Article
Cardiac & Cardiovascular Systems
Daniel E. Harris, Arron Lacey, Ashley Akbari, Fatemeh Torabi, Dave Smith, Geraint Jenkins, Daniel Obaid, Alex Chase, Mike Gravenor, Julian Halcox
Summary: The European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets and the addition of adjuvant treatments to statins for high- and very high-risk patients. A study found that the majority of patients did not achieve these lipid targets, and there were relatively low rates of prescribing intensive lipid-lowering therapy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Matias B. Yudi, Omar Farouque, Nick Andrianopoulos, Andrew E. Ajani, Angela Brennan, Alexandra C. Murphy, Jeffrey Lefkovits, Christopher M. Reid, Ernesto Oqueli, Martin Sebastian, Stephen J. Duffy, David J. Clark
Summary: The study found that ACS survivors who did not receive optimal secondary prevention pharmacotherapy had a higher long-term mortality rate, indicating the need for improvements in secondary prevention pharmacotherapy models to reduce long-term mortality.
INTERNAL MEDICINE JOURNAL
(2021)
Review
Medicine, General & Internal
Simona Giubilato, Fabiana Luca, Maurizio Giuseppe Abrignani, Laura Gatto, Carmelo Massimiliano Rao, Nadia Ingianni, Francesco Amico, Roberta Rossini, Giorgio Caretta, Stefano Cornara, Irene Di Matteo, Concetta Di Nora, Silvia Favilli, Anna Pilleri, Andrea Pozzi, Pier Luigi Temporelli, Marco Zuin, Antonio Francesco Amico, Carmine Riccio, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva, Michele Massimo Gulizia
Summary: Chronic coronary syndrome (CCS) is a clinical presentation of coronary artery disease (CAD) and is the leading cause of mortality worldwide. Despite advances in CAD treatment, patients with CCS remain at an elevated risk of residual cardiovascular events. Understanding the level and type of residual cardiovascular risk is crucial for appropriate diagnostic tests and follow-up procedures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Matthew E. Lapa, Gretchen M. Swabe, Bruce L. Rollman, Matthew F. Muldoon, Rebecca C. Thurston, Jared W. Magnani
Summary: Depression is associated with lower adherence to guideline-directed medical therapies following percutaneous coronary intervention.
Article
Cardiac & Cardiovascular Systems
Baris Gencer, Nicolas Vuilleumier, David Nanchen, Tinh-Hai Collet, Roland Klingenberg, Lorenz Raeber, Reto Auer, David Carballo, Sebastian Carballo, Soheila Aghlmandi, Dik Heg, Stephan Windecker, Thomas F. Luescher, Christian M. Matter, Nicolas Rodondi, Francois Mach
Summary: The study found a high prevalence of low total endogenous testosterone levels in men with acute coronary syndromes, but after adjusting for high-risk confounders, low testosterone levels were not significantly associated with mortality.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Stavros Dimitriadis, Evelyn Qian, Amy Irvine, Amer Harky
Summary: Secondary prevention after coronary artery bypass graft surgery involves different medication needs and responses for patients compared to the general cardiovascular population. Current drug regimens include aspirin, statins, and clopidogrel, but the effectiveness of some of these medications is debatable. There is a need for robust population-specific evidence in certain areas, which future research should address.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Peripheral Vascular Disease
Thierry Denolle, Claude Pellen, Anne Laure Serandour, Stephanie Lebreton, Florence Revault d'Allonnes
Summary: In patients with stable coronary heart disease, uncontrolled hypertension remains a significant issue even after cardiac rehabilitation, with 70% of hypertensive patients still not achieving target blood pressure levels 1 year later. Factors contributing to this include discontinuation of betablockade, physician inertia in managing hypertension, and poor adherence to international guidelines.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Medicine, General & Internal
Linda Mueller, Christiane Engelbertz, Holger Reinecke, Eva Freisinger, Nasser M. Malyar, Matthias Meyborg, Tobias J. Brix, Julian Varghese, Katrin Gebauer
Summary: Lower extremity artery disease (LEAD) affects elderly patients and is linked to increased cardiovascular morbidity and mortality. However, most patients do not achieve the recommended target levels for abnormal blood lipids, and the progression of cardiovascular events remains inevitable. This study highlights the importance of both pharmacological and lifestyle interventions in managing LEAD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yuesong Pan, Zixiao Li, Jiejie Li, Aoming Jin, Jinxi Lin, Jing Jing, Hao Li, Xia Meng, Yilong Wang, Yongjun Wang
Summary: Despite adherence to guideline-based secondary stroke prevention, there is still a significant residual risk of recurrent stroke at 12 months. Future research should focus on reducing this residual risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohamed M. Elzoghby, Mai M. A. Salama, Mohamed A. Elsetiha, Hanan M. El-Ahwal, Soha A. Romeih, Mahmoud N. Shaaban, Wesam E. Elmozy
