Article
Medicine, Research & Experimental
Zhong-Yan Zhou, Wen-Ting Shi, Jing Zhang, Wai-Rong Zhao, Ying Xiao, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Yu Wang
Summary: Sodium tanshinone IIA sulfonate (STS) exhibits potent endothelial protective effect against Hcy-induced cell injury, which is related to the inhibition of oxidative stress and mitochondrial dysfunction, as well as activation of AKT/MAPKs, SIRT1/NRF2/HO-1, and NNMT/MNA signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Article
Medicine, Research & Experimental
Cong Li, Shuang Jiang, Hengfei Wang, Yuhong Wang, Yanxing Han, Jiandong Jiang
Summary: Berberine has anti-aging effects on the heart by upregulating Klotho expression, reducing reactive oxygen species levels, inhibiting apoptosis, and alleviating mitochondrial dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Cell Biology
Yunjie Chen, Ning An, Xuan Zhou, Lin Mei, Yanru Sui, Gen Chen, Huinan Chen, Shengqu He, Cheng Jin, Zhicheng Hu, Wanqian Li, Yang Wang, Zhu Lin, Peng Chen, Litai Jin, Xueqiang Guan, Xu Wang
Summary: In this study, it was demonstrated that FGF20 protects against pathological cardiac hypertrophy by reducing oxidative stress through activation of the SIRT1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Shuangquan Wen, Mingchang Xu, Wenhua Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Summary: Cadmium is an environmental contaminant with neurotoxic effects, and mitochondrial dysfunction is a key factor in Cd-induced nervous system diseases. The protein Sirtuin 1 (SIRT1) has been identified as a key target protein impaired in Cd-induced mitochondrial dysfunction. In this study, it was found that Cd exposure inhibited SIRT1 expression, leading to oxidative stress and mitochondrial dysfunction in PC12 cells and rat cortical neurons. However, treatment with the antioxidant puerarin alleviated Cd-induced mitochondrial dysfunction. Additionally, activating SIRT1 using the agonist Srt1720 significantly reduced oxidative stress and mitochondrial dysfunction, ultimately preventing Cd-induced neuronal cell death. These findings provide new insights into the mechanisms of Cd-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Integrative & Complementary Medicine
Pei-Ying Pai, Wan-Ching Chou, Shih-Hung Chan, Shu-Yih Wu, Hsiu- Chen, Chi-Wen Li, Pei-Ling Hsieh, Pei-Ming Chu, Yu-An Chen, Hsiu-Chung Ou, Kun-Ling Tsai
Summary: The study demonstrated that EGCG can ameliorate homocysteine-induced endothelial cell apoptosis by enhancing the SIRT1/AMPK signaling pathway, providing potential benefits for hyperhomocysteinemia.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Sahib Zada, Trang Minh Pham, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Omar Elashkar, Jung-Hwan Kim, Dong Hee Kim, Deok Ryong Kim
Summary: The study demonstrates that chlorogenic acid (CGA) protects human chondrocytes against H2O2-induced apoptosis by decreasing apoptosis markers, increasing anti-apoptotic markers, and activating antioxidant response proteins through autophagy induction.
Review
Immunology
Gaber El-Saber Batiha, Hayder. M. M. Al-kuraishy, Ali. L. I. Al-Gareeb, Engy Elekhnawy
Summary: SIRT1 plays a crucial role in the neuropathology of Parkinson's disease by regulating inflammatory reactions and oxidative stress, thereby reducing neuronal cell death and the progression of degenerative brain diseases.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu, Xiangfeng Zhang, Chenyang Ran, Hongxin Wang, Meili Lu
Summary: This study found that As-IV can improve VED induced by chronic intermittent hypoxia through the calpain-1/SIRT1/AMPK signaling pathway, thereby enhancing endothelial function and increasing nitric oxide production, inhibiting inflammation, oxidative stress, and mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Matshediso Zachariah, Hatem Maamoun, Larissa Milano, Margaret P. Rayman, Lisiane B. Meira, Abdelali Agouni
Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Biochemistry & Molecular Biology
Cristina Banfi, Maura Brioschi, Lucia M. Vicentini, Maria Grazia Cattaneo
Summary: The human long pentraxin PTX3 has complex regulatory roles in innate immunity, inflammation, and tissue repair. This study compared the proteomic profiles of human endothelial cells (ECs) and found that PTX3 regulates angiogenesis, oxidative stress, and inflammation. Knockdown of PTX3 resulted in an increase in pro-inflammatory markers and a shift to a more oxidative state in ECs. These findings support the idea of a protective function for PTX3 in endothelial homeostasis and cardiovascular biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunxiu Zhou, Yi Tan, Baojun Xu, Yitao Wang, Wai-San Cheang
Summary: This study reveals the potential vaso-protective effect of TMS and its therapeutic potential against endothelial dysfunction in metabolic disorders.
