Article
Environmental Sciences
Baili Sun, Jing Li, Chenyan Hu, John P. Giesy, Paul K. S. Lam, Lianguo Chen
Summary: This study reveals the interaction behavior between PFBS and hypoxia, with hypoxia dramatically increasing the respiratory rate of medaka gill and PFBS exposure further enhancing this effect. Both hypoxia and PFBS disrupt gene transcriptions and enzymatic activity involved in osmoregulation in gills, disturbing homeostasis of major ions in blood. Additionally, hypoxia is the predominant driver of gill microbiome dysbiosis, causing a significant decrease in bacterial community diversity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Jing Li, Baili Sun, Paul K. S. Lam, Lianguo Chen
Summary: This study aimed to explore the interactive mode on the function of liver-gut axis by exposing adult marine medaka to environmentally realistic concentrations of PFBS under normoxia or hypoxia condition. The results showed that hypoxia exposure significantly disturbed lipid metabolism, caused oxidative damage, and induced inflammation in the livers of medaka. The composition of gut microbiota was also drastically shifted by hypoxia acute exposure. PFBS had a milder effect compared to hypoxia, and a time-course recovery from its toxicity was observed.
MARINE POLLUTION BULLETIN
(2023)
Article
Marine & Freshwater Biology
Dongmei Xie, Hongmai Zhang, Hui Wei, Lin Lin, Dazhi Wang, Minghua Wang
Summary: This study reveals that the combined exposure of polystyrene nanoplastics (PS NPs) and mercury (Hg) poses a greater threat to the survival and health of the copepod Tigriopus japonicus. Not only do PS NPs and Hg have adverse effects on their own, but PS NPs also enhance Hg bioaccumulation and toxicity in copepods. This study provides an early warning of nanoplastic pollution in the marine ecosystem.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Article
Marine & Freshwater Biology
Drew R. Peterson, Frauke Seemann, Miles T. Wan, Roy R. Ye, Lianguo Chen, Keng P. Lai, Peter Yu, Richard Y. C. Kong, Doris W. T. Au
Summary: Estrogenic endocrine disrupting chemicals (EEDC) can impact offspring in a transgenerational manner through modifications of the germline epigenome. Exposure to EE2 during parental gametogenesis and embryogenesis can induce transgenerational reproductive effects and phenotype persistence in unexposed offspring. EE2 exposure also leads to feminization and subsequent masculinization of directly exposed generations. While reproductive output is more sensitive in females, immune competence is not significantly affected. These findings highlight the potential transgenerational toxicity of EEDCs and the negative impact on fish population sustainability.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Chao Xu, Honghong Gong, Lili Niu, Tianyang Li, Hangqin Guo, Chenjian Hu, Xiaohui Sun, Ling Li, Weiping Liu
Summary: In this study, the maternal transfer risk of uranium in zebrafish was evaluated. The results showed that uranium could transfer from the maternal fish to their offspring, leading to adverse effects on thyroid function, oxidative stress, and embryonic development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Marine & Freshwater Biology
Shu-Qing Qiu, Guo-Yong Huang, Xiao-Pei Li, Dong-Qiao Lei, Chen-Si Wang, Guang-Guo Ying
Summary: The issue of additives leached from plastics and their endocrine disrupting effects have attracted attention. This study assessed the transcriptional responses of endocrinerelated genes in marine medaka embryos exposed to leachates from aged plastics immersed in simulated seawater or fish digest. The results showed significant differences in gene transcripts between the two types of leachates, and other leached additives may also impact gene transcription. This study provides molecular evidence of the endocrine disrupting effects of aged plastic leachates and calls for further research on the primary factors affecting transcriptional alterations.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Chloe Devoy, Yamin Raza, Makenna Kleiner, Paul D. Jones, Jon A. Doering, Steve Wiseman
Summary: The brominated flame retardant, TBCO, has been found to have multigenerational effects on the reproductive performance of Japanese medaka. The reproductive capacity of the fish was reduced in the first generation but fully recovered in the third generation. The mechanism behind these multigenerational effects is still unknown.
