Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Guorong Cheng, Zifeng Pi, Xiaoyu Zhuang, Zhong Zheng, Shu Liu, Zhiqiang Liu, Fengrui Song
Summary: Aloe-emodin (AE) can reverse multidrug resistance in tumor cells by inhibiting the efflux function of P-glycoprotein. Additionally, AE inhibits energy metabolism pathways, induces autophagy, and triggers apoptosis through DNA damage, ROS generation, and caspase-3 activation.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Zhikun Yang, Yue Cai, Shen Mao, Qihao Wu, Mengdi Zhu, Xiaoji Cao, Bin Wei, Jin-Miao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Sijia Wang, Yanlei Yu, Huawei Zhang, Xuanrong Sun, Zi-Ning Cui, Ya-Sheng Li, Hong Wang
Summary: By utilizing active skeleton splicing and structural optimization strategies, 50 novel 2,5-disubstituted furan derivatives were designed, synthesized, and screened for P-gp inhibitory activity based on the lead compound 5m. The identification of an important pharmacophore N-phenylbenzamide led to the discovery of a promising drug lead compound III-8 with broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells. Molecular docking analysis showed that III-8 had a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer is a severe global threat to health, and chemotherapy often faces the setback of tumor relapse and resistance. Photodynamic therapy shows promise as a treatment modality, but the emergence of resistant cell populations in breast cancer patients is a challenge. Studying resistant cells can provide insights into designing more effective treatment strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Toxicology
Alicja Zajdel, Joanna Nycz, Adam Wilczok
Summary: Lapatinib can reverse chemoresistance of breast cancer cells to paclitaxel, enhancing its anticancer activity, and thus may have potential benefits in the treatment of HER2-negative breast cancer.
TOXICOLOGY IN VITRO
(2021)
Article
Multidisciplinary Sciences
Weihua Gong, Panpan Fang, Maodong Leng, Ying Shi
Summary: This study aimed to explore the role of GSDME methylation in the sensitivity of chemotherapy for breast cancer. The results showed that decitabine could increase the expression of GSDME and induce cell apoptosis, improving the chemosensitivity of breast cancer cells to paclitaxel. Therefore, decitabine/GSDME/pyroptosis-based treatment strategies may provide a new approach to overcome the resistance of breast cancer to paclitaxel chemotherapy.
Article
Chemistry, Analytical
Suideng Qin, Zhixin Tian
Summary: N-linked glycosylation (N-glycosylation) is a common post-translational modification in mammalian proteins, with complex structural features. Loss or gain of glycosylation can lead to changes in protein structure and function. In this study, we characterized the glycoproteome of breast cancer drug-resistant cells and cancer stem cells, providing information about N-glycosite and N-glycan structures.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Haofei Zhou, Ye Yuan, Zhexu Wang, Zexin Ren, Mixia Hu, JingKun Lu, Hongxia Gao, Cheng Pan, Wenjie Zhao, Baohua Zhu
Summary: This study has developed a novel nanoplatform for delivering chemotherapy drugs and overcoming multidrug resistance. By using a combination strategy of quercetin and doxorubicin and utilizing the high-speed motion of the motor, this nanoplatform can increase the intracellular accumulation of drugs and enhance the killing effect on multidrug-resistant cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Syed Farooq Adil, Mohammed Rafi Shaik, Fahd A. Nasr, Ali S. Alqahtani, Mohammad Z. Ahmed, Wajhul Qamar, Mufsir Kuniyil, Adibah Almutairi, Abdulrahman Alwarthan, Mohammed Rafiq H. Siddiqui, Mohammad Rafe Hatshan, Mujeeb Khan
Summary: The study revealed that functionalized graphene nanocomposites have enhanced anticancer properties against human breast cancer cells, demonstrating improved physical stability and dispersibility.
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Article
Pharmacology & Pharmacy
Hanaa Hegazy, Maha M. Amin, Walid Fayad, Mohamed Y. Zakaria
Summary: The goal of this study was to design bilosomes coated with D-alpha-tocopheryl polyethylene glycol succinate (TPGS) as an oral delivery platform to enhance the effectiveness and permeability of Curcumin (CUR) for cancer treatment. Through factorial analysis, the optimal formulation was selected based on particle size, zeta potential, and entrapment efficiency, and further coated with TPGS. The results showed that the TPGS-coated bilosomes exhibited increased permeation and cellular uptake of CUR, leading to significant reduction in IC50 value against multidrug resistant tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Zhanwei Zeng, Shiyi Liao, Huan Zhou, Hongyu Liu, Jiantao Lin, Yunsheng Huang, Chenhui Zhou, Daohua Xu
Summary: Multidrug resistance (MDR) is a major cause of chemotherapy failure in cancers, and ABCB1 and ABCG2 play crucial roles in cancer cell MDR. Sigma-2 receptor ligands have shown promising cytotoxic effects against cancer cells and regulate the activity of ABCB1, but their specific mechanisms are still unclear. In this study, a sigma(2) receptor ligand called A011 demonstrated significant cytotoxicity against breast cancer cells and reversed drug resistance. A011 achieved these effects by increasing drug accumulation and down-regulating ABC transport protein expression. Additionally, A011 inhibited tumor growth. These findings suggest that A011 has potential as a therapeutic agent for overcoming tumor resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Hailun Yang, Feifei Xu, Yun Chen, Zhixin Tian
Summary: The differential expression of N-glycosylation in breast cancer stem cells identified multiple potential biomarkers, aiding in understanding the progression and treatment of breast cancer. The identification and quantification of N-glycopeptides with different structures could provide new strategies for cancer therapy.
Article
Biochemistry & Molecular Biology
Duopeng An, Xiaochen Yu, Lijing Jiang, Rui Wang, Peng He, Nanye Chen, Xiaohan Guo, Xiang Li, Meiqing Feng
Summary: This study developed an ApoA1-modified liposome for delivering the chemotherapeutic drug Dox to treat MDR tumors, showing improved therapeutic effects and reduced adverse effects on cardiac function and other organs. The designed liposomes represent a promising strategy for reversing MDR in cancer treatment.