Summary: MRI-FT can be used to assess the effect of coronary revascularization on territorial left ventricular function in patients with chronic coronary syndrome. The study found that coronary revascularization significantly improved territorial circumferential strain, but had no significant effect on territorial longitudinal and radial strains.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Clinical Neurology
Priscilla Abrafi Opare-Addo, Fred Stephen Sarfo, Patrick Opoku Berchie, Minas Aikins, Bruce Ovbiagele
Summary: One out of every four strokes is a highly preventable recurrent stroke, yet low- and middle-income countries (LMICs) have a disproportionate burden of stroke and are underrepresented in pivotal clinical trials. An examination of a global expert consensus guideline for stroke prevention found that LMICs were underrepresented in key clinical trials used to formulate the guideline.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Lindsey E. Garrison, Jessica E. Haberer
Summary: This narrative review examines the latest interventions and programs to improve PrEP adherence, with most published interventions focused on men who have sex with men. Future work should include all at-risk groups, such as African American and Latinx heterosexual populations and people who inject drugs. Promising approaches may need to be adapted with the introduction of long-acting pre-exposure prophylaxis formulations.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michel Komajda, Francesco Cosentino, Roberto Ferrari, Mathieu Kerneis, Elena Kosmachova, Cecile Laroche, Aldo P. Maggioni, Harald Rittger, Philippe G. Steg, Hanna Szwed, Luigi Tavazzi, Marco Valgimigli, Chris P. Gale
Summary: The CICD-LT registry is investigating outcomes and management in CCS patients in ESC member countries, finding common cardiovascular risk factors and suboptimal prescribing. Older and female patients were less likely to receive guideline-recommended drug combinations.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tamara Mertins, Henning Nilius, Robin Boss, Matthias Knuchel, Andri Signorell, Carola A. Huber, Eva Blozik, Johanna Anna Kremer Hovinga, Lucas M. Bachmann, Michael Nagler
Summary: This study aimed to assess the adherence of physicians to evidence-based guidelines in the treatment of VTE patients and identify associated factors. The results showed a low adherence to evidence-based guidelines and several patient-related predictors. However, non-adherence was not significantly associated with clinical outcomes such as mortality and hospitalization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emily Pan, Susanne J. Nielsen, Ari Mennander, Erik Bjorklund, Andreas Martinsson, Martin Lindgren, Emma C. Hansson, Aldina Pivodic, Anders Jeppsson
Summary: This study aimed to evaluate the association between statin use after coronary artery bypass grafting (CABG) and long-term adverse events. The results showed that ongoing statin use was significantly associated with a reduced incidence of adverse events and mortality, regardless of the statin dose.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Hanis Zulkifly, Gregory Y. H. Lip, Deirdre A. Lane
Summary: This study examined the quality of anticoagulation control, adverse clinical outcomes, and bleeding risk in atrial fibrillation patients aged 80 years and above. The results showed suboptimal anticoagulation control in all patients and increased bleeding risk in the older age group. However, there were no differences in thromboembolic events and all-cause mortality in this age group.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Editorial Material
Hematology
Leona A. Ritchie, Peter E. Penson, Deirdre A. Lane
THROMBOSIS AND HAEMOSTASIS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Peter Calvert, Gregory Y. H. Lip, Deirdre A. Lane
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Diana A. Gorog, Ying X. Gue, Tze-Fan Chao, Laurent Fauchier, Jose Luis Ferreiro, Kurt Huber, Stavros Konstantinidis, Deirdre A. Lane, Francisco Marin, Jonas Oldgren, Tatjana Potpara, Vanessa Roldan, Andrea Rubboli, Dirk Sibbing, Hung-Fat Tse, Gemma Vilahur, Gregory Y. H. Lip
Summary: This article comprehensively reviews the published evidence on bleeding risk assessments in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) and proposes consensus statements to summarize 'best practice' in antithrombotic therapy for these patients. The article discusses the epidemiology and size of the bleeding risk problem in AF and VTE, reviews established bleeding risk factors, and summarizes bleeding definitions. It also reviews the importance of patient values and preferences and balancing the risk of bleeding against thromboembolism.
