Article
Oncology
Agnieszka Pikula, Magdalena Skorzewska, Zuzanna Pelc, Radoslaw Mlak, Katarzyna Geca, Katarzyna Sedlak, Bogumila Cisel, Magdalena Kwietniewska, Karol Rawicz-Pruszynski, Wojciech P. Polkowski
Summary: The study confirmed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in advanced gastric cancer patients, serving as significant prognostic factors.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Lucy X. X. Ma, Yifan Wang, Osvaldo Espin-Garcia, Michael J. J. Allen, Gun Ho Jang, Amy Zhang, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Julie M. M. Wilson, Faiyaz Notta, Sandra E. E. Fischer, George Zogopoulos, Steven Gallinger, Robert C. C. Grant, Rama Khokha, Nathan Chan, Barbara T. T. Gruenwald, Jennifer J. J. Knox, Grainne M. M. O'Kane
Summary: By comparing five systemic inflammatory scores in advanced pancreatic adenocarcinoma, researchers found that some of the scores have good prognostic value and can help select patients for clinical trials.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Toshihiko Mikami, Akinori Funayama, Kanae Niimi, Kenta Haga, Masami Kawaharada, Akihiko Nakamura, Wataru Katagiri, Tadaharu Kobayashi
Summary: This study investigated the predictive value of LMR, NLR, PLR, and IRB score for disease-specific survival and delayed cervical lymph node metastasis in early-stage OSCC. The findings suggest that IRB score and mode of invasion are potentially independent risk factors for delayed cervical lymph node metastasis.
Review
Endocrinology & Metabolism
Elena Russo, Mathilda Guizzardi, Luca Canali, Francesca Gaino, Andrea Costantino, Gherardo Mazziotti, Andrea Lania, Silvia Uccella, Luca Di Tommaso, Fabio Ferreli, Luca Malvezzi, Giuseppe Spriano, Giuseppe Mercante
Summary: This meta-analysis showed no association between NLR, PLR, LMR and DFS in differentiated thyroid carcinoma (DTC). However, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Immunology
Neng Wang, Sike He, Yu Zheng, Lichun Wang
Summary: This study revealed that systemic inflammation is associated with the development and progression of hepatitis B-associated acute-on-chronic liver failure (HBV-ACLF). The monocyte-to-lymphocyte ratio (MLR) was found to be a prognostic inflammatory biomarker in HBV-ACLF patients. Furthermore, a decrease in CD8+ T-cell counts was associated with poor survival in HBV-ACLF patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Medicine, General & Internal
Giacomo Tondo, Davide Aprile, Fabiola De Marchi, Barbara Sarasso, Paola Serra, Giordana Borasio, Esther Rojo, Juan Francisco Arenillas, Cristoforo Comi
Summary: Growing evidence suggests that neuroinflammation plays a critical role in neurodegenerative diseases. Peripheral markers of inflammation, such as the neutrophil-to-lymphocyte ratio (NLR), could be used as reliable indicators of central nervous system inflammation. However, the role of peripheral inflammation in dementia and MCI needs further clarification.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Liang Yu, Runben Jiang, Wanjing Chen, Yanwei Liu, Gui Wang, Xin Gong, Yong Wang
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR) and CA19-9 were independent prognostic factors for gastric cancer patients. The NLR-CA19-9 score (NCS), which is a combination of the two factors, can provide more accurate predictions of the prognosis of gastric cancer patients, and its predictive value is significantly better than that of traditional inflammatory indicators or tumor markers.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhaocheng Zhuang, Yanfen Li, Yihong Hong, Lin Chen, Jiawen Qian, Jing Lin, Qing Chen, Yu Qiu, Lisong Lin, Bin Shi, Lizhen Pan, Xiaoyan Zheng, Jing Wang, Fengqiong Liu, Baochang He, Fa Chen
Summary: Systemic inflammatory biomarkers AGR and NLR are independent prognostic indicators for patients with oral squamous cell carcinoma, and their combined AGR-NLR score outperforms traditional TNM staging system in predicting patient outcomes.
