Article
Ophthalmology
Yoko Ogawa, Reza Dana, Stella Kim, Sandeep Jain, Mark I. Rosenblatt, Victor L. Perez, Janine A. Clayton, Monica Alves, Eduardo Melani Rocha, Francisco Amparo, Kyoung Yul Seo, Yan Wang, Joanne Shen, Joo Youn Oh, Murugesan Vanathi, Sridevi Nair, Kyung-Sun Na, Anjo Riemens, Kimberly Sippel, Matias Soifer, Shudan Wang, Marilia Trindade, Mee Kum Kim, Chang Ho Yoon, Ryuichiro Yagi, Ryo Hiratsuka, Mamoru Ogawa, Eisuke Shimizu, Yasunori Sato, Stephen Pflugfelder, Kazuo Tsubota
Summary: The study validates the consistency between ICCGVHD and NIH2014 in the diagnosis of chronic ocular GVHD. ICCGVHD score =6 can be useful in diagnosing ocular GVHD with or without systemic GVHD for clinical research.
Article
Clinical Neurology
Magnus Spangsberg Boesen, Morten Blinkenberg, Lau Caspar Thygesen, Jurgita Ilginiene, Annika Reynberg Langkilde
Summary: This study investigated the use of MRI to differentiate pediatric MS from ADEM and validated different MRI criteria. The results showed that specific MRI features can accurately distinguish between these two diseases.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Magnus Spangsberg Boesen, Annika Reynberg Langkilde, Jurgita Ilginiene, Melinda Magyari, Morten Blinkenberg
Summary: The aim of this study was to propose criteria for distinguishing multiple sclerosis (MS) from acute disseminated encephalomyelitis (ADEM) at onset based on age, sex, cerebrospinal fluid (CSF)-specific oligoclonal bands, and MRI. The study found that combining sex, age at onset, CSF-specific oligoclonal bands, and MRI provides highly reliable differentiation between pediatric MS and monophasic ADEM at onset.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Li Zhang, Andre L. Carvalho, Isabel Mosquera, Tianmeng Wen, Eric Lucas, Catherine Sauvaget, Richard Muwonge, Marc Arbyn, Elisabete Weiderpass, Partha Basu
Summary: By using a systematic review and Delphi process, this study established international consensus on the essential and desirable criteria for organized cancer screening. These harmonized criteria will serve as a guide for program managers and policymakers to prioritize interventions and resources, moving away from the simplistic approach of categorizing programs as organized or non-organized.
Article
Nursing
Susannah Brady, Fiona Bogossian, Kristen S. Gibbons
Summary: This study provides an in-depth understanding of how midwives worldwide perceive and practice woman-centred care. The findings will contribute to the development of an internationally informed evidence-based definition of woman-centred care.
Article
Allergy
Paul Leong, Anne E. Vertigan, Mark Hew, Malcolm Baxter, Debra Phyland, James H. Hull, Thomas L. Carroll, Peter G. Gibson, Vanessa M. McDonald, Thomas Halvorsen, Hege Havstad Clemm, Maria Vollsaeter, Ola Drange Roksund, Philip G. Bardin
Summary: This Delphi study achieved consensus on multiple aspects of VCD/ILO diagnosis, providing guidance for clinical practice and facilitating further research.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Anesthesiology
Milda Chmieliauskaite, Elisabeth A. Stelson, Joel B. Epstein, Gary D. Klasser, Arwa Farag, Barbara Carey, Rui Albuquerque, Lina Mejia, Anura Ariyawardana, Cibele Nasri-Heir, Andrea Sardella, Charles Carlson, Craig S. Miller
Summary: This study utilized the Delphi method to determine revisions in nomenclature and identify areas of consensus among experts for changes to the disease description and proposed diagnostic criteria of BMS under ICD-11. Consensus was reached for renaming BMS to burning mouth disorder, deletion of two diagnostic criteria, and clarifying the disease definition. Experts also recommended more separate diagnostic criteria and evaluation of potential secondary causes for oral burning. The revisions have the potential to improve diagnosis accuracy for this disorder.
