Review
Immunology
Alin Laurentiu Tatu, Thomas Nadasdy, Anca Arbune, Valentin Chioncel, Carmen Bobeica, Elena Niculet, Alina Viorica Iancu, Caterina Dumitru, Valentin Tudor Popa, Nicolas Kluger, Victor Gabriel Clatici, Claudiu Ionut Vasile, Cristian Onisor, Alexandru Nechifor
Summary: This article summarizes the roles of IL-4, IL-13, IL-31, and IL-33 from a multi-disciplinary perspective, highlighting the importance and potential value of interleukins in various organ system pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
Summary: IL-4 and IL-13 are structurally and functionally related cytokines that regulate immune responses and are involved in the pathogenesis of various human neoplasms. They can mediate tumor cell proliferation, survival, and metastasis in solid tumors through different receptors. This review summarizes their role in gastric and colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Yan Zhang, Danrong Jing, Jun Cheng, Xiang Chen, Minxue Shen, Hong Liu
Summary: IL-13 inhibitors lebrikizumab and tralokinumab have demonstrated good efficacy and safety in the treatment of moderate to severe AD. Compared to placebo treatment, these IL-13 inhibitors can significantly improve skin symptoms and quality of life in patients with AD, albeit with a higher risk of conjunctivitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Review
Medicine, General & Internal
Fangyuan Chen, Yiman Wang, Xinyi Chen, Nan Yang, Li Li
Summary: This review aims to discuss the role of IL-4/13 in the pathogenesis of BP and the potential of using IL-4/13 antagonists for treatment. The study found that IgE, eosinophils, IL-4, and IL-13 may interact with each other in the pathogenesis of BP, providing clues for finding targets for molecular treatment.
ANNALS OF MEDICINE
(2023)
Review
Engineering, Industrial
Jesse C. Duroha, Gretchen A. Macht
Summary: The adoption of solar photovoltaic (PV) technology and infrastructure is increasing rapidly, but the severity of occupational safety risks associated with their installation poses a challenge to their growth. This study conducts a systematic literature review to identify the occupational safety risks, mitigation measures, and research areas associated with PV installations.
Review
Medicine, General & Internal
Lawko Ahmed, Anastasia Constantinidou, Andreas Chatzittofis
Summary: Precision medicine has advanced due to technological developments but has also brought forth ethical concerns and potential risks. This study aimed to explore patients' perspectives on these issues. The results revealed eight main concerns from patients, including privacy and security of patient data, economic impact, psychosocial harms, discrimination risks, informed consent risks, mistrust in providers and research, diagnostic accuracy, and changes in the doctor-patient relationship. It is crucial to address these ethical issues and risks through patient education, dedicated research, and official policies.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Gloria Daziani, Alfredo Fabrizio Lo Faro, Vincenzo Montana, Gaia Goteri, Mauro Pesaresi, Giulia Bambagiotti, Eva Montanari, Raffaele Giorgetti, Angelo Montana
Summary: According to the EU Early Warning System (EWS), synthetic cathinones (SCs) are the second largest class of new psychoactive substances (NPS), with 162 types being monitored. They have a structure similar to cathinone, found in Catha Edulis, and exhibit stimulant effects similar to amphetamines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Integrative & Complementary Medicine
Shiyu Hu, Qingru Sun, Fei Xu, Ninghua Jiang, Jianli Gao
Summary: This review systematically evaluates and analyzes recent statistics on the pathologic classifications, risk factors, treatment strategies, and drug candidates of age-related hearing loss (ARHL), including those from traditional Chinese medicine (TCM), aiming to provide potential new approaches for preventing and treating ARHL.
Article
Medicine, Research & Experimental
Jesus Amo-Aparicio, Joana Garcia-Garcia, Isaac Francos-Quijorna, Andrea Urpi, Anna Esteve-Codina, Marta Gut, Albert Quintana, Ruben Lopez-Vales
Summary: The study found that while IL-13 induced anti-inflammatory markers in microglia and macrophages after SCI, it did not promote functional recovery as effectively as IL-4. IL-13 and IL-4 induced different gene signatures in these cells after SCI, with IL-4 shifting metabolism towards oxidative phosphorylation. This metabolic shift is important for minimizing cytotoxic responses of microglia and macrophages.
