Review
Oncology
Yipeng Xu, Jianmin Lou, Mingke Yu, Yingjun Jiang, Han Xu, Yueyu Huang, Yun Gao, Hua Wang, Guorong Li, Zongping Wang, An Zhao
Summary: Urinary exosomes have great potential as non-invasive biomarkers for diagnosing urological tumors, with high sensitivity and specificity. Further clinical trials are needed to validate and explore their utility in treatment decision-making.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Zicheng Deng, Shengming Wu, Yilong Wang, Donglu Shi
Summary: Circulating tumor cells (CTCs) play a crucial role in cancer diagnosis and prognosis. Current detection technologies have limitations due to tumor heterogeneity, but a new technique using superparamagnetic nanoprobe shows higher sensitivity and biomarker independence.
Review
Biochemistry & Molecular Biology
Alexey S. S. Rzhevskiy, Alina Y. Y. Kapitannikova, Denis V. V. Butnaru, Evgeniy V. V. Shpot, Simon A. A. Joosse, Andrei V. V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Currently, there is a lack of sensitive and specific methods for the detection and prognosis of early stage prostate cancer. Liquid biopsy, a novel technique that extracts biomarkers such as circulating tumor cells, exosomal miRNAs, and circulating DNAs, has been investigated as a supplement or alternative to the traditional screening methods for prostate cancer.
Review
Biochemistry & Molecular Biology
Panagiotis Skouras, Mariam Markouli, Theodosis Kalamatianos, George Stranjalis, Penelope Korkolopoulou, Christina Piperi
Summary: Liquid biopsy is a minimally invasive method for sampling and monitoring gliomas. Compared to tissue biopsy, it is less invasive and provides faster data for diagnosis, prognosis, and recurrence evaluation.
Review
Chemistry, Multidisciplinary
Giusi Alberti, Christian M. Sanchez-Lopez, Alexia Andres, Radha Santonocito, Claudia Campanella, Francesco Cappello, Antonio Marcilla
Summary: Tumor cell-derived extracellular vesicles play a crucial role in cancer metastasis by modulating the tumor microenvironment, suppressing the immune system, and forming pre-metastatic niches. These EVs, easily isolated from various biological fluids, serve as valuable biomarkers for cancer diagnosis, prognosis, monitoring cancer progression, and treatment response.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Swarna Ganesh, Priya Dharmalingam, Sunit Das, Krishnan Venkatakrishnan, Bo Tan
Summary: Lung cancer is a common and deadly disease, and accurate diagnosis of cancerous lesions is a challenge due to the lack of sensitive biomarkers. In this study, researchers developed an ultrasensitive nanosensor to detect specific immune-diagnostic signatures and achieved highly accurate diagnosis of lung cancer using T cells. This research shows the potential of immune diagnosis as a clinical technology for cancer management.
Review
Oncology
Shiyu Li, Ming Yi, Bing Dong, Ximin Tan, Suxia Luo, Kongming Wu
Summary: Exosomes, as a new type of liquid biopsy, have the potential to be diagnostic or prognostic biomarkers by delivering cargos including nucleic acids and protein, involving in tumorigenesis, tumor growth, metastasis, and drug resistance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, Research & Experimental
Chang Qi, Xian-Zhi Xiong
Summary: This study aimed to investigate the use of circulating tumor cell (CTC) detection in the early diagnosis and prediction of severity of thoracic diseases. The presence of CTCs was significantly correlated with disease metastasis and staging, but it could not differentiate benign and malignant diseases.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Kopystecka, Rafal Patryn, Magdalena Lesniewska, Julia Budzynska, Ilona Koziol
Summary: Hepatocellular carcinoma (HCC) is a common primary liver cancer with a poor prognosis. Imaging and liver biopsy have limitations in detecting small nodules and atypical features. Liquid biopsy and molecular analysis provide new biomarkers for early diagnosis and monitoring of HCC. ctDNA testing can benefit patients with liver and biliary malignancies, indicating personalized cancer treatment based on specific tumor DNA mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Effat Alemzadeh, Leila Allahqoli, Hamideh Dehghan, Afrooz Mazidimoradi, Alireza Ghasempour, Hamid Salehiniya
Summary: Liquid biopsy, which includes circulating tumor cells and circulating tumor DNA, is increasingly popular in diagnosing and managing breast cancer. These biomarkers can be used as markers for cancer progression and understanding metastasis and treatment resistance, providing a non-invasive method for cancer assessment and monitoring. However, more studies are needed to confirm its clinical usage in cancer diagnosis among patients. This review focuses on the application of circulating tumor biomarkers, particularly in breast cancer.
Review
Biochemistry & Molecular Biology
Grazia Menna, Giacomo Piaser Guerrato, Lal Bilgin, Giovanni Maria Ceccarelli, Alessandro Olivi, Giuseppe Maria Della Pepa
Summary: The lack of studies on liquid biopsy for brain tumors indicates that it is currently not widely used in the field of central nervous system cancers. This systematic review focuses on the application of machine learning to liquid biopsy for brain tumors, aiming to provide practical guidance for neurosurgeons and explore potential challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lu Chang, Jinming Li, Rui Zhang
Summary: Liquid biopsy, as an innovative method for early cancer diagnosis, has the potential to be a promising biomarker for non-invasive detection, especially for the early detection of NSCLC. It allows for the extraction of malignant features from body fluids that are not present in primary tumors, reducing the need for invasive treatments.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Chemistry, Analytical
Fulai Li, Hengyi Xu, Yufen Zhao
Summary: As a new type of liquid biopsy, circulating tumor cell (CTC) detection and analysis offer the possibility of real-time monitoring of metastatic development, cancer recurrence, and therapeutic efficacy. The rarity and heterogeneity of CTCs present great challenges, and magnetic particle-based methods show promise for effective CTC capture. Progress has been made in utilizing magnetic particles to enhance CTC capture, which is crucial for cancer diagnosis and prognosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Noemi Laprovitera, Irene Salamon, Francesco Gelsomino, Elisa Porcellini, Mattia Riefolo, Marianna Garonzi, Paola Tononi, Sabrina Valente, Silvia Sabbioni, Francesca Fontana, Nicolo Manaresi, Antonia D'Errico, Maria A. Pantaleo, Andrea Ardizzoni, Manuela Ferracin
Summary: Cancers of unknown primary (CUP) are rare metastatic tumors where targeted therapies could be proposed based on potentially druggable alterations in the CUP genome. Non-invasive liquid biopsy testing using circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) is feasible to identify actionable mutations in CUP cases with broad NGS panels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Saife N. Lone, Sabah Nisar, Tariq Masoodi, Mayank Singh, Arshi Rizwan, Sheema Hashem, Wael El-Rifai, Davide Bedognetti, Surinder K. Batra, Mohammad Haris, Ajaz A. Bhat, Muzafar A. Macha
Summary: Liquid biopsies are non-invasive methods that have revolutionized cancer diagnosis and monitoring. By analyzing tumor-derived entities in body fluids, liquid biopsies provide detailed information about tumor characteristics and can be used for detection, prognosis, and treatment monitoring.