Article
Endocrinology & Metabolism
Ri Liu, Lishu Gao, Lu Guo, Wenqi Xu, Shouling Wu, Dehu Tian
Summary: This study investigates the impact of FPG variability on osteoporotic fractures in the community population. By analyzing participants from three consecutive surveys, it is found that increased FPG variability is associated with an increased risk of osteoporotic fractures.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Mengyin Wu, Jieming Lu, Zongming Yang, Peng Shen, Zhebin Yu, Mengling Tang, Mingjuan Jin, Hongbo Lin, Kun Chen, Jianbing Wang
Summary: Our study found that long-term fluctuation of FPG was significantly associated with the risk of total and cancer mortality. The findings suggest that long-term fluctuation of FPG could be used as an efficient indicator for predicting the subsequent risk of mortality.
Article
Endocrinology & Metabolism
Jung A. Kim, Ji Sung Lee, Eyun Song, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
Summary: This study examined the relationship between fasting plasma glucose variability and osteoporotic fractures in individuals without diabetes using a nationwide cohort database. The results suggest that FPG variability may be an independent risk factor for osteoporotic fractures in the general population without diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jung A. Kim, Ji Sung Lee, Eyun Song, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
Summary: Although previous studies have linked long-term glucose variability to osteoporosis, this study is the first to investigate the relationship between glucose variability and fractures in individuals without diabetes. The results suggest that fasting plasma glucose variability may be an independent risk factor for osteoporotic fractures in the general population without diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Hye Soo Chung, Soon Young Hwang, Jung A. Kim, Eun Roh, Hye Jin Yoo, Sei Hyun Baik, Nan Hee Kim, Ji A. Seo, Sin Gon Kim, Nam Hoon Kim, Kyung Mook Choi
Summary: This study evaluated the impact of long-term glycemic variability on the risk of developing peripheral artery disease (PAD) in a general population without diabetes. The results showed that increased long-term glycemic variability significantly increased the risk of PAD, with a stronger effect in younger individuals, regular exercisers, and those with higher income.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Jingyi Lu, Chunfang Wang, Jinghao Cai, Yun Shen, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Gang Hu, Tian Xia, Jian Zhou
Summary: The relationship between HbA1c and all-cause mortality among patients with type 2 diabetes varies depending on the degree of glycemic variability. In patients with high glycemic variability, HbA1c may not be a robust marker of mortality, suggesting the need for new metrics for better diabetes management in these individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wanlu Li, Chi Pang Wen, Wenyuan Li, Zhijun Ying, Sai Pan, Yizhan Li, Zecheng Zhu, Min Yang, Huakang Tu, Yi Guo, Zhenya Song, David Ta-Wei Chu, Xifeng Wu
Summary: This study found that long-term increasing fasting plasma glucose (FPG) levels were associated with increased risk of mortality, especially among individuals with normal FPG levels at baseline. Adopting healthy lifestyle factors may prevent the occurrence of increasing FPG trajectories.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cardiac & Cardiovascular Systems
Kongyong Cui, Rui Fu, Jingang Yang, Haiyan Xu, Dong Yin, Weihua Song, Hongjian Wang, Chenggang Zhu, Lei Feng, Zhifang Wang, Qingsheng Wang, Ye Lu, Kefei Dou, Yuejin Yang, CAMI Registry Investigators
Summary: This study found that both fasting stress hyperglycemia ratio (SHR) and fasting plasma glucose (FPG) were strongly associated with in-hospital mortality in patients with acute myocardial infarction (AMI), regardless of diabetes status. Therefore, fasting SHR and FPG could be considered as useful markers for risk stratification in AMI patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ping Wang, Yuanfeng Zhang, Ruiqi Shan, Jing Wu, Sailimai Man, Yuhan Deng, Jun Lv, Xiaona Wang, Jianchun Yin, Yi Ning, Bo Wang, Liming Li
Summary: This study investigates the association between the trajectories of fasting plasma glucose (FPG) and osteoporosis risk for non-diabetic and diabetic populations. The findings indicate that distinct FPG trajectories are associated with differential risk of osteoporosis in these populations. Controlling a proper FPG level is necessary for osteoporosis prevention.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Jiji Xu, Ling Li, Shuangqing Huang, Haihong Song, Jinli Gao, Hengru Ni, Hong Lin, Shuangyuan Wang, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Jieli Lu, Yufang Bi, Yu Xu, Xiaozhong Qian
Summary: The study revealed a significant association between visit-to-visit variability in fasting plasma glucose and the risk of diabetes in Chinese adults, which was partially mediated by changes in insulin resistance.
