Article
Ophthalmology
Neeta S. Roy, Yi Wei, Gui-Shuang Ying, Maureen G. Maguire, Penny A. Asbell
Summary: The purpose of this study was to describe tear concentrations of IL-1 beta, Il-6, IL-8, IL-10, IL-17A, IFN gamma and TNF alpha in subjects with dry eye disease (DED) and their correlation with symptoms and signs. The results showed that IL-10, IL-17A, and IFN gamma were highly correlated with each other, but weakly correlated with certain DED signs. Further studies are needed to confirm and establish the pathological and clinical relevance of tear cytokines in DED.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Cindy S. Zhao, Yineng Chen, Gui-Shuang Ying, Penny A. Asbell
Summary: The study aimed to assess the relationship between tear inflammatory cytokine ratios and dry eye disease, and found weak correlations between some ratios and certain signs of dry eye disease, but not with symptoms.
CURRENT EYE RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Liandi Huang, Huanhuan Gao, Zhigang Wang, Yixin Zhong, Lan Hao, Zhiyu Du
Summary: The study successfully synthesized PFOB@LIP-Tet, which effectively treats dry eye disease through anti-inflammation with minimal impact on intraocular pressure.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Mojtaba Heydari, Mehdi Kalani, Younes Ghasemi, Mahmood Nejabat
Summary: This study evaluated the efficacy and safety of Latilactobacillus sakei as an ophthalmic bacterial lysate or oral probiotic on patients with dry eye disease (DED). Results showed that the ophthalmic drops significantly decreased DED signs and symptoms, while the oral capsules had no effect. The ophthalmic formulation containing L. sakei lysate improved DED and suppressed ocular surface inflammatory response.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Ophthalmology
Ramaraj Kannan, Samayitree Das, Rohit Shetty, Lei Zhou, Arkasubhra Ghosh, Vrushali Deshpande
Summary: Dry eye disease is a complex ocular surface condition characterized by compromised ocular lubrication and inflammation, resulting in itching, dryness, and vision impairment. Current treatments primarily focus on alleviating the symptoms, but the underlying etiology and diverse symptoms of the disease remain an area of active research. Proteomics has played a significant role in understanding the molecular changes and causative mechanisms of dry eye disease, particularly by identifying alterations in protein expression profiles in tears.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Biochemistry & Molecular Biology
M. Elizabeth Fini, Shinwu Jeong, Mark R. Wilson
Summary: Evidence supports the potential of the glycoprotein CLU as a novel therapeutic for dry eye, protecting and repairing the ocular surface while dampening the autoimmune response. Future work will focus on human clinical trials to further investigate the therapeutic promise of CLU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Ophthalmology
Valentin Navel, Vincent Sapin, Fanny Henrioux, Loic Blanchon, Antoine Labbe, Frederic Chiambaretta, Christophe Baudouin, Frederic Dutheil
Summary: The study revealed that levels of oxidative stress markers in patients with dry eye disease (DED) were significantly higher compared to healthy controls, while levels of antioxidants may be decreased. These findings suggest that oxidative stress markers are dysregulated in DED, leading to a local oxidative environment in tears, conjunctival cells, and tissues.
ACTA OPHTHALMOLOGICA
(2022)
Review
Pharmacology & Pharmacy
Lifei Yu, Chunjing Yu, He Dong, Yanan Mu, Rui Zhang, Qiaosi Zhang, Wei Liang, Wenjia Li, Xun Wang, Lijun Zhang
Summary: Dry eye disease is a common ophthalmology condition with increasing incidence, and immune inflammation is recognized as the core basis of the disease. This review systematically examines previous research on treating dry eye disease with immune inflammation, analyzing the latest viewpoints and research hotspots to provide references for prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gaia Favero, Enrico Moretti, Kristina Krajcikova, Vladimira Tomeckova, Rita Rezzani
Summary: Dry eye disease is a multifactorial pathology that affects the quality of life of patients, with current therapeutic strategies being unable to fully address the underlying causes. Polyphenols show promise in counteracting the main pathologic mechanisms of dry eye disease, reducing inflammation, oxidative stress, and apoptosis, and modulating tear film to potentially develop new ophthalmic drugs for treating the condition effectively and safely.
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Gun Tae Jung, Minha Kim, Jong Suk Song, Tae Im Kim, Tae Young Chung, Chul Young Choi, Hyun Seong Kim, Woo Ju An, Su Jin Jeong, Hye Sun Lee, Soyoung Jeon, Kwang Pyo Kim, Hyung Keun Lee
Summary: The study aimed to identify specific tear biomarkers for dry eye disease (DED) through tear proteomic analysis and clinical parameters. The results showed improvements in tear break-up time, corneal erosion, conjunctival erosion, and symptom assessment scores after treatment. However, no significant differences were found among the different drug groups, except for corneal erosion score. Useful tear protein biomarkers, clinically acceptable biomarker combinations, and adequate levels of specificity and sensitivity were not identified.
