Article
Oncology
Masanori Terashima, Takeshi Sano, Junki Mizusawa, Kohei Umemura, Masanori Tokunaga, Takeshi Omori, Haruhiko Cho, Yasuhiro Hasegawa, Yuji Akiyama, Hironori Tsujimoto, Yoshiyuki Kawashima, Yasuyuki Kawachi, Sang Woong Lee, Kazuki Kano, Hiroko Hasegawa, Narikazu Boku, Takaki Yoshikawa, Mitsuru Sasako
Summary: This study investigated the predictability of peritoneal recurrence and survival based on macroscopically and pathologically diagnosed serosal invasion. The results showed that both macroscopic and pathologic diagnoses were independent predictors of peritoneal recurrence, overall survival, and relapse-free survival.
Article
Multidisciplinary Sciences
Dexin Chen, Zhangyuanzhu Liu, Wenju Liu, Meiting Fu, Wei Jiang, Shuoyu Xu, Guangxing Wang, Feng Chen, Jianping Lu, Hao Chen, Xiaoyu Dong, Guoxin Li, Gang Chen, Shuangmu Zhuo, Jun Yan
Summary: A collagen signature derived from multiphoton imaging in the tumor microenvironment of the gastric serosa is significantly associated with a high risk of peritoneal metastasis in gastric cancer with serosal invasion. A competing-risk nomogram including the collagen signature, tumor size, tumor differentiation status, and lymph node metastasis demonstrates satisfactory discrimination and calibration, providing a convenient way to predict the risk of peritoneal metastasis in gastric cancer with serosal invasion after radical surgery.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Masahiro Yura, Takaki Yoshikawa, Takeyuki Wada, Sho Otsuki, Tsutomu Hayashi, Yukinori Yamagata, Hitoshi Katai, Toshirou Nishida
Summary: This study found that Macroscopic Serosal Change (MSC) may be an independent prognostic factor for early gastric cancer.
Article
Multidisciplinary Sciences
Dexin Chen, Jianbo Lai, Jiaxin Cheng, Meiting Fu, Liyan Lin, Feng Chen, Rong Huang, Jun Chen, Jianping Lu, Yuning Chen, Guangyao Huang, Miaojia Yan, Xiaodan Ma, Guoxin Li, Gang Chen, Jun Yan
Summary: Peritoneal recurrence is the most common and lethal type of recurrence in gastric cancer with serosal invasion after surgery. Current evaluation methods are not sufficient for predicting peritoneal recurrence in this type of gastric cancer. Pathomics analyses, consisting of multiple pathomics features extracted from stained images, have shown potential for risk stratification and outcome prediction. A pathomics signature was found to be significantly associated with peritoneal recurrence, and a pathomics nomogram was developed for more accurate prediction.
Article
Surgery
Seong-A Jeong, Sehee Kim, In-Seob Lee, Moon-Won Yoo, Beom Su Kim
Summary: Total omentectomy may not be essential for preventing peritoneal recurrence in AGC patients with serosal invasion. Partial omentectomy can be considered as a radical gastrectomy for T4a gastric cancer.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Lin Xiang, Shuai Jin, Peng Zheng, Ewetse Paul Maswikiti, Yang Yu, Lei Gao, Jing Zhang, Ying Zhang, Hao Chen
Summary: Peritoneal recurrence is the most common pattern of recurrence after radical gastric cancer resection, significantly affecting patient prognosis. There is currently no standard method for preventing peritoneal recurrence, with controversies over treatment methods. However, high expectations are placed on preoperative therapy, surgical skill improvement, and postoperative treatment to reduce the incidence of peritoneal recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Atsushi Sugimoto, Tomohisa Okuno, Gen Tsujio, Tomohiro Sera, Yurie Yamamoto, Koji Maruo, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Shingo Togano, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Masakazu Yashiro
Summary: The study found high expression of Tks5 in PMCs of advanced-stage gastric cancer patients, with positive expression being associated with greater tumor depth and increased rate of peritoneal recurrence. Tks5 might serve as a useful predictor for peritoneal recurrence in GC patients.
