Article
Plant Sciences
Magda Rhayanny Assuncao Ferreira, Alessandra Daniele-Silva, Lucas Ferreira De Almeida, Ewelyn Cintya Felipe Dos Santos, Janaina Carla Barbosa Machado, Alisson Macario De Oliveira, Matheus de Freitas Fernandes Pedrosa, Patricia Maria Guedes Paiva, Thiago Henrique Napoleao, Luiz Alberto Lira Soares
Summary: The study investigated the phytochemical composition, acute, subacute toxicity, and in vivo genotoxicity of the aqueous extract of Eugenia uniflora leaves. Results showed a dominance of phenolic compounds in the extract, with no signs of toxicity or genotoxicity in vivo.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Mohamed Amgad, LameesA Atteya, Hagar Hussein, Kareem Hosny Mohammed, Ehab Hafiz, Maha A. T. Elsebaie, Pooya Mobadersany, David Manthey, David A. Gutman, Habiba Elfandy, Lee A. D. Cooper
Summary: This article presents techniques for scalable nuclear detection, segmentation, and explainable classification to realize the potential of computational pathology in computer-aided diagnosis and discovery of morphologic biomarkers. The modifications to the Mask R-CNN architecture and the introduction of the DTALE explainability method contribute to improving accuracy and providing simple, quantitative explanations for classification models, addressing the need for explainability in deep learning models.
Article
Engineering, Environmental
Jason T. Magnuson, Leslie Caceres, Nathan Sy, Chenyang Ji, Philip Tanabe, Jay Gan, Michael J. Lydy, Daniel Schlenk
Summary: Exposure to bifenthrin led to changes in lipid composition in the brains of rainbow trout and caused histopathological lesions, indicating potential impacts on neuronal function.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Jason T. Magnuson, Leslie Caceres, Nathan Sy, Chenyang Ji, Philip Tanabe, Jay Gan, Michael J. Lydy, Daniel Schlenk
Summary: Exposure to bifenthrin resulted in concentration-dependent alterations in lipid metabolism in juvenile rainbow trout, with decreased levels of triglycerides and significant changes in phosphatidylcholines and phosphatidylethanolamines. Histopathological insults, such as focal hemorrhages and blood vessel congestion, were observed in the brains of bifenthrin-treated animals, indicating a potential association between altered lipid metabolism and neuronal cell structure and integrity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Anandha Rao Ravula, Suresh Yenugu
Summary: Long-term exposure to pyrethroids affects transgenerational fecundity by influencing changes in sperm proteome, indicating the potential adverse effects of these compounds on reproductive health.
Article
Food Science & Technology
Qian Tao, Dong Peng, Pan Li, Lanyu Lai, Wenzhi Li, Bing Du
Summary: This study assessed the toxicological characteristics of fermented Morinda officinalis (FMO) and found that FMO did not show any genotoxicity or acute toxicity at the tested dose. Furthermore, no adverse effects were observed in the subchronic toxicity study, indicating that FMO can be safely used as functional food and medicine.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Geology
Tito Aureliano, Carolina S. I. Nascimento, Marcelo A. Fernandes, Fresia Ricardi-Branco, Aline M. Ghilardi
Summary: This research provides detailed histological descriptions of severe bone inflammation and the exceptional preservation of soft-bodied parasitical microorganisms in the vascular canals of a non-avian dinosaur for the first time, bringing new insights to parasitology, pathology, and histology. An old titanosaur from Southeast Brazil in the Upper Cretaceous exhibited acute osteomyelitis, with tens of parasites found in the specimen's vascular canals, indicating a potential association between parasitic infestation and infectious bone disease.
CRETACEOUS RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Svetlana Smorodinskaya, Nikita Kochetkov, Kirill Gavrilin, Dmitry Nikiforov-Nikishin, Diana Reznikova, Aleksey Vatlin, Anastasia Klimuk, Maya Odorskaya, Alexei Nikiforov-Nikishin, Andrey Ponomarev, Maria Marsova, Valery Danilenko
Summary: In this study, the acute toxicity of Bisphenol A on zebrafish was evaluated. The results showed that Bisphenol A had a genotoxic effect on the fish, leading to an increase in erythrocyte nuclear abnormalities and changes in peripheral blood parameters. Histological analysis also revealed circulatory disturbances and inflammation/degradation foci in the head kidney's hematopoietic tissue. The study demonstrated the concentration-effect relationship and adaptive mechanisms in hematopoiesis under BPA exposure.
