Article
Endocrinology & Metabolism
Jennifer Fu, George Tomlinson, Denice S. Feig
Summary: This study assesses perinatal outcomes among women with type 2 diabetes and analyzes gestational weight gain. The study found that restricted weight gain has both benefits and harms, highlighting the importance of comprehensive counseling for patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Mariangela Gaudio, Nicoletta Dozio, Michael Feher, Marina Scavini, Amelia Caretto, Mark Joy, Jeremy Van Vlymer, William Hinton, Simon de Lusignan
Summary: The study aimed to describe trends in modifiable and non-modifiable unfavorable factors affecting pregnancy outcomes in women with diabetes of childbearing age from an English primary care perspective. Despite improvements in general diabetes care, the majority of women with Type 1 or Type 2 diabetes still have unfavorable, mostly modifiable factors for the start of pregnancy. Good diabetes care for women of childbearing age should consider the possibility of pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Endocrinology & Metabolism
Emma J. Hamilton, Wendy A. Davis, Ranita Siru, Mendel Baba, Paul E. Norman, Timothy M. E. Davis
Summary: The incidence of DFU hospitalizations in patients with type 2 diabetes has increased between different age groups, especially in younger participants. Factors such as PSN, peripheral arterial disease, and suboptimal glycemic control at baseline were identified as independent predictors of incident hospitalization for/with DFU.
Article
Endocrinology & Metabolism
Aneta Malinowska-Polubiec, Agnieszka Zawiejska, Ewa Romejko-Wolniewicz, Grzegorz Poprawski, Iwona Towpik, Jacek Brazert, Zuzanna Handziuk, Krzysztof Czajkowski
Summary: Double diabetes, characterized by the coexistence of type 1 diabetes and insulin resistance/metabolic syndrome/obesity, is a common complication in pregnant women with type 1 diabetes. This study found that early pregnancy DDiab status was associated with maternal complications such as excessive gestational weight gain, gestational hypertension, preterm delivery, congenital malformations, and NICU hospitalization.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Amelia S. Wallace, Alex R. Chang, Jung-Im Shin, Jodie Reider, Justin B. Echouffo-Tcheugui, Morgan E. Grams, Elizabeth Selvin
Summary: This study found that the prevalence of obesity is increasing in patients with type 1 diabetes (T1D), and obesity is associated with an increased risk of chronic kidney disease (CKD). After adjusting for age, the burden of CKD in T1D exceeds that in type 2 diabetes (T2D), highlighting the need for increased vigilance and assessment of kidney-protective medications in T1D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
J. Deitch, C. J. Yates, P. S. Hamblin, D. Kevat, I. Shahid, G. Teale, I. Lee
Summary: A study conducted in a tertiary hospital in Melbourne, Australia found that the prevalence of gestational diabetes mellitus (GDM) has significantly increased according to the IADPSG criteria, accompanied by an increase in type 2 diabetes (T2DM), maternal obesity, and large-for-gestational age (LGA), without improvement in perinatal outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Immunology
Annette K. Regan, Onyebuchi Arah, Deshayne B. Fell, Sheena G. Sullivan
Summary: Based on a national claims-based cohort study, prenatal SARS-CoV-2 infection is associated with increased risk of adverse pregnancy outcomes. Prevention measures could have benefits for fetal health.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Ulf Manuwald, Olaf Schoffer, Joachim Kugler, Henna Riemenschneider, Thomas Michael Kapellen, Wieland Kiess, Ulrike Rothe
Summary: The study investigated the trends of type 1 diabetes among children and adolescents in Saxony over the past 21 years, showing an increasing incidence rate but a stable point prevalence in recent years. Cohort prevalence is predicted to continue rising, suggesting the need for further research on environmental factors.
