Journal
ENVIRONMENTAL RESEARCH
Volume 160, Issue -, Pages 541-546Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2017.10.031
Keywords
P,p '-DDE; Left ventricular hypertrophy; Obesity; Glucose; Hypertension
Funding
- Swedish Research Council (VR) [2012-2407]
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) [2007-2047]
- USDA National Institute of Food and Agriculture [1002182]
- National Institutes of Health [ES019919, ES023513]
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Background and objectives: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass. Methods: p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. Results: We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). Conclusion: The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.
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