Article
Medicine, Research & Experimental
Ashley Stone, Jianyou Liu, Juan Lin, Bradley A. Schiff, Thomas J. Ow, Vikas Mehta, Richard V. Smith
Summary: This study investigated the effectiveness of intensive posttreatment surveillance for head and neck squamous cell carcinoma (HNSCC) and its association with recurrence and survival. Results showed that adherence to the National Comprehensive Cancer Network (NCCN) follow-up guidelines in the first year after treatment was associated with higher 5-year overall and disease-specific survival. However, consistent adherence over 5 years did not show a significant association with survival.
Review
Oncology
Francesca De Felice, Mary Lei, Richard Oakley, Andrew Lyons, Alastair Fry, Jean-Pierre Jeannon, Ricard Simo, Teresa Guerrero Urbano
Summary: Follow-up is essential for patients with head and neck squamous cell carcinoma (HNSCC) after treatment, and risk stratified follow-up interventions can help prevent and detect recurrences, manage treatment toxicities, and improve patients' quality of life.
Article
Oncology
Rustain L. Morgan, Megan M. Eguchi, Jessica McDermott, Adam C. Mueller, Arya Amini, Julie A. Goddard, Premal S. Trivedi, Sana D. Karam
Summary: The study found that posttreatment imaging with PET was associated with improved survival in patients with advanced laryngeal carcinoma compared to CT imaging. There was a trend towards improved cancer-specific survival in patients with oral cavity or oropharyngeal malignancies who underwent PET/CT imaging, but it did not reach statistical significance.
Article
Otorhinolaryngology
Emma J. A. Schepens, Abrahim Al-Mamgani, Luc H. E. Karssemakers, Daan van den Broek, Michiel. W. M. van den Brekel, Marta Lopez-Yurda
Summary: This study aimed to determine if the tumor marker SCC-Ag can contribute to the early detection of recurrence, metastasis, and second primary tumors in HNSCC patients. The study analyzed data from HNSCC patients treated in a hospital in the Netherlands between 2010 and 2020. The results showed that dichotomized SCC-Ag values and the change in SCC-Ag can predict EFS better.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Jean-Christophe Leclere, Camille Clement, Romain Le Pennec, Clementine Maheo, Dorothy M. Gujral, Ulrike Schick, Gregoire Le Gal, Remi Marianowski, Pierre-Yves Salaun, Ronan Abgral
Summary: In this case-control study, the use of (18)FDG-PET/CT in the standard annual follow-up of HNSCC was associated with a 3-year survival benefit, with a larger benefit for patients with advanced initial tumor stage (III-IV) and oropharyngeal disease.
Article
Medicine, General & Internal
Jean-Christophe Leclere, Camille Clement, Romain Le Pennec, Clementine Maheo, Dorothy M. Gujral, Ulrike Schick, Gregoire Le Gal, Remi Marianowski, Pierre-Yves Salaun, Ronan Abgral
Summary: This case-control study found that the use of 18FDG-PET/CT in the standard annual CFU of HNSCC was associated with a 3-year survival benefit, with a larger benefit for patients with advanced initial tumor stage (III-IV) and oropharyngeal disease.
