Review
Endocrinology & Metabolism
Mariana Fuertes, Belen Elguero, David Gonilski-Pacin, Florencia Herbstein, Josefina Rosmino, Nicolas Ciancio del Giudice, Manuel Fiz, Lara Falcucci, Eduardo Arzt
Summary: A small RWD domain-containing protein called RSUME or RWDD3 has been found to be upregulated in various tissues and involved in the regulation of several factors related to endocrine-related cancer. It modulates the post-translational modifications and activities of other proteins to contribute to the development of various diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Congxin Dai, Jun Kang, Xiaohai Liu, Yong Yao, Haijun Wang, Renzhi Wang
Summary: Pituitary tumors are complex and heterogeneous with a wide range of characteristics, and most are incidentally discovered and do not require treatment. The recent classification strategies rely on immunohistochemistry, but there are still controversies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Gabriele Molteni, Nicole Caiazza, Gianfranco Fulco, Andrea Sacchetto, Antonio Gulino, Daniele Marchioni
Summary: This study analyzed the pituitary endocrine secretion after endoscopic endonasal approach (EEA) for pituitary neuroendocrine tumors, aiming to identify potential predictors of functioning gland recovery. The results showed that younger patients and those with functioning tumors were more likely to completely recover pituitary hormonal function. This study is of great importance for preserving pituitary function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Giulia Cossu, Stefano La Rosa, Jean Philippe Brouland, Nelly Pitteloud, Ethan Harel, Federico Santoni, Maxime Brunner, Roy Thomas Daniel, Mahmoud Messerer
Summary: The expression of PD-L1 is associated with proliferative grades of Trouillas' classification and specific subtypes of PitNET expressing growth hormone.
Review
Endocrinology & Metabolism
Tae Nakano-Tateno, Kheng Joe Lau, Justin Wang, Cailin McMahon, Yasuhiko Kawakami, Toru Tateno, Takako Araki
Summary: Up to 35% of aggressive pituitary tumors recur and current treatment options often fail to inhibit tumor growth. Chemotherapeutic drugs and peptide receptor radionuclide therapy are being increasingly researched for their potential anti-tumor effects on aggressive pituitary tumors.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Linhang Mei
Summary: This study elucidated the relationship between PTTG1 and miRNAs in breast cancer, successfully identified several potential upstream ncRNAs, and found that the PTTG1-miR-186-5p/miR-655-3p axis is associated with TGF-beta and MAPK signaling pathways, further revealing the importance of AURKA.
Article
Endocrinology & Metabolism
Paulina Kober, Natalia Rusetska, Beata J. Mossakowska, Maria Maksymowicz, Monika Pekul, Grzegorz Zielinski, Andrzej Styk, Jacek Kunicki, Lukasz Dzialach, Przemyslaw Witek, Mateusz Bujko
Summary: Pituitary neuroendocrine corticotroph tumors commonly cause Cushing's disease (CD) due to increased ACTH secretion. However, some corticotroph tumors remain clinically non-functioning. Cortisol secretion is regulated by the hypothalamic-pituitary-adrenal axis, and glucocorticoids act through GR and MR receptors to reduce ACTH levels. This study aimed to determine the role of GR and MR expression in functioning and silent corticotroph tumors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyla Wright, Kristyn Galbraith, Matija Snuderl, Nidhi Agrawal
Summary: Histological diagnosis of sellar masses can be challenging, especially in rare cases without definitive biomarkers. DNA methylation profiling has emerged as a useful tool in assisting diagnosis, particularly in cases of atypical presentation or diagnostic uncertainty. This case illustrates the clinical utility of machine-learning-based DNA methylation classifiers in improving diagnostic accuracy and guiding therapeutic and prognostic decisions for CNS tumors.
Article
Oncology
Yonghui Gui, Xueni Liu, Chao Wang, Peng Yang
Summary: The PTTG family genes are overexpressed in kidney renal clear cell carcinoma, and their higher expression levels are associated with shorter overall survival and disease-free survival. The overexpression of these genes is also correlated with individual cancer stages and tumor grades. Furthermore, mutations in 18% of the PTTG family genes are related to short-term survival in patients with kidney renal clear cell carcinoma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Clinical Neurology
Mei Luo, Yiheng Tan, Wenli Chen, Bin Hu, Zongming Wang, Diming Zhu, Haosen Jiao, Chengbin Duan, Yonghong Zhu, Haijun Wang
Summary: Temozolomide demonstrates significant radiological and biochemical response rates in patients with APT and PC, leading to prolonged PFS and OS. Low/intermediate MGMT expression and functional subtype may serve as important predictors of TMZ efficacy. Combination therapy of radiotherapy with TMZ shows improved outcomes in clinical settings.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Henriett Butz
Summary: Pituitary neuroendocrine tumors (PitNET) are common intracranial neoplasms. Non-coding RNAs (ncRNAs) have emerged as potential biomarkers for PitNET due to their stability and tissue specificity. However, the origin of ncRNAs in PitNET and their causal involvement in the pathophysiology remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Chang-Wei Hu, Ya-Bing Li, Xiao-Yong Han, Gang-Feng Yin, Xi-Rui Wang
Summary: This study investigated the changes in motor and cognitive function of pituitary tumor rats after surgery. The experiment involved three groups: control, model, and operation (with 30 animals in each group). Results showed that the expression of PTTG, FGF-2, and VEGF in the operation group decreased compared to the model group, but was still higher than the control group. The water maze test demonstrated that the incubation period for searching the safe island was significantly shorter in the operation group compared to the control group on the 8th and 9th day after injury. Overall, this study suggests that motor memory in rats after pituitary tumor surgery can be improved to some extent.