Article
Gastroenterology & Hepatology
Ian A. Rowe, Richard Parker
Summary: This study quantified the contribution of placebo to liver fibrosis improvement in nonalcoholic steatohepatitis (NASH) patients through probabilistic simulation. The results showed that approximately 22% of NASH patients with fibrosis stage 2 or 3 at baseline improved by at least 1 fibrosis stage after receiving placebo treatment. The placebo response rate ranged from 15% to 30%, and an increase in observer variability further increased the placebo response.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Chemistry, Analytical
Alan M. Race, Daniel Sutton, Gregory Hamm, Gareth Maglennon, Jennifer P. Morton, Nicole Strittmatter, Andrew Campbell, Owen J. Sansom, Yinhai Wang, Simon T. Barry, Zoltan Takats, Richard J. A. Goodwin, Josephine Bunch
Summary: The article introduces a generic method for extracting information from different modalities using annotations from one microscopy modality and presents a fast, general multimodal registration workflow for automatic alignment of complex data sets. Experimental results demonstrate that the proposed methods help better understand tumor heterogeneity and the tumor microenvironment.
ANALYTICAL CHEMISTRY
(2021)
Article
Plant Sciences
Abdenego Rodrigues da Silva, Robson Raion de Vasconcelos Alves, Suellen Pedrosa da Silva, Simeone Julio dos Santos Castelo Branco, Amanda de Oliveira Marinho, Talita Giselly dos Santos Souza, Cristiano Aparecido Chagas, Patricia Maria Guedes Paiva, Alisson Macario de Oliveira, Thiago Henrique Napoleao
Summary: The study evaluated the cytotoxicity, hemolytic activity, acute toxicity, and genotoxicity of PgTeL in mice. PgTeL showed potential for antimicrobial application in vivo without significant toxicity to splenocytes and erythrocytes, and no acute toxicity was observed in vivo.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Environmental Sciences
Chunlian Yao, Lan Huang, Changsheng Li, Dongxing Nie, Yajie Chen, Xuanjun Guo, Niannian Cao, Xuefeng Li, Sen Pang
Summary: This study investigated the mixture acute toxicities of fenvalerate and tebuconazole on zebrafish and found that different mixing ratios of the two pesticides exhibited antagonistic or synergistic effects on the fish. Additionally, the mixture exposure also affected the swimming behavior of zebrafish larvae.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Environmental Sciences
Amina E. Essawy, Soheir S. El Sherif, Gamalat Y. Osman, Rehab M. El Morshedy, Abir S. Al-Nasser, Sherin K. Sheir
Summary: Nanoparticle pollution, particularly from copper oxide nanoparticles, is a global issue impacting marine organisms. This study used marine mussels to assess the toxic effects of CuO NPs, revealing accumulation in gills, increased neutral red uptake, decreased phagocytic abilities, DNA damage, and histopathological alterations in response to different concentrations and exposure times. These findings suggest that marine mussels can be valuable bioindicators for evaluating CuO NP toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hubert Szudrowicz, Maciej Kamaszewski, Antoni Adamski, Marek Skrobisz, Justyna Frankowska-Lukawska, Maciej Wojcik, Joanna Bochenek, Kacper Kawalski, Jakub Martynow, Patryk Bujarski, Pola Pruchniak, Ewelina Latoszek, Pawel Bury-Burzymski, Adrian Szczepanski, Slawomir Jaworski, Arkadiusz Matuszewski, Andrzej Przemyslaw Herman
Summary: This study investigates the short-term exposure effects of silver nanoparticles (AgNPs) on the homeostasis of livers and gonads in zebrafish. The results show that AgNPs cause an increase in hepatocyte area, hepatocyte proliferation, and interference with spermatogenesis and oogonesis. Additionally, AgNPs reduce the expression levels of specific genes in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Buket Bakan, Fatih Oltulu, Yeliz Yildirim, Altug Yavasoglu, Sinan Akgol, Nefise Ulku Karabay Yavasoglu
Summary: This study demonstrates that L-glutamic acid-g-p(HEMA) polymeric nanoparticles are biocompatible and have the potential to be used as a drug delivery system, as they show no toxicity in mice and can effectively distribute to organs and bone marrow.
