Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems

Serotonin and brain function: a tale of two receptors

(2017) RL Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Synthetic Pot: Not Your Grandfather’s Marijuana

(2017) Benjamin M. Ford et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

(2017) James Maksymetz et al.   Molecular Brain

Psychostimulant Effect of the Synthetic Cannabinoid JWH-018 and AKB48: Behavioral, Neurochemical, and Dopamine Transporter Scan Imaging Studies in Mice

(2017) Andrea Ossato et al.   Frontiers in Psychiatry

Psychosis associated with acute recreational drug toxicity: a European case series

(2016) Odd Martin Vallersnes et al.   BMC Psychiatry

Role of hypothalamic cannabinoid receptors in post-stroke depression in rats

(2016) Shanshan Wang et al.   BRAIN RESEARCH BULLETIN

Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies

(2016) Isabella Canazza et al.   PSYCHOPHARMACOLOGY

Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats

(2016) Michael B. Gatch et al.   PSYCHOPHARMACOLOGY

Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market

(2015) Michael B. Gatch et al.   BEHAVIOURAL PHARMACOLOGY

Chronic activation of CB2 cannabinoid receptors in the hippocampus increases excitatory synaptic transmission

(2015) Jimok Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects

(2015) Jan van Amsterdam et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner

(2015) S. Tai et al.   PHARMACOLOGICAL RESEARCH

JWH-018 in rhesus monkeys: Differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects

(2014) Jesse S. Rodriguez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy

(2014) Zofia Rogóż   Pharmacological Reports

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia

(2014) Pilar Sánchez-Blázquez et al.   Frontiers in Pharmacology

Role of CB2 Cannabinoid Receptors in the Rewarding, Reinforcing and Physical Effects of Nicotine

(2013) Francisco Navarrete et al.   NEUROPSYCHOPHARMACOLOGY

Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats

(2013) Jade M. Franklin et al.   NEUROSCIENCE LETTERS

Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence

(2013) T. Rubino et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Spicing things up: synthetic cannabinoids

(2013) Max Spaderna et al.   PSYCHOPHARMACOLOGY

Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings

(2012) Maren Hermanns-Clausen et al.   ADDICTION

Products containing synthetic cannabinoids and psychosis

(2012) Vlasios Brakoulias   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Synthetic Cannabinoid-Induced Psychosis: Two Adolescent Cases

(2012) Olumide O. Oluwabusi et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

The Effect of Marijuana Use on the Risk for Schizophrenia [CME]

(2012) A. Eden Evins et al.   JOURNAL OF CLINICAL PSYCHIATRY

Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT2A and dopamine D2 receptors in rat prefrontal cortex

(2012) Jade M Franklin et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

(2012) F. S. den Boon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies

(2012) Marie-Anne El Khoury et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids

(2012) Kathryn A. Seely et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia

(2012) Hui-Chun Tsuang et al.   PSYCHIATRY RESEARCH

Association of Cannabis Use during Adolescence, Prefrontal CB1 Receptor Signaling, and Schizophrenia

(2012) Adriana Caballero et al.   Frontiers in Pharmacology

Psychosis Associated With Synthetic Cannabinoid Agonists: A Case Series

(2011) Donald Hurst et al.   AMERICAN JOURNAL OF PSYCHIATRY

Synthetic cannabinoid JWH-018 and psychosis: An explorative study

(2011) Susanna Every-Palmer   DRUG AND ALCOHOL DEPENDENCE

Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: Implications for endocannabinoid control of hippocampal neural plasticity

(2011) Robert E. Hampson et al.   NEUROPHARMACOLOGY

Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice

(2011) Nobuaki Egashira et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity

(2011) Lisa K. Brents et al.   PLoS One

Psychiatric Sequelae of Spice, K2, and Synthetic Cannabinoid Receptor Agonists

(2011) Dawn M. Benford et al.   PSYCHOSOMATICS

WARNING: LEGAL SYNTHETIC CANNABINOID-RECEPTOR AGONISTS SUCH AS JWH-018 MAY PRECIPITATE PSYCHOSIS IN VULNERABLE INDIVIDUALS

(2010) SUSANNA EVERY-PALMER   ADDICTION

Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells

(2010) Qiang Li et al.   BRAIN RESEARCH

Endocannabinoid Binding to the Cannabinoid Receptors: What Is Known and What Remains Unknown

(2010) Patricia Reggio   CURRENT MEDICINAL CHEMISTRY

The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes

(2010) Helge Müller et al.   SCHIZOPHRENIA RESEARCH

Cannabis and psychosis/schizophrenia: human studies

(2009) Deepak Cyril D’Souza et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Signaling Pathways from Cannabinoid Receptor-1 Activation to Inhibition of N-Methyl-D-Aspartic Acid Mediated Calcium Influx and Neurotoxicity in Dorsal Root Ganglion Neurons

(2009) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling

(2009) K. A. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psychedelics and schizophrenia

(2009) Javier González-Maeso et al.   TRENDS IN NEUROSCIENCES

Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects

(2008) Emmanuel S. Onaivi et al.   PLoS One

Involvement of subthalamic nucleus in the stimulatory effect of Δ9-tetrahydrocannabinol on dopaminergic neurons

(2007) T. Morera-Herreras et al.   NEUROSCIENCE

Cannabinoid pharmacology: the first 66 years

(2006) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY