Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Matus Coma, Veronika Lachova, Petra Mitrengova, Peter Gal
Summary: Estrogen plays a complex role in wound healing and cancer, with current research focusing on naturally occurring SERMs. By utilizing natural products isolated from plants, such as genistein in soy, as potential alternatives, tissue-specific effects can be achieved in a promising manner.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Kai-Wen Zhang, Yuan Jia, Yue-Yue Li, Dan-Yang Guo, Xiao-Xiao Li, Kai Hu, Xiao-Xi Qian, Zhong-Hua Chen, Jun-Jie Wu, Zheng-Dong Yuan, Feng-Lai Yuan
Summary: Wound healing is a complex process that can lead to the formation of scars in adults. Leptin and leptin receptors have been found to affect multiple stages of wound healing, but their role in scarless wound healing is paradoxical.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Saige Yin, Ying Wang, Xinwang Yang
Summary: Amphibian-derived wound healing peptides offer new intervention measures and strategies for skin wound tissue regeneration. As novel drug lead molecules, they can help analyze new mechanisms and discover new drug targets.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Nallely Alvarez-Santos, Edgar Antonio Estrella-Parra, Jose del Carmen Benitez-Flores, Rocio Serrano-Parrales, Tomas Ernesto Villamar-Duque, Martha Angelica Santiago-Santiago, Maria del Rosario Gonzalez-Valle, Jose Guillermo Avila-Acevedo, Ana Maria Garcia-Bores
Summary: Wound healing is a crucial physiological process, but it can be hindered by various factors, resulting in scars and chronic wounds. This study found that Asterohyptis stellulata has antibacterial and antioxidant activities, as well as the ability to promote wound closure speed and skin regeneration.
Article
Cell Biology
Qianqian Guo, Zhen Liu, Junjun Zheng, Haiping Zhao, Chunyi Li
Summary: The research suggests that deer antlers' regenerative wound healing process could serve as a model for scar-free healing. Compared to scar healing in rats, regenerative healing of antler wounds showed weaker inflammatory response, lack of myofibroblast induction, and differences in ratios of collagen and growth factors. Additionally, the study demonstrated the therapeutic potential of antler stem cells in promoting wound healing and preventing scar formation across mammalian species.
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kento Takaya, Ayano Sunohara, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Kazuo Kishi
Summary: Multiple transitions occur in the healing ability of the skin during embryonic development in mice. Lhx2 is a regulator involved in the activation and maintenance of hair follicle stem cells. Analysis of surgically wounded mouse embryos revealed that Lhx2 expression is associated with cell division and scar formation.
Review
Biotechnology & Applied Microbiology
Cristiana Oliveira, Diana Sousa, Jose A. Teixeira, Pedro Ferreira-Santos, Claudia M. Botelho
Summary: Skin is an important indicator of health and greatly impacts a person's emotions and behavior. However, conventional wound healing materials often fail to provide sufficient healing, leading to scar formation. Therefore, the development of innovative biomaterials for wound healing is crucial. Both natural and synthetic polymers are extensively used for wound dressings and scaffold production, and their combination shows promising results in accelerating the healing process. This article describes commercially available solutions for skin wound management, explores the design of polymeric biomaterials, and addresses new directions and strategies for personalized care and faster healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Raquel Costa, Luis Costa, Ilda Rodrigues, Catarina Meireles, Raquel Soares, Paula Tamagnini, Rita Mota
Summary: The study suggests that Cyanoflan is a promising biopolymer for innovative applications in skin wound healing, as it does not affect cell viability, apoptosis, migration, or induce oxidative or inflammatory reactions.
Review
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
Summary: Tregs play a critical role in skin wound healing, helping to balance immune homeostasis and promote healthy wound repair. Understanding the function and mechanisms of Tregs is important for understanding wound pathologies and developing new treatment strategies.
MILITARY MEDICAL RESEARCH
(2023)
Review
Critical Care Medicine
Annika S. Walter, Elias Volkmer, Gerd Gauglitz, Wolfgang Boecker, Maximilian M. Saller
Summary: This systematic review summarizes the current knowledge on molecular pathways activated during burn wound healing and identifies key molecules and new research targets.
