Review
Immunology
Susanna Felsenstein, Andreas Otto Reiff
Summary: This review aims to combine current knowledge of the immunopathology of COVID-19 with evidence of available treatment options to provide frontline healthcare workers with an understanding of host response in COVID-19 patients and support their efforts in selecting tailored treatment options for their patients.
CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniele Santi, Giorgia Spaggiari, Carla Greco, Clara Lazzaretti, Elia Paradiso, Livio Casarini, Francesco Poti, Giulia Brigante, Manuela Simoni
Summary: Endothelial dysfunction is an early indicator of atherosclerosis and cardiovascular diseases, while also playing a crucial role in human fertility and reproduction. Evaluating markers of endothelial health is essential for clinical practice and research, shedding light on the connection between endothelial and reproductive health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Astronomy & Astrophysics
Jonathan R. Gair, Archisman Ghosh, Rachel Gray, Daniel E. Holz, Simone Mastrogiovanni, Suvodip Mukherjee, Antonella Palmese, Nicola Tamanini, Tessa Baker, Freija Beirnaert, Maciej Bilicki, Hsin-Yu Chen, Gergely Dalya, Jose Maria Ezquiaga, Will M. Farr, Maya Fishbach, Juan Garcia-Bellido, Tathagata Ghosh, Hsiang-Yu Huang, Christos Karathanasis, Konstantin Leyde, Ignacio Magana Hernandez, Johannes Noller, Gregoire Pierra, Peter Raffai, Antonio Enea Romano, Monica Seglar-Arroyo, Daniele A. Steer, Cezary Turski, Maria Paola Vaccaro, Sergio Andres Vallejo-Pena
Summary: The dark siren galaxy catalog method allows for cosmological inference using gravitational wave standard sirens, and avoids the challenge of identifying a unique host galaxy without a confident electromagnetic counterpart. Recent claims of biased estimates of the Hubble constant when implementing this method on mock data are addressed and demonstrated to be untrue, as long as the method is applied correctly.
ASTRONOMICAL JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Karim I. Budhwani, Zeelu H. Patel, Rachael E. Guenter, Areesha A. Charania
Summary: Cancer is a complex and personal disease, requiring new therapeutic approaches and predictive tools for personalized treatment options. Cancer models that recapitulate various aspects of the disease are crucial for advancing cancer treatment.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Thelvia I. I. Ramos, Carlos A. A. Villacis-Aguirre, Katherine V. V. Lopez-Aguilar, Leandro Santiago Padilla, Claudia Altamirano, Jorge R. R. Toledo, Nelson Santiago Vispo
Summary: Nanomedicine plays a crucial role in developing new therapies, but the clinical translation of nanomedicines faces safety and regulatory issues. A thorough understanding of the properties of nanodrugs is essential and additional safety, quality, and efficacy testing is required. The lack of specific regulatory framework for nanoformulations has resulted in differences in requirements for safety and efficacy testing.
Article
Chemistry, Physical
Yu Liu, Terry J. Frankcombe, Timothy W. Schmidt
Summary: This article introduces a method called fermionic tiling for analyzing and visualizing high-dimensional wave functions. The method allows for the visualization of the complete electronic structure, including correlation effects, and reproduces canonical chemical motifs. The article also provides examples of the application of fermionic tiling, including visualizing electron motions and electron correlation in resonance structures.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Editorial Material
Cell Biology
Francis C. Szoka
Summary: PEGylated lipid protein immunogens delivered intranasally to mice and macaques can stimulate the production of IgG and IgA antibodies at other mucosal sites.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Nicolo Zuin Fantoni, Afaf H. El-Sagheer, Tom Brown
Summary: Click chemistry, particularly azide-alkyne cycloadditions, is a powerful technique for the covalent conjugation of molecular entities. Its application in nucleic acid chemistry allows efficient and cost-effective labeling, ligation, and cyclization of oligonucleotides compared to traditional techniques. This review provides a guide to researchers approaching the field, discussing the chemistry and applications of AAC reactions in nucleic acids.
