Article
Medicine, General & Internal
Zi-Yang Peng, Chun-Ting Yang, Shihchen Kuo, Chih-Hsing Wu, Wei-Hung Lin, Huang-Tz Ou
Summary: This study used individual-level claims data to apply RMST analysis for assessing the treatment effects of SGLT2i on cardiovascular and kidney outcomes. The results showed significant differences between SGLT2i and DPP4i use, with variations among different patient populations.
Article
Environmental Sciences
Nian Wu, Lin Tao, Kunming Tian, Xia Wang, Caidie He, Songlin An, Yingkuan Tian, Xiang Liu, Wei Chen, Haonan Zhang, Pei Xu, Dengqing Liao, Juan Liao, Linglu Wang, Derong Fang, Zhongmei Hu, Hongyu Yuan, Jingyi Huang, Xiaoshan Chen, Li Zhang, Xiaohui Hou, Rong Zeng, Xingyan Liu, Shimin Xiong, Yan Xie, Yijun Liu, Quan Li, Xubo Shen, Yuanzhong Zhou, Xuejun Shang
Summary: This study investigated the urinary concentrations of nine phthalic acid ester (PAE) metabolites in pregnant women in China. The results showed cumulative exposure to PAEs among pregnant women, and residential characteristics were found to be associated with urinary PAE metabolite concentrations. Living in buildings and using coal/kerosene/wood/wheat straw as domestic fuel were associated with higher health risks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Luca Penserini, Beatrice Cantoni, Dirk Vries, Andrea Turolla, Patrick W. M. H. Smeets, Bas G. H. Bokkers, Manuela Antonelli
Summary: This article proposes a new method for quantitative chemical risk assessment of CEC mixtures (QCRA(MIX)). Through a case study, the potential of this method is illustrated. The method considers uncertainties in both exposure and hazard assessment to calculate a probabilistic mixture Benchmark Quotient (BQ(MIX)). The results show that the health risks posed by alkylphenols and phthalates in both tap water and bottled water are significant based on overall water consumption.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
M. Gustavsson, S. Molander, T. Backhaus, E. Kristiansson
Summary: In chemical risk assessment, comparing measured or modelled environmental concentrations to Environmental Exposure Limits (EELs) is essential. However, uncertainties and data gaps in EELs can make risk assessment and management strategies challenging. This study shows significant disagreements and uncertainties in EEL datasets, leading to different risk assessment outcomes.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Antonella Mirizzi, Laura R. Aballay, Giovanni Misciagna, Maria G. Caruso, Caterina Bonfiglio, Paolo Sorino, Antonella Bianco, Angelo Campanella, Isabella Franco, Ritanna Curci, Filippo Procino, Anna M. Cisternino, Maria Notarnicola, Pierina F. D'Aprile, Alberto R. Osella
Summary: The study found that lifestyle measured by the modified mWCRF/AICR scoring system was negatively associated with mortality related to various diseases, especially in the male sub-cohort. The results suggest that adherence to a healthy diet can reduce the risk of mortality.
Article
Environmental Sciences
Yu Zhang, Vicente Mustieles, Paige L. Williams, Blair J. Wylie, Irene Souter, Antonia M. Calafat, Melina Demokritou, Alexandria Lee, Stylianos Vagios, Russ Hauser, Carmen Messerlian
Summary: In this study, it was found that maternal exposure to BPA and DEHP, and paternal exposure to DEHP before conception were positively associated with preterm birth in subfertile couples. Both parents' windows of exposure jointly contributed to the outcome, suggesting that preterm birth may be a couple-based pregnancy outcome.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Mathematical & Computational Biology
Jihane Aouni, Nadia Gaudel-Dedieu, Bernard Sebastien
Summary: The MAIC method allows for indirect comparisons between two drugs in different studies, and it is more efficient to match treatment arms separately and use the Lasso technique to select covariates for matching, rather than matching a maximal set of covariates.
STATISTICS IN MEDICINE
(2021)
Article
Environmental Sciences
Jennifer J. Yland, Yu Zhang, Paige L. Williams, Vicente Mustieles, Stylianos Vagios, Irene Souter, Antonia M. Calafat, Russ Hauser, Carmen Messerlian
Summary: This study found that preconception and prenatal exposure to phthalates may increase the risk of preterm birth, particularly in late pregnancy, especially the DEHP metabolites. This suggests that these chemicals may have adverse effects on women's health and fetal development.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Jiahua Guo, Shan Liu, Li Zhou, Bo Cheng, Qi Li
Summary: In the last two decades, there has been an increase in the number of detected activated pharmaceutical ingredients (APIs) in the natural environment globally, leading to the need for prioritizing and ranking APIs of high concern. A new method was developed in this study to estimate the priority of APIs by using the number of products per API on the market multiplied by its daily dose, along with hazard assessment and risk scoring. This approach could potentially be applied in countries/regions where information on API usage is limited or non-existent.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Geosciences, Multidisciplinary
Chao-Yuan Lin, Pei-Ying Shieh, Shao-Wei Wu, Po-Cheng Wang, Yung-Chau Chen
Summary: This research uses big data to establish a risk model for the spatio-temporal distribution of wildfires, improving the accuracy of identifying wildfire locations and enabling the formulation of effective disaster prevention strategies.