Article
Pediatrics
Loren A. McLendon, Chethan K. Rao, Cintia Carla Da Hora, Florinda Islamovic, Fernando N. Galan
Summary: This study reported the youngest case of postinfectious ADEM due to SARS-CoV-2 in a toddler, with full neurologic recovery after treatment. Early recognition of autoimmune and inflammatory complications is crucial for aggressive immunomodulatory treatment and improved outcomes in SARS-CoV-2 patients.
Article
Immunology
Shuwen Deng, Ke Qiu, Ranran Tu, Haiping Zheng, Wei Lu
Summary: This study investigated the potential role of immune changes and activation of the HMGB1/TLR4/Nf-kappa B/IL-6 pathway at the maternal-fetal interface in the pathogenesis of pregnancy-related ADEM. The results showed increased expression levels of HMGB1, TLR4, Nf-kappa B, AQP4, and IL-6 in the patient with pregnancy-related ADEM compared to a woman with a normal pregnancy, indicating a potential association between local immune changes and ADEM pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Omar Abdel-Mannan, Michael Absoud, Christina Benetou, Helga Hickson, Cheryl Hemingway, Ming Lim, Sukhvir Wright, Yael Hacohen, Evangeline Wassmer
Summary: The majority of acquired demyelinating syndromes (ADS) presentations in children are monophasic, even at 10-year follow-up. It is important to extensively investigate multiple sclerosis and central nervous system autoantibody mimics given the implications for treatment strategies.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Clinical Neurology
Jonathan D. Santoro, Lina Patel, Ryan Kammeyer, Robyn A. Filipink, Grace Y. Gombolay, Kathleen M. Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L. Santoro, Sammer M. Marzouk, Mellad Khoshnood, Benjamin N. Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A. Stanley, Jessica S. Sanders, Alison Christy, Elise M. Sannar, Ruth Brown, Andrew A. McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A. Quinn, George T. Capone, Brian Chicoine, Brian G. Skotko, Michael S. Rafii
Summary: There is a lack of standardization in the evaluation and diagnosis of neurocognitive regression in Down syndrome. This study presents international consensus agreement on the nomenclature, diagnostic work up, and diagnostic criteria for this condition, providing a practical framework for future research and clinical practices.
FRONTIERS IN NEUROLOGY
(2022)
Review
Gastroenterology & Hepatology
Lucas Guillo, Maria Abreu, Remo Panaccione, William J. Sandborn, Valderilio F. Azevedo, Lianne Gensler, Bahar Moghaddam, Vineet Ahuja, Sabrina A. Ali, Matthieu Allez, Ashwin N. Ananthakrishnan, Abhik Bhattacharya, Marla Dubinsky, Anne Griffiths, Ailsa Hart, Burton Korelitz, Paulo G. Kotze, Iommaso E. Koutroubakis, Peter L. Lakatos, James O. Lindsay, Fernando Magro, Gerassimos J. Mantzaris, Slew C. Ng, Cohn O'Morain, Julian Panes, Tom Maso Parigi, Zhihua Ran, Gerhard Rogler, David T. Rubin, David B. Sachar, Britta Siegmund, Flavio Steinwurz, Curt Tysk, Stephan Vavricka, Sofa G. Verstraete, Antoine P. Brezin, Anna K. Haemel, Axel Dignass, Bruce E. Sands, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Extraintestinal manifestations are common in patients with inflammatory bowel disease and pose challenges for diagnosis and treatment. The EXTRA initiative aims to achieve international consensus on assessing these manifestations in clinical trials. A panel of experts identified methods for diagnosing extraintestinal manifestations and measuring treatment outcomes. They recommend specialist expertise for confirming the diagnosis in most cases, except for axial spondyloarthritis where typical symptoms and MRI can be sufficient. Easy-to-measure endpoints were identified for assessing treatment response without specialist involvement. Guidelines were proposed for comprehensive evaluation of extraintestinal manifestations in future trials.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mohammed Eslam, Naim Alkhouri, Pietro Vajro, Ulrich Baumann, Ram Weiss, Piotr Socha, Claude Marcus, Way Seah Lee, Deirdre Kelly, Gilda Porta, Mohamed A. El-Guindi, Anna Alisi, Jake P. Mann, Nezha Mouane, Louise A. Baur, Anil Dhawan, Jacob George
