Article
Psychiatry
Kim T. Mueser, Rachel F. Sussman, Nicole R. Detore, Elizabeth S. Eberlin, Susan R. Mcgurk
Summary: Impaired cognitive functioning is a core feature of schizophrenia, and early intervention services have been shown to improve symptoms and functioning in first episode psychosis. This study evaluated the long-term effects of early intervention services on cognitive functioning in first episode psychosis patients. The results showed that while there were no improvements in cognitive functioning for older patients, younger patients showed significant improvements in working memory. Overall, interventions targeting cognition may be necessary to enhance cognitive functioning in most first episode psychosis patients.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
N. R. DeTore, K. Bain, A. Wright, P. Meyer-Kalos, S. Gingerich, K. T. Mueser
Summary: This study evaluated the impact of early intervention services (EIS) on insight in first episode psychosis (FEP) patients. The results showed that EIS improved insight significantly more than usual community care (CC). Additionally, insight in the EIS group was more strongly associated with social relationships, suggesting a potential interaction between these two outcomes in treatment.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
Alexia Polillo, George Foussias, Wei Wang, Aristotle N. Voineskos, Jacqueline Veras, Nicole Davis-Faroque, Albert H. C. Wong, Nicole Kozloff
Summary: This retrospective cohort study shows disparities in referral pathways and initial engagement in early psychosis intervention (EPI) services. Improving access to EPI services may facilitate recovery among youths and young adults with psychosis.
Article
Health Care Sciences & Services
Kara Dempster, Annie Li, Priyadharshini Sabesan, Ross Norman, Lena Palaniyappan
Summary: The study examined how using a <50% improvement threshold for total symptoms in first episode schizophrenia patients could best predict global functioning over a period of 5 years.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychology, Clinical
Brian O'Donoghue, John Lyne, Eric Roche, Nathan Mifsud, Laoise Renwick, Caragh Behan, Mary Clarke
Summary: This study found that migrants from Africa have a nearly twofold increased risk of developing a psychotic disorder compared to those born in the Republic of Ireland, while migrants from certain Asian countries have a reduced risk. Further research into the factors behind this increased risk in specific migrant groups could provide insights into the cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Rigas F. Soldatos, Micah Cearns, Mette O. Nielsen, Costas Kollias, Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Irene Ralli, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Ioannis Kosteletos, Ilias I. Vlachos, Mirjana Selakovic, Stefania Foteli, Nikolaos Nianiakas, Leonidas Mantonakis, Theoni F. Triantafyllou, Aggeliki Ntigridaki, Vanessa Ermiliou, Marina Voulgaraki, Evaggelia Psarra, Mikkel E. Sorensen, Kirsten B. Bojesen, Karen Tangmose, Anne M. Sigvard, Karen S. Ambrosen, Toni Meritt, Warda Syeda, Birte Y. Glenthoj, Nikolaos Koutsouleris, Christos Pantelis, Bjorn H. Ebdrup, Nikos Stefanis
Summary: A clinical prediction model was developed to predict short-term remission in patients with first-episode psychosis, using baseline clinical data and tested in independent Danish cohorts. The model showed reliability in predicting early remission status, indicating potential utility as a routine clinical tool.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Franck Schurhoff, Cecile Corfdir, Baptiste Pignon, Mohamed Lajnef, Jean-Romain Richard, Elisabeth Marcos, Antoine Pelissolo, Marion Leboyer, Serge Adnot, Stephane Jamain, Andrei Szoke
Summary: This study compared telomere length between first-episode schizophrenia patients and controls, finding no significant association after adjusting for confounders. The results suggest that psycho-social stress may impact telomere length in individuals with schizophrenia, rather than telomere erosion contributing to the development of the disorder.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Brian O'Donoghue, Andrew Thompson, Patrick McGorry, Ellie Brown
Summary: Early intervention for psychosis services have superior outcomes compared to standard services, but the optimal duration of care is unknown. This study determined the discharge destinations from these services and factors associated with discharge to secondary care. The findings indicate a significant minority who may benefit from longer care with early intervention for psychosis services.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, Robert D. Gibbons, C. Hendricks Brown, Majnu John, Kim T. Mueser, David L. Penn, Robert A. Rosenheck, Jean Addington, Mary F. Brunette, Christoph U. Correll, Sue E. Estroff, Piper S. Mayer-Kalos, Jennifer D. Gottlieb, Shirley M. Glynn, David W. Lynde, Susan Gingerich, Ronny Pipes, Alexander L. Miller, Joanne B. Severe, John M. Kane
Summary: This study examined the long-term effects of early intervention services for first-episode psychosis. The results showed that compared to community care, early intervention services significantly improved patients' quality of life and symptoms, and reduced the number of hospitalization days.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Multidisciplinary Sciences
Dickens Akena, Aggrey Semeere, Philippa Kadama, Emmanuel K. Mwesiga, Juliet Nakku, Noeline Nakasujja
Summary: This study aims to determine the feasibility of recruiting and retaining patients with a first episode psychosis in low resourced settings, and to assess the preliminary efficacy of psycho-education on illness self-management, stigma, adherence to medications, and symptom severity. The researchers hypothesize recruiting 70% of eligible participants and accruing a sample size of 80 over 20 weeks.