Article
Endocrinology & Metabolism
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo, Kyung-Do Han
Summary: This study found a significant increase in the risk of insomnia in patients with diabetic retinopathy (DR). Men and younger age groups were more vulnerable to insomnia. Sex, age, DM duration, and chronic kidney disease (CKD) status interacted with DR status to further increase the risk of insomnia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Oliver Kuss, Annika Hoyer
Summary: A parametric proportional risk model is proposed for time-to-event outcomes, allowing for computing absolute effect measures and facilitating interpretation for a non-technical audience. The model addresses issues with traditional models and provides straightforward parameter estimation.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Toxicology
Thomas Colnot, Wolfgang Dekant
Summary: In its 2020 Scientific Opinion, EFSA evaluated the risks of per- and polyfluoroalkyl substances in food, covering 27 PFCAs and PFSAs of variable chain length. Grouping such structurally diverse compounds with limited toxicity data was a complex task, and various issues and pitfalls were encountered during the assessment process.
TOXICOLOGY LETTERS
(2021)
Article
Respiratory System
Gozde Gurdeniz, Madeleine Ernst, Daniela Rago, Min Kim, Julie Courraud, Jakob Stokholm, Klaus Bonnelykke, Anders Bjorkbom, Urvish Trivedi, Soren J. Sorensen, Susanne Brix, David Hougaard, Morten Rasmussen, Arieh S. Cohen, Hans Bisgaard, Bo Chawes
Summary: Cesarean section is related to newborn metabolomic profiles, gut microbiome data, and cord blood immunology, indicating an increased risk of childhood asthma.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Environmental Sciences
Danielle R. Stevens, Paige A. Bommarito, Alexander P. Keil, Thomas F. McElrath, Leonardo Trasande, Emily S. Barrett, Nicole R. Bush, Ruby H. N. Nguyen, Sheela Sathyanarayana, Shanna Swan, Kelly K. Ferguson
Summary: This study examined the association between prenatal phthalate metabolite mixtures and fetal growth, and found that the association was modified by fetal sex and omega-3 intake during pregnancy.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Obstetrics & Gynecology
Shruthi Mahalingaiah, Victoria Fruh, Erika Rodriguez, Sai Charan Konanki, Jukka-Pekka Onnela, Alexis de Figueiredo Veiga, Genevieve Lyons, Rowana Ahmed, Huichu Li, Nicola Gallagher, Anne Marie Z. Jukic, Kelly K. Ferguson, Donna D. Baird, Allen J. Wilcox, Christine L. Curry, Sanaa Suharwardy, Tyler Fischer-Colbrie, Gracee Agrawal, Brent A. Coull, Russ Hauser, Michelle A. Williams
Summary: The Apple Women's Health Study aims to gain a better understanding of the relationship between menstrual cycles, health, and behavior. The first 10,000 participants in this study were diverse in demographic characteristics and all used Apple iPhones.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Corina Lesseur, Khyatiben Pathak, Patrick Pirrotte, Melissa N. Martinez, Kelly K. Ferguson, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Daniele Mandrioli, Shanna H. Swan, Jia Chen
Summary: This study examined the association between prenatal glyphosate exposure and length of gestation, finding that maternal glyphosate and AMPA exposure were associated with shortened gestational length only among spontaneous deliveries. The results suggest widespread exposure to glyphosate in the general population, potentially impacting reproductive health. Larger confirmatory studies are needed to further investigate the effects, especially in vulnerable populations like pregnant women and newborns.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Pahriya Ashrap, Max T. Aung, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario-Pabon, Carmen M. Velez-Vega, Akram Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study identified associations between phthalate metabolite biomarkers and lipidomic profiles among pregnant women. The most strongly associated lipid markers with phthalate exposure were diacylglycerol 40:7 and plasmenyl-phosphatidylcholine 35:1. Understanding these mechanisms is important for maternal and children's health outcomes.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Danielle R. Stevens, Paige A. Bommarito, Alexander P. Keil, Thomas F. McElrath, Leonardo Trasande, Emily S. Barrett, Nicole R. Bush, Ruby H. N. Nguyen, Sheela Sathyanarayana, Shanna Swan, Kelly K. Ferguson
Summary: This study examined the association between prenatal phthalate metabolite mixtures and fetal growth, and found that the association was modified by fetal sex and omega-3 intake during pregnancy.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Amber L. Cathey, Deborah J. Watkins, Zaira Y. Rosario, Carmen Velez, Bhramar Mukherjee, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study investigated the association between phthalate metabolite mixtures and pregnancy outcomes using a longitudinal pregnancy cohort in Puerto Rico. The results showed that exposure to phthalate mixtures was associated with increased risk of preterm birth and highlighted the importance of studying mixtures by fetal sex.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Astrid N. Zamora, Deborah J. Watkins, Karen E. Peterson, Martha M. Tellez-Rojo, Howard Hu, John D. Meeker, Alejandra Cantoral, Adriana Mercado-Garcia, Erica C. Jansen