Summary: The proposed framework for pediatric fatty liver diseases includes an age-appropriate MAFLD definition based on sex and age percentiles, recognizing the possibility of other coexisting systemic fatty liver diseases in children. This new MAFLD diagnostic criteria provide pediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, aligning with a definition that is valid across the lifespan.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Clinical Neurology
Ruth Leadbetter, Michael MacAskill, Daniell J. Myall, Bruce Taylor, Purwa Joshi, Deborah F. Mason
Summary: A long-term study on multiple sclerosis patients in New Zealand found that their median survival age is 7.2 years lower than the general population and they have twice the mortality risk. The survival gap is greater for those with an early age of onset and progressive-onset disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Dominique Belpomme, George L. Carlo, Philippe Irigaray, David O. Carpenter, Lennart Hardell, Michael Kundi, Igor Belyaev, Magda Havas, Franz Adlkofer, Gunnar Heuser, Anthony B. Miller, Daniela Caccamo, Chiara De Luca, Lebrecht von Klitzing, Martin L. Pall, Priyanka Bandara, Yael Stein, Cindy Sage, Morando Soffritti, Devra Davis, Joel M. Moskowitz, S. M. J. Mortazavi, Martha R. Herbert, Hanns Moshammer, Gerard Ledoigt, Robert Turner, Anthony Tweedale, Pilar Munoz-Calero, Iris Udasin, Tarmo Koppel, Ernesto Burgio, Andre Vander Vorst
Summary: Clinical research is crucial in objectively identifying diseases and establishing diagnostic criteria. Provocation tests may not investigate the causal origin of electrohypersensitivity (EHS), but EMF exposure could still play a role as a symptomatic trigger.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Mette Sorensen, Ulla Arthur Hvidtfeldt, Aslak Harbo Poulsen, Lau Caspar Thygesen, Lise Marie Frohn, Jibran Khan, Ole Raaschou-Nielsen
Summary: This study found an association between transportation noise and higher risk of diabetes. The study relied on register-based confounder adjustment and aimed to investigate the effects of increasing confounder adjustment on the association between noise and type 2 diabetes.
ENVIRONMENTAL RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Juanita A. Haagsma, Lea S. Jakobsen, Vanessa Gorasso, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, Joao Vasco Santos, Scott A. McDonald, Dietrich Plass, Grant M. A. Wyper, Ricardo Assuncao, Elena von der Lippe, Balazs Adam, Ala'a AlKerwi, Jalal Arabloo, Ana Lucia Baltazar, Boris Bikbov, Maria Borrell-Pages, Iris Brus, Genc Burazeri, Serafeim C. Chaintoutis, Jose Chen-Xu, Nino Chkhaberidze, Seila Cilovic-Lagarija, Barbara Corso, Sarah Cuschieri, Carlotta Di Bari, Keren Dopelt, Mary Economou, Theophilus Emeto, Peter Fantke, Florian Fischer, Alberto Freitas, Juan Manuel Garcia-Gonzalez, Federica Gazzelloni, Mika Gissler, Artemis Gkitakou, Hakan Gulmez, Sezgin Gunes, Sebastian Haller, Romana Haneef, Cesar A. Hincapie, Paul Hynds, Jane Idavain, Milena Ilic, Irena Ilic, Gaetano Isola, Zubair Kabir, Maria Kamusheva, Pavel Kolkhir, Naime Meric Konar, Polychronis Kostoulas, Mukhtar Kulimbet, Carlo La Vecchia, Paolo Lauriola, Miriam Levi, Marjeta Majer, Enkeleint A. Mechili, Lorenzo Monasta, Stefania Mondello, Javier Munoz Laguna, Evangelia Nena, Edmond S. W. Ng, Paul Nguewa, Vikram Niranjan, Iskra Alexandra Nola, Ronan O'Caoimh, Marija Obradovic, Elena Pallari, Mariana Peyroteo, Vera Pinheiro, Nurka Pranjic, Miguel Reina Ortiz, Silvia Riva, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Tugce Schmitt, Niko Speybroeck, Maximilian Sprugel, Paschalis Steiropoulos, Aleksandar Stevanovic, Lau Caspar Thygesen, Fimka Tozija, Brigid Unim, Hilal Bektas Uysal, Orsolya Varga, Milena Vasic, Rafael Jose Vieira, Vahit Yigit, Brecht Devleesschauwer, Sara M. Pires