COMPUTER ASSISTED SURGERY
(2023)
Review
Oncology
Ding Nie, Qiuyue Fang, Wakam Wong, Songbai Gui, Peng Zhao, Chuzhong Li, Yazhuo Zhang
Summary: This study conducted a meta-analysis to evaluate the effect of endoscopic transsphenoidal somatotroph tumor resection on pituitary function. The results showed that after endoscopic surgery, there was an increased risk of pituitary dysfunction and insufficiency in patients with somatotroph tumors. However, preoperative thyroid insufficiency, gonadal insufficiency, and hyperprolactinemia symptoms were partially relieved.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Maria Florencia Clarens, Lucia Crivelli, Ismael Calandri, Patricio Chrem Mendez, Maria Eugenia Martin, Maria Julieta Russo, Jorge Campos, Ezequiel Surace, Silvia Vazquez, Gustavo Sevlever, Ricardo Francisco Allegri
Summary: This study suggests that the use of neuropsychological testing can contribute to the correct diagnosis of MCI due to AD in a South American cohort, with the best predictor being the delayed recall score on the AVLT.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Endocrinology & Metabolism
Juan F. Villalonga, Domenico Solari, Luigi M. Cavallo, Paolo Cappabianca, Daniel M. Prevedello, Ricardo Carrau, Rafael Martinez-Perez, Douglas Hardesty, Christoph Fuchssteiner, Amparo Saenz, Rosaria Viola Abbritti, Cristopher Valencia-Ramos, Ariel Kaen, Anne-Laure Bernat, Eugenio Cardenas, Lena Hirtler, Juan Luis Gomez-Amador, James Liu, Sebastien Froelich, Andres Cervio, Alvaro Campero
Summary: This multicentric study investigated the association between sellar barrier types observed on preoperative MRI and CSF leak rates during endoscopic pituitary surgery. The results showed that patients with weak sellar barrier had higher risk of intraoperative CSF leak, while those with strong sellar barrier had lower risk. The assessment of sellar barrier preoperatively could help surgeons prepare for CSF leak repair during surgery.
Article
Neurosciences
Francisco Marco del Pont, Sebastian Juan Maria Giovannini, Tomas Ries Centeno, Guido Caffaratti, Emiliano Lorefice, Andres Cervio
Summary: The open-door laminoplasty technique is used in the treatment of multilevel cervical myelopathy. This article describes the surgical technique step by step, with the addition of unilateral C4-5 foraminotomy, and evaluates the results obtained so far, focusing on C5 palsy. Out of 20 patients operated on with this technique, only 1 (5%) had postoperative C5 palsy, with a postoperative recovery rate of 54.5%.
Article
Clinical Neurology
T. Ries Centeno, F. Villamil, F. Marco del Pont, S. Giovannini, G. Caffaratti, A. Cervio
Summary: This study aims to systematize the posterior fossa surgical regions and the endoscopic surgical corridors, providing a quick reference for anatomy and surgical nuances. By dividing the posterior fossa into three regions and defining surgical corridors for each region, a simple and concise systematization is proposed.
Article
Clinical Neurology
Facundo Villamil, Francisco Varela, Guido Caffaratti, Mario Ricciardi, Angel Cammarota, Andres Cervio
Summary: This article reports 3 cases of Global rostral midbrain syndrome (GRMS) and Corpus Callosum (CC) infarction, and discusses the causes and related factors of this disease.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
Mauro Ruella, Francisco Marco del Pont, Aguilar Martin, Sebastian Juan Maria Giovannini, Tomas Ries Centeno, Andres Cervio
Summary: The scalpel sign is a characteristic radiological finding related to dorsal arachnoid webs. However, other spine-related conditions may mimic this sign, leading to misdiagnosis. This study reviewed cases with characteristic focal dorsal indentation of the spinal cord, highlighting the importance of accurate diagnosis for treatment planning.