Review
Oncology
Jack Horan, Conor Reid, Michael R. Boland, Gordon R. Daly, Stephen Keelan, Angus J. Lloyd, Eithne Downey, Adam Walmsley, Marie Staunton, Colm Power, Abeeda Butt, Deirdre Duke, Arnold D. K. Hill
Summary: This study evaluated diagnostic modalities for recurrent breast cancer, with a focus on the role of annual clinical examination. The results showed that clinical examination provides little value in diagnosing recurrence, suggesting that surveillance programs should reduce focus on this modality and instead prioritize regular radiological assessment and ensuring easy access to breast clinics for patients with new symptoms/signs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sara B. Strauss, Ashley H. Aiken, Joshua E. Lantos, C. Douglas Phillips
Summary: Imaging surveillance is crucial in posttreatment management of head and neck cancers, with varying approaches used by different practitioners and institutions. NI-RADS simplifies communication between radiologists and clinicians, providing management guidance based on levels of suspicion.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Oncology
Susanne Flach, Karen Howarth, Sophie Hackinger, Christodoulos Pipinikas, Pete Ellis, Kirsten McLay, Giovanni Marsico, Tim Forshew, Christoph Walz, Christoph A. Reichel, Olivier Gires, Martin Canis, Philipp Baumeister
Summary: This study demonstrates the potential of ctDNA as a biomarker for detecting minimal residual disease and recurrence in HNSCC and shows the feasibility of personalized ctDNA assays for disease detection prior to clinical recurrence.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Cecile van de Weerd, Boukje A. C. van Dijk, Matthias A. W. Merkx, Robert P. Takes, Maria T. Brands
Summary: This study investigates the incidence and timing of disease manifestations during five years of follow-up after head and neck cancer (HNC) treatment. Analysis of follow-up events such as local recurrence, regional recurrence, second primary tumor, distant metastasis, and death was performed for different types of squamous cell carcinoma (SCC) in the oral cavity, oropharynx, larynx, and hypopharynx, as well as all HNC patients. The results suggest that one year of follow-up is sufficient for detecting manifestations of disease in oral cavity SCC, while 1.5 years is needed for oropharynx SCC, larynx SCC, and hypopharynx SCC.
Article
Oncology
Giulia Siravegna, Connor J. O'Boyle, Shohreh Varmeh, Natalia Queenan, Alexa Michel, Jarrod Stein, Julia Thierauf, Peter M. Sadow, William C. Faquin, Simon K. Perry, Adam Z. Bard, Wei Wang, Daniel G. Deschler, Kevin S. Emerick, Mark A. Varvares, Jong C. Park, John R. Clark, Annie W. Chan, Vanessa Carlota Andreu Arasa, Osamu Sakai, Jochen Lennerz, Ryan B. Corcoran, Lori J. Wirth, Derrick T. Lin, A. John Iafrate, Jeremy D. Richmon, Daniel L. Faden
Summary: This study demonstrates that a noninvasive diagnostic approach for HPV+HNSCC has improved accuracy, reduced cost, and a shorter time to diagnosis compared with standard clinical workup, making it a viable alternative in the future.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Tooba Alwani, Jennifer N. Shehan, Jessica LeClair, Taylor F. Mahoney, Pratima Agarwal, Salil T. Chaudhry, Judy J. Wang, Jacob P. Noordzij, Lauren F. Tracy, Heather A. Edwards, Gregory Grillone, Andrew R. Salama, Scharukh M. Jalisi, Anand K. Devaiah
Summary: This study explores the impact of social determinants of health on follow-up care in head and neck cancers. Factors such as income, primary language, country of birth, race/ethnicity, insurance status, and markers of educational attainment do not appear to influence follow-up care at a safety-net, tertiary care institution, but distance from hospital remains a significant contributor to care disparities.
Article
Obstetrics & Gynecology
M. C. Rulanda, O. Mogensen, P. T. Jensen, D. G. Hansen, C. Wu, M. M. Jeppesen
Summary: This study compares the effects of patient initiated follow up (PIFU) versus hospital based follow up (HBFU) on fear of cancer recurrence (FCR), quality of life (QoL), and healthcare use after 34 months of follow up. The results indicate that patient initiated follow up is a valid alternative to hospital based follow up for low-intermediate risk endometrial carcinoma patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Cecile van de Weerd, Tom Ebbers, Donna E. M. Smilde, Julia J. van Tol-Geerdink, Robert P. Takes, Guido B. van den Broek, Rosella P. M. G. Hermens, Rudolf B. Kool
Summary: A remote monitoring app was developed for head and neck cancer follow-up during the SARS-CoV-2 pandemic. The usability and patients' experiences with the app were studied through a mixed-methods approach. The app was found to be user-friendly and made patients feel more in control, but there were some barriers that need to be resolved before it can be used in regular follow-up.