Review
Biochemistry & Molecular Biology
Yunna Lee, Eunok Im
Summary: Natural antioxidants play a crucial role in combating cardiovascular diseases, potentially exerting cardioprotective effects through various mechanisms. Research suggests that miRNAs are key players in regulating oxidative stress in cardiovascular diseases, affecting endothelial function by targeting eNOS and SIRT1.
Article
Chemistry, Medicinal
Wenda Zhang, Ting Ma, Shanshan Li, Yanwei Yang, Jianpeng Guo, Wenying Yu, Lingyi Kong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Chen Chen, Ting Ma, Chao Zhang, Hao Zhang, Lijuan Bai, Lingyi Kong, Jianguang Luo
MOLECULAR CARCINOGENESIS
(2017)
Article
Biochemistry & Molecular Biology
Ting Ma, Zhen Wang, Yang-Mei Zhang, Jian-Guang Luo, Ling-Yi Kong
Article
Oncology
Pei Yu, Chao Zhang, Cai-Yun Gao, Ting Ma, Hao Zhang, Miao-Miao Zhou, Yan-Wei Yang, Lei Yang, Ling-Yi Kong
Article
Engineering, Biomedical
Chao Han, Can Zhang, Ting Ma, Chao Zhang, Jianguang Luo, Xiao Xu, Huijun Zhao, Yan Chen, Lingyi Kong
ACTA BIOMATERIALIA
(2018)
Article
Multidisciplinary Sciences
Wenda Zhang, Jianpeng Guo, Shanshan Li, Ting Ma, Dingqiao Xu, Chao Han, Feiyan Liu, Wenying Yu, Lingyi Kong
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun, Xiao-Ju Zhang
CANCER CELL INTERNATIONAL
(2019)
Article
Chemistry, Medicinal
Ting Ma, Qi-Sheng Ma, Bin Yu, Hong-Min Liu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
Qianqian Song, Siqi Feng, Wenjun Peng, Anqi Li, Ting Ma, Bin Yu, Hong-Min Liu
Summary: Gastric carcinoma poses a serious threat to human health with high morbidity and mortality rates. The ubiquitination modification, specifically involving CRLs, plays a crucial role in the pathogenesis of gastric carcinoma by regulating various cellular pathways. Targeting a certain CULs member neddylation may be a promising strategy for selectively controlling cellular protein levels in cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Spectroscopy
Wenda Zhang, Yubing Zhou, Duolu Li, Ting Ma
Summary: A new NIR fluorescent probe F-1 with a large Stokes shift and high sensitivity was reported, which can emit bright NIR fluorescence triggered by HNE and successfully track HNE in A549 cells, serving as an excellent tool for detecting enzymatic activity and NE related diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Medicine, Research & Experimental
Ting Ma, Anqi Li, Yueyang Guo, Shaotong Li, Meng Li, Siqi Feng, Hongmin Liu
Summary: Epigenetics plays a critical role in autophagy, and LSD1, as an important epigenetic enzyme, directly regulates the expression of autophagy-related genes and activates autophagy through regulating the activities of other proteins. Dysregulation of autophagy is closely related to the occurrence of various diseases, and development of LSD1 inhibitors provides a new direction for their treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Gui-Min Xue, Chen-Guang Zhao, Jin-Feng Xue, Kun Du, Jiang-Jing Duan, Hao Pan, Meng Li, Hui Chen, Yan-Jun Sun, Wei-Sheng Feng, Ting Ma, Wen -Da Zhang
Summary: Chemical investigation of Achillea alpina L. led to the isolation of twenty sesquiterpenoids. Among them, achigermalide D not only significantly enhanced glucose consumption but also regulated insulin resistance by suppressing the NLRP3 inflammasome pathway.
Article
Chemistry, Multidisciplinary
Yu Wang, Wenda Zhang, Ting Ma, Duolu Li, Yubing Zhou, Xiaojian Zhang, Jianbo Gao
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Oncology
Jie Luo, Yuanzheng Xia, Jun Luo, Junhe Li, Chao Zhang, Hao Zhang, Ting Ma, Lei Yang, Lingyi Kong
Article
Pharmacology & Pharmacy
Ting Ma, Yi Zhang, Chao Zhang, Jian-Guang Luo, Ling-Yi Kong
BIOCHEMICAL PHARMACOLOGY
(2017)