Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Majid Alsahafi, Hebah Mimish, Fatma Salem, Mohammed Hijazi, Emad Aljahdli, Hani Jawa, Salim Bazarah, Rana Bokhary, Yousef Qari, Mahmoud Mosli
Summary: BE was reported endoscopically in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Behavioral Sciences
Xiaoduo Liu, Tao Wei, Lubo Shi, Shaojiong Zhou, Yufei Liu, Weiyi Song, Xinwei Que, Zhibin Wang, Yi Tang
Summary: A bidirectional Mendelian randomization analysis revealed a potential risk-increasing effect of GERD on epilepsy, particularly generalized epilepsy. However, BE did not show a significant causal relationship with the risks of generalized and focal epilepsy.
BRAIN AND BEHAVIOR
(2023)
Article
Pathology
Michael Andersen Jr, Bing Ren, Megan E. Romano, Shannon N. Schutz, Richard I. Rothstein, Arief A. Suriawinata, Xiaoying Liu, Mikhail Lisovsky
Summary: Anecdotal evidence suggests that there is infrequent overlap between pancreatic acinar metaplasia (PAM) and intestinal metaplasia (IM) at the gastroesophageal junction/distal esophagus (GEJ/DE). The study aimed to evaluate the significance of PAM at GEJ/DE in relation to IM in patients with gastroesophageal reflux disease (GERD). The results showed that PAM at the GEJ/DE is associated with a protective effect against IM, indicating a decreased susceptibility to IM.
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Article
Surgery
Colin P. Dunn, Justin C. Henning, Jason A. Sterris, Paul Won, Caitlin Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: This retrospective study evaluated the effectiveness of MSA for Barrett's esophagus patients, showing significant reduction in Barrett's length and prevention of progression to dysplasia or neoplasia. The results remained consistent after 2 years of follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Nicholas J. Shaheen, Gary W. Falk, Prasad G. Iyer, Rhonda F. Souza, Rena H. Yadlapati, Bryan G. Sauer, Sachin Wani
Summary: Barrett's esophagus is a common condition associated with chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The revised guidelines propose recommendations for the definition, diagnosis, screening, surveillance, and treatment of Barrett's esophagus, including important changes such as expanding acceptable screening methods and volume criteria for treatment centers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Surgery
Bashar Qumseya, Yazen Qumsiyeh, Ahmed Sarheed, Robyn Rosasco, Amira Qumseya
Summary: This study aimed to assess the effect of Roux-en-Y gastric bypass (RNY) on Barrett's esophagus (BE) in obese patients. The systematic review and meta-analysis of studies showed that a majority of patients with BE who underwent RNY had remission or improvement, while a significant minority showed no change on follow-up endoscopy.
Article
Pharmacology & Pharmacy
Shaoze Ma, Xiaozhong Guo, Chunmei Wang, Yue Yin, Guangqin Xu, Hongxin Chen, Xingshun Qi
Summary: This meta-analysis indicates a negative correlation between Helicobacter pylori infection and Barrett's esophagus, particularly with CagA-positive H. pylori infection. The study highlights the potential role of H. pylori infection in the development of Barrett's esophagus.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Medicine, General & Internal
Ahmed Gouda, Mohamed El-Kassas
Summary: This case highlights the importance of upper endoscopy screening for Barrett's esophagus in patients with eating disorders.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Gastroenterology & Hepatology
Yan-Lin Du, Ru-Qiao Duan, Li-Ping Duan
Summary: The study found a significant inverse relationship between Hp, especially the CagA-positive Hp strain, and BE, but no significant difference in Hp infection prevalence was observed between BE patients and the GERD control group. Hp was negatively correlated with long-segment BE and associated with a reduced risk of dysplasia, but had no correlation with short-segment BE.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Sung-Goo Kang, Hyun Jee Hwang, Youngwoo Kim, Junseak Lee, Jung Hwan Oh, Jinsu Kim, Chul-Hyun Lim, Seung Bae Youn, Sung Hoon Jung
Summary: The study evaluated the association between reflux esophagitis and fatigue, finding no statistically significant association between reflux esophagitis and daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, being women, anxiety, and depression. Further research is needed to clarify the relationship between fatigue and reflux esophagitis.
JOURNAL OF CLINICAL MEDICINE
(2021)