Article
Psychiatry
Alba Toll, Emilio Pechuan, Daniel Berge, Teresa Legido, Laura Martinez-Sadurni, Khadija El-Abidi, Victor Perez-Sola, Anna Mane
Summary: The risk of suicide is high in individuals experiencing first-episode psychosis (FEP), but the factors associated with this risk are not well-understood. This study aimed to identify the sociodemographic and clinical factors that contribute to suicide attempts in FEP patients over a two-year period. The findings revealed that prior suicide attempts, low functionality, depression, and feelings of guilt were significantly associated with suicide attempts. These findings highlight the importance of targeted interventions, particularly during the prodromal stage, in identifying and treating FEP patients with a high suicide risk.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Veronica Larach, Luis F. Varela, Guillermo Vergara, Irma Rojas, Viviana Hernandez, Rodrigo Casanueva, Matias Irarrazaval
Summary: The study analyzed the Ministry of Health's (MINSAL) administrative database of the Universal Health Coverage (UHC) program for First Episode of Schizophrenia Spectrum Disorders (FEP-SSD) in Chile. A total of 33,207 suspected cases were registered between 2004 and 2017, with 68% confirmed as FEP-SSD. Male patients entered at a younger age and had a higher proportion in all groups.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychiatry
Pontus Stralin, Maria Skott, Johan Cullberg
Summary: The study found that the majority of first episode psychosis cases had hospitalizations in the first year after inclusion, with a substantial portion requiring multiple hospitalizations for psychosis after the first year. However, a significant number of cases did not require new hospitalizations for psychosis, with many able to discontinue antipsychotic medication within a year of FEP onset. Early antipsychotic medication use was associated with later psychosis hospitalizations, highlighting the importance of careful medication management in FEP cases.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2021)
Article
Psychiatry
Oihane Mentxaka, Maria Recio-Barbero, Eunate Arana-Arri, Rafael Segarra
Summary: Patients with first-episode psychosis (FEP) are not more likely to be involved in crimes than the general population. The types of violent acts committed by individuals with FEP are diverse, with extreme violence being uncommon.
Article
Psychiatry
D. Khan Amiri, Trine Madsen, Marie Norredam, Svend Erik Brande, Ellenor Mittendorfer-Rutz, Merete Nordentoft, Annette Erlangsen
Summary: This study found that asylum-seekers in Denmark have higher rates of suicide attempts compared to the general population, especially among unaccompanied minors. The results emphasize the importance of focusing on mental health and suicidal behavior among asylum-seekers.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Psychology, Clinical
Katrine M. Ineson, Annette Erlangsen, Merete Nordentoft, Michael E. Benros, Trine Madsen
Summary: This study found that individuals with prior hospital diagnosed traumatic brain injury (TBI) had higher rates of suicide attempts and violent crimes compared to individuals without TBI. Multiple TBI and temporal proximity to TBI were associated with increased rates of suicide attempts and violent crimes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Anna Lund Jacobsen, Trine Madsen, Anne Ranning, Agnieszka Storgaard Nielsen, Merete Nordentoft, Annette Erlangsen
Summary: This study analyzed data from calls answered at a Danish helpline for suicide prevention and found that a significant proportion of callers were evaluated to be at risk of suicide, even when using a clinical scale. The findings highlight the potential for counselors to prevent suicidal behavior.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Review
Clinical Neurology
Judit Simon, Dennis Wienand, A-La Park, Christoph Wippel, Susanne Mayer, Daniel Heilig, Agata Laszewska, Ines Stelzer, Guy M. Goodwin, David McDaid
