Article
Immunology
Celia Ruperez, Gemma Ferrer-Curriu, Aina Cervera-Barea, Laura Florit, Mariona Guitart-Mampel, Gloria Garrabou, Monica Zamora, Fatima Crispi, Joaquim Fernandez-Sola, Josep Lupon, Antoni Bayes-Genis, Francesc Villarroya, Anna Planavila
Summary: Meteorin-like/Meteorin-beta, secreted by skeletal muscle and adipose tissue, plays a crucial role in cardiac hypertrophy and dysfunction. It directly inhibits hypertrophy development in cardiomyocytes and acts as a new biomarker for heart failure in patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lowell Dilworth, Aldeam Facey, Felix Omoruyi
Summary: Adipose tissues, particularly brown and white adipose tissues, play key roles in communication and insulin sensitivity in the development and treatment of type 2 diabetes. Adipocytokines produced by adipose tissues, like leptin and adiponectin, vary in conditions such as metabolic dysfunction, diabetes, and inflammation. The regulation of satiety, energy metabolism, and insulin release by adipose tissues indicates their significance in the pathogenesis of diabetes mellitus and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Faraz Alizadeh, Amanda O'Halloran, Areej Alghamdi, Charlotte Chen, Maria Trissal, Avram Traum, Danielle DeCourcey
Summary: This is a novel case of a 16-month-old boy with a rare combination of prematurity, intrauterine growth restriction, microcephaly, pachygyria, agenesis of the corpus callosum, postnatal embolic stroke, new-onset diabetes mellitus with diabetic ketoacidosis, severe acute respiratory syndrome coronavirus 2 infection, and atypical hemolytic syndrome (aHUS). The patient showed remarkable insulin resistance before aHUS diagnosis, which improved after eculizumab therapy, suggesting a potential connection between COVID-19 and complement-mediated microangiopathic thrombotic disease. Whole-exome sequencing did not reveal a clear etiology for aHUS, indicating that this could be a case of COVID-19-triggered aHUS rather than an idiopathic one unmasked by the infection.
Review
Medicine, General & Internal
Robert Modzelewski, Magdalena Maria Stefanowicz-Rutkowska, Wojciech Matuszewski, Elzbieta Maria Bandurska-Stankiewicz
Summary: Gestational diabetes mellitus is the most common medical complication in pregnancy, affecting approximately 15% of pregnancies worldwide. It increases the risk of complications and may lead to the development of type 2 diabetes in both the mother and infant. The increasing incidence of GDM also poses a significant economic burden.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jung Eun Yoo, Dahye Kim, Kyungdo Han, Sang Youl Rhee, Dong Wook Shin, Hyun Lee
Summary: The study found that there is an association between diabetes status and the development of tuberculosis. Individuals with diabetes have a higher risk of developing tuberculosis compared to those without diabetes, and the risk of tuberculosis increases with longer duration of diabetes.
Review
Pharmacology & Pharmacy
Jingqian Su, Lu Tang, Yingsheng Luo, Jingran Xu, Songying Ouyang
Summary: This article provides a comprehensive analysis of the structure and function of INSR and IRS proteins, as well as the drugs used for the treatment of diabetes. It serves as a valuable reference for the advancement of novel therapeutic agents for diabetes management.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen
Summary: This study aims to find a new potential method and mechanism for the treatment of DM. The findings suggest that alfuzosin can improve oxidative stress, glycative stress, and insulin resistance. In a HFD/STZ-induced diabetic mouse model, alfuzosin reduces fasting blood glucose and improves insulin sensitivity, and it achieves this by activating PGK1 to stimulate the AKT signaling pathway.
Review
Medicine, Research & Experimental
Yinai Liu, Qianqian Chen, Yaoqi Li, Liuliu Bi, Zhiying He, Chuxiao Shao, Libo Jin, Renyi Peng, Xingxing Zhang
Summary: Diabetes is a serious disease that threatens global human health. Insulin is the most effective treatment, but it can cause hypoglycemia and insulin resistance. Recent studies have found that fibroblast growth factors can safely and effectively reduce hyperglycemia, providing a new approach for diabetes treatment.