Summary: This study found associations between maternal prenatal pesticide exposure and longer sleep duration and later sleep timing among adolescent offspring within a cohort of mother-adolescent pairs. These associations may be specifically related to female offspring.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Christine Kim, Amber L. L. Cathey, Deborah J. J. Watkins, Bhramar Mukherjee, Zaira Y. Y. Rosario-Pabon, Carmen M. M. Velez-Vega, Akram N. N. Alshawabkeh, Jose F. F. Cordero, John D. D. Meeker
Summary: This study explored the associations between maternal blood metal levels and MMPs among 617 pregnant women in Puerto Rico, revealing significant associations between certain metals and MMPs. These associations varied by fetal sex, indicating potential new avenues for understanding heavy metal-induced adverse birth outcomes and diagnostic tool development.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Stefanie A. Busgang, Syam S. Andra, Paul Curtin, Elena Colicino, Matthew J. Mazzella, Moira Bixby, Alison P. Sanders, John D. Meeker, Marissa Hauptman, Shirisha Yelamanchili, Wanda Phipatanakul, Chris Gennings
Summary: Environmental research often relies on urinary biomarkers which require dilution correction to accurately measure exposures. Specific gravity (SG) and creatinine (UCr) are commonly measured urinary dilution factors. Epidemiologic studies may assess only one of these measures, making it difficult to pool studies that may otherwise be able to be combined.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
P. A. Bommarito, D. R. Stevens, B. M. Welch, D. Weller, J. D. Meeker, D. E. Cantonwine, T. F. McElrath, K. K. Ferguson
Summary: This study analyzed data from 900 singleton pregnancies in the LIFECODES Fetal Growth Study and found that exposure to phthalate replacements and bisphenol S increased, while exposure to phthalates and most phenols decreased. The study also found that the levels of chemical exposures varied with sociodemographic characteristics, with higher concentrations observed in non-Hispanic Black or Hispanic participants.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Reproductive Biology
Theresa M. Boyer, Paige A. Bommarito, Barrett M. Welch, John D. Meeker, Tamarra James-Todd, David E. Cantonwine, Thomas F. McElrath, Kelly K. Ferguson
Summary: Excessive gestational weight gain can lead to adverse maternal and neonatal outcomes. This study explores the association between maternal exposure to phthalates and altered gestational weight gain. The findings suggest that phthalates may be related to higher gestational weight gain, especially among individuals with pre-pregnancy obesity. Further research should investigate the sensitivity to phthalate exposures in pregnant people with obesity.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Environmental Sciences
Astrid N. Zamora, Erica C. Jansen, Jaclyn M. Goodrich, Martha M. Tellez-Rojo, Peter X. K. Song, John D. Meeker, Dana C. Dolinoy, Libni A. Torres-Olascoaga, Alejandra Cantoral, Karen E. Peterson
Summary: This study examines the relationship between endocrine-disrupting chemicals (EDCs) and metabolic syndrome (MetS) risk in adolescents. The findings from the analysis of data from 344 Mexican youths indicate that exposure to EDCs is associated with an increased risk of MetS and lipid abnormalities in adolescents, especially among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ram C. Siwakoti, Amber Cathey, Kelly K. Ferguson, Wei Hao, David E. Cantonwine, Bhramar Mukherjee, Thomas F. McElrath, John D. Meeker
Summary: This study found that prenatal exposure to PFAS may have an impact on pregnancy outcomes, including preterm birth and large-for-gestational age (LGA). However, the effects of PFAS on these outcomes depend on the fetal sex. Specifically, certain PFAS were associated with placental preterm birth, with stronger associations observed in male fetuses. For LGA, different PFAS had different effects in females and males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Amber Cathey, Marcela Tamayo-Ortiz, Juan Tamayo-Orozco, John D. Meeker, Karen E. Peterson, Belem Trejo-Valdivia, Martha Maria Tellez-Rojo, Deborah J. Watkins
Summary: Phthalates exposure during pregnancy is associated with perinatal bone health, particularly affecting bone remodeling. The study highlights the importance of considering calcium supplementation and body mass index as effect modifiers in understanding the effects of environmental exposures on bone health.
ENVIRONMENTAL RESEARCH
(2023)
Meeting Abstract
Developmental Biology
K. K. Ferguson, B. M. Welch, A. P. Keil, J. Buckley, S. Engel, T. James-Todd, A. Zota
BIRTH DEFECTS RESEARCH
(2022)
Meeting Abstract
Developmental Biology
P. A. Bommarito, B. M. Welch, A. P. Keil, D. E. Cantonwine, T. F. Mcelrath, K. K. Ferguson
BIRTH DEFECTS RESEARCH
(2022)