Review
Biochemistry & Molecular Biology
C. Frieke Kuper, Raymond H. H. Pieters, Jolanda H. M. van Bilsen
Summary: This article discusses the important role of the serosal immune system in the thoracic and peritoneal cavities, as well as the effects of nanomaterials on this system. ILCs are crucial in the first defense against pathogenic viruses and bacteria, and exposure to NMs may reduce resistance to pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rita A. Busuttil, Joshy George, Colin M. House, Stephen Lade, Catherine Mitchell, Natasha S. Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas
Summary: The study identified secreted frizzled-related protein 4 (SFRP4) as a biomarker for predicting gastric cancer invasion and recurrence. The functional role of this gene in invasion was confirmed, and changes in serum levels could accurately predict the risk of disease recurrence when combined with AJCC stage.
Article
Oncology
Jiabin Wang, Qingzhu Qiu, Ningzi Lian, Huagen Wang, Qiaoling Zheng, Yinghong Yang, Yubin Ma, Yajun Zhao, Ping Li, Jianxian Lin, Jun Lu, Qiyue Chen, Longlong Cao, Mi Lin, Changming Huang, Jianwei Xie
Summary: Inhibition of the immune microenvironment is the main cause of tumor recurrence after surgery in patients with gastric cancer. By evaluating immunosuppressive indicators and immune biomarkers, we constructed an immunosuppressive recurrence score and found that it can accurately and reliably predict recurrence. An elevated score is associated with locoregional recurrence and chemotherapy failure.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Akihiro Takeuchi, Toshiyasu Ojima, Masahiro Katsuda, Keiji Hayata, Taro Goda, Junya Kitadani, Shinta Tominaga, Naoki Fukuda, Tomoki Nakai, Hiroki Yamaue
Summary: This study found that the long-term prognosis of patients with early gastric cancer (EGC) is good, but lymph node metastasis and venous invasion are independent risk factors for recurrence. Postoperative adjuvant chemotherapy may efficiently improve the prognosis of patients with pT1N + v + gastric cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Minning Zhao, Lili Feng, Ke Zhao, Yanfen Cui, Zhenhui Li, Chenglu Ke, Xinyue Yang, Qing Qiu, Weirong Lu, Yanting Liang, ChuanMiao Xie, Xiangbo Wan, Zaiyi Liu
Summary: This study developed an MRI-based scoring system to predict the risk of recurrence in patients with locally advanced rectal cancer. The scoring system proved to be effective in predicting the prognosis and can assist clinicians in making clinical decisions.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Corrado Pedrazzani, Giulia Turri, Daniele Marrelli, Hye Jin Kim, Eun Jung Park, Gaya Spolverato, Caterina Foppa, Antonino Spinelli, Salvatore Pucciarelli, Seung Hyuk Baik, Gyu Seog Choi
Summary: The aim of this study was to establish the incidence of metachronous peritoneal metastases (mPM) after surgery for colon cancer (CC) and develop a statistical model to predict the risk of recurrence. The study found that CA 19-9, pT stage, pN stage, extent of lymphadenectomy, and lymphovascular invasion were significant predictors of mPM. A scoring system was developed to calculate individual risk scores, and the model demonstrated high negative predictive value and accuracy for scores below five.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Yong Xiang Gwee, Daryl Kai Ann Chia, Jimmy So, Wim Ceelen, Wei Peng Yong, Patrick Tan, Chin-Ann Johnny Ong, Raghav Sundar