Article
Gastroenterology & Hepatology
Liang Guo, Qi Wang, Kang Chen, Hai-Peng Liu, Xiao Chen
Summary: In this study, the combination of preoperative NLR and CA19-9 was found to independently predict the overall survival of patients with gastric cancer, providing a convenient, economical, and effective prognostic system for clinical practice. The NLR + CA19-9 score indicator showed better predictive ability than other combined or single score indicators, based on inflammation and tumor markers.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Elisa Giannetta, Anna La Salvia, Laura Rizza, Giovanna Muscogiuri, Severo Campione, Carlotta Pozza, Annamaria Anita LIvia Colao, Antongiulio Faggiano
Summary: Given the increasing incidence of neuroendocrine neoplasms (NENs) over the past few decades, there is an urgent need for a better understanding of their pathophysiological bases and the identification of innovative NEN biomarkers. Inflammatory biomarkers have been identified as critical in various tumors, including NENs, with a bidirectional relationship between chronic inflammation and the development of NENs reported. Studies have shown promising potential for circulating inflammatory markers such as NLR, PLR, cytokines, and tissue inflammatory markers (PD-1/PD-L1) in the management of NENs, although further validation and clarification of their utility is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomasz Urbanowicz, Anna Olasinska-Witniewska, Michel Michalak, Bartlomiej Perek, Ahmed Al-Imam, Michal Rodzki, Anna Witkowska, Ewa Straburzynska-Migaj, Michal Bocianski, Marcin Misterski, Maciej Lesiak, Marek Jemielity
Summary: This study aimed to investigate the predictive role of preoperative inflammatory indexes in off-pump coronary artery bypass grafting on long-term survival. The findings suggest that a preoperative value of systemic inflammatory response index (SIRI) above 1.27 is associated with worse long-term prognosis after off-pump surgery.
Article
Surgery
Ryoichi Miyamoto, Yukio Oshiro, Ken Nakayama, Keisuke Kohno, Shinji Hashimoto, Kiyoshi Fukunaga, Tatsuya Oda, Nobuhiro Ohkohchi
Article
Engineering, Electrical & Electronic
Eiji Kita, Hideto Yanagihara, Mikio Kishimoto, Kouji Ota, Ryoichi Miyamoto, Tatsuya Oda, Nobuhiro Ohkohchi
IEEE TRANSACTIONS ON MAGNETICS
(2017)
Article
Gastroenterology & Hepatology
Ryoichi Miyamoto, Tatsuya Oda, Shinji Hashimoto, Tomohiro Kurokawa, Keisuke Kohno, Yoshimasa Akashi, Yusuke Ohara, Keiichi Yamada, Tsuyoshi Enomoto, Nobuhiro Ohkohchi
Article
Medicine, General & Internal
Atsushi Uchida, Masayoshi Ozawa, Yumi Ueda, Yoko Murai, Yuka Nishimura, Hiromi Ishimatsu, Yoshimi Okouchi, Kazuya Ishiguro, Yoshitaka Hamada, Rumiko Sasamoto, Masashi Watanabe, Naoki Sano, Ryoichi Miyamoto, Satoshi Inagawa, Kazunori Kikuchi
Article
Gastroenterology & Hepatology
Ryoichi Miyamoto, Yukio Oshiro, Naoki Sano, Satoshi Inagawa, Nobuhiro Ohkohchi
Article
Oncology
Ryoichi Miyamoto, Naoki Sano, Michihiro Maeda, Satoshi Inagawa, Nobuhiro Ohkohchi
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2019)
Review
Surgery
Ryoichi Miyamoto, Kazunori Kikuchi, Atsushi Uchida, Masayoshi Ozawa, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Tatsuya Oda, Nobuhiro Ohkohchi
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2019)
Article
Gastroenterology & Hepatology
Ryoichi Miyamoto, Yukio Oshiro, Naoki Sano, Satoshi Inagawa, Nobuhiro Ohkohchi
GASTROINTESTINAL TUMORS
(2018)
Article
Medicine, General & Internal
Ryoichi Miyamoto, Kazunori Kikuchi, Atsushi Uchida, Masayoshi Ozawa, Akira Kemmochi, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Shinya Adachi, Masayoshi Yamamoto
SAGE OPEN MEDICAL CASE REPORTS
(2018)
Meeting Abstract
Oncology
Ryoichi Miyamoto, Naoki Sano, Sosuke Tadano, Satoshi Inagawa
Article
Gastroenterology & Hepatology
Ryoichi Miyamoto, Yukio Oshiro, Ken Nakayama, Nobuhiro Ohkohchi
GASTROINTESTINAL TUMORS
(2017)
Review
Surgery
Ryoichi Miyamoto, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Shinya Adachi, Masayoshi Yamamoto
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2017)
Article
Medicine, General & Internal
Ryoichi Miyamoto, Yukio Oshiro, Naoki Sano, Satoshi Inagawa, Nobuhiro Ohkohchi
ANNALS OF MEDICINE AND SURGERY
(2018)
Meeting Abstract
Oncology
Ryoichi Miyamoto, Satoshi Inagawa, Naoki Sano, Sosuke Tadano, Masayoshi Yamamoto
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.