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Lixia Shen, Dongyu Wang, Yihong Huang, Lisha Ye, Caixia Zhu, Shaofeng Zhang, Shiqin Cai, Zilian Wang, Haitian Chen
Summary: This study investigated the correlation between lipid profiles and insulin indices as well as the development of gestational diabetes mellitus (GDM) in pregnant women. The results showed that triglycerides (TG) were consistently correlated with insulin indices and glucose metabolism indices. Persistently high TG levels were independent risk factors for persistent insulin resistance (IR) and second-trimester IR alone. Lowering TG levels in early and middle pregnancy could help reduce the risk of developing IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study aimed to resolve conflicting findings about GLP-1 levels in different glucose tolerance states among Malay, Chinese, and Indian ethnicities. The results showed that GLP-1 levels were higher in T2DM and pre-DM compared to NGT, suggesting a possible adaptive compensatory response. Among the three ethnic groups, Indians had the highest levels of GLP-1 and insulin resistance, supporting the notion of an adaptive compensatory secretion of GLP-1.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
K. Tuncer Kara, M. Kizil, E. Cakmak, T. T. Yildirim, F. Kilinc, T. Kuloglu, N. Gozel
Summary: This study compares the plasma and salivary levels of Metrnl in patients newly diagnosed with type-2 diabetes who were treated with metformin for three months with those of a healthy volunteer group, and analyzes the immunoreactivity of Metrnl in salivary glands through immunohistochemical staining. The results show that plasma Metrnl levels are higher in the newly diagnosed diabetes group, and salivary Metrnl levels are higher after three months of metformin treatment. Immunohistochemical staining reveals Metrnl immunoreactivity in specific locations of the parotid and submandibular glands.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Oncology
Kyong Hye Joung, Ji Min Kim, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Jaehyun Bae, Kee-Ho Song, Jong Suk Park, Jae Hyuk Lee, In-Kyung Jeong, Hyun Jin Kim, Young-Hyo Lim, Jae-Hyoung Cho, Sung Hee Choi, Yoon-Sok Chung, Eun Seok Kang
Summary: A postmarketing surveillance study of linagliptin in Korean patients with type 2 diabetes demonstrated excellent safety and glycaemic effectiveness. Adverse drug reactions were mainly gastrointestinal and metabolic disorders, with special interest in pancreatic diseases, cardiac diseases, and hypoglycaemia. Factors associated with better effectiveness included lower BMI, shorter diabetes duration, and higher baseline HbA1c, while diabetic complications, dyslipidaemia, and use of sulphonylureas were linked to a poorer response.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cell Biology
Seul-Gi Kang, Seong-Eun Lee, Min-Jeong Choi, Joon-Young Chang, Jung-Tae Kim, Ben-Yuan Zhang, Yea-Eun Kang, Ju-Hee Lee, Hyon-Seung Yi, Minho Shong
Summary: IL-4 and IL-13 increase the secretion of FGF21 in the liver through the JAK-STAT6 signaling pathway and PPARα. IL-4 administration increased FGF21 protein levels in the liver in a STAT6-dependent manner, but did not induce FGF21 secretion in the epididymal white adipose tissue.