Article
Endocrinology & Metabolism
Rose Gubitosi-Klug, Xiaoyu Gao, Rodica Pop-Busui, Ian H. de Boer, Neill White, Lloyd P. Aiello, Ryan Miller, Jerry Palmer, William Tamborlane, Amisha Wallia, Mikhail Kosiborod, John M. Lachin, Ionut Bebu
Summary: The study found that the presence of microvascular disease in type 1 diabetes patients was associated with an increased risk of subsequent cardiovascular disease and major adverse cardiovascular events (MACE) in the DCCT/EDIC cohort. These associations remained significant even after adjusting for age and HbA(1c).
Article
Endocrinology & Metabolism
Bendix Carstensen, Pernille Falberg Ronn, Marit Eika Jorgensen
Summary: A study in the Danish population found that while improvements in disease burden have occurred at the individual level for both type 1 and type 2 diabetes, the increasing number of patients with type 2 diabetes has contributed to a large increase in the total lost lifetime at the population level over the past two decades.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Pharmacology & Pharmacy
Yannis Simos, Konstantinos Spyrou, Michaela Patila, Niki Karouta, Haralambos Stamatis, Dimitrios Gournis, Evangelia Dounousi, Dimitrios Peschos
Summary: Current oral modalities for treating type 2 diabetes mellitus have drawbacks such as low bioavailability, immediate release of the drug necessitating increased dosing frequency, and potential adverse effects. Advances in nanotechnology offer the potential to improve drug bioavailability, prolong release, reduce dosing frequency, and enhance patient compliance and quality of life.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Jean M. Lawrence, Jasmin Divers, Scott Isom, Sharon Saydah, Giuseppina Imperatore, Catherine Pihoker, Santica M. Marcovina, Elizabeth J. Mayer-Davis, Richard F. Hamman, Lawrence Dolan, Dana Dabelea, David J. Pettitt, Angela D. Liese
Summary: The prevalence of type 1 and type 2 diabetes among children and adolescents in the US increased significantly from 2001 to 2017, with particular attention on the rise in type 1 diabetes among those younger than 19 years old.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Gul Anil Anakok, Susanne F. Awad, Cigdem Caglayan, Peijue Huangfu, Laith J. Abu-Raddad, Belgin Unal, Julia Alison Critchley
Summary: Using a mathematical model, this study predicts the future prevalence of type 2 diabetes and modifiable risk factors in Turkey. The results highlight the significant impact of obesity, especially among women, and suggest that interventions targeting obesity could reduce the disease burden.
Article
Endocrinology & Metabolism
Jay Bae, Dongju Liu, Chanadda Chinthammit, Zbigniew Kadziola, Kristina Boye, Kieren Mather
Summary: Medication use trends among patients with type 2 diabetes were investigated from 2015 to 2019 in relation to the clinical group-specific recommendations. The study found that the utilization of recommended therapies is increasing overall, but there is a persistent gap in utilization between Commercial and Medicare populations.
DIABETES OBESITY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Alastair G. Sutcliffe, Mitana Purkayastha, Daniel R. Brison, Scott M. Nelson, Stephen A. Roberts, Deborah A. Lawlor
Summary: This study examined the effects of assisted reproductive technology on hospital admissions in children. It found that children born after assisted reproductive technology had a higher risk of hospitalization compared to naturally conceived children, but no significant difference was observed when compared to their naturally conceived siblings.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Clara Calvert, Jade Carruthers, Cheryl Denny, Jack Donaghy, Lisa E. M. Hopcroft, Leanne Hopkins, Anna Goulding, Laura Lindsay, Terry McLaughlin, Emily Moore, Bob Taylor, Maria Loane, Helen Dolk, Joan Morris, Bonnie Auyeung, Krishnan Bhaskaran, Cheryl L. Gibbons, Srinivasa Vittal Katikireddi, Maureen O'Leary, David McAllister, Ting Shi, Colin R. Simpson, Chris Robertson, Aziz Sheikh, Sarah J. Stock, Rachael Wood
Summary: This study using electronic health records from Scotland found no increased risk of congenital anomalies associated with COVID-19 vaccination or SARS-CoV-2 infection during early pregnancy.