Article
Allergy
Laura Maintz, Thomas Welchowski, Nadine Herrmann, Juliette Brauer, Claudia Traidl-Hoffmann, Regina Havenith, Svenja Mueller, Claudio Rhyner, Anita Dreher, Matthias Schmid, Thomas Bieber
Summary: This study found that many patients with mild-to-moderate atopic dermatitis have elevated levels of biomarkers, suggesting a systemic impact of skin inflammation. Identifying different patient subtypes can better predict their response to specific treatments.
Review
Medicine, General & Internal
Jie He, Lingmeng Song, Pengcheng Zheng
Summary: The study aimed to evaluate the significance of IL-4 concentration in patients with tuberculosis. The results showed a significantly increased level of serum IL-4 in patients with tuberculosis, while there was no significant difference in plasma IL-4 levels. Subgroup analysis revealed that Asian populations had higher serum IL-4 levels in tuberculosis patients. Patients with active tuberculosis and pulmonary tuberculosis also exhibited increased serum IL-4 levels.
Article
Allergy
Marc Humbert, Arnaud Bourdin, Nikolaos G. Papadopoulos, Stephen T. Holgate, Nicola A. Hanania, David M. G. Halpin, Kenneth R. Chapman, Marcela Gavornikova, David B. Price, Alan Kaplan, Liam G. Heaney
Summary: Systemic corticosteroids are commonly used for treating asthma, but their prolonged or repeated use can result in significant adverse effects. Referring asthma patients who have received multiple courses of corticosteroids and still have uncontrolled symptoms to specialists for evaluation and treatment is crucial in improving patient outcomes.
Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Giorgio Walter Canonica, Thomas Casale, Tomas Chivato, Jonathan Corren, Derek K. Chu, Stefano Del Giacco, Thomas Eiwegger, Breda Flood, Davide Firinu, James E. Gern, Eckard Hamelmann, Nicola Hanania, Irene Hernandez-Martin, Rebeca Knibb, Mika Makela, Parameswaran Nair, Liam O'Mahony, Nikolaos G. Papadopoulos, Alberto Papi, Hae-Sim Park, Luis Perez de Llano, Oliver Pfaar, Santiago Quirce, Joaquin Sastre, Mohamed Shamji, Jurgen Schwarze, Oscar Palomares, Marek Jutel
Summary: Severe asthma poses significant challenges in management, but targeted treatments with biologicals offer new hope for patients. However, further research is needed on issues such as selection of biologicals, response definition, treatment duration, and cost-effectiveness.
Article
Critical Care Medicine
Nicola A. Hanania, David M. Mannino, Gerard J. Criner, Mark T. Dransfield, MeiLan K. Han, C. Elaine Jones, Sally Kilbride, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert A. Wise, David M. G. Halpin, Robson Lima, David A. Lipson
Summary: In the IMPACT trial, FF/UMEC/VI demonstrated superior efficacy compared to FF/VI and UMEC/VI in patients with symptomatic COPD and a history of exacerbations across all age groups, with a comparable safety profile.
Article
Critical Care Medicine
Abebaw M. Yohannes, Sheila Dryden, Richard Casaburi, Nicola A. Hanania
Summary: An effective 8-week PR program provides sustained improvement in anxiety and quality of life for COPD patients over a 2-year period, but short-term improvements in dyspnea, depression, and stress symptoms at 8 weeks were not maintained at 2 years.
Editorial Material
Respiratory System
Zuzana Diamant, Nicola A. Hanania
CURRENT OPINION IN PULMONARY MEDICINE
(2021)
Review
Respiratory System
Sara M. Assaf, Svitlana P. Tarasevych, Zuzana Diamant, Nicola A. Hanania
Summary: Recent studies suggest that asthma patients may have a lower susceptibility to COVID-19 due to underlying type 2 airway inflammation, decreased expression of ACE2 and TMPRSS2 receptors, and improved adherence to controller therapies during the pandemic. It is recommended that all asthma patients continue with their controller therapies, but management for severe uncontrolled asthma infected by SARS-CoV-2 should be tailored on an individual basis.
