The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Altered gene expression profile in a mouse model of SCN8A encephalopathy

(2017) Ryan S. Sprissler et al.   EXPERIMENTAL NEUROLOGY

Aberrant Sodium Channel Currents and Hyperexcitability of Medial Entorhinal Cortex Neurons in a Mouse Model of SCN8A Encephalopathy

(2017) Matteo Ottolini et al.   JOURNAL OF NEUROSCIENCE

Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors

(2017) Cynthia Harden et al.   NEUROLOGY

CaMKII modulates sodium current in neurons from epilepticScn2amutant mice

(2017) Christopher H. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal hyperexcitability in a mouse model ofSCN8Aepileptic encephalopathy

(2017) Luis F. Lopez-Santiago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

(2017) Lyndsey L. Anderson et al.   Scientific Reports

TheSCN8Aencephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin

(2016) Bryan S. Barker et al.   EPILEPSIA

SCN8Aencephalopathy: Research progress and prospects

(2016) Miriam H. Meisler et al.   EPILEPSIA

Cardiac arrhythmia in a mouse model of sodium channelSCN8Aepileptic encephalopathy

(2016) Chad R. Frasier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sudden unexpected death in epilepsy: Identifying risk and preventing mortality

(2015) Samden Lhatoo et al.   EPILEPSIA

The phenotypic spectrum of SCN8A encephalopathy

(2015) J. Larsen et al.   NEUROLOGY

Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

(2015) Ragna S. Boerma et al.   Neurotherapeutics

Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy

(2015) Jacy L. Wagnon et al.   Frontiers in Neurology

Free phenytoin toxicity

(2014) Syed Haider Imam et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Antiepileptic activity of preferential inhibitors of persistent sodium current

(2014) Lyndsey L. Anderson et al.   EPILEPSIA

Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy

(2014) Jacy L. Wagnon et al.   HUMAN MOLECULAR GENETICS

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Modeling human epilepsy by TALEN targeting of mouse sodium channelScn8a

(2013) Julie M. Jones et al.   GENESIS

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

(2013) Serge Sicouri et al.   HEART RHYTHM

Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts

(2013) Arash Pezhouman et al.   HEART RHYTHM

Persistent Sodium Current Drives Conditional Pacemaking in CA1 Pyramidal Neurons under Muscarinic Stimulation

(2013) J. Yamada-Hanff et al.   JOURNAL OF NEUROSCIENCE

De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP

(2012) Krishna R. Veeramah et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

(2012) Ryoko Hirakawa et al.   NEUROPHARMACOLOGY

Phenytoin-induced visual disturbances mimicking Delirium Tremens in a child

(2010) Laura López Marín et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota

(2010) D. C. Hesdorffer et al.   NEUROLOGY