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2023)
Article
Fisheries
Ryuller Gama Abreu Reis, Pablo Costa Jastes Alves, Higo Andrade Abe, Natalino da Costa Sousa, Peterson Emmanuel Guimaraes Paixao, Glauber David Almeida Palheta, Nuno Filipe Alves Correia de Melo, Rodrigo Yudi Fujimoto, Ronald Kennedy Luz, Rodrigo Takata
Summary: The study confirmed the feasibility of using Artemia salina nauplii as the first exogenous feeding in the larviculture of Hypancistrus sp., and recommended the initial daily concentration of 400 nauplii/L and a stocking density of 5 larvae/L for optimal growth.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Juliana Oliveira Meneses, Izadora Cibely Alves da Silva, Ana Flavia Santos da Cunha, Joao Carlos Nunes de Souza, Victor Ruan Silva Nascimento, Cindy Caroline Moura Santos, Fernanda dos Santos Cunha, Peterson Emmanuel Guimaraes Paixao, Joel Artur Rodrigues Dias, Natalino da Costa Sousa, Marcia Valeria Silva do Couto, Higo Andrade Abe, Ricardo Marques Nogueira Filho, Thays Brito Reis Santos, Francisco Jose dos Santos, Luiz Pereira da Costa, Juliana Cordeiro Cardoso, Rodrigo Yudi Fujimoto
Summary: A nanocomposite based on silver nanoparticles and extract of Terminalia catappa showed synergistic antifungal effects in vitro and in vivo conditions, with stable spheroidal silver nanoparticles and active compounds such as gallic acid and ellagic acid. The nanocomposite demonstrated fungistatic and fungicide effects against fungal mycelium, especially in preventing zoospore infectivity in fish eggs, suggesting its potential as an alternative treatment for saprolegniosis in fish farming.
Article
Fisheries
Joel A. R. Dias, Lumar L. Alves, Marcia V. S. Couto, Francisco A. L. Barros, Carlos A. M. Cordeiro, Peterson E. G. Paixao, Juliana O. Meneses, Fernanda S. Cunha, Scheila A. Pereira, Mauricio L. Martins, Jose Luiz P. Mourino, Leandro E. C. Diniz, Alexandre N. Maria, Paulo C. F. Carneiro, Rodrigo Y. Fujimoto
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Juliana Oliveira Meneses, Izadora Cibely Alves da Silva, Ana Flavia Santos da Cunha, Fernanda dos Santos Cunha, Joel Artur Rodrigues Dias, Higo Andrade Abe, Peterson Emmanuel Guimaraes Paixao, Natalino da Costa Sousa, Marcia Valeria Silva do Couto, Bruno Santos Lima, Antonio Guilherme Carvalho Neto, Adriano Antunes de Souza Araujo, Luiz Pereira da Costa, Francisco Jose dos Santos, Juliana Cordeiro Cardoso, Leandro Eugenio Cardamone Diniz, Rodrigo Yudi Fujimoto
Summary: The study found that hot aqueous extract of Terminalia catappa was the most effective in preventing saprolegniosis in angelfish eggs, especially at concentrations of 5 and 10 g/L in liquid medium.
AQUACULTURE RESEARCH
(2022)
Article
Fisheries
Marcia Valeria Silva do Couto, Natalino da Costa Sousa, Peterson Emmanuel Guimaraes Paixao, Estela dos Santos Medeiros, Higo Andrade Abe, Juliana Oliveira Meneses, Fernanda Santos Cunha, Ricardo Marques Nogueira Filho, Ricardo Coelho de Sousa, Alexandre Nizio Maria, Paulo Cesar Falanghe Carneiro, Carlos Alberto Martins Cordeiro, Rodrigo Yudi Fujimoto
Summary: This study evaluated the antimicrobial activity of virgin coconut oil (VCO) and lauric acid (LA) against three fish pathogens. The results showed that lauric acid had a stronger effect in controlling the pathogen development.
Article
Agronomy
Dalton R. B. Brito, Delia M. Pinto-Zevallos, Jose G. de Sena Filho, Caroline R. Coelho, Paulo C. L. Nogueira, Helio W. L. de Carvalho, Adenir V. Teodoro
Summary: The study showed that the essential oil extracted from 'Pera' sweet orange leaves is toxic to coconut mites but not to predatory mites. It does not repel coconut mites, only being toxic to them in the initial hours of exposure. The essential oil also does not negatively impact the growth rate of the predatory mite.
Article
Fisheries
Higo Andrade Abe, Natalino da Costa Sousa, Marcia Valeria Silva do Couto, Peterson Emmanuel Guimaraes Paixao, Ricardo Marques Nogueira Filho, Ryuller Gama Abreu Reis, Ruana Vitoria Silva Bomfim, Rodrigo Yudi Fujimoto
Summary: The study found that feeding frequency of 2 and 4 times a day had no significant impact on growth performance of Heros severus fingerlings. However, feeding twice a day resulted in lower weight uniformity. Increasing feeding rate from 3% to 6% or 9% promoted growth, but lower feeding rate caused changes in blood parameters.