Review
Biochemistry & Molecular Biology
Tiago Oliveira, Morten Thaysen-Andersen, Nicolle H. Packer, Daniel Kolarich
Summary: Protein glycosylation is essential for cell function and changes in glycosylation are associated with many diseases, making glycoproteins important biomarkers and therapeutic targets. Glycoproteomics is a powerful tool for functional analysis of protein glycosylation, providing insight into complex glycoproteomes and enabling deep identification and characterization of glycoproteins in regulating cell function.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Computer Science, Information Systems
Abhinau K. Venkataramanan, Chengyang Wu, Alan C. Bovik, Ioannis Katsavounidis, Zafar Shahid
Summary: The study compared the functions and performances of different implementations of the SSIM algorithm, and provided recommendations on how to use SSIM most effectively, including ways to reduce its computational burden.
Review
Chemistry, Multidisciplinary
Xavier S. Streety, Jennifer C. Obike, Steven D. Townsend
Summary: Oligosaccharides, found ubiquitously in molecular biology, have various functions but their exact roles are not well understood due to their heterogeneous nature in nature, making purification and structure-activity relationship characterization challenging. The synthesis and modification of pure materials are major bottlenecks in glycoscience research. This article aims to provide an entry-level overview of fundamental principles in carbohydrate chemistry, focusing on both solved problems and persisting issues, to inform new researchers of key gaps in the field.
ACS CENTRAL SCIENCE
(2023)
Article
Cell Biology
Irene M. G. M. Hemel, Bob P. H. Engelen, Nicole Luber, Mike Gerards
Summary: The study analyzed five open source ImageJ tools and found that the Mitochondrial Analyzer outperforms other tools in accurate identification and structural segregation of mitochondria, making it the best open source tool for mitochondrial network morphology quantification.
Article
Biochemistry & Molecular Biology
Dmitrii Smirnov, Pavel Mazin, Maria Osetrova, Elena Stekolshchikova, Ekaterina Khrameeva
Summary: Lipidomics is a rapidly growing discipline that involves the identification and quantification of thousands of lipids. This paper provides guidelines for analyzing lipidome data obtained using untargeted LC-MS methods, focusing on practical approaches for data analysis. The paper also outlines potential applications of untargeted lipidomics for biological studies and includes a detailed R notebook for data analysis based on xcms software.
Editorial Material
Cell Biology
Kerrie L. Marie, Glenn Merlino, Chi -Ping Day
Summary: Melanoma evolution may resemble the embryonic development of neural crest, generating cell subpopulations with distinct functions, including growth and metastasis.
DEVELOPMENTAL CELL
(2022)
Article
Chemistry, Medicinal
Yan Ivanenkov, Bogdan Zagribelnyy, Alex Malyshev, Sergei Evteev, Victor Terentiev, Petrina Kamya, Dmitry Bezrukov, Alex Aliper, Feng Ren, Alex Zhavoronkov
Summary: This article provides a comprehensive overview of the most recent research outcomes on artificial intelligence-generated molecular structures from the perspective of medicinal chemists. The focus is on studies that involve synthesis, in vitro validation, and analysis of the relevance and novelty of these structures in modern medicinal chemistry. The authors believe that this review will be valuable to the medicinal chemistry and AI-driven drug design communities as a comprehensive approach for evaluating different research outcomes in AIDD.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Medicinal
Suresh Velnati, Elisa Ruffo, Alberto Massarotti, Maria Talmon, Konduru Sai Sandeep Varma, Alessandro Gesu, Luigia Grazia Fresu, Andrew L. Snow, Alessandra Bertoni, Daniela Capello, Gian Cesare Tron, Andrea Graziani, Gianluca Baldanzi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Sveva Pelliccia, Jussara Amato, Domenica Capasso, Sonia Di Gaetano, Alberto Massarotti, Marialuisa Piccolo, Carlo Irace, Gian Cesare Tron, Bruno Pagano, Antonio Randazzo, Ettore Novellino, Mariateresa Giustiniano
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Suresh Velnati, Alberto Massarotti, Annamaria Antona, Maria Talmon, Luigia Grazia Fresu, Alessandra Silvia Galetto, Daniela Capello, Alessandra Begoni, Valentina Mercalli, Andrea Graziani, Gian Cesare Tron, Gianluca Baldanzi
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Organic
Sveva Pelliccia, Antonella Ilenia Alfano, Paolo Luciano, Ettore Novellino, Alberto Massarotti, Gian Cesare Tron, Davide Ravelli, Mariateresa Giustiniano
