Article
Environmental Sciences
Seung Min Chung, Dong-Gyu Heo, Ju-Hyun Kim, Ji Sung Yoon, Hyoung Woo Lee, Jong-Yeon Kim, Jun Sung Moon, Kyu Chang Won
Summary: This study aimed to investigate the association between serum levels of PFOA and PFOS and diabetes. The results showed that exposure to PFOA and PFOS may have a detrimental effect on blood glucose, with particularly high risk for diabetes in individuals exposed to PFOA.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Jing-Yuan Lei, Pan-Pan Wang, Hong-Li Wang, Yuan Wang, Liang Sun, Bing Hu, Su-Fang Wang, Dong-Mei Zhang, Gui-Mei Chen, Chun-Mei Liang, Fang-Biao Tao, Lin-Sheng Yang, Qing-Si Wu
Summary: This study examines the relationship between non-essential metals and fasting plasma glucose (FPG) levels in Chinese older adults without diabetes. The results show positive associations between aluminum and cesium with FPG levels, as well as an inverted U-shaped association between cesium and FPG levels. Additionally, the study finds that the levels of non-essential metal mixture are linearly related to FPG levels, with cesium being the primary contributor. There may also be a positive interaction between arsenic and cesium on FPG levels. Further research is needed to confirm these findings and explore the underlying mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Bo-Ying Zang, Li-Xia He, Ling Xue
Summary: Obesity and diabetes are significant health issues, and moderate weight loss is important for reducing the risk of metabolic diseases. Intermittent fasting (IF) is a popular weight loss strategy, but more research is needed, especially regarding its application in obese and type 2 diabetic patients.
Article
Environmental Sciences
Yuxiong Chen, Siqin Feng, Zhen'ge Chang, Yakun Zhao, Jia Fu, Yijie Liu, Siqi Tang, Yitao Han, Yanbo Liu, Yuanxun Zhang, Shuyang Zhang, Zhongjie Fan
Summary: The use of household solid fuel for cooking and heating is positively associated with diabetes and fasting blood glucose levels. These findings suggest that reducing household solid fuel use may contribute to a decrease in diabetes development in China.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Othmar Moser, Max L. Eckstein, Alexander Mueller, Norbert J. Tripolt, Hakan Yildirim, Farah Abbas, Peter N. Pferschy, Nandu Goswami, Felix Aberer, Anna Obermayer, Thomas R. Pieber, Harald Kojzar, Caren Sourij, Martina Brunner, Tobias Niedrist, Markus Herrmann, Harald Sourij
Summary: The study demonstrated that individuals with type 1 diabetes can safely undergo a 36-hour fasting period with a low risk of hypoglycemia and ketoacidosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jessica J. J. Denton, Yenni E. E. Cedillo
Summary: Family history of diabetes is a significant predictor of fasting glucose and fasting insulin in healthy weight adults, which contributes to the understanding of diabetes development and could be used for personalized prevention strategies.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Seo Young Kang, Young Sik Kim
Summary: This study found that as fasting glucose levels increased, the proportions of obesity, abdominal obesity, and heavy drinking also increased. The risk of hypertension, high triglycerides, and low HDL cholesterol also increased with higher fasting glucose levels.
JOURNAL OF DIABETES
(2022)
Article
Chemistry, Analytical
Maria Pinelli, Emanuele Lettieri, Andrea Boaretto, Carlo Casile, Giuseppe Citro, Bernardino Zazzaro, Adriana Ravazzoni
Summary: This study investigates the physical and cognitive issues related to the usage of glucometers by T2DM patients aged 65 years and over. The results show that the Accu-Chek(R) Instant glucometer's characteristics are generally satisfactory, but improvements can still be made.