Article
Environmental Sciences
Laura Gaspari, Marie-Odile Soyer-Gobillard, Francoise Paris, Nicolas Kalfa, Samir Hamamah, Charles Sultan
Summary: The report discusses a family where females exposed to DES during pregnancy developed endometriosis, suggesting a possible impact of DES exposure on the pathogenesis of adult diseases like endometriosis. It highlights potential multigenerational and transgenerational effects of EDCs.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Xueyou Li, Yue Liu, Yuebi Chen, Xinlin Song, Xiaotian Chen, Ning Zhang, Huichen Li, Yusong Guo, Zhongduo Wang, Zhongdian Dong
Summary: Bisphenols (BPA, BPF, and BPAF) have adverse effects on aquatic organisms and their hepatic toxicity in marine fish is not fully understood. In this study, exposure to these bisphenols affected the growth, liver histology, antioxidant defense mechanisms, and gene expression profiles in marine medaka. BPAF exposure showed higher body weight, lower survival rate, vacuolization and lesions in the liver, altered antioxidant enzyme activity, anxiolytic effects, reduced swimming distance, and changes in gene expression levels. Overall, bisphenols can adversely affect the growth and metabolism of marine medaka.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Toxicology
Sharlene Matten, Dawn Fallacara, Alaa Kamel, Scott G. G. Lynn, Douglas J. J. Fort, Jeffrey C. C. Wolf, Tom Leak, Haley von Holst, Ronnie Joe Bever, Amy Thomas, Vincent J. J. Brown
Summary: This study investigated the toxicity of 2-ethylhexyl 4-hydroxybenzoate (2-EHHB) and found adverse effects on the growth, development, and reproduction of fish, possibly mediated by the endocrine system. The results suggest that this compound may pose potential risks to the environment and organisms.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Environmental Sciences
Halina Binde Doria, Markus Pfenninger
Summary: This study investigated early Cd contamination across five generations of the model organism Chironomus riparius using spiked water exposure scenario. Results showed that exposure to brief and low Cd concentrations can affect all measured endpoints, with initial Cd pollution detected after just five consecutive generations. Importantly, fertility was greatly impaired at 100 μg/L of Cd after three generations. PGR calculation proved to be a sensitive tool for monitoring early pollution of Cd, and no adaptation to Cd was observed over five generations.
Article
Marine & Freshwater Biology
Eulalia Maria Beltran, Miguel Gonzalez-Doncel, Jose Enrique Garcia-Maurino, Pilar Garcia Hortiguela, Maria Victoria Pablos
Summary: This study investigated the effects of BDE-47 on the growth and reproduction of medaka fish through a full life cycle dietary exposure. The results showed that BDE-47 did not significantly affect the growth and reproduction of medaka fish, and there were no apparent effects on early progeny stages, despite effective bioaccumulation and maternal transfer.
AQUATIC TOXICOLOGY
(2022)
Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Zhongdian Dong, Yuebi Chen, Xueyou Li, Ning Zhang, Yusong Guo, Yan-Qiu Liang, Zhongduo Wang
Summary: Norethindrone (NET) has been found to affect the growth, sex differentiation, and gonadal maturation of marine medaka fish, and it significantly alters the transcriptional expression levels of HPG axis-related genes.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Jiezhang Mo, Miles Teng Wan, Doris Wai-Ting Au, Jingchun Shi, Nathan Tam, Xian Qin, Napo K. M. Cheung, Keng Po Lai, Christoph Winkler, Richard Yuen-Chong Kong, Frauke Seemann
Summary: Benzo[a]pyrene (BaP), a common environmental pollutant, can induce bone toxicity in unexposed offspring. This study found that exposure of medaka to BaP resulted in reduced bone thickness in subsequent generations, and dysregulation of various molecular pathways involved in bone formation and bone resorption. Additionally, epigenetic factors were also implicated in the transgenerational effects of BaP on bone health. These findings highlight the importance of further research on the mechanisms and potential biomarkers of BaP-induced bone disease.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Review
Environmental Sciences
Jia-Yong Lao, Yuefei Ruan, Kenneth M. Y. Leung, Eddy Y. Zeng, Paul K. S. Lam
Summary: This comprehensive review examines the occurrence of organophosphate esters (OPEs) in various environments over the past decade and explores age-specific exposure to OPEs. The results suggest that dietary ingestion is the main exposure pathway, followed by dust ingestion. Exposure in schools/daycare centers and offices contributes significantly to OPE intake in non-adults and adults, respectively. Infants are the most vulnerable group, largely due to breast milk ingestion.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Linlin Ma, Xiao Hu, Yuan Min, Xinyu Zhang, Wujun Liu, Paul Kwan Sing Lam, Molly Meng Jung, Raymond Jianxiong Zeng, Ruquan Ye
Summary: The development of new green technologies for chemical and material production is driven by the need to combat global warming. Microalgae can convert CO2 into biofuels, making them important for carbon neutrality. This study demonstrates that microalgae biomass can be upgraded into single-atom site catalysts with high oxygen reduction reaction (ORR) activity. The resulting catalysts show remarkable stability and resistance to poisoning, and outperform commercial catalysts in a zinc-air battery. The research offers a sustainable pathway for converting CO2-capture biomass into high-performance catalysts, addressing environmental and energy concerns simultaneously.