NATURE COMMUNICATIONS
(2023)
Review
Pediatrics
Emma Stewart, Anna Pearce, Joanne Given, Ruth Gilbert, Sinead Brophy, Richard Cookson, Pia Hardelid, Katie L. Harron, Alastair Leyland, Rachael Wood, Ruth Dundas
Summary: A comprehensive policy review in the UK has identified three policy areas - pregnancy grants, early years education and childcare, and Universal Credit - as suitable candidates for natural experiment evaluation using administrative data. However, many potentially impactful policies were excluded due to various limitations.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Judith Yargawa, Hannah Blencowe, Ellen Bradley, Yemisrach B. Okwaraji, Veronica Pingray, Luz Gibbons, Adrienne Gordon, Kara Warrilow, Enny S. Paixao, Ila Rocha Falcao, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raul Caulier-Cisterna, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Lili Abuladze, Mika Gissler, Mohammad Heidarzadeh, Maziar Moradi-Lakeh, Khalid A. Yunis, Ayah Al Bizri, Shamala D. Karalasingam, Ravichandran Jeganathan, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Luis Huicho, Hugo Guillermo Quezada-Pinedo, Kim Nail Cajachagua-Torres, Fawziya Alyafei, Mai AlQubaisi, Geum Joon Cho, Ho Yeon Kim, Neda Razaz, Jonas Soederling, Lucy K. Smith, Jennifer Kurinczuk, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Eric O. Ohuma, Joy E. Lawn
Summary: This study aims to examine the prevalence of novel newborn types among 165 million live births in 23 countries from 2000 to 2021. The distribution of newborn types varies across countries, with the highest prevalence of small newborn types in West Asian countries and large newborn types in European countries.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Hannah Blencowe, Yemisrach B. Okwaraji, Judith Yargawa, Ellen Bradley, Adrienne Gordon, Vicki S. Flenady, Enny L. Paixao, Mauricio Barreto, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Liili A. Abuladze, Khalid Yunis, Ayah Al Bizri, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Fawziya O. Alyafei, Tawa Olukade, Neda Razaz, Jonas K. Soderling, Lucy S. Smith, Elizabeth Draper, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella O. Pravia, Eric E. Ohuma, Joy Lawn
Summary: A study compared neonatal mortality rates in 125.5 million live births across 15 countries from 2000 to 2020. The findings showed that preterm newborns with small size for gestational age had the highest mortality rates. At the population level, preterm newborns with appropriate size for gestational age contributed the most to neonatal deaths.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Endocrinology & Metabolism
Huan Wang, Ruth L. M. Cordiner, Yu Huang, Louise Donnelly, Simona Hapca, Andrew Collier, John J. McKnight, Brian R. Kennon, Fraser R. Gibb, Paul McKeigue, Sarah Wild, Helen Colhoun, John Chalmers, John Petrie, Naveed Sattar, Thomas MacDonald, Rory McCrimmon, Daniel Morales, Ewan Pearson
Summary: This study developed a robust methodology for causal inference and assessed the real-world cardiovascular safety of sulfonylureas compared to dipeptidyl peptidase 4 inhibitors and thiazolidinediones. The findings suggest that second-line sulfonylureas are unlikely to increase cardiovascular risk or all-cause mortality.
Article
Endocrinology & Metabolism
India Thomson, Niall Anderson, Louise Bath, Sarah Kiff, Chris Patterson, Sam Philip, Norman Waugh, Sarah H. H. Wild
Summary: This study aimed to investigate the incidence of type 1 diabetes in Scotland from 2006 to 2019. Annual cross-sectional studies were conducted using data from SCI-DC. The results showed that the incidence of type 1 diabetes remained stable during the study period and varied by age, sex, and socio-economic status.
