Journal
DEVELOPMENT
Volume 145, Issue 2, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.155879
Keywords
Mesenchymal stem cells; Pdgfr alpha; Brachyury; Sox1; Pmx1 (Prrx1)
Categories
Funding
- Ministry of Health, Labor and Welfare
- Japan Agency for Medical Research and Development (AMED)
- Core Research for Evolutional Science and Technology (CREST)
- Japan Science and Technology Agency (JST)
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Mesenchymal stem cells (MSCs) are somatic stem cells that can be derived from adult bone marrow (BM) and white adipose tissue (WAT), and that display multipotency and self-renewal capacity. Although MSCs are essential for tissue formation and have already been used in clinical therapy, the origins and markers of these cells remain unknown. In this study, we first investigated the developmental process of MSCs in mouse embryos using the gene encoding platelet-derived growth factor receptor alpha (Pdgfra) as a marker. We then traced cells expressing Pdgfra and other genes (brachyury, Sox1 and Pmx1) in various mutant mouse embryos until the adult stage. This tracing of MSC origins and destinies indicates that embryonic MSCs emerge in waves and that almost all adult BM MSCs and WAT MSCs originate from mesoderm and embryonic Pdgfr alpha-positive cells. Furthermore, we demonstrate that adult Pdgfr alpha-positive cells are involved in some pathological conditions.
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