Article
Environmental Sciences
Chao Shen, Xijing Zhao, Chengyong He, Zhenghong Zuo
Summary: This study found that exposure to R-, S-, and RS-PG enantiomers did not exhibit basic developmental toxicity in zebrafish larvae, but high doses may potentially cause neurotoxicity and ocular developmental toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jong-Su Park, Palas Samanta, Sangwoo Lee, Jieon Lee, Jae-Woo Cho, Hang-Suk Chun, Seokjoo Yoon, Woo-Keun Kim
Summary: Acrylamide induces neurotoxicity and developmental toxicity in zebrafish, leading to various developmental abnormalities and impaired locomotor behavior. The zebrafish model offers a rapid and cost-efficient approach to studying acrylamide neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Cong M. Tran, Hyojin Lee, Byoungcheun Lee, Jin-Sung Ra, Ki-Tae Kim
Summary: This study compared the developmental toxicities of six major OPEs in chorionated and dechorionated zebrafish embryos using a fixed exposure scheme. Removal of the chorion increased sensitivity to OPEs, leading to higher incidence of mortality and malformation. Behaviorally, zebrafish larvae exhibited inhibited locomotive activity by OPEs regardless of chorion presence. At the molecular level, the presence of the chorion influenced the expression of certain genes in zebrafish embryos exposed to specific OPEs.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Hojun Lee, Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: This study demonstrates the toxic effects of molinate on zebrafish larvae, including reduced viability and successful hatching, and the induction of apoptosis, inflammation, and endoplasmic reticulum stress response. Additionally, molinate exposure leads to abnormal cardiovascular, neuronal, and liver development in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Marine & Freshwater Biology
Bangeppagari Manjunatha, B. Deekshitha, Eunseok Seo, Jeongju Kim, Sang Joon Lee
Summary: Research shows that exposure to PM2.5 leads to increased mortality, reduced hatching rates, lower heart rates, and various developmental abnormalities in zebrafish. It also causes damage in skin cell layers, abnormalities in neurons, heart, liver, gills, brain, and eyes, and increased organelle dissolution at cellular/subcellular levels. Further investigation is needed to understand the specific elements in diesel pollution that contribute to this toxicity.
AQUATIC TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosalia Crupi, Domenico Britti
Summary: Perfluorinated and polyfluorinated alkyl substances (PFAS), numbering more than 4700, are persistent chemicals that accumulate in living organisms and the environment. Due to their extensive use, PFAS are globally present, presenting concerns for animals, humans, and the environment. They can have various adverse health effects, and dietary intake is the most significant source of exposure. The review analyzes the characteristics, uses, and environmental presence of PFAS, highlighting the toxic potential, exposure, and related mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang Lu
Summary: Pesticides, such as haloxyfop-p-methyl, are harmful to the aquatic ecosystem as they leave residues in soil, water, and agricultural products. This study investigated the toxic effects of haloxyfop-p-methyl on zebrafish and found developmental, neurotoxic, and immunotoxic effects. Zebrafish larvae exhibited spinal deformities, decreased body length, slow heart rate, and enlarged yolk sac area. Behavior analysis showed reduced activity, accompanied by higher AChE activity. Exposure to haloxyfop-p-methyl also induced oxidative stress and affected immune cell populations in the thymus. Furthermore, haloxyfop-p-methyl caused neutrophil apoptosis and increased expression of proinflammatory cytokine genes. These findings provide insights into the toxicological mechanisms of haloxyfop-p-methyl in teleosts.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Yang Xu, Jihyun Jang, Myung Chan Gye
Summary: The contamination of phthalate ester plasticizers poses a threat to wildlife and human health. This study evaluated the developmental toxicity and cellular stress-inducing potential of commonly used phthalate esters and emerging alternatives. The results showed that these plasticizers had varying effects on animal development and cellular stress at different concentrations.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Hannes Reinwald, Julia Alvincz, Gabriela Salinas, Christoph Schafers, Henner Hollert, Sebastian Eilebrecht
Summary: This study characterized the transcriptomic responses to six insecticides in zebrafish embryos, aiming to identify biomarker candidates for specific modes of action. Abamectin showed the most unique signature related to lipid metabolic processes. Differentially expressed genes after imidacloprid exposure were primarily associated with immune system and inflammation. The findings provide insights into early molecular events in response to the analyzed modes of action.
Article
Environmental Sciences
Federica Persico, Frederic Coulon, Melissa Ladyman, Tracey Temple
Summary: This study developed an environmental hazard-based rating methodology to assess the severity of chemical contamination to ecological soil systems, and categorized the chemicals into different environmental hazard priorities for decision-making process.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Environmental Sciences
Junchao Ma, Zeming Wang, Chao Qin, Tingting Wang, Xiaojie Hu, Wanting Ling
Summary: The widespread use of consumer products containing benzophenone-type ultraviolet filters has led to their presence in the human body and environment. Increasing evidence shows that these filters are endocrine disruptors, raising concerns about their carcinogenicity and effects on reproduction and development. Due to the varied types of benzophenone-type filters and limited toxicity studies, there is a need for a systematic review to expand knowledge on their health risks and identify safer alternatives.