Summary: This systematic literature review provides an overview of studies applying the disability-adjusted life years (DALY) concept for infectious diseases in European countries. Among the 105 included studies, food- and water-borne diseases were the most frequently studied. The number of burden of infectious disease studies has increased over time, but there is less consensus in methodological approaches.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Pediatrics
Selina K. K. Berg, Nina M. M. Birk, Anne B. B. Thorsted, Siri Rosenkilde, Louise B. B. Jensen, Ulrikka Nygaard, Henning Bundgaard, Lau C. C. Thygesen, Annette K. K. Ersboll, Susanne D. D. Nielsen, Anne V. V. Christensen
Summary: This study investigated the risk of weight changes among Danish children during the COVID-19 pandemic and explored the associations with psychological symptoms and long COVID symptoms. The results showed that 2-3-year-old children with COVID-19 had a higher likelihood of weight loss, while 4-18-year-old children had a lower likelihood of unintended weight gain. Any long COVID-related symptom was associated with weight changes regardless of COVID-19 status. There was no evidence of increasing obesity rates among Danish children post-pandemic.
Article
Clinical Neurology
Zsofia Kokas, Anett Jardanhazy, Daniel Sandi, Tamas Biernacki, Zsanett Fricska-Nagy, Judit Fuvesi, Halina Bartosik-Psujek, Vanja Basic Kes, Thomas Berger, Achim Berthele, Jelena Drulovic, Bernhard Hemmer, Dana Horakova, Alenka Horvat Ledinek, Eva Kubala Havrdova, Melinda Magyari, Konrad Rejdak, Cristina Tiu, Peter Turcani, Peter Klivenyi, Zsigmond Tamas Kincses, Laszlo Vecsei, Krisztina Bencsik
Summary: In most Central-Eastern European countries, the recommendations for multiple sclerosis (MS) care units are met, but there are still some deficiencies, such as the lack of speech therapists, specialists for continence, pain and spasticity, neuro-ophthalmologists, and otoneurologists. Although multiple disease-modifying therapies (DMTs) are reimbursed, not every center provides all available DMTs. Additionally, only Austria and the Czech Republic require national registry use. Therefore, in countries where MSCU recommendations are not fulfilled, a strictly regulated center system similar to the Austrian and Czech model, with a registry-based quality control, may ensure appropriate care for MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Trine Allerslev Horsbol, Susan Ishy Michelsen, Tina Harmer Lassen, Knud Juel, Janne Bigaard, Christina Engel Hoei-Hansen, Ilse Vejborg, Lau Caspar Thygesen
Summary: This study examined participation in the Danish national breast cancer screening program among women with intellectual disability (ID) and found that women with ID were significantly less likely to participate compared with women without ID. The findings suggest a need for tailored guidelines and approaches for breast cancer screening in this group of women.
Article
Education, Special
Lau Caspar Thygesen, Tina Harmer Lassen, Trine Allerslev Horsbol, Isabelle Pascale Mairey, Knud Juel, Christina Engel Hoei-Hansen, Susan Ishoy Michelsen
Summary: This study establishes a nationwide Danish cohort of persons with intellectual disability and compares their mortality patterns to a reference cohort. The findings show that individuals with intellectual disability have higher mortality rates, particularly among younger people and females. Life expectancies are significantly lower for people with intellectual disability compared to the reference cohort, and decrease with severity of intellectual disability.
JOURNAL OF INTELLECTUAL DISABILITIES
(2023)
Article
Public, Environmental & Occupational Health
Simone G. Kjeld, Lau C. Thygesen, Dina Danielsen, Gitte S. Jakobsen, Marie P. Jensen, Teresa Holmberg, Lotus S. Bast, Lisbeth Lund, Charlotta Pisinger, Susan Andersen
Summary: This study examined the effects of a school-based multi-component intervention on students' smoking behavior. The overall intervention did not show significant effects, but significant reduction in smoking was found in certain subgroups. The study suggests the need to develop relevant intervention programs for high-risk groups and ensure their full implementation.
