Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Multidisciplinary Sciences
Rugang Li, Min He, Qilin Yang, Zezhi Liang, Ying li, Ling Huang, Rong Wu, Jieping Huang
Summary: This study explores the association between baseline serum creatinine level and new-onset type 2 diabetes in the Chinese population. The findings reveal that low serum creatinine is independently associated with an increased risk of type 2 diabetes among Chinese adults, and this association is consistent across different subgroups.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Elena Massimino, Anna Izzo, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Sarcopenia, defined as the age-related decrease in skeletal muscle mass and loss of muscle power and function, is more prevalent in patients with type 2 diabetes mellitus (T2DM). Glucose-lowering drugs prescribed for T2DM patients may impact sarcopenia through various mechanisms, affecting the balance between protein anabolism and catabolism in skeletal muscle. In addition to their glucose-lowering effects, these drugs can influence muscle strength, quantity/quality, and physical performance, leading to potential harmful or beneficial effects on skeletal muscle in individuals with T2DM.
Article
Endocrinology & Metabolism
Alexandra Fahrner, Nikoleta Alchus Laiferova, Barbara Ukropcova, Jozef Ukropec, Jan Krutzfeldt
Summary: Type 2 diabetes negatively affects muscle health. Paracrine signaling in the adult muscle stem cells niche is activated in T2D. The PDGF-miR-501 signaling pathway could be used to classify patients in clinical trials aiming to improve muscle health and glucose homeostasis in diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Summary: This study suggests that higher postpartum muscle mass is associated with a lower risk of prediabetes and type 2 diabetes in Korean women with gestational diabetes mellitus. This association was observed in normal weight women but not in overweight women.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Oncology
Hiroki Nishikawa, Shinya Fukunishi, Akira Asai, Keisuke Yokohama, Hideko Ohama, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in energy metabolism and glucose uptake. Conditions like type 2 diabetes, frailty, and aging can impact muscle health. Exercise and proper nutrition interventions are key in maintaining muscle health and preventing various diseases.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, General & Internal
Wenchao Hu, Yingqiang Ma, Lanjie He, Dongming Xing
Summary: This study aimed to evaluate the association between serum creatine kinase (CK) and low muscle mass in patients with type 2 diabetes mellitus (T2DM). The results showed that CK was associated with a reduced risk of low muscle mass in both male and female T2DM patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Review
Nutrition & Dietetics
Stefano Sbrignadello, Christian Goebl, Andrea Tura
Summary: Sarcopenia is a severe complication in type 2 diabetes, and nutritional aspects play a role in its development. Bioelectrical impedance analysis is an effective and cost-efficient method to assess body composition in T2DM patients with sarcopenia or at risk. However, more validation studies are needed in this specific population.
Article
Medicine, Research & Experimental
Chuan Wang, Chen Jin, Xiaofei Yin, Jidong Liu, Jinbo Liu
Summary: The study found a positive association between bilirubin and muscle mass in male patients with T2DM, with indirect bilirubin shown to provide protection against sarcopenia in this population.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Juergen G. Okun, Patricia M. Rusu, Andrea Y. Chan, Yuqin Wu, Yann W. Yap, Thomas Sharkie, Jonas Schumacher, Kathrin V. Schmidt, Katherine M. Roberts-Thomson, Ryan D. Russell, Annika Zota, Susanne Hille, Andreas Jungmann, Ludovico Maggi, Young Lee, Matthias Bluher, Stephan Herzig, Michelle A. Keske, Mathias Heikenwalder, Oliver J. Mueller, Adam J. Rose
Summary: Elevated hepatic alanine catabolism promotes hyperglycaemia and reduces skeletal muscle protein synthesis, linking sarcopenia with hyperglycaemia in type 2 diabetes. Obesity and sarcopenia are often associated in aging and may together contribute to the progression of conditions such as diabetes and frailty. Liver alanine metabolism driven by chronic glucocorticoid and glucagon signaling promotes hyperglycaemia and skeletal muscle wasting, revealing a metabolic inter-tissue cross-talk in type 2 diabetes.