Article
Engineering, Environmental
Linjie Jin, Qi Wang, Meng Yan, Jiarui Gu, Kai Zhang, Paul K. S. Lam, Yuefei Ruan
Summary: This study reported for the first time the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers, S-(-)-metoprolol versus R-(+)-metoprolol and S- (+)-venlafaxine versus R-(-)-venlafaxine, in marine medaka. The results showed a higher bioaccumulation potential of S-venlafaxine compared to R-venlafaxine, while there was no significant difference between S- and R-metoprolol. Furthermore, the main metabolites were identified, and the eyes were found to have the highest tissue-specific bioconcentration factors (BCFs) for all four enantiomers.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Eriko Yamazaki, Heesoo Eun, Sachi Taniyasu, Toshihiro Sakamoto, Nobuyasu Hanari, Hideyuki Inui, Rongben Wu, Huiju Lin, Paul K. S. Lam, Jerzy Falandysz, Nobuyoshi Yamashita
Summary: This study investigated the accumulation of PFAS in rice and found that PFAS exists in atmospheric particles, rainwater, irrigated water, soil, and rice plants. PFAS primarily enter the paddy field through atmospheric particles, and rainfall is a significant source of irrigation water contamination. Although there were no major differences in the residual PFAS trends in different rice varieties, the distribution of PFAS in soil, air, and rainwater varied. These findings are important for the daily exposure assessment of PFAS in rice consumption by different populations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Qi Wang, Yuefei Ruan, Linjie Jin, Lily S. R. Tao, Han Lai, Guifeng Li, Leo W. Y. Yeung, Kenneth M. Y. Leung, Paul K. S. Lam
Summary: The ban/elimination of legacy PFASs has resulted in an increase in the production and use of emerging PFASs. However, the trophodynamics of these emerging PFASs in aquatic food webs are still not well understood. This study investigated the biomagnification potential of legacy and emerging PFASs in seawaters and marine organisms from the South China Sea. Significant trophic magnification was observed for 22 PFASs, including the first reported trophic magnification factors for certain PFASs. The presence of PFASs in seafood from the South China Sea suggests a potential human health risk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Qi Wang, Yuefei Ruan, Linjie Jin, Brian C. W. Kot, Kenneth Mei Yee Leung, Paul K. S. Lam
Summary: This study conducted target analysis and suspect screening of halogenated flameretardants (HFRs) and their metabolites in the blubber of stranded finless porpoises and Indo-Pacific humpback dolphins in Hong Kong between 2013 and 2020. The concentrations of tetra-/penta-/hexa-bromodiphenyl ethers (tetra-/penta-/hexa-BDEs) in porpoises and dolphins decreased over time, possibly due to the phasing out of these chemicals in China. Positive correlation was found between the concentrations of tetra-BDE and Me-MeO-tetra-BDE, suggesting the potential metabolism of tetra-BDE as a source of Me-MeO-tetra-BDE in marine mammals.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Jing Li, Baili Sun, Paul K. S. Lam, Lianguo Chen
Summary: This study aimed to explore the interactive mode on the function of liver-gut axis by exposing adult marine medaka to environmentally realistic concentrations of PFBS under normoxia or hypoxia condition. The results showed that hypoxia exposure significantly disturbed lipid metabolism, caused oxidative damage, and induced inflammation in the livers of medaka. The composition of gut microbiota was also drastically shifted by hypoxia acute exposure. PFBS had a milder effect compared to hypoxia, and a time-course recovery from its toxicity was observed.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Hoi Shan Chau, Shaopeng Xu, Yue Ma, Qi Wang, Yaru Cao, Guangling Huang, Yuefei Ruan, Meng Yan, Mengyang Liu, Kai Zhang, Paul K. S. Lam
Summary: This study used a concurrent sampling strategy to investigate the flux of microplastics (MPs) in the Pearl River Estuarine (PRE). The results showed that tidal effect had a significant impact on MP abundances, and the ecological risk assessment revealed that less urbanized and populated rural areas on the western side have been underestimated.