Article
Biochemistry & Molecular Biology
Sorim Choung, Ji Min Kim, Kyong Hye Joung, Hyun Jin Kim, Seon Mee Kang, Jae-Wook Jeong, Bon Jeong Ku
Summary: The study reveals that Mig-6 affects glucose tolerance and thermogenesis in BAT, indicating its regulatory role in BAT.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
Summary: The study showed that teneligliptin effectively reduced HbA1c levels, improved time spent within the target range, and decreased glycemic variability in elderly patients with type 2 diabetes mellitus, without increasing the risk of hypoglycemia.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Medicine, Research & Experimental
Jun Choul Lee, Ji Min Kim, Kyong Hye Joung, Seon Mee Kang, Hyun Jin Kim, Bon Jeong Ku
Summary: The relationship between serum MIG6 concentration and low-density lipoprotein cholesterol in patients undergoing cholesterol-lowering treatment was evaluated.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yea Eun Kang, Kyong Hye Joung, Ji Min Kim, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Summary: This study aimed to analyze the relationship between serum CD14 concentration and metabolic parameters related to diabetes and obesity. The study found that circulating CD14 concentration was significantly negatively correlated with certain metabolic parameters in participants with obesity but without diabetes.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Oncology
Woo Sun Rou, Hyuk Soo Eun, Sorim Choung, Hong Jae Jeon, Jong Seok Joo, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, In Sun Kwon, Bon Jeong Ku, Byung Seok Lee
Summary: One of the great advantages of serum biomarkers is that they provide easily obtainable information on tumor characteristics and prognosis. In this study, serum ERBB2 and NRG4 were found to be independent prognostic factors for survival and tumor recurrence in hepatocellular carcinoma (HCC). They showed a possible synergistic effect and could be used for evaluating prognosis and monitoring treatment response in HCC patients.
Article
Medicine, General & Internal
Kwi Hwa Park, Seung-Joo Na, Youngjon Kim, Sun Jung Myung, Ju Hee Lee, Sun Woo Lee, Bo Young Yoon
Summary: This study assessed the gap between defined competencies and learners' achievement in IM training education, aiming to promote patient-centered outcomes. The results showed that IM specialists perceived their achievement levels in core competencies to be lower than their importance levels, and had insufficient evaluation and assessment of essential skills and symptoms.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Yea Eun Kang, Hyon-Seung Yi, Min-Kyung Yeo, Jung Tae Kim, Danbit Park, Yewon Jung, Ok Soon Kim, Seong Eun Lee, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Bon Jeong Ku, Mina Lee, Hyun Jin Kim
Summary: This study found that gestational diabetes mellitus (GDM) placentas exhibited upregulation of mitochondria or DNA replication related pathways and downregulation of T-cell immunity related pathways. The GDM group had a higher proportion of CD4+ T cells and CD8+ T cells in the maternal placenta, along with increased senescent T cells. These findings suggest that changes in senescent T cells and immune-escape signaling may be related to the pathophysiology of GDM.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Sang Hyeon Ju, Bon Jeong Ku
Summary: A decade ago, systemic inflammation was recognized as a cause of type 2 diabetes mellitus and its complications. Recent studies have shown that statins and ezetimibe have anti-inflammatory effects. This study aims to explore the effects of statin/ezetimibe therapy on CD8+ T cell senescence in patients with type 2 diabetes and hypercholesterolemia.
Article
Medicine, General & Internal
Jun Choul Lee, Kyong Hye Joung, Ji Min Kim, Seon Mee Kang, Hyun Jin Kim, Bon Jeong Ku
Summary: Soluble epidermal growth factor receptor (sEGFR) levels are elevated in patients with type 2 diabetes mellitus and positively correlate with blood glucose and cholesterol levels. Cholesterol-lowering treatment can significantly reduce sEGFR levels, with the reduction being more significant when LDL-C levels are lowered. sEGFR may play a significant role in insulin resistance and inflammation, and can be used as a biomarker to predict lipid-lowering treatment response in type 2 diabetes patients with hypercholesterolemia.
Article
Endocrinology & Metabolism
Ju Hee Lee, Saet-Byel Jung, Seong Eun Lee, Ji Eun Kim, Jung Tae Kim, Yea Eun Kang, Seul Gi Kang, Hyon-Seung Yi, Young Bok Ko, Ki Hwan Lee, Bon Jeong Ku, Minho Shong, Hyun Jin Kim
Summary: The study demonstrated that mitochondrial stress response in visceral adipose tissue is associated with the elevated expression of LONP1 in obese individuals, which is correlated with enhanced glucose and lipid metabolism. Mice with higher Lonp1 expression in adipose tissue showed better systemic glucose metabolism, indicating a potential role of LONP1 in regulating metabolic phenotypes in obesity.
ENDOCRINOLOGY AND METABOLISM
(2021)