Article
Endocrinology & Metabolism
Qiuhong Gong, Ping Zhang, Jinping Wang, Edward W. Gregg, Yiling J. Cheng, Guangwei Li, Peter H. Bennett
Summary: This study found that lifestyle intervention can reduce the incidence of type 2 diabetes in individuals with impaired glucose tolerance, regardless of their baseline fasting plasma glucose levels. Additionally, in those with FPG <100 mg/dL, lifestyle intervention led to a significant delay in the onset of diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Bin Wang, Chi Chen, Wen Zhang, Yi Chen, Fangzhen Xia, Ningjian Wang, Yingli Lu
Summary: Co-exposure to lead and cadmium is significantly associated with elevated fasting plasma glucose (FPG) and type 2 diabetes in the general population in East China.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Letter
Medicine, General & Internal
Michael Fang, Elizabeth Selvin
Summary: This study utilizes 2021 National Health Interview Survey data to investigate the extent to which insulin rationing is prevalent among adults under the age of 65 in the United States, focusing on demographic characteristics.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Manqi Zheng, Shouling Wu, Shuohua Chen, Xiaoyu Zhang, Yingting Zuo, Chao Tong, Haibin Li, Changwei Li, Xinghua Yang, Lijuan Wu, Anxin Wang, Deqiang Zheng
Summary: The aim of this study was to develop and validate sex-specific risk prediction models for predicting 5-year risk of type 2 diabetes (T2D) in individuals with impaired fasting glucose (IFG) using easily obtainable clinical data. The models outperformed existing models and showed well-validated performance in both internal and external validation. A risk scoring system and a web calculator were constructed as practical tools for public use.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Xiao Tong Teong, Kai Liu, Andrew D. Vincent, Julien Bensalem, Bo Liu, Kathryn J. Hattersley, Lijun Zhao, Christine Feinle-Bisset, Timothy J. Sargeant, Gary A. Wittert, Amy T. Hutchison, Leonie K. Heilbronn
Summary: Intermittent fasting plus early time-restricted eating (iTRE) is an effective approach to improve glucose metabolism in adults at increased risk of developing type 2 diabetes, with greater improvements seen in the short term compared to continuous calorie restriction (CR).
Article
Public, Environmental & Occupational Health
Binur Orazumbekova, Alpamys Issanov, Kuralay Atageldiyeva, Salim Berkinbayev, Gulnara Junusbekova, Laura Danyarova, Zhanmedet Shyman, Akmaral Tashmanova, Antonio Sarria-Santamera
Summary: This study aimed to estimate the prevalence of impaired fasting glucose (IFG), undiagnosed, and prior-diagnosed Type 2 diabetes mellitus (T2DM) in Kazakhstan. The results showed a high prevalence of IFG and a significant proportion of newly diagnosed T2DM in Kazakhstan. The identified risk factors can be used to strengthen the identification of undiagnosed patients and provide preventive or therapeutic interventions to reduce the incidence of T2DM and its complications.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Yan He, Hanyun Zhu, Min Zhang, Jing Li, Shengqi Ma, Yin Lu, Linan Chen, Mingzhi Zhang, Hao Peng
Summary: The study found a negative association between serum furin and prediabetes and diabetes in Chinese adults.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
Summary: This study aimed to investigate the association between resting heart rate (RHR) and the prevalence of undiagnosed diabetes. The results showed that participants with higher RHR had a significantly higher prevalence of undiagnosed diabetes, and this association was stronger among younger and leaner individuals. Therefore, RHR can be used as an indicator to identify and prevent undiagnosed diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Minyoung Lee, Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
Summary: This study investigated the clinical relevance of ketone bodies in newly diagnosed type 2 diabetes patients. The results showed that patients with higher initial serum β-hydroxybutyrate (BHB) levels had greater improvement in glycemic control after 6 months of anti-diabetic treatment, as indicated by lower HbA1c levels and better blood sugar control.
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Yong-Joon Lee, Jae Young Cho, Seng Chan You, Yong-Ho Lee, Kyeong Ho Yun, Yun-Hyeong Cho, Won-Yong Shin, Sang Wook Im, Woong Chol Kang, Yongwhi Park, Sung Yoon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy among patients with diabetes mellitus and atherosclerotic cardiovascular disease. The study found that the combination therapy had similar outcomes in terms of cardiovascular events compared to the monotherapy, but had a higher rate of intolerance-related discontinuation or dose reduction. However, the combination therapy was more effective in achieving lower LDL cholesterol levels.