Article
Environmental Sciences
Garam An, Taeyeon Hong, Hahyun Park, Whasun Lim, Gwonhwa Song
Summary: In this study, the developmental toxicity of the carbamate insecticide oxamyl on zebrafish larvae was examined. Oxamyl was found to have adverse effects on the development of the neuron, notochord, and vascular system. Furthermore, it was found to impact the mitochondrial electron transport chain and the PI3K/Akt and p38 Mapk signaling pathways in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Jinsoo Lee, Seong-Jin Choi, Ji-Seong Jeong, Sang Yun Kim, Seung-Jin Lee, Sang-Ki Baek, Nayun Kwon, Sang-Hyub Lee, Woojin Kim, Jae-Woo Cho, Eun Mi Koh, Kyuhong Lee, Eun Ju Jeong, Sang-Yoon Nam, Wook-Joon Yu
Summary: Polyhexamethylene guanidine phosphate (PHMG-P), a primary biocide in humidifier disinfectants, can cause fatal pulmonary disease in Korea. Inhalation of PHMG-P during pregnancy adversely affects maternal health and embryo-fetal development. Prenatal exposure to PHMG-P results in increased perinatal death rates, decreased viability index, lower birth weight, and systemic toxicities in offspring. These findings suggest that prenatal PHMG-P exposure has long-term effects on offspring health and could impact human risk assessment.
Article
Pharmacology & Pharmacy
Lindsey St Mary, Lisa Truong, Andrew A. Bieberich, Raymond O. Fatig III, Bartek Rajwa, Robyn L. Tanguay
Summary: Modern toxicology has benefited from alternative models, laboratory automation, and machine learning to increase throughput. This study compared the bioactivity of a developmental neurotoxicant library in zebrafish and a high-throughput cell culture system, finding that the zebrafish assays were more comprehensive and using both models together allowed for rapid hazard assessment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Guixiang Ji, Jie Gu, Min Guo, Linjun Zhou, Zhen Wang, Lili Shi, Aihua Gu
Summary: This study evaluated the developmental vascular toxicity of bisphenol A (BPA) and its substitutes using zebrafish embryos and human vascular endothelial cells (HUVECs). The results showed that the substitutes hindered vascular growth and inhibited in vitro angiogenesis. BP exposure also increased oxidative stress. The ranking of toxicity and oxidative stress potency of the substitutes was BPAF > BPF > BPA > BPS.
Article
Engineering, Environmental
Leah M. Thornton, Elise M. Path, Gunnar S. Nystrom, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Environmental Sciences
Leah M. Thornton, Elise M. Path, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2016)
Article
Environmental Sciences
Alexandra T. Yost, Leah M. Thornton, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Fisheries
Leah M. Thornton, Meriel C. LeSueur, Alexandra T. Yost, Dane A. Stephens, James T. Oris, Marlo K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Environmental Sciences
Kyle S. Roush, Julie C. Krzykwa, Jacob A. Malmquist, Dane A. Stephens, Marlo K. Sellin Jeffries
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Article
Fisheries
Leah M. Thornton, Elise M. Path, Gunnar S. Nystrom, Barney J. Venables, Mario K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Steven E. Fiester, Brock A. Arivett, Robert E. Schmidt, Amber C. Beckett, Tomislav Ticak, Mary V. Carrier, Rajarshi Ghosh, Emily J. Ohneck, Maeva L. Metz, Marlo K. Sellin Jeffries, Luis A. Actis
Article
Environmental Sciences
Teresa J. Norberg-King, Michelle R. Embry, Scott E. Belanger, Thomas Braunbeck, Joshua D. Butler, Phil B. Dorn, Brianna Farr, Patrick D. Guiney, Sarah A. Hughes, Marlo Jeffries, Romain Journel, Marc Leonard, Mark McMaster, James T. Oris, Kathy Ryder, Helmut Segner, Thomas Senac, Glen Van Der Kraak, Graham Whale, Peter Wilson
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2018)
Article
Environmental Sciences
Kyle S. Roush, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2019)
Article
Environmental Sciences
Julie C. Krzykwa, Asal Saeid, Mario K. Sellin Jeffries
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Environmental Sciences
Julie C. Krzykwa, Marlo K. Sellin Jeffries
Article
Fisheries
Leah M. Thornton Hampton, Christopher J. Martyniuk, Barney J. Venables, Marlo K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Julie C. Krzykwa, Marlo K. Jeffries
Article
Multidisciplinary Sciences
Leah M. Thornton Hampton, Marlo K. Sellin Jeffries, Barney J. Venables