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Toru Asou, Kazuo Kishi
Summary: Skin wounds in developing mouse fetuses can heal without scar formation, unlike adult mammalian wounds. It has been found that the fibroblast growth factor (FGF) family plays a crucial role in fetal wound healing, with FGF7 potentially being associated with scar formation. Administration of FGF7 can inhibit fibrosis and promote epithelialization, providing a potential therapeutic option for scarless wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Robyn E. Reeve, Kyla Quale, Grace H. Curtis, Erica J. Crespi
Summary: Experimental evidence demonstrates that leptin promotes wound healing in the South African clawed frog, Xenopus laevis, by increasing wound closure rate and reducing bacterial infection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Tetsuya Bando, Hitoshi Yokoyama, Harukazu Nakamura
DEVELOPMENT GROWTH & DIFFERENTIATION
(2018)
Review
Cell Biology
Shinichi Hayashi, Koji Tamura, Hitoshi Yokoyama
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2020)
Review
Cell Biology
Gembu Abe, Toshinori Hayashi, Keigo Yoshida, Takafumi Yoshida, Hidehiro Kudoh, Joe Sakamoto, Ayumi Konishi, Yasuhiro Kamei, Takashi Takeuchi, Koji Tamura, Hitoshi Yokoyama
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Noriyuki Kinoshita, Yutaka Hashimoto, Naoko Yasue, Makoto Suzuki, Ileana M. Cristea, Naoto Ueno
Editorial Material
Cell Biology
Hajime Ogino, Yasuhiro Kamei, Toshinori Hayashi, Joe Sakamoto, Makoto Suzuki, Takeshi Igawa
DEVELOPMENT GROWTH & DIFFERENTIATION
(2021)
Editorial Material
Cell Biology
Hajime Ogino, Yasuhiro Kamei, Toshinori Hayashi, Joe Sakamoto, Makoto Suzuki, Takeshi Igawa
DEVELOPMENT GROWTH & DIFFERENTIATION
(2022)
Editorial Material
Cell Biology
Hajime Ogino, Yasuhiro Kamei, Toshinori Hayashi, Joe Sakamoto, Makoto Suzuki, Takeshi Igawa
DEVELOPMENT GROWTH & DIFFERENTIATION
(2021)
Article
Anatomy & Morphology
Hitoshi Uemasu, Hiromi Ikuta, Takeshi Igawa, Makoto Suzuki, Mitsuki Kyakuno, Yui Iwata, Ichiro Tazawa, Hajime Ogino, Yukio Satoh, Takashi Takeuchi, Noriyuki Namba, Toshinori Hayashi
Summary: Through cryo-injury experiments on newts, we discovered that cardiac tissue can regenerate through changes in gene expression. Compared to the amputation model, the cryo-injury method is more suitable for comparing the process of cardiac regeneration.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Cell Biology
Mikio Tanouchi, Takeshi Igawa, Nanoka Suzuki, Makoto Suzuki, Nusrat Hossain, Haruki Ochi, Hajime Ogino
Summary: The study developed an image analysis technique to evaluate the effectiveness of the CRISPR/Cas9 method for gene disruption in Xenopus laevis. The results suggest that injecting a specific amount of the CRISPR reagent and culturing the embryos at a specific temperature are optimal conditions for achieving high efficiency gene disruption.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2022)
Article
Cell Biology
Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori
Summary: Pattern formation and morphogenesis of cell populations are crucial for successful embryogenesis. This theoretical study examined the effects of area elasticity and the coefficient of friction on pattern formation and morphogenesis, revealing that differential cellular stiffness may contribute to tissue elongation within an expanding environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Riona Ishii, Mana Yoshida, Nanoka Suzuki, Hajime Ogino, Makoto Suzuki
Summary: This study explored the use of X-ray micro-computed tomography (microCT) to observe the three-dimensional soft tissues of Xenopus tadpoles. Major organs such as the brain, heart, and kidneys were visualized with high contrast using phosphotungstic acid staining after fixation. The study also analyzed the regenerative process of the telencephalon in Xenopus tadpoles using microCT, revealing that the amputated telencephalon could recover to over 80% of its original length within approximately 1 week. Temporary shrinkage and subsequent expansion of the ventricles, observed in both amputated and transgenic tadpoles, may play a significant role in tissue homeostasis during brain injury and regeneration.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Editorial Material
Cell Biology
Hajime Ogino, Yasuhiro Kamei, Toshinori Hayashi, Joe Sakamoto, Makoto Suzuki, Takeshi Igawa, Mariko Kondo, Masanori Taira
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Cell Biology
Nusrat Hossain, Takeshi Igawa, Makoto Suzuki, Ichiro Tazawa, Yuta Nakao, Toshinori Hayashi, Nanoka Suzuki, Hajime Ogino
Summary: CRISPR-based genome editing technology has been successfully used to model human genetic diseases in Xenopus tropicalis, but mostly limited to non-syndromic diseases. This study attempted to model the syndromic disease campomelic dysplasia (CD) by generating sox9 crispants in X. tropicalis, which showed various defects in jaw, gill, ear, heart, and gut, recapitulating part of the CD phenotype. These results demonstrate the value of Xenopus crispants for investigating phenotype-genotype relationships and tissue-specific functions of proteins in syndromic diseases.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Kazuki Kitamura, Takayoshi Yamamoto, Haruki Ochi, Makoto Suzuki, Nanoka Suzuki, Takeshi Igawa, Tadashi Yoshida, Mitsuru Futakuchi, Hajime Ogino, Tatsuo Michiue
Summary: This study analyzed the gene expression in tumor tissues of three Xenopus tropicalis individuals and identified 55 differentially expressed genes (DEGs). Gene ontology (GO) analysis showed that the upregulated genes in the tumor tissues were enriched in GO terms related to the extracellular matrix and collagen fibril organization. Hierarchical clustering showed that the gene expression patterns of tumor tissues in X. tropicalis were comparable to those of human connective, soft, and subcutaneous tissue-derived cancers. Pathway analysis revealed that these DEGs were associated with multiple pathways, including the extracellular matrix, collagen fibril organization, MET signaling, and keratan sulfate. The expression tendency of some DEGs that have not been well analyzed in the cancer field clearly determines the prognosis of human cancer patients. This study provides a remarkable reference for future experimental work on X. tropicalis to identify gene sets involved in human cancer.
SCIENTIFIC REPORTS
(2023)