JOURNAL OF DIABETES
(2022)
Article
Cardiac & Cardiovascular Systems
Karim Kohansal, Soroush Masrouri, Davood Khalili, Azra Ramezankhani, Fereidoun Azizi, Michael J. Blaha, Farzad Hadaegh
Summary: This study aimed to assess the gender-specific impact of 3-year changes in fasting plasma glucose (FPG) status on the risk of all-cause, cardiovascular (CV), and cancer mortality. The findings showed that women with any change in FPG status, except IFG-NFG, had a higher risk of all-cause mortality compared to those with a stable normal FPG status. In contrast, among men, only the conversion to T2DM was associated with an increased risk of all-cause mortality.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
H. Xu, Y. Zhang, W. Xu, L. Chen, M. Zhang, H. Su, Y. Cheng, N. Zhao, D. Xu, G. Qin
Summary: The study revealed that in people with type 2 diabetes, variability in visit-to-visit fasting glucose may be a more sensitive predictor of risk of death than mean fasting glucose.
DIABETES & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Xingyun Zhu, Chu Lin, Li Li, Suiyuan Hu, Xiaoling Cai, Linong Ji
Summary: SGLT2 inhibitors treatment increases plasma fasting glucagon levels in patients with diabetes, potentially leading to reduced insulin levels and elevated ketone body levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jian Liu, Yuhua Ma, Geping Yu, Weiming Wang
Summary: The study aimed to investigate the association between longitudinal changing patterns of fasting plasma glucose (FPG) and kidney function change in the general population. The results showed that discrete FPG trajectories were significantly associated with the risk of fast decline in kidney function, particularly among individuals with long-term normal blood glucose levels.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Agyei Helena Lartey, Xiaona Li, Zhongqi Li, Qun Zhang, Jianming Wang
Summary: The study found that fasting plasma glucose (FPG) variability is influenced by age and sex, with males showing 34.1% higher variability compared to females. Variability also differs across age groups, with significant effects observed for month and date interactions. Intervention strategies should target specific age groups and sexes to optimize FPG control and reduce the risk of diabetes and cardiovascular events.
Article
Nutrition & Dietetics
Chia-Lin Lee, Wei-Ju Liu, Jun-Sing Wang
Summary: The study found that diurnal calorie trajectory was associated with all-cause mortality, with a higher risk of mortality linked to a high-calorie trajectory. Further investigation on the impact of a large meal on mortality is warranted.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Chia-Lin Lee, Wei-Ju Liu, Jun-Sing Wang
Summary: This study utilizing NHANES data found that low-carbohydrate and low-fat diets were associated with reduced all-cause mortality in individuals with prediabetes, particularly in those with lower insulin resistance.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Jun-Sing Wang, I-Te Lee, Wen-Jane Lee, Shih-Yi Lin, Wen-Lieng Lee, Kae-Woei Liang, Wayne Huey-Herng Sheu
Summary: The study investigated the association between postchallenge glucose increment and hemoglobin glycation index (HGI) in subjects with no history of diabetes. It found that the 2-hour glucose increment after an OGTT was independently associated with HGI, suggesting that postchallenge glucose increment may have predictive value for diabetes in this population.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Review
Endocrinology & Metabolism
Jun-Sing Wang, Fu-Shun Yen, Kun-Der Lin, Shyi-Jang Shin, Yueh-Han Hsu, Chih-Cheng Hsu
Summary: DKD is a critical microvascular complication of diabetes, with increasing prevalence especially among individuals with type 2 diabetes in Taiwan. Risk factors for DKD development include age, race, family history, hyperglycemia, hypertension, dyslipidemia, dietary patterns, and lifestyles. Improving kidney care and prognosis of DKD in Asian populations is essential based on updated epidemiological features.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Genetics & Heredity
Wen-Jane Lee, Han-Ni Chuang, Yi-Ming Chen, Kae-Woei Liang, Hsin Tung, Jun-Peng Chen, I-Te Lee, Jun-Sing Wang, Ching-Heng Lin, Hsueh-Ju Lin, Wayne Huey-Herng Sheu, Wen-Lieng Lee, Tzu-Hung Hsiao
Summary: The study found that individuals with FH genetic variations who underwent coronary angiography had a significantly higher risk of CAD and early CAD, despite similar LDL cholesterol levels. Additionally, FH genetic variation carriers underwent more revascularization procedures after a mean follow-up of 6.1 years.
Article
Nutrition & Dietetics
Meng-Chun Lu, I-Te Lee, Ling-Zong Hong, Eyal Ben-Arie, Yu-Hsuan Lin, Wei-Ting Lin, Pei-Yu Kao, Mei-Due Yang, Yin-Ching Chan
Summary: The study found that coffeeberry can protect the liver through multiple pathways, including reducing oxidative stress, regulating the CaMKII/CREB/BDNF pathway, and improving autophagic and apoptotic expressions.