Summary: Individuals with mental health disorders have worse physical health, utilize healthcare resources more frequently and incur higher costs. Comorbid physical health conditions are major drivers of resource use and costs for individuals with mental health disorders, affecting different care segments. Significant physical health gains and cost savings can be achieved through prevention, earlier identification, management and treatment.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Antonio Jose Grande, Mauricio Scopel Hoffmann, Sara Evans-Lacko, Carolina Ziebold, Claudio Torres de Miranda, David Mcdaid, Cristiane Tomasi, Wagner Silva Ribeiro
Summary: This study aimed to identify school-based interventions that have been tested in treating mental health problems among children and adolescents in low- and middle-income countries. The results showed that overall, interventions delivered in the school environment are effective in reducing mental health problems among children and adolescents.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Lucy Pollyanna Goldsmith, Katie Anderson, Geraldine Clarke, Chloe Crowe, Heather Jarman, Sonia Johnson, Jo Lomani, David McDaid, A-La Park, Jared G. Smith, Steven Gillard
Summary: Internationally, hospital-based short-stay crisis units have been introduced to provide a safe space for stabilisation and further assessment for those in psychiatric crisis. This study assessed changes to service use following a service user's first visit to a unit, characterised the population accessing these units, and examined equality of access to the units. The results showed that short-stay crisis units are typically accessed by a young population, including those who previously were unknown to mental health services, who proceed to access a broader range of mental health services following discharge.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Ella Arensman, Mallorie Leduc, Cliodhna O'Brien, Paul Corcoran, Eve Griffin, Caleb Leduc, Evelien Coppens, Fotini Tsantila, Victoria Ross, Kahar Abdulla, Pia Hauck, Benedikt L. Amann, Birgit Aust, Arlinda Cerga Pashoja, Johanna Cresswell-Smith, Luigia D'Alessandro, Naim Fanaj, Birgit A. Greiner, Jeroen Luyten, Sharna Mathieu, Margaret Maxwell, Gentiana Qirjako, Hanna Reich, Sarita Sanches, Monika Ditta Toth, Joseph Kilroy, Karen Michell, Nicola Reavley, David McDaid, Chantal Van Audenhove, MENTUPP Consortium
Summary: This paper presents the protocol for the MENTUPP intervention, which aims to support small- and medium-sized enterprises in creating mentally healthy workplaces. The online intervention is tailored to each sector and designed to help employees and leaders deal with mental health difficulties and combat stigma. The cluster randomised controlled trial will assess the effectiveness of the intervention in improving mental health and wellbeing in employees.
Article
Gerontology
David McDaid, A-La Park
Summary: Loneliness is increasingly recognized as a public health issue due to its negative impacts on physical and mental health. Addressing loneliness as part of mental health promotion and recovery strategies is crucial, especially in the post-Covid era. This study explored the experiences of a personalized support and community response service for loneliness in Worcestershire, England, finding that multiple entry pathways and volunteer support played significant roles in promoting engagement and positive outcomes. However, the program's appeal varied, highlighting the importance of early identification, understanding determinants of loneliness, and flexibility in program design.
JOURNAL OF AGING & SOCIAL POLICY
(2023)
Article
Psychiatry
Anne M. de Graaff, Pim Cuijpers, Jos W. R. Twisk, Barbara Kieft, Sam Hunaidy, Mariam Elsawy, Noer Gorgis, Theo K. Bouman, Miriam J. J. Lommen, Ceren Acarturk, Richard Bryant, Sebastian Burchert, Katie S. Dawson, Daniela C. Fuhr, Pernille Hansen, Mark Jordans, Christine Knaevelsrud, David McDaid, Naser Morina, Hanspeter Moergeli, A-La Park, Bayard Roberts, Peter Ventevogel, Nana Wiedemann, Aniek Woodward, Marit Sijbrandij
Summary: This study examines the effectiveness of a peer-provided psychological intervention (PM+) in reducing symptoms of common mental disorders (CMDs) among Syrian refugees in the Netherlands. The findings suggest that PM+ has positive effects on reducing symptoms of depression/anxiety, depression, anxiety, PTSD symptoms, and self-identified problems among Syrian refugees, but its effectiveness in improving functional impairment is not significant.