EUROPEAN HEART JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong-Ho Lee, Ji-Hye Kim, Seung Up Kim
Summary: There is an association between metabolic dysfunction-associated fatty liver disease (MAFLD) or NAFLD and cardiovascular disease (CVD) risk, with MAFLD potentially being a better identifier for CVD risk than NAFLD. Fibrosis assessment can provide helpful prognostic information for subjects with MAFLD.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho
Summary: In this study, the researchers found that O-GlcNAcylation plays a suppressive role in erythrocyte necroptosis. Through experiments on mice injected with lipopolysaccharide, it was observed that decreased O-GlcNAcylation led to accelerated erythrocyte necroptosis and increased formation of RIPK1-RIPK3 complex. In addition, the study also discovered that O-GlcNAcylation inhibits the phosphorylation of RIPK1, suppressing its necroptotic activity and the formation of RIPK1-RIPK3 complex in Ripk1(-/-) MEFs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Sejeong Lee, Jaehyun Bae, Doo Ri Jo, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Summary: In newly diagnosed type 2 diabetes patients, intact ketogenesis may be associated with a decreased risk of metabolic-associated fatty liver disease (MAFLD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Hematology
Moonho Kim, Yongchel Ahn, Heui-June Ahn, Suk-Hun Ha, Ho-Suk Oh, Jae-Seok Song, Woong-Sub Park, Sang-Wook Yi
Summary: Primary prophylaxis with long-acting granulocyte colony-stimulating factor (G-CSF) reduced the risk of febrile neutropenia-related hospitalization in DLBCL patients receiving R-CHOP, but did not benefit survival.
ANNALS OF HEMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
Summary: The aim of this study was to investigate the mechanism by which SGLT2 inhibitors reduce steatosis in NASH patients. The results showed that SGLT2 expression and O-GlcNAcylation were increased in the livers of NASH patients. In vitro and in vivo experiments demonstrated that SGLT2 inhibitor treatment reduced hepatocellular glucose uptake and promoted autophagy, leading to alleviation of lipid accumulation, inflammation, and fibrosis in NASH.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Correction
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Seong Gyu Choi, Minsuk Oh, Dong-Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study compares the prediction performance of machine learning-based undiagnosed diabetes prediction models and traditional statistics-based prediction models. The results show that the machine learning-based models have higher AUC values when using features such as sex, age, and waist circumference. Similarly, when additional features including family history of diabetes, hypertension, alcohol consumption, and smoking status are included, the machine learning-based models still outperform the traditional statistics-based models. The study concludes that machine learning-based prediction models using anthropometric and lifestyle measurements may be more accurate in predicting undiagnosed diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Hyung-Bok Park, Reza Arsanjani, Sung-Jin Hong, Jee-Jeon Yi, Sang-Wook Yi
Summary: This study aimed to investigate the association between TG levels and CVD mortality, taking into account LDL-C and age in the general population. The results showed a clear log-linear association between TG levels and overall CVD mortality, with higher TG levels increasing the risk of CVD mortality. This association remained present in individuals with low LDL-C levels. The younger population showed stronger associations between TG levels and mortality from overall CVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The mitochondrial-derived peptide SHLP2 plays a crucial role in energy homeostasis by activating hypothalamic neurons and binding to CXCR7. It protects against obesity and improves insulin sensitivity in mice fed a high-fat diet.
NATURE COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Antoine Behr, Julia Salleron, Charles Mazeaud, Clement Larose, Andrea Dagry, Beverley Balkau, Jacques Hubert, Pascal Eschwege
Summary: This study evaluated the three most commonly used surgical treatments for medium-sized benign prostatic hyperplasia (BPH) in France: transurethral resection of the prostate (TURP), Holmium Laser Enucleation of the Prostate (HoLEP), and laser vaporization procedures. The study found that laser vaporization techniques resulted in fewer complications. However, the study only documented complications during hospitalizations.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Endocrinology & Metabolism
Yong-Joon Lee, Sang-Hyup Lee, Seng Chan You, Yong-ho Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The study evaluated the safety and efficacy of a moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease. The combination therapy showed comparable cardiovascular benefits with lower drug intolerance and low-density lipoprotein cholesterol levels compared to monotherapy, but no significant difference in new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