Article
Endocrinology & Metabolism
Wen Wei, Shanggang Li, Jin Liu, Yong Liu, Kaihong Chen, Shiqun Chen, Mei Tu, Hong Chen
Summary: The serum creatinine-to-cystatin C ratio (Scr/Scys) has been suggested as a surrogate marker for muscle mass and a predictor of adverse outcomes. This study aimed to assess the prognostic value of Scr/Scys in patients with type 2 diabetes mellitus (T2DM). The results showed that low muscle mass assessed by Scr/Scys was associated with an increased risk of long-term all-cause mortality in diabetic patients.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Geriatrics & Gerontology
Ayoung Kim, Ja Hyun Koo, Xing Jin, Wondong Kim, Shi-Young Park, Sunghyouk Park, Eugene P. Rhee, Cheol Soo Choi, Sang Geon Kim
Summary: The research findings demonstrate the crucial role of USP21 in skeletal muscle in regulating myofibre type switch, muscle mass control, mitochondrial function, and heat generation, suggesting the potential of USP21 and its downstream substrates network as targets for treating and preventing muscle dysfunction and associated metabolic diseases.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Mingzhong Yu, Min Pan, Yebei Liang, Xiaoling Li, Jingyan Li, Li Luo
Summary: The aim of this study was to establish a clinical screening model to identify sarcopenia early in the population with type 2 diabetes mellitus. The results showed that age, sex, BMI, WHR, and heart rate were key factors for detecting sarcopenia in patients with type 2 diabetes mellitus. This novel screening model is an accurate, easy-to-implement, and low-cost tool for early identification of sarcopenia in Chinese patients with type 2 diabetes mellitus.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Yuriko Kondo, Takuya Fukuda, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This prospective cohort study aimed to investigate the impact of different vitamin intakes on the loss of muscle mass in older individuals with type 2 diabetes. The study found that vitamin D intake was significantly associated with muscle mass loss, and there was a trend towards a relationship between vitamin B12 intake and muscle mass loss. However, intakes of vitamin A, B2, B6, C, and E were not found to be related to muscle mass loss.
Article
Geriatrics & Gerontology
Jie Cheng, Xuena Wang, Shinan Gan, Qing Zhang, Ge Meng, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Yawen Wang, Magdalena J. Gorska, Tingjing Zhang, Mingxu Ye, Tong Ji, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This study found that in older adults, a higher ASMI/TFM ratio was associated with a lower prevalence of T2DM. The predictive value of ASMI/TFM for T2DM may be stronger than traditional measures such as BMI and WC in this population.
Review
Food Science & Technology
Qi Cui, Yang Xia, Qijun Wu, Qing Chang, Kaijun Niu, Yuhong Zhao
Summary: Food frequency questionnaires (FFQs) are commonly used tools for assessing dietary intake. This study comprehensively evaluated the validity of FFQs and found that they are suitable for assessing overall dietary intake in nutritional epidemiological studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Huiping Li, Xiaoxi Zheng, Rayamajhi Sabina, Thapa Amrish, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Jun Dong, Zhixia Cao, Xu Zhang, Xinrong Dong, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This prospective cohort study aimed to investigate the association between organ meat consumption and risk of non-alcoholic fatty liver disease (NAFLD) in a general Chinese adult population. The study found that organ meat consumption was related to a modestly higher risk of NAFLD among Chinese adults.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Shunming Zhang, Yan Yan, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yan Borne, Lu Qi, Yu-Ming Chen, Kaijun Niu
Summary: This study suggests that replacing animal protein foods with plant protein foods significantly reduces the risk of NAFLD, with whole grains showing the strongest benefit.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jinguo Jiang, Tingjing Zhang, Yashu Liu, Qing Chang, Yuhong Zhao, Chuanji Guo, Yang Xia
Summary: The purpose of this article is to systematically review and meta-analyze the prevalence of diabetes in patients with hyperuricemia and gout. Previous studies have shown that hyperuricemia and gout are associated with an increased risk of diabetes. The meta-analysis revealed that the prevalence of diabetes in patients with hyperuricemia and gout was 19.10% and 16.70%, respectively.
CURRENT DIABETES REPORTS
(2023)
Article
Transplantation
Yixiao Zhang, Yang Xia, Qing Chang, Chao Ji, Yuhong Zhao, Hehua Zhang
Summary: Based on the samples from the Northeast China Biobank, this study found that long-term exposure to air pollution is associated with an increased risk of metabolic kidney diseases (MKD). Various air pollutants such as PM2.5, PM10, sulfur dioxide, and ozone are correlated with MKD, diabetic kidney disease, hypertensive kidney disease, hyperlipidemic kidney disease, and obese kidney disease. Age, ethnicity, and air pollution interact to impact the risk of MKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Rheumatology
Tingjing Zhang, Xin Xu, Qing Chang, Yanling Lv, Yuhong Zhao, Kaijun Niu, Liangkai Chen, Yang Xia
Summary: This study found that there is an interaction between ultraprocessed food (UPF) consumption and genetic predisposition to gout. Analyzing 181,559 individuals from the UK Biobank study, it was observed that UPF consumption is associated with a higher risk of gout, especially in individuals with genetic predisposition. Replacing UPF with unprocessed or minimally processed food can reduce the risk of gout, particularly in those who are genetically susceptible. Therefore, reducing UPF consumption is crucial for gout prevention.
