Article
Chemistry, Analytical
Peter Preben Eggertsen, Jakob Hansen, Malene Lundfold Andersen, Jurgen Feldbaek Nielsen, Rikke Katrine Jentoft Olsen, Johan Palmfeldt
Summary: In this study, a reliable and robust LC-MS method was developed for simultaneous targeted and untargeted metabolomics. This method was shown to be suitable for the quantification of key kynurenine metabolites and the analysis of other metabolites. The study also revealed gender differences in kynurenine metabolite levels.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, General & Internal
Yukichi Takada, Tatsuki Shibuta, Mayu Hatano, Kenichi Sato, Mari Koga, Ayaka Ishibashi, Tetsuhiro Harada, Takashi Hisatomi, Hanae Shimura, Noriyasu Fukushima, Kamonlak Leecharoenkiat, Supat Chamnanchanunt, Saovaros Svasti, Suthat Fucharoen, Tsukuru Umemura
Summary: Circulating microRNAs are useful biomarkers for hemolysis. The study found that blood drawing and pre-analytical modifications can lead to significant increases in RBC-related miRNAs, but these modifications do not interfere with the clinical utility of RBC-derived miRNAs as biomarkers for hemolytic diseases, such as anemia. Serum miR-451a was significantly elevated in patients with hemolytic anemia more than the levels of pre-analytical modification, suggesting its potential as a biomarker for this condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Zuhu Yu, Chong Lu, Yongqing Lai
Summary: In this study, the expression profiles of miRNAs in serum samples of bladder cancer patients and healthy controls were detected, and five differentially expressed miRNAs were identified. A three-miRNA signature consisting of miR-27b-3p, miR-381-3p, and miR-451a was constructed with a high diagnostic efficiency for bladder cancer. This three-miRNA signature may serve as a promising non-invasive biomarker for early diagnosis of bladder cancer.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Tao Rui, Xiaobing Zhang, Jufeng Guo, Aizhai Xiang, Ning Tang, Jian Liu, Zonglei Mao
Summary: This study analyzed the small RNA species in serum exosomes and found that miRNAs were the most important components. Three serum-exosome-derived miRNAs (miR-122-5p, let-7d-5p, and miR-425-5p) were found to have significant diagnostic values for hepatocellular carcinoma (HCC). The results suggest that serum-exosome-derived miRNAs could be promising biomarkers for HCC diagnosis.
Article
Biochemistry & Molecular Biology
Anna Pula, Pawel Robak, Dariusz Jarych, Damian Mikulski, Malgorzata Misiewicz, Izabela Drozdz, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak
Summary: This study aimed to analyze the expression of selected miRNAs in the serum of MM patients treated with bortezomib-based regimens and determine their ability to predict early mortality. Two miRNAs, hsa-miR-328-3p and hsa-miR-409-3p, were significantly downregulated in the early mortality group. Logistic regression analysis showed that the final model, including these miRNAs, age, and R-ISS 3, had high sensitivity and specificity in predicting early mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xinyue Zhang, Ruling Yang, Mengjie Ma, Siyu Chen, Kaiyin Guo, Li Zhang, Yingnan You, Hailin Jia, Bo Han
Summary: This study investigated the plasma exosome miRNA profile in pediatric fulminant myocarditis (FM) using small RNA microarray. Differential expression of 266 miRNAs was observed, including 197 upregulated and 69 downregulated candidate genes. Through analysis, FM-specific target genes related to inflammation and/or the immune system were identified. CeRNA networks between cardiomyocytes and peripheral blood mononuclear cells were established, and specific miRNAs were validated as potential biomarkers for FM diagnosis.