Article
Otorhinolaryngology
Vaibhav H. Ramprasad, Jinhong Li, Karley Atchison, Dan P. Zandberg, David A. Clump, Jonas T. Johnson, Marci L. Nilsen
Summary: In this study, the quality of life and symptoms of patients with head and neck squamous cell carcinoma (HNSCC) who received different treatment modalities were evaluated. The findings suggest that multimodality therapy, especially for recurrent and second primary HNSCC, is more likely to result in diminished quality of life and symptoms. This information is important for informed discussions with patients regarding treatment options.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Marieke Brands, Andre Verbeek, Sandra Geurts, Thijs Merkx
Summary: Guidelines for follow-up after oral cancer treatment lack site-specificity and may need to be personalized based on individual risk factors. Education of patients to report new symptoms early is crucial, as most new diseases present symptomatically. In survivorship care, other healthcare professionals such as specialist nurses and dentists play a key role.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Oncology
Marissa Meegdes, Sandra M. E. Geurts, Frans L. G. Erdkamp, Marcus Wouter Dercksen, Birgit E. P. J. Vriens, Kirsten N. A. Aaldering, Manon J. A. E. Pepels, Linda M. H. Winkel, Nathalie J. A. Teeuwen, Maaike Boer, Vivianne C. G. Tjan-Heijnen
Summary: This study evaluated the implementation of CDK4/6 inhibitors in the Netherlands and found that 50% of patients have used CDK4/6 inhibitors within 2 years after diagnosis since August 2017. Furthermore, the implementation of targeted therapy has led to a decrease in the use of chemotherapy as first-line therapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Marissa Meegdes, Khava I. E. Ibragimova, Dorien J. A. Lobbezoo, Ingeborg J. H. Vriens, Loes F. S. Kooreman, Frans L. G. Erdkamp, M. Wouter Dercksen, Birgit E. P. J. Vriens, Kirsten N. A. Aaldering, Manon J. A. E. Pepels, Linda M. H. van de Winkel, Jolien Tol, Joan B. Heijns, Agnes J. van de Wouw, Natascha A. J. B. Peters, Ananda Hochstenbach-Waelen, Marjolein L. Smidt, Sandra M. E. Geurts, Vivianne C. G. Tjan-Heijnen
Summary: This study evaluated the biopsy rate and receptor subtype discordance rate in patients with advanced breast cancer. The study found that the HR+/HER2+ subtype had the highest discordance rate and lowest biopsy rate, highlighting the importance of obtaining a biopsy of metastatic disease.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Evelien J. M. de Jong, Quisette P. Janssen, Tessa F. A. Simons, Marc G. Besselink, Bert A. Bonsing, Stefan A. W. Bouwense, Sandra M. E. Geurts, Marjolein Y. Homs, Vincent E. de Meijer, Vivianne C. G. Tjan-Heijnen, Hanneke W. M. van Laarhoven, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Lydia G. van der Geest, Bas Groot Koerkamp, Judith de Vos-Geelen
Summary: In a nationwide cohort of patients with pancreatic ductal adenocarcinoma, adjuvant GEMCAP was associated with superior survival compared to GEM monotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Evelien J. M. de Jong, Lydia G. van der Geest, Marc G. Besselink, Stefan A. W. Bouwense, Jeroen Buijsen, C. H. C. Dejong, Bas G. Koerkamp, Lara R. Heij, Ignace H. J. T. de Hingh, Chantal Hoge, Geert Kazemier, Hanneke W. M. van Laarhoven, Vincent E. de Meijer, Martijn W. J. Stommel, Vivianne C. G. Tjan-Heijnen, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Sandra M. E. Geurts, Judith de Vos-Geelen
Summary: This retrospective study identified significant differences in treatment modalities and overall survival between the four origins of periampullary cancer. Improved overall survival after adjuvant chemotherapy could not be demonstrated in patients with ampullary cancer and duodenal adenocarcinoma.
Article
Oncology
Renee. S. J. M. Schmitz, Sandra. M. E. Geurts, Khava. I. E. Ibragimova, Dominique. J. P. Tilli, Vivianne. C. G. Tjan-Heijnen, Maaike De Boer
Summary: New treatment options in cancer have led to increased healthcare resources used near the end of life, especially for patients with advanced breast cancer. In a study on patients with advanced breast cancer, it was found that ICU admissions and CPR were rare in the last six months of life, but hospital admissions were common, particularly among those receiving new chemotherapy. Patients receiving chemotherapy near the end of life were more likely to die in hospital, with disease progression being the primary cause of death.