WORLD NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Mariana Fuertes, Belen Elguero, David Gonilski-Pacin, Florencia Herbstein, Josefina Rosmino, Nicolas Ciancio del Giudice, Manuel Fiz, Lara Falcucci, Eduardo Arzt
Summary: A small RWD domain-containing protein called RSUME or RWDD3 has been found to be upregulated in various tissues and involved in the regulation of several factors related to endocrine-related cancer. It modulates the post-translational modifications and activities of other proteins to contribute to the development of various diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Lucila Domecq Laplace, Mauro Ruella, Guido Caffaratti, Facundo Villamil, Martin Monsalve, Santiago Condomi Alcorta, Andres Cervio
Summary: This study reported the clinical features of three patients with posterior fossa CAPNON, two presenting with acute hydrocephalus and one with progressive cranial nerve palsy. All patients showed perilesional edema on preoperative MRI, and all had favorable outcomes after surgery.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Andromachi Pouikli, Monika Maleszewska, Swati Parekh, Ming Yang, Chrysa Nikopoulou, Juan Jose Bonfiglio, Constantine Mylonas, Tonantzi Sandoval, Anna-Lena Schumacher, Yvonne Hinze, Ivan Matic, Christian Frezza, Peter Tessarz
Summary: This study reveals the impact of normal oxygen levels on the differentiation of bone-derived mesenchymal stem cells. High oxygen concentration promotes chromatin compaction and histone hypo-acetylation, resulting in osteogenic defects. Additionally, decreased activity of citrate carrier leads to the accumulation of acetyl-CoA inside mitochondria. Restoring cytosolic acetyl-CoA levels rescues the osteogenic defects.
Article
Surgery
J. F. Villalonga, D. Solari, R. Cuocolo, V. De Lucia, L. Ugga, C. Gragnaniello, J. I. Pailler, A. Cervio, A. Campero, L. M. Cavallo, P. Cappabianca
Summary: This study validates the application of the sellar barrier concept for predicting intraoperative cerebrospinal fluid (CSF) leak in endoscopic endonasal surgery for pituitary adenomas using a machine learning approach. The results show a true correlation between the type of sellar barrier at MRI and its in vivo features observed during surgery.
FRONTIERS IN SURGERY
(2022)
Article
Biology
Jose Ignacio Pailler, Juan Francisco Villalonga, Tomas Ries-Centeno, Amparo Saenz, Matias Baldoncini, Derek Orlando Pipolo, Eugenio Cardenas Ruiz-Valdepenas, Ariel Kaen, Lena Hirtler, David Roytowski, Domenico Solari, Andres Cervio, Alvaro Campero
Summary: This study aimed to analyze the association between sellar barrier thickness and intraoperative cerebrospinal fluid leakage in patients with pituitary apoplexy. A retrospective study was conducted on 47 patients who underwent surgical treatment. The preoperative MRI classification was found to predict the intraoperative findings.
Article
Clinical Neurology
Melanie Catena Baudo, Facundo Villamil, Pablo Sebastian Paolinelli, Nicolas Cristian Domenech, Andres Cervio, Lucia Alba Ferrara, Mariana Bendersky
Summary: The frontal aslant tract (FAT) connects the supplementary motor area with the pars opercularis and is now known as the extended FAT (eFAT). The eFAT is believed to play a role in various brain functions, including verbal fluency. This study successfully reconstructed and analyzed the morphology and anatomical characteristics of the eFAT.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Marcos Ezequiel Yasuda, Daniela Renedo, Soledad Sosa, Karina Danilowicz, Rodolfo Recalde, Roberto Zaninovich, Santiago Gonzalez Abbati, Andres Cervio, Sebastian Giovannini, Juan Villalonga, Liezel Ulloque-Caamano, Kesava Reddy, Mariano Socolovsky, Alvaro Campero
Summary: This multicenter case series analyzed the medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection. The study identified female and young patients as independent risk factors for developing transient DI after surgery.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Mauro Ruella, Guido Caffaratti, Debora Katz, Ricardo Marengo, Andres Cervio
Summary: This paper reports a case of pituitary apoplexy in a patient with COVID-19 and unknown pituitary macroadenoma, and discusses the potential mechanisms underlying the connection between the two conditions.
MEDICINA-BUENOS AIRES
(2023)
Article
Neurosciences
Sebastian J. M. Giovannini, Mauro Ruella, Facundo Villamil, Emiliano Lorefice, Guido Caffaratti, Andres Cervio
Summary: This article describes a step-by-step surgical treatment of a IV ventricle CAPNON with hydrocephalus, which resulted in a favorable outcome.