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Giulia Opassi, Helena Nordstrom, Arne Lundin, Valeria Napolitano, Francesca Magari, Tom Dzus, Gerhard Klebe, U. Helena Danielson
Article
Biochemistry & Molecular Biology
Joao Encarnacao, Valeria Napolitano, Giulia Opassi, U. Helena Danielson, Grzegorz Dubin, Grzegorz M. Popowicz, Helene Munier-Lehmann, Jos Buijs, Karl Andersson, Hanna Bjorkelund
Article
Chemistry, Medicinal
Marta Serafini, Enza Torre, Silvio Aprile, Erika Del Grosso, Alessandro Gesu, Alessia Griglio, Giorgia Colombo, Cristina Travelli, Salvatore Paiella, Annalisa Adamo, Elena Orecchini, Alice Coletti, Maria Teresa Pallotta, Stefano Ugel, Alberto Massarotti, Tracey Pirali, Silvia Fallarini
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Marta Serafini, Sarah Cargnin, Alberto Massarotti, Tracey Pirali, Armando A. Genazzani
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Oncology
Marco Varalda, Annamaria Antona, Valentina Bettio, Konkonika Roy, Ajay Vachamaram, Vaibhav Yellenki, Alberto Massarotti, Gianluca Baldanzi, Daniela Capello
FRONTIERS IN ONCOLOGY
(2020)
Article
Chemistry, Medicinal
Valentina Sala, Sophie Julie Cnudde, Alessandra Murabito, Alberto Massarotti, Emilio Hirsch, Alessandra Ghigo
Summary: Cystic fibrosis (CF) is a common rare genetic disease affecting over 70,000 people worldwide, characterized by lung blockage and chronic infections. Peptides hold promise as therapeutics for respiratory diseases like CF due to their high specificity, efficacy, and low toxicity, but face challenges like retention within mucus, proteolysis, immunogenicity, and aggregation in the development process. Solutions to overcome these issues and advancements in peptide design are being explored.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Marta Serafini, Sarah Cargnin, Alberto Massarotti, Gian Cesare Tron, Tracey Pirali, Armando A. Genazzani
Summary: This article explains the process of assigning common drug names by the World Health Organization and analyzes chemical entities from 2000 to 2021, describing changes in chemical structure, newer therapeutic targets (such as kinases), significant increases in the use of fluorine and heterocycles, as well as progressive increases in molecular weight. These analyses also reveal small signs of change, such as the rise in spirocyclic scaffolds and small rings, and the emergence of unconventional structural moieties that may predict future trends.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Alberto Massarotti, Francesca Brunelli, Silvio Aprile, Mariateresa Giustiniano, Gian Cesare Tron
Summary: Isocyanides, with their metal coordinating properties, have carved out a niche in ecological systems through evolution. Despite their potential biological activity, medicinal chemists have been skeptical of isocyanides due to concerns about reactivity and stability. This review aims to showcase the rich biological activity of isocyanide-containing molecules and advocate for their consideration in future drug design.
Article
Chemistry, Medicinal
Silvia Fallarini, Irene P. Bhela, Silvio Aprile, Enza Torre, Alice Ranza, Elena Orecchini, Eleonora Panfili, Maria T. Pallotta, Alberto Massarotti, Marta Serafini, Tracey Pirali
Summary: Inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) are considered a promising strategy in cancer immunotherapy, and recent studies have revealed additional roles of IDO1 beyond its catalytic activity. A novel class of compounds, originated from a structure-based virtual screening on IDO1 active site, has shown improved potency, metabolic stability, and selectivity after rational and in silico-guided design of analogues.
Article
Multidisciplinary Sciences
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch
Summary: The cytokinetic process in the lens, which depends on PI3K-C2alpha, PI(3,4)P-2, and VPS36, is essential for preventing premature senescence and cataract. Loss of these components impairs cytokinesis and leads to cell damage, triggering senescence in the lens of fish, mice, and humans.
Article
Biochemistry & Molecular Biology
Rosa Merlo, Diego Caprioglio, Michele Cillo, Anna Valenti, Rosanna Mattossovich, Castrese Morrone, Alberto Massarotti, Franca Rossi, Riccardo Miggiano, Antonio Leonardi, Alberto Minassi, Giuseppe Perugino
Summary: The SNAP-tag (R) technology for protein/enzyme labeling can be enhanced and improved by using a chemo-enzymatic approach with a BG-substrate containing an azide group for subsequent conjugation.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
