Journal
EUROPEAN JOURNAL OF CANCER
Volume 91, Issue -, Pages 107-115Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2017.12.017
Keywords
Peri-prostatic adipose tissue; Fatty acids; Prostate cancer; Cancer aggressiveness; Linoleic acid
Categories
Funding
- Lipid project 'ARD Bio-medicaments'
- Ministere de l'Enseignement Superieur et de la Recherche
- Canceropole Grand Ouest: Region Centre, Region Pays de Loire, Region Bretagne, Region Poitou-Charentes
- Ligue Nationale contre le Cancer
- 'Institut National de la Sante et de la Recherche Medicale' (Inserm)
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Background: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. Methods: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. Results: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. Conclusion: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness. (C) 2017 Elsevier Ltd. All rights reserved.
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