JOURNAL OF APPLIED ICHTHYOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ighor C. Barreto, Anderson S. de Almeida, Jose G. Sena Filho
Summary: Sesquiterpenes are secondary metabolites formed by the bonding of three isoprene units, playing a crucial role in plant defense and adaptation. This review focuses on the presence of sesquiterpenes in the genus Vitex, highlighting their diversity and importance, particularly in relation to insecticidal activities and defensive responses.
Article
Fisheries
Joel Artur Rodrigues Dias, Lumar Lucena Alves, Francisco Alex Lima Barros, Carlos Alberto Martins Cordeiro, Juliana Oliveira Meneses, Thays Brito Reis Santos, Cindy Caroline Moura Santos, Peterson Emmanuel Guimaraes Paixa, Ricardo Marques Nogueira Filho, Mauricio Laterca Martins, Scheila Anelise Pereira, Jose Luiz Pedreira Mourin, Leandro Eugenio Cardamone Diniz, Alexandre Nizio Maria, Paulo Cesar Falanghe Carneiro, Rodrigo Yudi Fujimoto
Summary: This study evaluated the effects of different probiotic strains on the growth and infection resistance of tilapia. The results showed that feeding tilapia with a multi-strain mixture of probiotics improved their survival rate and infection resistance. Additionally, probiotic supplementation also increased various blood parameters in the fish.
Article
Fisheries
Joel Artur Rodrigues Dias, Lumar Lucena Alves, Francisco Alex Lima Barros, Carlos Alberto Martins Cordeiro, Juliana Oliveira Meneses, Thays Brito Reis Santos, Cindy Caroline Moura Santos, Peterson Emmanuel Guimaraes Paixao, Ricardo Marques Nogueira Filho, Mauricio Laterca Martins, Scheila Anelise Pereira, Jose Luiz Pedreira Mourino, Leandro Eugenio Cardamone Diniz, Alexandre Nizio Maria, Paulo Cesar Falanghe Carneiro, Rodrigo Yudi Fujimoto
Summary: This study found that feeding neotropical fish with probiotic diets enhanced their zootechnical performance, prevented dysbiosis, and increased disease resistance.
AQUACULTURE RESEARCH
(2022)
Article
Agronomy
Jose Guedes de Sena Filho, Anderson Soares de Almeida, Delia Pinto-Zevallos, Ighor Costa Barreto, Socrates Cabral de Holanda Cavalcanti, Rogeria Nunes, Adenir Vieira Teodoro, Haroudo Satiro Xavier, Jose Maria Barbosa Filho, Leluo Guan, Andre L. A. Neves, Jennifer M. Duringer
Summary: Monoterpenes are diverse chemical scents produced by plants as a defense against herbivores. Monoterpenes from Lamiaceae species have shown acaricidal activity against mites and ticks, but their mechanism of action is poorly understood. In this study, we reviewed the bioactivity of these compounds and assessed their potential toxicity to mites and ticks by measuring their docking ability to Drosophila melanogaster acetylcholinesterase (AChE). We identified several monoterpenoids that strongly bind to D. melanogaster AChE and suggest further exploration of linalool as a potential target for optimization studies.
Article
Agricultural Engineering
Ighor Costa Barreto, Salvana Priscylla Manso Costa, Adriana de Jesus Santos, Adriano Pimentel Farias, Victor Hugo Vitorino Sarmento, Adenir Vieira Teodoro, Rogeria de Souza Nunes, Jose Guedes de Sena Filho
Summary: In this study, the acaricidal activity of microemulsions containing EOVG against coconut mites was investigated. Results showed that microemulsions with EOVG exhibited higher toxicity towards coconut mites, especially when EOVG was added with both oil phases.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Chemistry, Medicinal
Luana Marilia Santos Oliveira, Thaysnara Batista Brito, Jose Guedes de Sena Sena Filho, Socrates Cabral de Holanda Cavalcanti
Summary: Larvicides are effective in controlling the spread of Ae. aegypti, but the issue of resistance to existing larvicides necessitates the search for new alternatives. The selection of new larvicides should consider their toxicity to humans, animals, and the environment. Derivatives of natural products show promise as they exhibit selectivity towards mosquitoes while being relatively safe for humans and the environment.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