CURRENT OPINION IN PULMONARY MEDICINE
(2021)
Article
Critical Care Medicine
Laurie A. Lee, Zelie Bailes, Neil Barnes, Louis-Philippe Boulet, Dawn Edwards, Andrew Fowler, Nicola A. Hanania, Huib A. M. Kerstjens, Edward Kerwin, Robert Nathan, John Oppenheimer, Alberto Papi, Steven Pascoe, Guy Brusselle, Guy Peachey, Neal Sule, Maggie Tabberer, Ian D. Pavord
Summary: In patients with uncontrolled moderate or severe asthma using ICS/LABA, adding UMEC improved lung function but did not significantly reduce moderate and/or severe exacerbations. Single-inhaler FF/UMEC/VI is an effective treatment option with a favorable risk-benefit profile. Higher dose FF primarily reduced exacerbations, especially in patients with elevated biomarkers of type 2 airway inflammation. Further studies are needed to confirm the effects of type 2 inflammatory biomarkers on treatment outcomes in asthma.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Respiratory System
Abebaw M. Yohannes, Michelle N. Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert Henderson, Anna M. Baker, Anne S. Casper, David A. Kaminsky, Alexis L. Rea, Anne M. Mathews, Loretta G. Que, Joe W. Ramsdell, Lynn B. Gerald, Robert A. Wise, Nicola A. Hanania
Summary: The study found that characteristics such as age, African-American race, sleep disturbance, and persistent phlegm are associated with mild cognitive impairment in patients with chronic obstructive pulmonary disease (COPD).
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tommi Tervonen, Fernando J. Martinez, Nicola A. Hanania, Sebastian Heidenreich, James M. Eudicone, Ileen Gilbert
Summary: The study reveals that patients prioritize attributes such as reduced exacerbations and faster onset of action in different treatment classes. Patients with asthma prefer budesonide/formoterol fumarate dihydrate (80/4.5 μg) pMDI, while those with COPD favor budesonide/formoterol fumarate dihydrate (160/4.5 μg) pMDI.
RESPIRATORY MEDICINE
(2021)
Review
Allergy
Amber N. Pepper, Nicola A. Hanania, Marc Humbert, Thomas B. Casale
Summary: Five biologic medications approved for treating uncontrolled asthma target elevated type 2 inflammatory markers like eosinophils, nitric oxide, or IgE. Factors such as asthma severity, biomarkers, and treatment goals should guide initial biologic choice, with shared decision-making with patients to optimize adherence. Monitoring response and troubleshooting are essential for patients with suboptimal responses, with potential need for changing biologic therapy or exploring other treatment options.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Immunology
Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas, Yohannes T. Ghebre
Summary: This study suggests that PPIs, such as esomeprazole, may have an antifibrotic role in IPF by directly regulating the MAPK/Nrf2/HO1 pathway to influence the disease process favorably. The research found that esomeprazole controls pro-inflammatory and profibrotic molecules through Nrf2 nuclear translocation and induction of HO1, with additional involvement of the MAPK pathway. High throughput RNA-seq analysis supported the antifibrotic effect of esomeprazole and revealed novel potential targets for IPF treatment.
JOURNAL OF INFLAMMATION-LONDON
(2021)
Article
Respiratory System
Nicola A. Hanania, Abebaw M. Yohannes, Ayca Ozol-Godfrey, Michael Tocco, Thomas Goodin, Sanjay Sharma, Shahin Sanjar
Summary: In patients with moderate-to-very-severe COPD, those with comorbid anxiety and depression (A/D) showed improvements in FEV1 and SGRQ scores following treatment with nebulized glycopyrrolate (GLY) 25 μg. Regardless of baseline A/D status, GLY demonstrated significant improvements in symptoms.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Arnaud Bourdin, Gerard Criner, Gilles Devouassoux, Mark Dransfield, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Ravi Kalhan, Peter Lange, Sally Lettis, David A. Lipson, David A. Lomas, Jose M. Echave-Sustaeta Maria-Tome, Neil Martin, Fernando J. Martinez, Holly Quasny, Lynda Sail, Thomas M. Siler, Dave Singh, Byron Thomashow, Henrik Watz, Robert Wise, Nicola A. Hanania
Summary: The IMPACT trial demonstrated that FF/UMEC/VI reduced moderate/severe exacerbation rates and risks, and improved lung function in both Western Europe and North America. However, differences were observed between the regions in terms of SGRQ total score and pneumonia incidence.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2021)
Meeting Abstract
Allergy
Zachary Schwartz, Carolyn Skowronski, Anne Roc, Bradley Chipps, Nicola Hanania, Linda Rogers, Eileen Wang, Michael Wechsler
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Meeting Abstract
Allergy
Nicola Hanania, Zelie Bailes, Sarah Chang, Andrew Fowler, Robson Lima, David Mannino, Mark Millard, Joseph Spahn, Steve Weinstein, Robert Nathan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)