Review
Public, Environmental & Occupational Health
Sandra M. E. Geurts, Anne M. W. M. Aarts, Andre L. M. Verbeek, Tony H. H. Chen, Mireille J. M. Broeders, Stephen W. Duffy
Summary: This study provides an overview of mathematical estimation approaches used to quantify the duration of the preclinical detectable phase (PCDP) in cancer screening programs. The authors identified different types of mathematical approaches and found that using multiple methods for estimation is recommended due to the variability in results. They also emphasized the importance of selecting the appropriate method based on available data.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Oncology
Evelien J. M. de Jong, Irene Mommers, Arantza Farina Sarasqueta, Lydia G. van der Geest, Lara Heij, Ignace H. J. T. de Hingh, Marjolein Y. Homs, Vivianne C. G. Tjan-Heijnen, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Sandra M. E. Geurts, Judith De Vos-Geelen
Meeting Abstract
Oncology
S. M. E. Geurts, K. Ibragimova, M. Meegdes, F. L. G. Erdkamp, J. B. Heijns, J. Tol, B. E. P. J. Vriens, W. Dercksen, K. N. A. Aaldering, M. J. A. E. Pepels, L. V. D. Winkel, N. Peters, A. J. van de Wouw, A. Hochstenbach, M. De Boer, V. C. G. Tjan-Heijnen
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
M. Meegdes, S. M. E. Geurts, F. L. G. Erdkamp, W. Dercksen, B. E. P. J. Vriens, K. N. A. Aaldering, M. J. A. E. Pepels, L. V. D. Winkel, J. Tol, J. B. Heijns, A. J. van de Wouw, N. Peters, A. J. O. Fallois, M. A. C. E. van Kats, V. C. G. Tjan-Heijnen
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
Kristien Keymeulen, Sandra Geurts, Loes Kooreman, Lucien Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri Voogd, Vivianne Tjan-Heijnen
Meeting Abstract
Oncology
V. C. G. Tjan-Heijnen, S. W. M. Lammers, S. M. E. Geurts, I. J. H. Vriens, A. C. P. Swinkels, C. H. Smorenburg, M. van der Sangen, J. R. Kroep, H. de Graaf, A. H. Honkoop, F. L. G. Erdkamp, W. K. de Roos, S. C. Linn, A. L. T. Imholz
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Iris N. Polee, Bregtje C. M. Hermans, Jan Maarten van der Zwan, Stefan A. W. Bouwense, Marcus W. Dercksen, Ferry A. L. M. Eskens, Bastiaan Havekes, Johannes Hofland, Thomas M. A. Kerkhofs, Heinz-Josef Klumpen, Loes M. Latten-Jansen, Ernst-Jan M. Speel, Frederik A. Verburg, Annemiek M. E. Walenkamp, Sandra M. E. Geurts, Judith de Vos-Geelen
Summary: This study aimed to assess the long-term survival and prognostic factors associated with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). The results demonstrate significant differences in survival based on different grades, tumour stages, and primary origins of GEP-NENs.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
E. J. M. de Jong, D. H. L. Lemmers, A. Benedetti Cacciaguerra, S. A. W. Bouwense, S. M. E. Geurts, V. C. G. Tjan-Heijnen, L. B. J. Valkenburg-van Iersel, J. W. Wilmink, M. G. Besselink, M. Abu Hilal, J. de Vos-Geelen
Summary: This international survey study highlights the existing variation in the management of patients with Ampullary adenocarcinoma (AAC), especially regarding the use of (neo)adjuvant therapy. More data from trials and international registries are needed to develop evidence-based guidelines on surgical and oncological management with the ultimate aim to improve outcomes for patients with AAC.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristien B. I. M. Keymeulen, Sandra M. E. Geurts, Loes F. S. Kooreman, Lucien E. M. Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri C. Voogd, Vivianne C. G. Tjan-Heijnen
Summary: Breast MRI at primary DCIS diagnosis can detect additional synchronous cDCIS and cIBC, and is associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding is most evident in younger patients.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.