspected non-radiographic axial spondyloarthritis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sofia Ramiro, Elena Nikiphorou, Alexandre Sepriano, Augusta Ortolan, Casper Webers, Xenofon Baraliakos, Robert B. M. Landewe, Filip E. Van den Bosch, Boryana Boteva, Ann Bremander, Philippe Carron, Adrian Ciurea, Floris A. van Gaalen, Pal Geher, Lianne Gensler, Josef Hermann, Manouk de Hooge, Marketa Husakova, Uta Kiltz, Clementina Lopez-Medina, Pedro M. Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compan, Michael J. Nissen, Fernando M. Pimentel-Santos, Denis Poddubnyy, Fabian Proft, Martin Rudwaleit, Mark Telkman, Sizheng Steven Zhao, Nelly Ziade, Desiree van der Heijde
Summary: The ASAS-EULAR recommendations provide updated guidance on the management of axial spondyloarthritis, including treatment targets, non-pharmacological interventions, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) as the first-line pharmacological treatment. For patients with comorbidities, the use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) is recommended. The recommendations also cover the management of extramusculoskeletal manifestations, tapering of bDMARDs, and surgical interventions.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Casper Webers, Augusta Ortolan, Alexandre Sepriano, Louise Falzon, Xenofon Baraliakos, Robert B. M. Landewe, Sofia Ramiro, Desiree van der Heijde, Elena Nikiphorou
Summary: This study aims to provide updated evidence on the efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) for the revision of management recommendations. The results showed significant efficacy of tumor necrosis factor inhibitors (TNFi) and interleukin-17 inhibitors (IL-17i), while IL-23 inhibitors failed to demonstrate relevant effects. Observational studies are required to confirm the long-term safety of IL-17i.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Gastroenterology & Hepatology
Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi
Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Rheumatology
Sytske Anne Bergstra, Alexandre Sepriano, Andreas Kerschbaumer, Desiree van der Heijde, Roberto Caporali, Christopher John Edwards, Patrick Verschueren, Savia de Souza, Janet E. Pope, Tsutomu Takeuchi, Kimme L. Hyrich, Kevin L. Winthrop, Daniel Aletaha, Tanja A. Stamm, Jan W. Schoones, Josef S. Smolen, Robert B. M. Landewe
Summary: This systematic literature review examines the efficacy, duration of use, and safety of glucocorticoids (GCs) in the management of rheumatoid arthritis (RA). The study confirms the effectiveness of GCs in treating RA, with most patients able to stop GCs within 12-24 months. However, the use of GCs also carries well-known safety risks, including osteoporotic fractures, serious infections, diabetes, and mortality.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Ophthalmology
Lotte M. J. Scheres, Frank J. H. M. van den Biggelaar, Bjorn Winkens, Stefani Kujovic-Aleksov, Rogier P. H. M. Muskens, Peter W. T. de Waard, Ronald M. P. C. de Crom, Paul J. G. Ernest, Benjamin J. Pijl, Wishal D. Ramdas, Laurentius J. van Rijn, Annelie Tan, Carmen D. Dirksen, Henny J. M. Beckers
Summary: This study aims to compare the effectiveness and cost-effectiveness of MicroShunt implantation with standard trabeculectomy, and to address the lack of evidence in this area. It also aims to determine if MicroShunt implantation is non-inferior to trabeculectomy in terms of postoperative intraocular pressure.
Article
Environmental Sciences
Yingyi Wu, Pascal W. M. Van Gerven, Renate H. M. de Groot, Bert O. Eijnde, Jan Seghers, Bjorn Winkens, Hans H. C. M. Savelberg
Summary: University students sit too much, which is detrimental to their physical and mental health. This study found that the scheduled education time and self-study time are associated with students' physical activity levels. Providing a study environment that reduces sedentary behavior and promotes light-intensity physical activity is crucial for improving students' physical activity behaviors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Primary Health Care
Danny Claessens, Esther A. Boudewijns, Lotte C. E. M. Keijsers, Annerika H. M. Gidding-Slok, Bjorn Winkens, Onno C. P. van Schayck
Summary: This study evaluated the validity and reliability of the ABCC scale in patients with COPD, asthma, and T2D. The ABCC scale showed good convergent validity and internal consistency when compared with other related questionnaires. The study concluded that the ABCC scale is a valid and reliable tool for assessing the burden of chronic conditions in patients with COPD, asthma, or T2D.
ANNALS OF FAMILY MEDICINE
(2023)
Article
Rheumatology
Xenofon Baraliakos, Effie Pournara, Laura C. Coates, Victoria Navarro-Compan, Ricardo Blanco, Eamonn O'Brien, Barbara Schulz, Robert Landewe
Summary: The re-read of baseline spinal MRIs from the MAXIMISE trial revealed that bone marrow oedema, spinal process inflammation, and post-inflammatory changes are common in PsA patients and can predict treatment effects. Post-inflammatory changes were associated with better clinical outcomes, while degenerative changes were associated with worse outcomes.
Article
Rheumatology
Janne W. Bolt, Caroline J. Aalbers, Laura Walet, Leonieke J. J. van Mens, Christiaan van Denderen, Irene van der Horst-Bruinsma, Lisa G. M. van Baarsen, Robert Landewe, Marleen G. H. van de Sande
Summary: The clear target for treating axial spondyloarthritis (axSpA) has not been defined yet, and the targets may not always reflect inflammation. This study found discrepancies between physicians' and patients' opinions and composite indices regarding residual disease activity, which influenced treatment decisions.
Correction
Gastroenterology & Hepatology
Ayla Thijssen, Ramon-Michel Schreuder, Roger Fonolla, Quirine van der Zander, Thom Scheeve, Bjorn Winkens, Sharmila Subramaniam, Pradeep Bhandari, Peter de With, Ad Masclee, Fons van der Sommen, Erik Schoon
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Critical Care Medicine
Michelle R. Baggerman, Ingeborg M. Dekker, Bjorn Winkens, Steven W. M. Olde Damink, Sandra N. Stapel, Peter J. M. Weijs, Marcel C. G. van de Poll
Summary: This study investigated the association between visceral obesity, BMI and 90-day mortality in critically ill patients. The results showed no significant association between visceral obesity and BMI with 90-day mortality, although obesity and visceral obesity tended to be associated with improved 90-day mortality.
JOURNAL OF CRITICAL CARE
(2023)
Article
Rheumatology
Santiago Rodrigues-Manica, Alexandre Sepriano, Sofia Ramiro, Robert Landewe, Pascal Claudepierre, Anna Molto, Maxime Dougados, Miranda van Lunteren, Desiree van der Heijde
Summary: This study aimed to investigate the association between bone marrow edema (BME) and the development of structural lesions at the same anatomical location of the sacroiliac joints (SIJ) in patients with early axial spondyloarthritis (axSpA). The results showed that BME in each quadrant of the SIJ was associated with sclerosis, erosions, and fatty lesions, and the persistent BME pattern was associated with higher structural damage.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