Article
Psychiatry
Roberto Mediavilla, Mireia Felez-Nobrega, Kerry R. McGreevy, Anna Monistrol-Mula, Maria-Fe Bravo-Ortiz, Carmen Bayon, Iago Gine-Vazquez, Rut Villaescusa, Ainoa Munoz-Sanjose, Salvatore Aguilar-Ortiz, Natasha Figueiredo, Pablo Nicaise, A-La Park, Papoula Petri-Romao, Marianna Purgato, Anke B. Witteveen, James Underhill, Corrado Barbui, Richard Bryant, Raffael Kalisch, Vincent Lorant, David McDaid, Maria Melchior, Marit Sijbrandij, Josep Maria Haro, Jose Luis Ayuso-Mateos
Summary: This study evaluated the effectiveness of a mental health intervention in reducing anxiety and depression symptoms among healthcare workers in crisis settings. The results showed that the intervention significantly reduced anxiety and depression symptoms among healthcare workers.
Article
Medical Informatics
Gabriel Davis Jones, Symon M. Kariuki, Anthony K. Ngugi, Angelina Kakooza Mwesige, Honorati Masanja, Seth Owusu-Agyei, Ryan Wagner, J. Helen Cross, Josemir W. Sander, Charles R. Newton, Arjune Sen
Summary: Researchers have developed a machine-learning questionnaire and predictive model to identify convulsive seizures in sub-Saharan Africa, and implemented them into a free app for healthcare workers in multiple African countries.
LANCET DIGITAL HEALTH
(2023)
Article
Psychiatry
Sara Evans-Lacko, Ricardo Araya, Annette Bauer, Emily Garman, Alejandra alvarez-Iglesias, David McDaid, Philipp Hessel, Alicia Matijasevich, Cristiane Silvestre Paula, A-La Park, Crick Lund
Summary: Mental health is closely related to poverty and future life chances. Cash transfer programmes have the potential to improve youth mental health and break the cycle of disadvantage. This article presents a conceptual framework for understanding how cash transfers can enhance mental health and life chances, and suggests using theories from behavioral economics and cognitive psychology to optimize their impact. It also highlights the need for further research and policy action in this area.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Review
Psychiatry
David McDaid, A-La Park
Summary: Currently, only 2.1% of total domestic governmental health expenditure per capita is used for mental health. It is necessary to invest more in mental health due to its long-term adverse impacts. This paper focuses on the economic evidence to support global mental health action, particularly for refugees and displaced people affected by conflict.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Marianna Purgato, Giulia Turrini, Federico Tedeschi, Riccardo Serra, Lorenzo Tarsitani, Beatrice Compri, Giulia Muriago, Camilla Cadorin, Giovanni Ostuzzi, Pablo Nicaise, Vincent Lorant, Marit Sijbrandij, Anke B. B. Witteveen, Jose Luis Ayuso-Mateos, Roberto Mediavilla, Josep Maria Haro, Mireia Felez-Nobrega, Natasha Figueiredo, Giulia Pollice, David McDaid, A-La Park, Raffael Kalisch, Papoula Petri-Romao, James Underhill, Richard A. A. Bryant, Michela Nose, Corrado Barbui
Summary: This study aims to assess the effectiveness and cost-effectiveness of a psychological intervention program tailored for migrant populations. Participants will be randomized into two groups, one receiving usual care and the other receiving a self-help stress management guide and a cognitive behavioral intervention. The study will evaluate the program's impact on anxiety and depression symptoms, as well as other mental health indicators and cost-effectiveness. This study is important for improving the mental health and wellbeing of migrant populations.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Merete Nordentoft, Mikkel Rasmussen, Lene Hogh, Christian Legind, Jakob Kjellberg
Summary: Denmark has agreed on a 10-year plan for psychiatry, which was developed collaboratively by the Danish Health Authority and the Danish Authority for Social Services and Housing, involving various stakeholders. The government has recently proposed an investment plan to increase the overall budget in Danish regions and municipalities by nearly 20 percent over 10 years. The need for improvement in psychiatric services was emphasized by epidemiological research showing shortened life expectancy and high disease burden among individuals with mental disorders. The Psychiatry Alliance, a unified organization consisting of user organizations, trade unions, and scientific societies in the field of mental health, took a proactive approach to influence politicians and media, resulting in significant impact.
EUROPEAN PSYCHIATRY
(2023)