Summary: Peritoneal metastasis is a common occurrence in advanced gastric cancer and is associated with a poor prognosis. Traditional systemic therapy is often ineffective in treating this specific disease state. Recent studies and clinical trials have focused on understanding the biology of peritoneal metastasis and identifying potential molecular targets. Peritoneal-specific clinical trials are being designed to combine local and systemic therapy for a more effective treatment approach.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Priyanka Narayan, Jessica Flynn, Zhigang Zhang, Erin F. Gillespie, Boris Mueller, Amy J. Xu, John Cuaron, Beryl McCormick, Atif J. Khan, Oren Cahlon, Simon N. Powell, Hannah Wen, Lior Z. Braunstein
Summary: This study explored the association between perineural invasion (PNI) and locoregional recurrence (LRR) in breast cancer patients, finding that PNI significantly increases the risk of LRR. Multivariable Fine-Gray regression modeling confirmed the potentiated association between PNI and LRR. Propensity score matching analysis further supported the significant link between PNI and LRR.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Peng-liang Wang, Fang-tao Xiao, Bao-cheng Gong, Fu-nan Liu, Hui-mian Xu
JOURNAL OF GASTROINTESTINAL SURGERY
(2017)
Article
Oncology
Songcheng Yin, Zhifeng Miao, Yuen Tan, Pengliang Wang, Xiaoyu Xu, Chao Zhang, Wenbin Hou, Jinyu Huang, Huimian Xu
Article
Oncology
Shijie Duan, Pengliang Wang, Funan Liu, Hanwei Huang, Wen An, Siwei Pan, Xin Wang
Article
Oncology
Pengliang Wang, Jingyu Deng, Zhe Sun, Wei Wang, Zhenning Wang, Huimian Xu, Zhiwei Zhou, Han Liang
Article
Cell Biology
Zizhen Wu, Huifang Liu, Weilin Sun, Yingxin Du, Wenting He, Shiwei Guo, Liqiao Chen, Zhenzhen Zhao, Pengliang Wang, Han Liang, Jingyu Deng
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang, Zizhen Wu, Yinping Dong, Fenglin Cai, Liqiao Chen, Huifang Liu, Han Liang, Jingyu Deng
Summary: ADAMTS9 in gastric cancer cells exerts inhibitory effects, with its decreased expression associated with malignant phenotypes and poor prognosis. Restoration of ADAMTS9 significantly suppressed the viability and motility of GC cells.
CELL DEATH & DISEASE
(2021)
Article
Surgery
Fenglin Cai, Yinping Dong, Pengliang Wang, Li Zhang, Yang Yang, Yong Liu, Xuejun Wang, Rupeng Zhang, Han Liang, Yan Sun, Jingyu Deng
Summary: This study established a risk score model for lymph node metastasis to guide the optimal treatment of patients with early gastric cancer. The model includes independent risk factors such as tumor size, depth, histological type, and lymphovascular involvement.
Article
Cell Biology
Yi Zeng, Gang Ma, Fenglin Cai, Pengliang Wang, Han Liang, Rupeng Zhang, Jingyu Deng, Yong Liu
Summary: SMYD3 is highly expressed in gastric cancer tissues and is associated with aggressive clinical characteristics and poor prognosis. Inhibition of SMYD3 expression significantly reduces the proliferation of gastric cancer cells and Akt signaling pathway activity. SMYD3 epigenetically represses the expression of EMP1 through H4K20me3-dependent mechanisms.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Songcheng Yin, Huifang Liu, Zhijun Zhou, Xiaoyu Xu, Pengliang Wang, Wei Chen, Guofei Deng, Han Wang, Hong Yu, Liang Gu, Mingyu Huo, Min Li, Leli Zeng, Yulong He, Changhua Zhang
Summary: In gastric cancer, PUM1 induces metabolic reprogramming through post-transcriptional regulation of DEPTOR, and its elevated expression is associated with recurrence, metastasis, and poor survival. Inhibition of PUM1 can suppress the proliferation and metastasis of gastric cancer cells and suppress glycolytic metabolism. PUM1 mediates DEPTOR upregulation by directly binding to DEPTOR mRNA, inhibiting mTORC1 and activating the PI3K-Akt signal and glycolysis.
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.