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Deirdre A. Lane, Radoslaw Lenarczyk, Giuseppe Boriani, Wolfram Doehner, Laura A. Benjamin, Marc Fisher, Deborah Lowe, Ralph L. Sacco, Renate Schnabel, Caroline Watkins, George Ntaios, Tatjana Potpara
Summary: Managing patients with stroke involves a multidisciplinary approach and coordination among various healthcare professionals, caregivers, and next-of-kin. The European Society of Cardiology Council on Stroke has proposed a consensus on Integrated care management to optimize the treatment of stroke and related heart disease, focusing on evidence-based practices and practical approaches for everyday clinical practice.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Vincenzo L. Malavasi, Marco Vitolo, Marco Proietti, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y. H. Lip, Giuseppe Boriani
Summary: This study evaluated the outcomes of European atrial fibrillation (AF) patients with active or prior malignancy. The results showed that active malignancy was independently associated with all-cause death, MACE, and bleeding events. However, the use of oral anticoagulants was not significantly associated with higher risks of all-cause death or bleeding in patients with active malignancies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Geriatrics & Gerontology
Stephanie L. Harrison, Gregory Y. H. Lip, Ashley Akbari, Fatemeh Torabi, Leona A. Ritchie, Asangaedem Akpan, Julian Halcox, Sarah Rodgers, Joe Hollinghurst, Daniel Harris, Deirdre A. Lane
Summary: This study found that older individuals with a history of stroke in the 12 months prior to moving to a care home are at a higher risk of experiencing another stroke and mortality following a stroke. It was also observed that these individuals are often not prescribed medications for secondary stroke prevention.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Clinical Neurology
Peter Bronnum Nielsen, Line Melgaard, Thure Filskov Overvad, Martin Jensen, Torben Bjerregaard Larsen, Gregory Y. H. Lip
Summary: The study found that patients with ICH and AF have a high risk of cerebrovascular ischemic events and a very high risk of all-cause death one year after the incident. Further clinical trials are needed to determine the optimal stroke prevention treatment for ICH survivors with AF.
Article
Cardiac & Cardiovascular Systems
Alena Shantsila, Gregory Y. H. Lip, Deirdre A. Lane
Summary: This study established a registry to examine the management of UK patients with atrial fibrillation (AF) by different healthcare professionals. The study found that guideline-adherent oral anticoagulation significantly reduced the risk of death and stroke at 1 year, but only a quarter of patients received rhythm-control management.
Review
Health Care Sciences & Services
Donato Giuseppe Leo, Benjamin J. R. Buckley, Mahin Chowdhury, Stephanie L. Harrison, Masoud Isanejad, Gregory Y. H. Lip, David J. Wright, Deirdre A. Lane
Summary: Telemonitoring is an effective approach to improve medical care for patients with long-term conditions, and patients have a high level of acceptance towards this technology. Meta-analyses revealed that telemonitoring can reduce mortality, improve blood pressure and glycated hemoglobin, but it does not have a significant impact on patients' quality of life, and there may be an increased risk of hospitalization.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Multidisciplinary Sciences
Anita Slade, Margaret O'Hara, David Quinn, Laura Marley, Stephen Griffith, Melanie Calvert, M. Sayeed A. Haque, Hoong Sern Lim, Philippa Doherty, Deirdre Lane
Summary: This study used GCM software to remotely capture and structure the experiences of LVAD recipients, identifying important domains and items. The positive impact of the LVAD received the highest ratings, with other important domains including physical and cognitive limitations, LVAD restrictions, partner/family support, and equipment and clothing.
Article
Geriatrics & Gerontology
Leona A. Ritchie, Stephanie L. Harrison, Peter E. Penson, Ashley Akbari, Fatemeh Torabi, Joe Hollinghurst, Daniel Harris, Oluwakayode B. Oke, Asangaedem Akpan, Julian P. Halcox, Sarah E. Rodgers, Gregory Y. H. Lip, Deirdre A. Lane
Summary: The prevalence of atrial fibrillation (AF) is relatively high among older care home residents, and it is closely associated with cardiovascular disease and mortality risk. This suggests the need for appropriate treatment and management of AF in older adults, even in the presence of other risk factors.
Editorial Material
Cardiac & Cardiovascular Systems
Theresa J. Hydes, Gregory Y. H. Lip, Deirdre A. Lane
Article
Cardiac & Cardiovascular Systems
Ina Qvist, Deirdre A. Lane, Signe Stelling Risom, Jeroen M. Hendriks, Anette Arbjerg Hojen, Soren Paaske Johnsen, Lars Frost
Summary: Education for patients with atrial fibrillation in Denmark varied in terms of coverage, organization, and content. Initially, almost half of the hospitals did not provide patient education, but at 1-year follow-up, 69% of hospitals started offering patient education. Patient education differed in terms of delivery, frequency, and duration.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Letter
Cardiac & Cardiovascular Systems
Benjamin J. R. Buckley, Stephanie L. Harrison, Deirdre A. Lane, Andrew Hill, Gregory Y. H. Lip
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