Article
Nutrition & Dietetics
Chih-Yun Chang, Chia-Lin Lee, Wei-Ju Liu, Jun-Sing Wang
Summary: This study investigated the relationship between adherence to the Mediterranean diet and all-cause and cardiovascular mortality in heart failure patients. The findings suggest that adherence to the Mediterranean diet is not associated with a lower risk of all-cause and cardiovascular mortality. A lower intake of red/processed meat was found to be associated with a higher risk of mortality, which requires further investigation.
Article
Environmental Sciences
Chung-Mao Kao, Jun-Sing Wang, Wei-Li Ho, Tai-Ming Ko, Hsian-Min Chen, Ching-Heng Lin, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study investigated potential risk factors for major adverse cardiovascular events (MACE) in newly diagnosed patients with ankylosing spondylitis (AS) receiving medical therapy. The results showed that residence in rural regions, well-known associated comorbidities, and the use of corticosteroids and selective COX-2 inhibitors were associated with MACE development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Wen-Chien Wang, Yun-Che Wu, Yu-Hsien Lin, Yu-Tsung Lin, Kun-Hui Chen, Chien-Chou Pan, Jun-Sing Wang, Cheng-Hung Lee
Summary: The study found that in patients undergoing vertebroplasty, a BMI >= 25 kg/m2 was associated with a lower risk of mortality, while a low BMI (<22 kg/m2) may be a risk factor for postoperative long-term mortality in this aging population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hsuan Li, Min-Huan Wu, Wen-Jane Lee, I-Te Lee
Summary: This study found that there is a synergistic effect between high plasma DKK-1 levels and obstructive CAD in predicting MACEs in patients with angina.
Article
Medicine, General & Internal
Chun-Ting Fan, Shih-Tien Hsu, Lou Sun, Sheau-Feng Hwang, Chih-Ku Liu, Yu-Hsiang Shih, Ming-Jer Chen, Hsin-Ni Li, Jun-Sing Wang, Mei-Chin Wen, Chien-Hsing Lu
Summary: Tumor-infiltrating lymphocytes (TILs) have a prognostic role in endometrial cancer (EC), but their role in EC with different histology grades and molecular types is unclear. This study included 237 patients with primary EC and evaluated TILs using a standardized method. The results showed that TILs were not associated with disease progression in EC overall, but were associated with better progression-free survival in high-grade EC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yu-Tsung Lin, Jun-Sing Wang, Wei-En Hsu, Yu-Hsien Lin, Yun-Che Wu, Kun-Hui Chen, Chien-Chou Pan, Cheng-Hung Lee
Summary: This study aimed to investigate the relationship between quantitative anatomic parameters in MRI and patient-reported outcomes in degenerative lumbar foraminal stenosis. It included 58 patients who underwent surgery for this condition. The findings showed that decreased superior foraminal width was significantly associated with better improvement in disability and quality of life at the one-year follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Yu-Cheng Cheng, Yu-Hsuan Li, Hsiu-Chen Liu, Chiann-Yi Hsu, Wan-Jen Chang, I-Te Lee, Chin-Li Lu
Summary: This retrospective cohort study examined the changes of HbA1c levels in adults with type 2 diabetes before and after the COVID-19 lockdown in Taiwan. The results showed that HbA1c levels were significantly lower after the lockdown in 2019, 2020, and 2021. However, the absolute seasonal reduction in HbA1c during the COVID-19 pandemic was slightly less compared to the year without COVID-19.
Article
Microbiology
Hsueh-Ju Lin, Han-Ni Chuang, Pei-Pei Jhan, Han-Yu Ye, I-Te Lee, Tzu-Hung Hsiao, Po-Yu Liu
Summary: This study investigated the urinary microbiome of Taiwanese T2D patients undergoing treatment with SGLT2 inhibitors. The results showed that patients with pyuria had lower diversity and dominated by Escherichia-Shigella spp. These findings suggest an association between pyuria and dysbiosis of the urinary microbiota in T2D patients.
MICROBIOLOGY RESEARCH
(2023)
Article
Hematology
Wayne Huey-Herng Sheu, Keng-Hung Lin, Jun-Sing Wang, De-Wei Lai, Wen-Jane Lee, Fu-Yu Lin, Po-Hsun Chen, Cheng-Hsu Chen, Hsiang-Yu Yeh, Sheng-Mao Wu, Chin-Chang Shen, Maw-Rong Lee, Shing-Hwa Liu, Meei-Ling Sheu
Summary: The study demonstrates that the inhibition of Tpl2 can effectively block inflammation and vascular abnormalities in diabetic retinopathy, which has potential therapeutic implications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)