Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 57, Issue -, Pages 70-75Publisher
ELSEVIER
DOI: 10.1016/j.etap.2017.11.011
Keywords
Sirtuin-1; FOXO3a; PM2.5; N-acetyl-L-cysteine; Oxidative stress
Funding
- Hebei Provincial Science and Technology Plan Projects [1527701D]
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Silent information regulator 1 (SIRT1), a class III histone deacetylase, plays a major role in combating cellular oxidative stress injury. However, the role of SIRT1 in oxidative stress induced by particulate matter remains unclear. A total of 32 healthy male Sprague Dawley rats were divided into PM2.5, PM2.5 + NAC, filtered air (control), and filtered air + NAC (NAC control) groups. The expressions of MnSOD, SIRT1, and FOXO3a were examined at both transcriptional and protein levels. The expression levels of MnSOD, SIRT1, and FOXO3a reduced significantly (P < 0.05) in the PM2.5 group as compared to the control group. However, their expression levels were increased after NAC intervention. These results suggested that SIRT1 exerted a protective effect against PM2.5-induced respiratory oxidative damage by regulating the expression of FOXO3a. NAC can activate SIRT1 and exert an anti-oxidative role in PM2.5-induced oxidative injury.
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