Review
Health Care Sciences & Services
Graziella Zangger, Alessio Bricca, Behnam Liaghat, Carsten B. Juhl, Sofie Rath Mortensen, Rune Martens Andersen, Camma Damsted, Trine Gronbek Hamborg, Mathias Ried-Larsen, Lars Hermann Tang, Lau Caspar Thygesen, Soren T. Skou
Summary: This systematic review and meta-analysis aimed to investigate the benefits and harms of digital health interventions in promoting physical activity in people with chronic conditions. The study found that digital health interventions can increase objectively measured physical activity and improve physical function in individuals with chronic conditions, but the effects on depression, anxiety, and health-related quality of life were only observed at the end of the intervention.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Christine A. Mair, Lau C. Thygesen, Melissa Aldridge, Djin L. Tay, Katherine A. Ornstein
Summary: The population of older adults who are unpartnered and childless (i.e., kinless) is increasing globally, but little research exists on their end-of-life experiences. This study examines the associations between family structure and intensity of end-of-life experiences among kinless older adults in Denmark.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Psychiatry
Lau Caspar Thygesen, Siri Rosenkilde, Sanne Pagh Moller, Annette Kjaer Ersboll, Ziggi Ivan Santini, Maj Britt Dahl Nielsen, Morten Klocker Gronbaek, Ola Ekholm
Summary: Numerous studies have shown that the COVID-19 pandemic had a large influence on mental health during the first lockdown. In a national longitudinal study, the researchers examined mental well-being before and during the pandemic and found that mental well-being decreased from 2019 to 2020 and slightly increased from 2020 to 2021 without reaching the pre-pandemic level. The changes are statistically significant but small, suggesting that COVID-19 may only have had a small long-term influence on mental health in the general population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Ziggi Ivan Santini, Lau Caspar Thygesen, Steinar Krokstad, Lars Ole Bonde, Robert J. Donovan, Vibeke Koushede, Anita Jensen, Ai Koyanagi, Ola Ekholm
Summary: This study aims to assess the associations between engagement in arts and culture activities and incident/persistent depression as well as mental wellbeing among Danish adults. The results showed a negative correlation between engagement in arts and culture activities and the risk of incident and persistent depression, as well as higher odds for moderate mental wellbeing.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Oncology
Heidi Amalie Rosendahl Jensen, Trine Allerslev Horsbol, Lau Caspar Thygesen, Michael Davidsen, Anne Illemann Christensen, Ola Ekholm
Summary: This study examines the accuracy of self-reported cancer history and its negative predictive value using registry data as the criterion standard. The results show that the negative predictive value is consistently high, but sensitivity varies greatly across different cancer types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
Louise Bering, Anne Vinggaard Christensen, Nina Marie Birk, Lau Caspar Thygesen, Henning Bundgaard, Thomas Benfield, Ulrikka Nygaard, Jesper Johannesen, Susanne Dam Nielsen, Selina Kikkenborg Berg
Summary: This nationwide matched cohort study investigated the association between SARS-CoV-2 infection and new-onset type 1 diabetes (T1D) in children and adolescents. The study found that the risk of new-onset T1D in children and adolescents was not significantly increased after SARS-CoV-2 infection within 6 months.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Clinical Neurology
Josefine Windfeld-Mathiasen, Henrik Horwitz, Johanna Balslev Andersen, Elisabeth Framke, Christina Gade, Jon Traerup Andersen, Melinda Magyari
Summary: This retrospective matched cohort study investigated the impact of exposure to interferon-beta during pregnancy on the risk of significant infections in early childhood. The study included 510 children born to mothers with multiple sclerosis who were exposed to interferon-beta in utero. The results showed that exposure to interferon-beta had little to no impact on the risk of acquiring significant infections during the first five years of childhood.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Sanne Pagh Moller, Andrea Willson, Lau Caspar Thygesen
Summary: This study aims to identify different trajectories of healthcare utilization and social inequalities among different population groups. The study found five trajectory groups, with higher utilization groups showing more social inequalities in terms of parental education, income, and employment.
PREVENTIVE MEDICINE
(2023)