Article
Medicine, General & Internal
Moritz Oberndorfer, Paul M. Henery, Ruth Dundas, Alastair H. Leyland, Shantini Paranjothy, Sarah Jane Stock, Rachael Wood, Scott M. Nelson, Rachel Kearns, Anna Pearce
Summary: This study aims to analyze the impact of the COVID-19 pandemic on pregnancy and birth outcomes in Scotland. The data from before and during the pandemic will be compared to examine changes in maternal behavior, pregnancy and birth outcomes, and service use. The study also aims to assess the inequalities in the effects of mitigation measures on outcomes, considering various factors such as ethnicity, area deprivation, and social position.
Editorial Material
Medicine, General & Internal
Rachel J. Kearns, Scott M. Nelson
Article
Computer Science, Information Systems
Joseph Mellor, Wenhua Jiang, Alan Fleming, Stuart J. McGurnaghan, Luke Blackbourn, Caroline Styles, Amos J. Storkey, Paul M. McKeigue, Helen M. Colhoun
Summary: The objective of this study was to evaluate whether deep learning (DL) on retinal photographs from a diabetic retinopathy screening programme improves prediction of incident cardiovascular disease (CVD). DL scores were independently associated with incident CVD in both type 1 and type 2 diabetes cohorts. However, the incremental improvements in C-statistics were small.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Public, Environmental & Occupational Health
Emma Stewart, Sinead Brophy, Richard Cookson, Ruth Gilbert, Joanne Given, Pia Hardelid, Katie Harron, Alastair Leyland, Anna Pearce, Rachael Wood, Ruth Dundas
Summary: Reducing health inequalities is a societal priority, and early interventions are crucial for improving childhood outcomes. The UK has a strong commitment to invest in the early years and tackle health inequalities through national policy interventions. Evaluating the impact of country-wide policies on child health outcomes is challenging but necessary, given the current social and economic context.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Eric O. Ohuma, Chia-Jung Chang, Elizabeth A. Hazel, Judith Yargawa, Yemisrach B. Okwaraji, Ellen Bradley, Adrienne Gordon, Jessica Sexton, Harriet L. S. Lawford, Enny S. Paixao, Ila R. Falcao, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik T. Sorensen, Luule Sakkeus, Lili Abuladze, Khalid A. Yunis, Ayah Al Bizri, Sonia Lopez Alvarez, Lisa Broeders, Aimee E. van Dijk, Fawziya Alyafei, Mai Alqubaisi, Neda Razaz, Jonas Soederling, Lucy K. Smith, Ruth J. Matthews, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Joy E. Lawn, Hannah Blencowe
Summary: In this study, the prevalence and neonatal mortality of large for gestational age (LGA) and macrosomia were compared among live births in 15 countries. The results showed that LGA babies had a lower risk of neonatal mortality compared to babies that were appropriate for gestational age (AGA), while macrosomia babies weighing over 4500 grams had a higher risk of mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yemisrach B. Okwaraji, Lorena Suarez-Idueta, Eric O. Ohuma, Ellen Bradley, Judith Yargawa, Veronica Pingray, Gabriela Cormick, Adrienne Gordon, Vicki Flenady, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Liili Abuladze, Mohammed Heidarzadeh, Narjes Khalili, Khalid A. Yunis, Ayah Al Bizri, Shamala D. Karalasingam, Ravichandran Jeganathan, Arturo Barranco, Aimee E. van Dijk, Lisa Broeders, Fawzya Alyafei, Mai Alqubaisi, Neda Razaz, Jonas Soderling, Lucy K. Smith, Ruth J. Matthews, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Sarka Lisonkova, Qi Wen, Joy E. Lawn, Hannah Blencowe
Summary: This study examines the impact of preterm birth and size-for-gestational age on stillbirths using six different "newborn types". The findings reveal that nearly three-quarters of stillbirths are preterm, while one-fifth are small-for-gestational-age. The combination of preterm and small-for-gestational-age births is associated with the highest stillbirth rates.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)