Article
Ophthalmology
Zhi-zheng Li, Yan-ping Zou, Hui Zhu, Wei-zhen Zeng, Yi Ding, Jia-zeng Su, Guang-yan Yu
Summary: The purpose of this study was to establish a Beagle dog model of dry eye disease (DED). The DED models were induced by surgical removal of orbital lacrimal glands and entire resection of third eyelids in the left eyes of six Beagle dogs. The results showed that signs of DED appeared within one month after surgery and remained stable over time. The surgery-induced Beagle dog DED model is easily accessible and stable over a relatively long time.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Qiankun Chen, Zhengjiang Wei, Leying Wang, Xizhan Xu, Zhenyu Wei, Panpan Zheng, Kai Cao, Zijun Zhang, Kexin Chen, Qingfeng Liang
Summary: Patients with schizophrenia are more likely to experience asymptomatic dry eye disease, with mild symptoms and obvious signs. The inflammatory cytokines in the tears of schizophrenic patients differed greatly from that of non-schizophrenic patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ming-Tse Kuo, Po-Chiung Fang, Shu-Fang Kuo, Alexander Chen, Yu-Ting Huang
Summary: Most studies on dry eye disease have focused on investigating one eye and drawing conclusions based on monocular results, while studies on tear proteomics have typically involved pooling tears from multiple DED patients. However, research has shown that the ocular surface performance and tear proteome of both eyes in DED patients may display both similarities and differences. It is important to consider the differences in ocular surface homeostasis markers and associations with tear proteins between bilateral eyes when conducting studies on tear film homeostasis of DED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Gairik Kundu, Rohit Shetty, Sharon D'Souza, Bhavya Gorimanipalli, Ameeta Koul, Swaminathan Sethu
Summary: This study investigates the effects of maqui-berry extract (MBE) in improving signs and symptoms of dry eye disease (DED) and ocular surface inflammation in patients with DED. The results show that consumption of MBE can alleviate DED symptoms and reduce ocular surface inflammation.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Fiona Buckmaster, E. Ian Pearce
Article
Ophthalmology
Ali A. Abusharha, E. Ian Pearce, Raied Fagehi
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2016)
Review
Ophthalmology
C. Willshire, A. J. Bron, E. A. Gaffney, E. Ian Pearce
PROGRESS IN RETINAL AND EYE RESEARCH
(2018)
Article
Ophthalmology
Louise C. McCann, Alan Tomlinson, Edward I. Pearce, Vincenzo Papa
Article
Medicine, Research & Experimental
Glyn Walsh, E. Ian Pearce
MEDICAL HYPOTHESES
(2010)
Article
Ophthalmology
Saleh Alshammeri, Louise Madden, Suzanne Hagan, E. Ian Pearce
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2020)
Article
Ophthalmology
Ali Abusharha, Ian E. Pearce, Tayyaba Afsar, Ali Alsaqr, Raied Fagehi, Suhail Razak
Summary: This study aimed to evaluate the efficacy of hydroxypropyl guar (HP) formulation (Systane) in protecting tear film parameters in a desiccating environment, using both protection and relief treatment modalities. The subjects were exposed to adverse environmental conditions in a Controlled Environment Chamber (CEC) with 5% relative humidity (RH) and 21 degrees C ambient temperature, and their tear film parameters were evaluated. The results showed that HP-Guar significantly improved tear film parameters, except for tear evaporation rate, under a desiccating environment. Therefore, the use of HP-Guar eye drops can effectively protect tear film under adverse environmental conditions.
Article
Ophthalmology
Nikhil Sharma, Eilidh Martin, Edward Ian Pearce, Suzanne Hagan, Christine Purslow
Summary: This study investigated the knowledge, attitudes, and practice of optometrists in India towards Demodex blepharitis. The results showed that only 30% of surveyed optometrists were willing to intervene in diagnosing and managing Demodex blepharitis. The study suggests that Demodex blepharitis is an underdiagnosed condition in India.
CLINICAL OPTOMETRY
(2023)
Article
Medicine, General & Internal
Ali Abusharha, E. Ian Pearce, Tayyaba Afsar, Suhail Razak
Summary: This study evaluated the efficacy of a formulation containing TSP/HA in treating dry-eye symptoms. The results showed that TSP/HA eye drops can protect tear-film parameters and improve tear stability in a dry environment.
MEDICINA-LITHUANIA
(2023)
Article
Ophthalmology
Raied Fagehi, E. Ian Pearce, Katherine Oliver, Ali A. Abusharha, Alan Tomlinson
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2017)
Meeting Abstract
Ophthalmology
Saleh Alshammeri, Suzanne Hagan, Louise Madden, Ian Pearce
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Meeting Abstract
Ophthalmology
Suzanne Hagan, Eilidh Martin, Katherine Oliver, E. Ian Pearce
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Meeting Abstract
Ophthalmology
Eilidh Martin, Suzanne Hagan, Katherine Oliver, Ian Pearce, Alan Tomlinson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)
Article
Ophthalmology
Alan Tomlinson, Anthony J. Bron, Donald R. Korb, Shiro Amano, Jerry R. Paugh, E. Ian Pearce, Richard Yee, Norihiko Yokoi, Reiko Arita, Murat Dogru
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.