MARINE POLLUTION BULLETIN
(2023)
Article
Engineering, Environmental
Jia-Yong Lao, Shaopeng Xu, Kai Zhang, Huiju Lin, Yaru Cao, Rongben Wu, Danyang Tao, Yuefei Ruan, Kenneth Mei Yee Leung, Paul K. S. Lam
Summary: This study analyzed the concentrations of organophosphate esters (OPEs) and their transformation products (TPs) in urban stormwater and wastewater in Hong Kong. The results showed that OPEs and TPs have ecological impacts, and TPs may cause endocrine disruption in marine organisms. A novel framework integrating various factors has been proposed to assess and regulate the risks of these emerging contaminants in urban environments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yachen Bai, Qi Wang, Jing Li, Bingsheng Zhou, Paul K. S. Lam, Chenyan Hu, Lianguo Chen
Summary: This study examined the influence of chemical speciation on the toxicity of perfluoroalkyl acids (PFAAs) and found that PFAAs were generally more toxic than their corresponding pH control, while PFAA salts showed mild hazards. Fingerprinting the changes along the thyroidal axis demonstrated distinct modes of endocrine disruption for PFAAs and PFAA salts. Furthermore, biolayer interferometry monitoring revealed that PFAA acids bound more strongly with albumin proteins than did their salts. These findings highlight the importance of chemical forms in developmental toxicity and call for discriminative risk assessment and management of PFAAs and salts.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yumiao Sun, Xiaochen Wang, Shanqi Zhou, Yuxi Zhou, Jianghuan Hua, Yongyong Guo, Yan Wang, Wei Zhang, Lihua Yang, Bingsheng Zhou
Summary: This study investigates the toxicity and mechanism of the novel brominated flame retardant DBDPE in zebrafish over multiple generations. It finds that environmentally relevant concentrations of DBDPE can induce transgenerational neurotoxicity in zebrafish and highlights potential impacts on wild gregarious fish.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Yuefei Ruan, Paul K. S. Lam, Jia-Yong Lao, Guangling Huang, Kai Zhang, Qi Wang, Shaopeng Xu, Jiaxue Wu, Kenneth M. Y. Leung, Eddy Y. Zeng, Bensheng Huang
Summary: Due to the lack of monitoring networks and criteria for emerging contaminants in rivers, it is challenging to quantify the influences of human activities on their occurrence and ecological impacts. In this study, organophosphate esters (OPEs) were investigated in the urban estuary of Pearl River Estuary (PRE) in South China. The results showed that OPEs occurrence was mainly influenced by land-based emissions and hydrological conditions. Tributyl phosphate and tris(2-chloroethyl) phosphate were identified as priority OPEs, requiring further monitoring and control measures in this estuary. The study indicates that urbanized riverine outlets are more environmentally stressed and have lower resilience to OPE pollution.
Review
Chemistry, Analytical
Qi Wang, Yuefei Ruan, Calista N. T. Yuen, Huiju Lin, Leo W. Y. Yeung, Kenneth M. Y. Leung, Paul K. S. Lam
Summary: This review summarizes the advantages of three target analysis supplementary approaches for tracking PFASs in the aquatic environment and proposes considering more targets and developing comprehensive sample treatment strategies. It also suggests including PFASs screened via HRMS in mass balance analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)