Article
Cardiac & Cardiovascular Systems
Xue Bao, Biao Xu, Lars Lind, Gunnar Engstrom
Summary: Subclinical carotid atherosclerosis is an important factor in cardiovascular risk estimation by SCORE2. Carotid ultrasound improves the predictive performance of SCORE2 for cardiovascular risk assessment. SCORE2 may over-predict the risk in individuals without carotid plaque and under-predict the risk in those with carotid plaque.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Qianjia Sun, Tingjing Zhang, Laeeqa Manji, Yashu Liu, Qing Chang, Yuhong Zhao, Yang Ding, Yang Xia
Summary: The purpose of this meta-analysis is to summarize all available evidence and assess the associations between serum uric acid (SUA) levels and nonalcoholic fatty liver disease (NAFLD). The results showed that increased SUA levels are positively associated with NAFLD. Reducing SUA levels can be a potential strategy for the prevention of NAFLD.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Shiwen Li, Tingjing Zhang, Honghao Yang, Qing Chang, Yuhong Zhao, Liangkai Chen, Li Zhao, Yang Xia
Summary: Metabolic syndrome and genetic predisposition have an impact on the risk of developing chronic obstructive pulmonary disease (COPD), with individuals with MetS being at higher risk and those with high genetic predisposition having an increased risk. However, there is no significant interaction between MetS and genetic risk in relation to COPD risk.
DIABETES OBESITY & METABOLISM
(2023)
Article
Peripheral Vascular Disease
Xuan Sun, Yuting Feng, Chenyi Gong, Xue Bao, Zhonghai Wei, Lei Chang, Haiting Chen, Biao Xu
Summary: Hypertension leads to proinflammatory Th1-like Treg subsets with compromised suppressive capacity. Dysfunction Tregs induced by hypertension play a pathogenic role in the progression of myocardial ischemia-reperfusion injury. Targeting disturbed Tregs may be a new strategy to treat AMI patients with hypertension.
Review
Biochemistry & Molecular Biology
Sijie Cheng, Lishen Shan, Zhuying You, Yang Xia, Yuhong Zhao, Hehua Zhang, Zhiying Zhao
Summary: A meta-analysis showed that a plant-based dietary pattern is negatively associated with serum uric acid levels and hyperuricemia. Therefore, a plant-based dietary pattern is recommended for the management of serum uric acid levels and the prevention of hyperuricemia.
Review
Biochemistry & Molecular Biology
Zhuying You, Lishen Shan, Sijie Cheng, Yang Xia, Yuhong Zhao, Hehua Zhang, Zhiying Zhao
Summary: Excessive gestational weight gain (EGWG) is associated with gestational complications and adverse birth outcomes. This meta-analysis evaluated the association between different dietary patterns and EGWG using articles from PubMed, Embase, and Web of Science databases. The results showed a significant negative association between healthy dietary patterns and EGWG, and a significant association between unhealthy dietary patterns and EGWG. Pregnant women are recommended to follow a healthy dietary pattern to prevent EGWG.
Review
Biochemistry & Molecular Biology
Wenqi Liu, Daokuan Zhai, Tingjing Zhang, Nyasha Grace Mudoti, Qing Chang, Yashu Liu, Yuhong Zhao, Yang Ding, Yang Xia
Summary: Based on a meta-analysis of multiple studies, this research found a positive correlation between the intake of major foods with added fructose and the prevalence of non-alcoholic fatty liver disease (NAFLD). Reducing added fructose consumption may serve as an early strategy to mitigate or prevent NAFLD.
Article
Biochemistry & Molecular Biology
Liping Shan, Jianxiu Shi, Jia Li, Chunyu Pan, Yang Xia, Kaijun Niu, Zhenhua Li, Song Bai
Summary: In a study conducted in a Chinese population, it was found that there is a negative association between whole grains intake and hospitalized nephrolithiasis, while there is a positive association between refined grains intake and hospitalized nephrolithiasis. Therefore, substituting refined grains with whole grains consumption may help prevent hospitalized nephrolithiasis.
Article
Biochemistry & Molecular Biology
Mengrui Luo, Tiancong Liu, Hao Ju, Yang Xia, Chao Ji, Yuhong Zhao
Summary: This study found that the traditional dietary pattern is associated with a reduced risk of CKD combined with hyperuricemia, while the sweet foods pattern is associated with an increased risk.