Article
Oncology
Xueying Qin, Yunzhang Wang, Nancy L. Pedersen, Bowen Tang, Sara Hagg
Summary: Blood lipid and DNA methylation levels change after statin treatment initiation, with the latter mostly responding to alterations in lipid levels.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Xiaofei Yin, Orla Prendiville, Aoife E. McNamara, Lorraine Brennan
Summary: This study evaluated the reproducibility of metabolites in a freeliving population over a period of four months. The results showed that more than half of the metabolites demonstrated good to excellent reproducibility. A single measurement per subject could appropriately reflect the metabolites' long-term concentration levels and may also be sufficient for assessing disease risk in epidemiologic studies.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Multidisciplinary Sciences
Patrick Altmann, Markus Ponleitner, Paulus Stefan Rommer, Helmuth Haslacher, Patrick Mucher, Fritz Leutmezer, Axel Petzold, Christoph Wotawa, Rupert Lanzenberger, Thomas Berger, Henrik Zetterberg, Gabriel Bsteh
Summary: The study found that the soluble serum and plasma NfL concentration remains stable when unprocessed blood samples are stored up to 7 days at room temperature, which is crucial for ensuring reliable study protocols.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Xiuquan Nie, Ge Mu, Yanjun Guo, Shijie Yang, Xing Wang, Zi Ye, Qiyou Tan, Mengyi Wang, Min Zhou, Jixuan Ma, Weihong Chen
Summary: This study found that urinary selenium concentration was positively associated with total cholesterol and low-density lipoprotein, but not with triglycerides and high-density lipoprotein. Methylation sites cg06964030 and cg15824094 partly mediated the association between selenium and total cholesterol. These findings provide insights into the effects and mechanisms of selenium exposure on lipid metabolism and highlight the importance of controlling selenium exposure and intake to prevent high blood lipids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Zhenming Li, Dexin Wu, Yu Guo, Weili Mao, Nan Zhao, Meirong Zhao, Hangbiao Jin
Summary: The distribution pattern of phthalate metabolites (PMs) in human blood was investigated in this study. It was found that mono methyl phthalate, mono (2-ethylhexyl) phthalate, and mono butyl phthalate were the predominant PMs in both serum and whole blood samples. The mean serum concentrations of PMs were higher in females than males.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Christiane Muehle, Johannes Kornhuber
Summary: The activity of neutral sphingomyelinase (NSM) has been detected in human serum and plasma samples, which hydrolyzes fluorescently labeled sphingomyelin to ceramide. This discovery could lead to the development of new biomarkers or therapeutic targets for diseases affected by sphingolipid derangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mukesh Gautam, Renata Del Carratore, Benjamin Helmold, Alessandra Tessa, Oge Gozutok, Navdeep Chandel, Halil Idrisoglu, Paolo Bongioanni, Roberta Battini, P. Hande Ozdinler
Summary: This study investigated the metabolites in the serum and plasma of ALS patients with ALS2 mutations, revealing perturbed cellular pathways and a distinct set of key metabolites. These findings lay the foundation for using metabolites as potential biomarkers for a subset of ALS.
Article
Medical Laboratory Technology
Claus Vinter Bodker Hviid, Anne Tranberg Madsen, Anne Winther-Larsen
Summary: Serum NfL exhibits tight homeostatic regulation with minimal diurnal and day-to-day variation, but significant between-subject variation. This highlights its suitability as a biomarker for disease monitoring, but caution is advised when interpreting NfL levels in relation to reference intervals in a clinical setting.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sau-Yeen Loke, Peter Tsun-Hon Wong, Wei-Yi Ong
NEUROCHEMISTRY INTERNATIONAL
(2017)
Article
Oncology
Yoon-Sim Yap, Prabhakaran Munusamy, Cindy Lim, Claire H. T. Chan, Aldo Prawira, Sau-Yeen Loke, Swee-Ho Lim, Kong-Wee Ong, Wei-Sean Yong, Sarah B. H. Ng, Iain B. H. Tan, David F. Callen, Jeffrey C. T. Lim, Aye-Aye Thike, Puay-Hoon Tan, Ann S. G. Lee
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Biochemistry & Molecular Biology
Sau-Yeen Loke, Kazuhiro Tanaka, Wei-Yi Ong
JOURNAL OF NEUROCHEMISTRY
(2013)
Article
Neurosciences
S. -Y. Loke, N. J. Siddiqi, A. S. Alhomida, H. -C. Kim, W. -Y. Ong
Article
Multidisciplinary Sciences
Wei-Yi Ong, Mary Pei-Ern Ng, Sau-Yeen Loke, Shalai Jin, Ya-Jun Wu, Kazuhiro Tanaka, Peter Tsun-Hon Wong
Article
Oncology
Sau Yeen Loke, Prabhakaran Munusamy, Geok Ling Koh, Claire Hian Tzer Chan, Preetha Madhukumar, Jee Liang Thung, Kiat Tee Benita Tan, Kong Wee Ong, Wei Sean Yong, Yirong Sim, Chung Lie Oey, Sue Zann Lim, Mun Yew Patrick Chan, Teng Swan Juliana Ho, Boon Kheng James Khoo, Su Lin Jill Wong, Choon Hua Thng, Bee Kiang Chong, Ern Yu Tan, Veronique Kiak-Mien Tan, Ann Siew Gek Lee
Article
Oncology
Claire Hian Tzer Chan, Prabhakaran Munusamy, Sau Yeen Loke, Geok Ling Koh, Edward Sern Yuen Wong, Hai Yang Law, Chui Sheun Yoon, Min-Han Tan, Yoon Sim Yap, Peter Ang, Ann Siew Gek Lee
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)