Journal
EARLY HUMAN DEVELOPMENT
Volume 120, Issue -, Pages 80-87Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2018.02.007
Keywords
Therapeutic hypothermia (TH); Hypoxic ischaemic encephalopathy (HIE); Neurodevelopmental outcome
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Funding
- Science Foundation Ireland Research Centre Award [INFANT - 12/RC/2272]
- Irish Health Research Board Award (HRB) [CSA/2012/40]
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Aims: Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE. Methods: Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at >= 18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean. Result Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome. Conclusion: A significant proportion of infants with mild HIE have abnormal outcome at follow up.
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